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Compile Data Set for Download or QSAR

Found 79 hits Enz. Inhib. hit(s) with Target = 'Ghrelin receptor' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ghrelin receptor


(Rattus norvegicus)
BDBM50096215
PNG
(CHEMBL3593815)
Show SMILES Cc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C#CC(C)(C)O)cc1C(F)F
Show InChI InChI=1S/C35H51N5O7/c1-5-22(2)32-31(43)21-39-18-12-11-16-29(39)35(46)36-26(14-7-6-8-17-30(42)23(3)41)33(44)37-27(34(45)38-32)19-24-20-40(47-4)28-15-10-9-13-25(24)28/h9-10,13,15,20,22-23,26-27,29,32,41H,5-8,11-12,14,16-19,21H2,1-4H3,(H,36,46)(H,37,44)(H,38,45)/t22?,23?,26-,27-,29+,32-/m0/s1
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n/an/a 0.280n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096217
PNG
(CHEMBL3593632)
Show SMILES CC(=O)N1C[C@H]2CC[C@@H]1CC(=C2)c1cnc(NCc2ccc3CCOc3c2)c(c1)C(=O)NC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C34H49N5O7/c1-5-22(2)31-29(40)21-38-18-12-11-16-28(38)34(44)35-25(14-7-6-8-17-30(41)45-3)32(42)36-26(33(43)37-31)19-23-20-39(46-4)27-15-10-9-13-24(23)27/h9-10,13,15,20,22,25-26,28,31H,5-8,11-12,14,16-19,21H2,1-4H3,(H,35,44)(H,36,42)(H,37,43)/t22?,25-,26-,28+,31-/m0/s1
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n/an/a 0.960n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50312778
PNG
((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Show SMILES C[C@H]1CN(CCN1C(=O)c1ccc2cc[nH]c2c1)C(=O)c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C27H24FN3O2/c1-18-17-30(14-15-31(18)27(33)22-11-8-20-12-13-29-25(20)16-22)26(32)21-9-6-19(7-10-21)23-4-2-3-5-24(23)28/h2-13,16,18,29H,14-15,17H2,1H3/t18-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence a...


