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Found 99 hits Enz. Inhib. hit(s) with Target = 'Glucagon receptor' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon receptor


(Mus musculus)
BDBM50075766
PNG
(4-[5-(4-Chloro-phenyl)-3-(2-propoxy-phenyl)-1H-pyr...)
Show SMILES CCCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H21ClN2O/c1-2-15-28-23-6-4-3-5-20(23)21-16-22(17-7-9-19(25)10-8-17)27-24(21)18-11-13-26-14-12-18/h3-14,16,27H,2,15H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075775
PNG
(4-[3-(5-Bromo-2-propoxy-phenyl)-5-(4-chloro-phenyl...)
Show SMILES CCCOc1ccc(Br)cc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H20BrClN2O/c1-2-13-29-23-8-5-18(25)14-20(23)21-15-22(16-3-6-19(26)7-4-16)28-24(21)17-9-11-27-12-10-17/h3-12,14-15,28H,2,13H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075787
PNG
(4-[3-(4-Bromo-2-propoxy-phenyl)-5-(4-chloro-phenyl...)
Show SMILES CCCOc1cc(Br)ccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H20BrClN2O/c1-2-13-29-23-14-18(25)5-8-20(23)21-15-22(16-3-6-19(26)7-4-16)28-24(21)17-9-11-27-12-10-17/h3-12,14-15,28H,2,13H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075783
PNG
(4-[5-(4-Chloro-phenyl)-3-(5-chloro-2-propoxy-pheny...)
Show SMILES CCCOc1ccc(Cl)cc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H20Cl2N2O/c1-2-13-29-23-8-7-19(26)14-20(23)21-15-22(16-3-5-18(25)6-4-16)28-24(21)17-9-11-27-12-10-17/h3-12,14-15,28H,2,13H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075748
PNG
(4-[5-(4-Chloro-phenyl)-3-cyclohexyl-1H-pyrrol-2-yl...)
Show SMILES Clc1ccc(cc1)-c1cc(C2CCCCC2)c([nH]1)-c1ccncc1
Show InChI InChI=1S/C21H21ClN2/c22-18-8-6-16(7-9-18)20-14-19(15-4-2-1-3-5-15)21(24-20)17-10-12-23-13-11-17/h6-15,24H,1-5H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075780
PNG
(4-[5-(4-Chloro-phenyl)-3-isopropyl-1H-pyrrol-2-yl]...)
Show SMILES CC(C)c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN2/c1-12(2)16-11-17(13-3-5-15(19)6-4-13)21-18(16)14-7-9-20-10-8-14/h3-12,21H,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075772
PNG
(4-[3-(2-Butoxy-phenyl)-5-(4-chloro-phenyl)-1H-pyrr...)
Show SMILES CCCCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H23ClN2O/c1-2-3-16-29-24-7-5-4-6-21(24)22-17-23(18-8-10-20(26)11-9-18)28-25(22)19-12-14-27-15-13-19/h4-15,17,28H,2-3,16H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007239
PNG
(CHEMBL3238226)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cncc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C33H43ClN8O2/c1-31(2,3)14-13-26(21-7-9-22(10-8-21)29(43)36-20-27-38-40-41-39-27)42-30(44)28(23-17-25(34)19-35-18-23)37-33(42)15-11-24(12-16-33)32(4,5)6/h7-10,17-19,24,26H,11-16,20H2,1-6H3,(H,36,43)(H,38,39,40,41)/t24-,26-,33-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007231
PNG
(CHEMBL3238221)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1ccc(F)cc1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C34H44FN7O2/c1-32(2,3)18-17-27(22-7-9-24(10-8-22)30(43)36-21-28-38-40-41-39-28)42-31(44)29(23-11-13-26(35)14-12-23)37-34(42)19-15-25(16-20-34)33(4,5)6/h7-14,25,27H,15-21H2,1-6H3,(H,36,43)(H,38,39,40,41)/t25-,27-,34-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007240
PNG
(CHEMBL3238228)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cnccc1C(F)(F)F)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C34H43F3N8O2/c1-31(2,3)15-13-26(21-7-9-22(10-8-21)29(46)39-20-27-41-43-44-42-27)45-30(47)28(24-19-38-18-14-25(24)34(35,36)37)40-33(45)16-11-23(12-17-33)32(4,5)6/h7-10,14,18-19,23,26H,11-13,15-17,20H2,1-6H3,(H,39,46)(H,41,42,43,44)/t23-,26-,33-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007228