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096218
PNG
(CHEMBL3593633)
Show SMILES CC(=O)N1C[C@H]2CC[C@@H]1CC(=C2)c1cnc(NCc2ccc3CCOc3c2)c(c1)C(=O)NCCOc1ccccc1
Show InChI InChI=1S/C35H49N5O7/c1-5-22(2)32-31(43)21-39-18-12-11-16-29(39)35(46)36-26(14-7-6-8-17-30(42)23(3)41)33(44)37-27(34(45)38-32)19-24-20-40(47-4)28-15-10-9-13-25(24)28/h9-10,13,15,20,22,26-27,29,32H,5-8,11-12,14,16-19,21H2,1-4H3,(H,36,46)(H,37,44)(H,38,45)/t22?,26-,27-,29+,32-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094223
PNG
(CHEMBL3586033)
Show SMILES CC(C)N1[C@@H]2CC[C@H]1C=C(C2)c1cnc(NCc2ccc3CCOc3c2)c(c1)C(=O)NC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C28H44O2/c1-4-6-8-20(5-2)9-7-16-28(30)18-15-26-25-12-10-21-19-22(29)11-13-23(21)24(25)14-17-27(26,28)3/h11,13,19-20,24-26,29-30H,4-10,12,14-18H2,1-3H3/t20?,24?,25?,26?,27-,28-/m0/s1
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n/an/a 4.10n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50097492
PNG
(CHEMBL3586019)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
Show InChI InChI=1/C79H109N19O12/c1-46(2)38-59(68(83)100)91-70(102)60(39-47(3)4)92-73(105)64(43-51-45-88-56-28-14-12-25-53(51)56)95-72(104)61(40-48-20-7-5-8-21-48)93-74(106)63(42-50-44-87-55-27-13-11-24-52(50)55)94-69(101)57(32-33-67(82)99)89-71(103)62(41-49-22-9-6-10-23-49)96-76(108)66-31-19-37-98(66)78(110)58(29-15-16-34-80)90-75(107)65-30-18-36-97(65)77(109)54(81)26-17-35-86-79(84)85/h5-14,20-25,27-28,44-47,54,57-66,87-88H,15-19,26,29-43,80-81H2,1-4H3,(H2,82,99)(H2,83,100)(H,89,103)(H,90,107)(H,91,102)(H,92,105)(H,93,106)(H,94,101)(H,95,104)(H,96,108)(H4,84,85,86)/t54-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-/s2
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n/an/a 5.20n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096215
PNG
(CHEMBL3593815)
Show SMILES Cc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C#CC(C)(C)O)cc1C(F)F
Show InChI InChI=1S/C35H51N5O7/c1-5-22(2)32-31(43)21-39-18-12-11-16-29(39)35(46)36-26(14-7-6-8-17-30(42)23(3)41)33(44)37-27(34(45)38-32)19-24-20-40(47-4)28-15-10-9-13-25(24)28/h9-10,13,15,20,22-23,26-27,29,32,41H,5-8,11-12,14,16-19,21H2,1-4H3,(H,36,46)(H,37,44)(H,38,45)/t22?,23?,26-,27-,29+,32-/m0/s1
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n/an/a 5.40n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096216
PNG
(CHEMBL3593636)
Show SMILES COc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C2=C[C@@H]3CC[C@H](C2)N(C3)C(C)=O)cc1Cl
Show InChI InChI=1S/C34H49N5O6S/c1-5-22(2)31-30(41)21-38-17-11-10-16-29(38)34(44)35-26(14-7-6-12-18-46-23(3)40)32(42)36-27(33(43)37-31)19-24-20-39(45-4)28-15-9-8-13-25(24)28/h8-9,13,15,20,22,26-27,29,31H,5-7,10-12,14,16-19,21H2,1-4H3,(H,35,44)(H,36,42)(H,37,43)/t22?,26-,27-,29+,31-/m0/s1
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n/an/a 5.60n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096220
PNG
(CHEMBL3593635)
Show SMILES COc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3CCOc3c2)C2=C[C@@H]3CC[C@H](C2)N(C3)C(C)=O)cc1Cl
Show InChI InChI=1S/C35H50FN5O6/c1-5-22(3)32-31(43)21-40-18-12-11-17-29(40)35(46)37-26(15-9-8-14-25(36)30(42)6-2)33(44)38-27(34(45)39-32)19-23-20-41(47-4)28-16-10-7-13-24(23)28/h7,10,13,16,20,22,25-27,29,32H,5-6,8-9,11-12,14-15,17-19,21H2,1-4H3,(H,37,46)(H,38,44)(H,39,45)/t22?,25?,26-,27-,29+,32-/m0/s1
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n/an/a 5.90n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096214
PNG
(CHEMBL3593814)
Show SMILES COc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C#CC(C)(C)NC(C)=O)cc1Cl
Show InChI InChI=1S/C33H49N5O5S/c1-5-22(2)30-29(39)21-37-17-11-10-16-28(37)33(42)34-25(14-7-6-12-18-44-4)31(40)35-26(32(41)36-30)19-23-20-38(43-3)27-15-9-8-13-24(23)27/h8-9,13,15,20,22,25-26,28,30H,5-7,10-12,14,16-19,21H2,1-4H3,(H,34,42)(H,35,40)(H,36,41)/t22?,25-,26-,28+,30-/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096219
PNG
(CHEMBL3593634)
Show SMILES CC(=O)N1C[C@H]2CC[C@@H]1CC(=C2)c1cnc(NCc2ccc3OCOc3c2)c(c1)C(=O)NCCOc1ccccc1
Show InChI InChI=1S/C35H50FN5O6/c1-5-22(2)32-31(43)21-40-18-12-11-16-29(40)35(46)37-26(14-7-6-8-17-30(42)23(3)36)33(44)38-27(34(45)39-32)19-24-20-41(47-4)28-15-10-9-13-25(24)28/h9-10,13,15,20,22-23,26-27,29,32H,5-8,11-12,14,16-19,21H2,1-4H3,(H,37,46)(H,38,44)(H,39,45)/t22?,23?,26-,27-,29+,32-/m0/s1
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n/an/a 9.10n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096220
PNG
(CHEMBL3593635)
Show SMILES COc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3CCOc3c2)C2=C[C@@H]3CC[C@H](C2)N(C3)C(C)=O)cc1Cl
Show InChI InChI=1S/C35H50FN5O6/c1-5-22(3)32-31(43)21-40-18-12-11-17-29(40)35(46)37-26(15-9-8-14-25(36)30(42)6-2)33(44)38-27(34(45)39-32)19-23-20-41(47-4)28-16-10-7-13-24(23)28/h7,10,13,16,20,22,25-27,29,32H,5-6,8-9,11-12,14-15,17-19,21H2,1-4H3,(H,37,46)(H,38,44)(H,39,45)/t22?,25?,26-,27-,29+,32-/m0/s1
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n/an/a 9.40n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096216
PNG
(CHEMBL3593636)
Show SMILES COc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C2=C[C@@H]3CC[C@H](C2)N(C3)C(C)=O)cc1Cl
Show InChI InChI=1S/C34H49N5O6S/c1-5-22(2)31-30(41)21-38-17-11-10-16-29(38)34(44)35-26(14-7-6-12-18-46-23(3)40)32(42)36-27(33(43)37-31)19-24-20-39(45-4)28-15-9-8-13-25(24)28/h8-9,13,15,20,22,26-27,29,31H,5-7,10-12,14,16-19,21H2,1-4H3,(H,35,44)(H,36,42)(H,37,43)/t22?,26-,27-,29+,31-/m0/s1
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n/an/a 9.80n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096215
PNG
(CHEMBL3593815)
Show SMILES Cc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C#CC(C)(C)O)cc1C(F)F
Show InChI InChI=1S/C35H51N5O7/c1-5-22(2)32-31(43)21-39-18-12-11-16-29(39)35(46)36-26(14-7-6-8-17-30(42)23(3)41)33(44)37-27(34(45)38-32)19-24-20-40(47-4)28-15-10-9-13-25(24)28/h9-10,13,15,20,22-23,26-27,29,32,41H,5-8,11-12,14,16-19,21H2,1-4H3,(H,36,46)(H,37,44)(H,38,45)/t22?,23?,26-,27-,29+,32-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secret...