PNG
(CHEMBL3238219)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cccc(F)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C34H44FN7O2/c1-32(2,3)17-16-27(22-10-12-23(13-11-22)30(43)36-21-28-38-40-41-39-28)42-31(44)29(24-8-7-9-26(35)20-24)37-34(42)18-14-25(15-19-34)33(4,5)6/h7-13,20,25,27H,14-19,21H2,1-6H3,(H,36,43)(H,38,39,40,41)/t25-,27-,34-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007223
PNG
(CHEMBL3238215)
Show SMILES CC(C)(C)[C@H]1CC[C@]2(CC1)N=C(C(=O)N2[C@H](CCC1(C)CC1)c1ccc(cc1)C(=O)NCc1nn[nH]n1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C34H41Cl2N7O2/c1-32(2,3)24-9-13-34(14-10-24)38-29(23-17-25(35)19-26(36)18-23)31(45)43(34)27(11-12-33(4)15-16-33)21-5-7-22(8-6-21)30(44)37-20-28-39-41-42-40-28/h5-8,17-19,24,27H,9-16,20H2,1-4H3,(H,37,44)(H,39,40,41,42)/t24-,27-,34-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007219
PNG
(CHEMBL3238214)
Show SMILES CC(C)(C)[C@H]1CC[C@]2(CC1)N=C(C(=O)N2[C@H](CCC(F)(F)F)c1ccc(cc1)C(=O)NCc1nn[nH]n1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C31H34Cl2F3N7O2/c1-29(2,3)21-8-11-30(12-9-21)38-26(20-14-22(32)16-23(33)15-20)28(45)43(30)24(10-13-31(34,35)36)18-4-6-19(7-5-18)27(44)37-17-25-39-41-42-40-25/h4-7,14-16,21,24H,8-13,17H2,1-3H3,(H,37,44)(H,39,40,41,42)/t21-,24-,30-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50360601
PNG
(CHEMBL1933349)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H27Cl2N3O4/c1-19(20-3-5-21(6-4-20)32(40)35-12-11-31(38)39)37-30(18-29(36-37)25-14-26(33)17-27(34)15-25)24-8-7-23-16-28(41-2)10-9-22(23)13-24/h3-10,13-19H,11-12H2,1-2H3,(H,35,40)(H,38,39)/t19-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucagon receptor


(Mus musculus)
BDBM50007296
PNG
(CHEMBL3238246)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C34H43Cl2N7O2/c1-32(2,3)14-13-27(21-7-9-22(10-8-21)30(44)37-20-28-39-41-42-40-28)43-31(45)29(23-17-25(35)19-26(36)18-23)38-34(43)15-11-24(12-16-34)33(4,5)6/h7-10,17-19,24,27H,11-16,20H2,1-6H3,(H,37,44)(H,39,40,41,42)/t24-,27-,34-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007226
PNG
(CHEMBL3238218)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cccc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C34H44ClN7O2/c1-32(2,3)17-16-27(22-10-12-23(13-11-22)30(43)36-21-28-38-40-41-39-28)42-31(44)29(24-8-7-9-26(35)20-24)37-34(42)18-14-25(15-19-34)33(4,5)6/h7-13,20,25,27H,14-19,21H2,1-6H3,(H,36,43)(H,38,39,40,41)/t25-,27-,34-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007225
PNG
(CHEMBL3238217)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(F)cc(F)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C34H43F2N7O2/c1-32(2,3)14-13-27(21-7-9-22(10-8-21)30(44)37-20-28-39-41-42-40-28)43-31(45)29(23-17-25(35)19-26(36)18-23)38-34(43)15-11-24(12-16-34)33(4,5)6/h7-10,17-19,24,27H,11-16,20H2,1-6H3,(H,37,44)(H,39,40,41,42)/t24-,27-,34-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007233
PNG
(CHEMBL3238223)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cccc(c1)C(F)(F)F)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C35H44F3N7O2/c1-32(2,3)17-16-27(22-10-12-23(13-11-22)30(46)39-21-28-41-43-44-42-28)45-31(47)29(24-8-7-9-26(20-24)35(36,37)38)40-34(45)18-14-25(15-19-34)33(4,5)6/h7-13,20,25,27H,14-19,21H2,1-6H3,(H,39,46)(H,41,42,43,44)/t25-,27-,34-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075752
PNG
(4-[5-(4-Chloro-phenyl)-3-(2-isobutoxy-phenyl)-1H-p...)
Show SMILES CC(C)COc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H23ClN2O/c1-17(2)16-29-24-6-4-3-5-21(24)22-15-23(18-7-9-20(26)10-8-18)28-25(22)19-11-13-27-14-12-19/h3-15,17,28H,16H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007224
PNG
(CHEMBL3238216)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(F)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C34H43ClFN7O2/c1-32(2,3)14-13-27(21-7-9-22(10-8-21)30(44)37-20-28-39-41-42-40-28)43-31(45)29(23-17-25(35)19-26(36)18-23)38-34(43)15-11-24(12-16-34)33(4,5)6/h7-10,17-19,24,27H,11-16,20H2,1-6H3,(H,37,44)(H,39,40,41,42)/t24-,27-,34-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007232
PNG
(CHEMBL3238222)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1ccc(F)c(F)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C34H43F2N7O2/c1-32(2,3)16-15-27(21-7-9-22(10-8-21)30(44)37-20-28-39-41-42-40-28)43-31(45)29(23-11-12-25(35)26(36)19-23)38-34(43)17-13-24(14-18-34)33(4,5)6/h7-12,19,24,27H,13-18,20H2,1-6H3,(H,37,44)(H,39,40,41,42)/t24-,27-,34-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007230
PNG
(CHEMBL3238220)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C35H44F3N7O2/c1-32(2,3)18-17-27(22-7-9-24(10-8-22)30(46)39-21-28-41-43-44-42-28)45-31(47)29(23-11-13-26(14-12-23)35(36,37)38)40-34(45)19-15-25(16-20-34)33(4,5)6/h7-14,25,27H,15-21H2,1-6H3,(H,39,46)(H,41,42,43,44)/t25-,27-,34-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50071899
PNG
(4-[5-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-1H-pyrr...)
Show SMILES Fc1ccc(cc1)-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H14ClFN2/c22-17-5-1-15(2-6-17)20-13-19(14-3-7-18(23)8-4-14)21(25-20)16-9-11-24-12-10-16/h1-13,25H
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007241
PNG
(CHEMBL3238229)
Show SMILES CC(C)[C@H]1CC[C@]2(CC1)N=C(C(=O)N2[C@H](CCC(C)(C)C)c1ccc(cc1)C(=O)NCc1nn[nH]n1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C33H41Cl2N7O2/c1-20(2)21-10-14-33(15-11-21)37-29(24-16-25(34)18-26(35)17-24)31(44)42(33)27(12-13-32(3,4)5)22-6-8-23(9-7-22)30(43)36-19-28-38-40-41-39-28/h6-9,16-18,20-21,27H,10-15,19H2,1-5H3,(H,36,43)(H,38,39,40,41)/t21-,27-,33-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075764
PNG
(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Show SMILES Clc1ccc(cc1)-c1cc(c([nH]1)-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H14Cl2N2/c22-17-5-1-14(2-6-17)19-13-20(15-3-7-18(23)8-4-15)25-21(19)16-9-11-24-12-10-16/h1-13,25H
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075751
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-...)
Show SMILES Fc1ccc(cc1)-c1cc([nH]c1-c1ccncc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H14FN3/c23-19-7-5-16(6-8-19)20-13-21(17-3-1-15(14-24)2-4-17)26-22(20)18-9-11-25-12-10-18/h1-13,26H
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075767
PNG
(4-[3-(3-Bromo-phenyl)-5-(4-chloro-phenyl)-1H-pyrro...)