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50153528
PNG
(5-(2-Benzo[1,3]dioxol-5-yl-ethyl)-3-(2,6-dichloro-...)
Show SMILES CCN(CC)[C@H]1CC[C@@H](CC1)NC(=O)c1c(CCc2ccc3OCOc3c2)onc1-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C29H33Cl2N3O4/c1-3-34(4-2)20-12-10-19(11-13-20)32-29(35)27-24(15-9-18-8-14-23-25(16-18)37-17-36-23)38-33-28(27)26-21(30)6-5-7-22(26)31/h5-8,14,16,19-20H,3-4,9-13,15,17H2,1-2H3,(H,32,35)/t19-,20-
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n/an/a 12n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat Growth hormone secretagogue receptor


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096215
PNG
(CHEMBL3593815)
Show SMILES Cc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C#CC(C)(C)O)cc1C(F)F
Show InChI InChI=1S/C35H51N5O7/c1-5-22(2)32-31(43)21-39-18-12-11-16-29(39)35(46)36-26(14-7-6-8-17-30(42)23(3)41)33(44)37-27(34(45)38-32)19-24-20-40(47-4)28-15-10-9-13-25(24)28/h9-10,13,15,20,22-23,26-27,29,32,41H,5-8,11-12,14,16-19,21H2,1-4H3,(H,36,46)(H,37,44)(H,38,45)/t22?,23?,26-,27-,29+,32-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellula...


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096214
PNG
(CHEMBL3593814)
Show SMILES COc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C#CC(C)(C)NC(C)=O)cc1Cl
Show InChI InChI=1S/C33H49N5O5S/c1-5-22(2)30-29(39)21-37-17-11-10-16-28(37)33(42)34-25(14-7-6-12-18-44-4)31(40)35-26(32(41)36-30)19-23-20-38(43-3)27-15-9-8-13-24(23)27/h8-9,13,15,20,22,25-26,28,30H,5-7,10-12,14,16-19,21H2,1-4H3,(H,34,42)(H,35,40)(H,36,41)/t22?,25-,26-,28+,30-/m0/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096218
PNG
(CHEMBL3593633)
Show SMILES CC(=O)N1C[C@H]2CC[C@@H]1CC(=C2)c1cnc(NCc2ccc3CCOc3c2)c(c1)C(=O)NCCOc1ccccc1
Show InChI InChI=1S/C35H49N5O7/c1-5-22(2)32-31(43)21-39-18-12-11-16-29(39)35(46)36-26(14-7-6-8-17-30(42)23(3)41)33(44)37-27(34(45)38-32)19-24-20-40(47-4)28-15-10-9-13-25(24)28/h9-10,13,15,20,22,26-27,29,32H,5-8,11-12,14,16-19,21H2,1-4H3,(H,36,46)(H,37,44)(H,38,45)/t22?,26-,27-,29+,32-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096216
PNG
(CHEMBL3593636)
Show SMILES COc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C2=C[C@@H]3CC[C@H](C2)N(C3)C(C)=O)cc1Cl
Show InChI InChI=1S/C34H49N5O6S/c1-5-22(2)31-30(41)21-38-17-11-10-16-29(38)34(44)35-26(14-7-6-12-18-46-23(3)40)32(42)36-27(33(43)37-31)19-24-20-39(45-4)28-15-9-8-13-25(24)28/h8-9,13,15,20,22,26-27,29,31H,5-7,10-12,14,16-19,21H2,1-4H3,(H,35,44)(H,36,42)(H,37,43)/t22?,26-,27-,29+,31-/m0/s1
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n/an/a 33n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secret...


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096214
PNG
(CHEMBL3593814)
Show SMILES COc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C#CC(C)(C)NC(C)=O)cc1Cl
Show InChI InChI=1S/C33H49N5O5S/c1-5-22(2)30-29(39)21-37-17-11-10-16-28(37)33(42)34-25(14-7-6-12-18-44-4)31(40)35-26(32(41)36-30)19-23-20-38(43-3)27-15-9-8-13-24(23)27/h8-9,13,15,20,22,25-26,28,30H,5-7,10-12,14,16-19,21H2,1-4H3,(H,34,42)(H,35,40)(H,36,41)/t22?,25-,26-,28+,30-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellula...


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096214
PNG
(CHEMBL3593814)
Show SMILES COc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C#CC(C)(C)NC(C)=O)cc1Cl
Show InChI InChI=1S/C33H49N5O5S/c1-5-22(2)30-29(39)21-37-17-11-10-16-28(37)33(42)34-25(14-7-6-12-18-44-4)31(40)35-26(32(41)36-30)19-23-20-38(43-3)27-15-9-8-13-24(23)27/h8-9,13,15,20,22,25-26,28,30H,5-7,10-12,14,16-19,21H2,1-4H3,(H,34,42)(H,35,40)(H,36,41)/t22?,25-,26-,28+,30-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secret...


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096217
PNG
(CHEMBL3593632)
Show SMILES CC(=O)N1C[C@H]2CC[C@@H]1CC(=C2)c1cnc(NCc2ccc3CCOc3c2)c(c1)C(=O)NC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C34H49N5O7/c1-5-22(2)31-29(40)21-38-18-12-11-16-28(38)34(44)35-25(14-7-6-8-17-30(41)45-3)32(42)36-26(33(43)37-31)19-23-20-39(46-4)27-15-10-9-13-24(23)27/h9-10,13,15,20,22,25-26,28,31H,5-8,11-12,14,16-19,21H2,1-4H3,(H,35,44)(H,36,42)(H,37,43)/t22?,25-,26-,28+,31-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094224
PNG
(CHEMBL3586032)
Show SMILES CC(=O)N1[C@@H]2CC[C@H]1C=C(C2)c1cnc(NCc2ccc3CCOc3c2)c(c1)C(=O)NC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C28H44O2/c1-3-4-5-6-7-8-9-10-17-28(30)19-16-26-25-13-11-21-20-22(29)12-14-23(21)24(25)15-18-27(26,28)2/h12,14,20,24-26,29-30H,3-11,13,15-19H2,1-2H3/t24?,25?,26?,27-,28-/m0/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50049481
PNG
((R)-N-(1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)meth...)
Show SMILES CC(C)(N)CC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C1=O
Show InChI InChI=1S/C29H31N7O2/c1-29(2,30)17-26(37)31-24-16-15-21-7-3-6-10-25(21)36(28(24)38)18-19-11-13-20(14-12-19)22-8-4-5-9-23(22)27-32-34-35-33-27/h3-14,24H,15-18,30H2,1-2H3,(H,31,37)(H,32,33,34,35)/t24-/m1/s1
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n/an/a 60n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Inhibition of the compound against rat growth hormone secretagogue (GHS) receptor