Show SMILES Clc1ccc(cc1)-c1cc(c([nH]1)-c1ccncc1)-c1cccc(Br)c1
Show InChI InChI=1S/C21H14BrClN2/c22-17-3-1-2-16(12-17)19-13-20(14-4-6-18(23)7-5-14)25-21(19)15-8-10-24-11-9-15/h1-13,25H
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on ...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075758
PNG
(4-[5-(4-Chloro-phenyl)-3-(4-methoxy-phenyl)-1H-pyr...)
Show SMILES COc1ccc(cc1)-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H17ClN2O/c1-26-19-8-4-15(5-9-19)20-14-21(16-2-6-18(23)7-3-16)25-22(20)17-10-12-24-13-11-17/h2-14,25H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075775
PNG
(4-[3-(5-Bromo-2-propoxy-phenyl)-5-(4-chloro-phenyl...)
Show SMILES CCCOc1ccc(Br)cc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H20BrClN2O/c1-2-13-29-23-8-5-18(25)14-20(23)21-15-22(16-3-6-19(26)7-4-16)28-24(21)17-9-11-27-12-10-17/h3-12,14-15,28H,2,13H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on ...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075749
PNG
(4-[3-(2-Allyloxy-phenyl)-5-(4-chloro-phenyl)-1H-py...)
Show SMILES Clc1ccc(cc1)-c1cc(c([nH]1)-c1ccncc1)-c1ccccc1OCC=C
Show InChI InChI=1S/C24H19ClN2O/c1-2-15-28-23-6-4-3-5-20(23)21-16-22(17-7-9-19(25)10-8-17)27-24(21)18-11-13-26-14-12-18/h2-14,16,27H,1,15H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007218
PNG
(CHEMBL3237928)
Show SMILES CC(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C33H41Cl2N7O2/c1-20(2)6-11-27(21-7-9-22(10-8-21)30(43)36-19-28-38-40-41-39-28)42-31(44)29(23-16-25(34)18-26(35)17-23)37-33(42)14-12-24(13-15-33)32(3,4)5/h7-10,16-18,20,24,27H,6,11-15,19H2,1-5H3,(H,36,43)(H,38,39,40,41)/t24-,27-,33-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007214
PNG
(CHEMBL3237925)
Show SMILES CCCCC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C33H41Cl2N7O2/c1-5-6-7-8-27(21-9-11-22(12-10-21)30(43)36-20-28-38-40-41-39-28)42-31(44)29(23-17-25(34)19-26(35)18-23)37-33(42)15-13-24(14-16-33)32(2,3)4/h9-12,17-19,24,27H,5-8,13-16,20H2,1-4H3,(H,36,43)(H,38,39,40,41)/t24-,27-,33-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075757
PNG
(4-[5-(2,4-Dichloro-phenyl)-3-(4-fluoro-phenyl)-1H-...)
Show SMILES Fc1ccc(cc1)-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H13Cl2FN2/c22-15-3-6-17(19(23)11-15)20-12-18(13-1-4-16(24)5-2-13)21(26-20)14-7-9-25-10-8-14/h1-12,26H
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075754
PNG
(4-[5-(4-Chloro-phenyl)-3-(2-ethoxy-phenyl)-1H-pyrr...)
Show SMILES CCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClN2O/c1-2-27-22-6-4-3-5-19(22)20-15-21(16-7-9-18(24)10-8-16)26-23(20)17-11-13-25-14-12-17/h3-15,26H,2H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075784
PNG
(4-[5-(4-Chloro-phenyl)-3-(2-hexyloxy-phenyl)-1H-py...)
Show SMILES CCCCCCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H27ClN2O/c1-2-3-4-7-18-31-26-9-6-5-8-23(26)24-19-25(20-10-12-22(28)13-11-20)30-27(24)21-14-16-29-17-15-21/h5-6,8-17,19,30H,2-4,7,18H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007210
PNG
(CHEMBL3237922)
Show SMILES CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C30H35Cl2N7O2/c1-5-24(18-6-8-19(9-7-18)27(40)33-17-25-35-37-38-36-25)39-28(41)26(20-14-22(31)16-23(32)15-20)34-30(39)12-10-21(11-13-30)29(2,3)4/h6-9,14-16,21,24H,5,10-13,17H2,1-4H3,(H,33,40)(H,35,36,37,38)/t21-,24-,30-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007440
PNG
(CHEMBL3237917)
Show SMILES C[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nnn[nH]1
Show InChI InChI=1S/C29H33Cl2N7O2/c1-17(18-5-7-19(8-6-18)26(39)32-16-24-34-36-37-35-24)38-27(40)25(20-13-22(30)15-23(31)14-20)33-29(38)11-9-21(10-12-29)28(2,3)4/h5-8,13-15,17,21H,9-12,16H2,1-4H3,(H,32,39)(H,34,35,36,37)/t17-,21-,29-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075786
PNG
(4-[5-(4-Chloro-phenyl)-3-(2-methoxy-phenyl)-1H-pyr...)