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096219
PNG
(CHEMBL3593634)
Show SMILES CC(=O)N1C[C@H]2CC[C@@H]1CC(=C2)c1cnc(NCc2ccc3OCOc3c2)c(c1)C(=O)NCCOc1ccccc1
Show InChI InChI=1S/C35H50FN5O6/c1-5-22(2)32-31(43)21-40-18-12-11-16-29(40)35(46)37-26(14-7-6-8-17-30(42)23(3)36)33(44)38-27(34(45)39-32)19-24-20-41(47-4)28-15-10-9-13-25(24)28/h9-10,13,15,20,22-23,26-27,29,32H,5-8,11-12,14,16-19,21H2,1-4H3,(H,37,46)(H,38,44)(H,39,45)/t22?,23?,26-,27-,29+,32-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50096216
PNG
(CHEMBL3593636)
Show SMILES COc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C2=C[C@@H]3CC[C@H](C2)N(C3)C(C)=O)cc1Cl
Show InChI InChI=1S/C34H49N5O6S/c1-5-22(2)31-30(41)21-38-17-11-10-16-29(38)34(44)35-26(14-7-6-12-18-46-23(3)40)32(42)36-27(33(43)37-31)19-24-20-39(45-4)28-15-9-8-13-25(24)28/h8-9,13,15,20,22,26-27,29,31H,5-7,10-12,14,16-19,21H2,1-4H3,(H,35,44)(H,36,42)(H,37,43)/t22?,26-,27-,29+,31-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellula...


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094230
PNG
(CHEMBL3586026)
Show SMILES CCn1cc(cn1)-c1cnc(NCc2ccc3OCOc3c2)c(c1)C(=O)NC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C15H12N2O2/c1-19-11-6-4-5-10(9-11)14-16-13-8-3-2-7-12(13)15(18)17-14/h2-9H,1H3,(H,16,17,18)
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n/an/a 110n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094233
PNG
(CHEMBL3586023)
Show SMILES CCCn1cc(cn1)-c1cnc(NCc2ccc3CCOc3c2)c(c1)C(=O)NCC1COc2ccccc2O1
Show InChI InChI=1/C30H31N5O4/c1-2-10-35-18-23(16-34-35)22-13-25(30(36)33-17-24-19-38-26-5-3-4-6-27(26)39-24)29(32-15-22)31-14-20-7-8-21-9-11-37-28(21)12-20/h3-8,12-13,15-16,18,24H,2,9-11,14,17,19H2,1H3,(H,31,32)(H,33,36)
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n/an/a 140n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50097492
PNG
(CHEMBL3586019)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
Show InChI InChI=1/C79H109N19O12/c1-46(2)38-59(68(83)100)91-70(102)60(39-47(3)4)92-73(105)64(43-51-45-88-56-28-14-12-25-53(51)56)95-72(104)61(40-48-20-7-5-8-21-48)93-74(106)63(42-50-44-87-55-27-13-11-24-52(50)55)94-69(101)57(32-33-67(82)99)89-71(103)62(41-49-22-9-6-10-23-49)96-76(108)66-31-19-37-98(66)78(110)58(29-15-16-34-80)90-75(107)65-30-18-36-97(65)77(109)54(81)26-17-35-86-79(84)85/h5-14,20-25,27-28,44-47,54,57-66,87-88H,15-19,26,29-43,80-81H2,1-4H3,(H2,82,99)(H2,83,100)(H,89,103)(H,90,107)(H,91,102)(H,92,105)(H,93,106)(H,94,101)(H,95,104)(H,96,108)(H4,84,85,86)/t54-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-/s2
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n/an/a 146n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094232
PNG
(CHEMBL3586024)
Show SMILES CCCn1cc(cn1)-c1cnc(NCc2ccc3OCOc3c2)c(c1)C(=O)NCC1COc2ccccc2O1
Show InChI InChI=1/C29H29N5O5/c1-2-9-34-16-21(14-33-34)20-11-23(29(35)32-15-22-17-36-24-5-3-4-6-26(24)39-22)28(31-13-20)30-12-19-7-8-25-27(10-19)38-18-37-25/h3-8,10-11,13-14,16,22H,2,9,12,15,17-18H2,1H3,(H,30,31)(H,32,35)
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n/an/a 170n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50097492
PNG
(CHEMBL3586019)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
Show InChI InChI=1/C79H109N19O12/c1-46(2)38-59(68(83)100)91-70(102)60(39-47(3)4)92-73(105)64(43-51-45-88-56-28-14-12-25-53(51)56)95-72(104)61(40-48-20-7-5-8-21-48)93-74(106)63(42-50-44-87-55-27-13-11-24-52(50)55)94-69(101)57(32-33-67(82)99)89-71(103)62(41-49-22-9-6-10-23-49)96-76(108)66-31-19-37-98(66)78(110)58(29-15-16-34-80)90-75(107)65-30-18-36-97(65)77(109)54(81)26-17-35-86-79(84)85/h5-14,20-25,27-28,44-47,54,57-66,87-88H,15-19,26,29-43,80-81H2,1-4H3,(H2,82,99)(H2,83,100)(H,89,103)(H,90,107)(H,91,102)(H,92,105)(H,93,106)(H,94,101)(H,95,104)(H,96,108)(H4,84,85,86)/t54-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-/s2
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094227
PNG
(CHEMBL3586029)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1cnc(NCc2ccc3CCOc3c2)c(c1)C(=O)NC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C16H14N2O3/c1-20-11-7-10(8-12(9-11)21-2)15-17-14-6-4-3-5-13(14)16(19)18-15/h3-9H,1-2H3,(H,17,18,19)
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n/an/a 350n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094229
PNG
(CHEMBL3586027)
Show SMILES Clc1cc(ccn1)-c1cnc(NCc2ccc3CCOc3c2)c(c1)C(=O)NCC1COc2ccccc2O1
Show InChI InChI=1S/C19H19N3O2/c1-24-15-6-4-5-13(11-15)18-20-17-8-7-14(22-9-2-3-10-22)12-16(17)19(23)21-18/h4-8,11-12H,2-3,9-10H2,1H3,(H,20,21,23)
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n/an/a 390n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094236
PNG
(CHEMBL3586020)
Show SMILES CCCn1cc(cn1)-c1cnc(NCc2ccc3sccc3c2)c(c1)C(=O)NCC1COc2ccccc2O1
Show InChI InChI=1S/C17H16N2O4/c1-21-11-6-4-5-10(7-11)16-18-13-9-15(23-3)14(22-2)8-12(13)17(20)19-16/h4-9H,1-3H3,(H,18,19,20)
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094226
PNG
(CHEMBL3586030)
Show SMILES O=C(NC[C@H]1COc2ccccc2O1)c1cc(cnc1NCc1ccc2OCOc2c1)N1C[C@@H]2CC[C@H](C1)O2
Show InChI InChI=1S/C29H32O2/c1-28-15-13-25-24-12-10-22(30)17-20(24)9-11-26(25)27(28)14-16-29(28,31)18-21-7-4-6-19-5-2-3-8-23(19)21/h2-8,10,12,17,25-27,30-31H,9,11,13-16,18H2,1H3/t25?,26?,27?,28-,29+/m0/s1
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n/an/a 560n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094235
PNG
(CHEMBL3586021)
Show SMILES CCCn1cc(cn1)-c1cnc(NCc2ccc3occc3c2)c(c1)C(=O)NCC1COc2ccccc2O1
Show InChI InChI=1S/C21H23N3O2/c1-14-8-10-24(11-9-14)16-6-7-19-18(13-16)21(25)23-20(22-19)15-4-3-5-17(12-15)26-2/h3-7,12-14H,8-11H2,1-2H3,(H,22,23,25)
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n/an/a 720n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094234
PNG
(CHEMBL3586022)
Show SMILES CCCn1cc(cn1)-c1cnc(NCc2ccc3ncsc3c2)c(c1)C(=O)NCC1COc2ccccc2O1
Show InChI InChI=1S/C15H11FN2O2/c1-20-11-4-2-3-9(7-11)14-17-13-6-5-10(16)8-12(13)15(19)18-14/h2-8H,1H3,(H,17,18,19)
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n/an/a 900n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094228
PNG
(CHEMBL3586028)
Show SMILES O=C(NC[C@H]1COc2ccccc2O1)c1cc(cnc1NCc1ccc2OCOc2c1)N1CCOCC1
Show InChI InChI=1S/C17H17N3O2/c1-20(2)12-7-8-15-14(10-12)17(21)19-16(18-15)11-5-4-6-13(9-11)22-3/h4-10H,1-3H3,(H,18,19,21)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094225
PNG
(CHEMBL3586031)
Show SMILES CC(=O)N1CCC(=CC1)c1cnc(NCc2ccc3OCOc3c2)c(c1)C(=O)NC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C32H36O3/c1-31-17-15-28-27-14-10-25(33)19-24(27)9-13-29(28)30(31)16-18-32(31,34)20-22-7-11-26(12-8-22)35-21-23-5-3-2-4-6-23/h2-8,10-12,14,19,28-30,33-34H,9,13,15-18,20-21H2,1H3/t28?,29?,30?,31-,32+/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50094231
PNG
(CHEMBL3586025)
Show SMILES CCn1cc(cn1)-c1cnc(NCc2ccc3OCOc3c2)c(c1)C(=O)NC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C15H12N2O2/c1-19-13-9-5-3-7-11(13)14-16-12-8-4-2-6-10(12)15(18)17-14/h2-9H,1H3,(H,16,17,18)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50049478
PNG
(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CN(c3ccccc23)S(C)(=O)=O)CC1
Show InChI InChI=1S/C27H36N4O5S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27/h4-12,22H,13-19,28H2,1-3H3,(H,29,33)/t22-/m1/s1
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n/an/an/an/a 1.30n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro growth hormone release was determined in rat pituitary cell assay


Bioorg Med Chem Lett 8: 107-12 (1999)

More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50066812
PNG
((E)-5-Amino-5-methyl-hex-2-enoic acid ((R)-1-{[(R)...)
Show SMILES C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)\C=C\CC(C)(C)N
Show InChI InChI=1S/C34H44N4O4/c1-24(39)23-36-32(41)29(21-25-12-7-6-8-13-25)38(5)33(42)30(37(4)31(40)16-11-19-34(2,3)35)22-26-17-18-27-14-9-10-15-28(27)20-26/h6-18,20,24,29-30,39H,19,21-23,35H2,1-5H3,(H,36,41)/b16-11+/t24-,29-,30-/m1/s1
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n/an/an/an/a 8.90n/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Tested for GH-releasing property using classical rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50073033
PNG
(1N-[1-(1H-3-indolylmethyl)-2-oxo-2-[4-oxospiro[3,4...)
Show SMILES CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(C1)CC(=O)c1ccccc1O2
Show InChI InChI=1S/C28H32N4O4/c1-27(2,29)26(35)31-22(14-18-16-30-21-10-5-3-8-19(18)21)25(34)32-13-7-12-28(17-32)15-23(33)20-9-4-6-11-24(20)36-28/h3-6,8-11,16,22,30H,7,12-15,17,29H2,1-2H3,(H,31,35)/t22-,28?/m1/s1
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n/an/an/an/a 1.80n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro growth hormone release was determined in rat pituitary cell assay


Bioorg Med Chem Lett 8: 107-12 (1999)

More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50049481
PNG
((R)-N-(1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)meth...)
Show SMILES CC(C)(N)CC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C1=O
Show InChI InChI=1S/C29H31N7O2/c1-29(2,30)17-26(37)31-24-16-15-21-7-3-6-10-25(21)36(28(24)38)18-19-11-13-20(14-12-19)22-8-4-5-9-23(22)27-32-34-35-33-27/h3-14,24H,15-18,30H2,1-2H3,(H,31,37)(H,32,33,34,35)/t24-/m1/s1
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n/an/an/an/a 60n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro growth hormone release was determined in rat pituitary cell assay


Bioorg Med Chem Lett 8: 107-12 (1999)

More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50073034
PNG
(1N-[1-(1H-3-indolylmethyl)-2-oxo-2-spiro[3,4-dihyd...)
Show SMILES CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1
Show InChI InChI=1S/C28H34N4O3/c1-27(2,29)26(34)31-23(16-20-17-30-22-10-5-4-9-21(20)22)25(33)32-15-7-13-28(18-32)14-12-19-8-3-6-11-24(19)35-28/h3-6,8-11,17,23,30H,7,12-16,18,29H2,1-2H3,(H,31,34)/t23-,28?/m1/s1
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n/an/an/an/a 2.90n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro growth hormone release was determined in rat pituitary cell assay


Bioorg Med Chem Lett 8: 107-12 (1999)

More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50073035
PNG
(1N-[1-(1H-3-indolylmethyl)-2-oxo-2-[4-oxospiro[3,4...)
Show SMILES CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2
Show InChI InChI=1S/C28H32N4O4/c1-27(2,29)26(35)31-22(15-18-17-30-21-9-5-3-7-19(18)21)25(34)32-13-11-28(12-14-32)16-23(33)20-8-4-6-10-24(20)36-28/h3-10,17,22,30H,11-16,29H2,1-2H3,(H,31,35)/t22-/m1/s1
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n/an/an/an/a 37n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro growth hormone release was determined in rat pituitary cell assay


Bioorg Med Chem Lett 8: 107-12 (1999)

More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50073036
PNG
(1N-[2-[4-hydroxyspiro[3,4-dihydro-2H-chromene-2,3'...)
Show SMILES CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1
Show InChI InChI=1S/C28H34N4O4/c1-27(2,29)26(35)31-22(14-18-16-30-21-10-5-3-8-19(18)21)25(34)32-13-7-12-28(17-32)15-23(33)20-9-4-6-11-24(20)36-28/h3-6,8-11,16,22-23,30,33H,7,12-15,17,29H2,1-2H3,(H,31,35)/t22-,23?,28?/m1/s1
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n/an/an/an/a 1.20n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro growth hormone release was determined in rat pituitary cell assay


Bioorg Med Chem Lett 8: 107-12 (1999)

More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50066103
PNG
(1N-[1-(1H-3-indolylmethyl)-2-oxo-2-[4-oxo-(2'S)-sp...)
Show SMILES CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(C1)CC(=O)c1ccccc1O2
Show InChI InChI=1S/C28H32N4O4/c1-27(2,29)26(35)31-22(14-18-16-30-21-10-5-3-8-19(18)21)25(34)32-13-7-12-28(17-32)15-23(33)20-9-4-6-11-24(20)36-28/h3-6,8-11,16,22,30H,7,12-15,17,29H2,1-2H3,(H,31,35)/t22-,28+/m1/s1
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n/an/an/an/a 57n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro growth hormone release was determined in rat pituitary cell assay


Bioorg Med Chem Lett 8: 107-12 (1999)

More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50073038
PNG
(1N-[2-[1-hydroxyspiro[2,3-dihydro-1H-indene-2,4'-(...)
Show SMILES CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(Cc3ccccc3C2O)CC1
Show InChI InChI=1S/C28H34N4O3/c1-27(2,29)26(35)31-23(15-19-17-30-22-10-6-5-8-20(19)22)25(34)32-13-11-28(12-14-32)16-18-7-3-4-9-21(18)24(28)33/h3-10,17,23-24,30,33H,11-16,29H2,1-2H3,(H,31,35)/t23-,24?/m1/s1
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n/an/an/an/a 19n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro growth hormone release was determined in rat pituitary cell assay


Bioorg Med Chem Lett 8: 107-12 (1999)

More data for this
Ligand-Target Pair
Ghrelin receptor


(Rattus norvegicus)
BDBM50073040
PNG
(1N-[1-(1H-3-indolylmethyl)-2-oxo-2-spiro[2,3-dihyd...)
Show SMILES CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1
Show InChI InChI=1S/C28H34N4O2/c1-27(2,29)26(34)31-24(14-21-17-30-23-11-6-5-10-22(21)23)25(33)32-13-7-12-28(18-32)15-19-8-3-4-9-20(19)16-28/h3-6,8-11,17,24,30H,7,12-16,18,29H2,1-2H3,(H,31,34)/t24-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro growth hormone release was determined in rat pituitary cell assay


Bioorg Med Chem Lett 8: 107-12 (1999)

More data for this
Ligand-Target Pair
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