Show SMILES COc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H17ClN2O/c1-26-21-5-3-2-4-18(21)19-14-20(15-6-8-17(23)9-7-15)25-22(19)16-10-12-24-13-11-16/h2-14,25H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007212
PNG
(CHEMBL3237924)
Show SMILES CCCC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C32H39Cl2N7O2/c1-5-6-7-26(20-8-10-21(11-9-20)29(42)35-19-27-37-39-40-38-27)41-30(43)28(22-16-24(33)18-25(34)17-22)36-32(41)14-12-23(13-15-32)31(2,3)4/h8-11,16-18,23,26H,5-7,12-15,19H2,1-4H3,(H,35,42)(H,37,38,39,40)/t23-,26-,32-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007215
PNG
(CHEMBL3237927)
Show SMILES CC(C)C[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C32H39Cl2N7O2/c1-19(2)14-26(20-6-8-21(9-7-20)29(42)35-18-27-37-39-40-38-27)41-30(43)28(22-15-24(33)17-25(34)16-22)36-32(41)12-10-23(11-13-32)31(3,4)5/h6-9,15-17,19,23,26H,10-14,18H2,1-5H3,(H,35,42)(H,37,38,39,40)/t23-,26-,32-/m1/s1
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n/an/a 420n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075753
PNG
(4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Show SMILES Fc1ccc(cc1)-c1cc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H14F2N2/c22-17-5-1-14(2-6-17)19-13-20(15-3-7-18(23)8-4-15)25-21(19)16-9-11-24-12-10-16/h1-13,25H
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075781
PNG
(CHEMBL348555 | {2-[5-(4-Chloro-phenyl)-2-pyridin-4...)
Show SMILES CCCNc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H22ClN3/c1-2-13-27-22-6-4-3-5-20(22)21-16-23(17-7-9-19(25)10-8-17)28-24(21)18-11-14-26-15-12-18/h3-12,14-16,27-28H,2,13H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075788
PNG
(4-[5-(3-Chloro-phenyl)-3-(4-fluoro-phenyl)-1H-pyrr...)
Show SMILES Fc1ccc(cc1)-c1cc([nH]c1-c1ccncc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H14ClFN2/c22-17-3-1-2-16(12-17)20-13-19(14-4-6-18(23)7-5-14)21(25-20)15-8-10-24-11-9-15/h1-13,25H
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075750
PNG
(5-(4-Chloro-phenyl)-2-pyridin-4-yl-1H-pyrrole-3-ca...)
Show SMILES CCOC(=O)c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H15ClN2O2/c1-2-23-18(22)15-11-16(12-3-5-14(19)6-4-12)21-17(15)13-7-9-20-10-8-13/h3-11,21H,2H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007211
PNG
(CHEMBL3237923)
Show SMILES CCC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1
Show InChI InChI=1S/C31H37Cl2N7O2/c1-5-6-25(19-7-9-20(10-8-19)28(41)34-18-26-36-38-39-37-26)40-29(42)27(21-15-23(32)17-24(33)16-21)35-31(40)13-11-22(12-14-31)30(2,3)4/h7-10,15-17,22,25H,5-6,11-14,18H2,1-4H3,(H,34,41)(H,36,37,38,39)/t22-,25-,31-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50007245
PNG
(CHEMBL3238234)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C35H45Cl2N3O4/c1-33(2,3)15-13-28(22-7-9-23(10-8-22)31(43)38-18-14-29(41)42)40-32(44)30(24-19-26(36)21-27(37)20-24)39-35(40)16-11-25(12-17-35)34(4,5)6/h7-10,19-21,25,28H,11-18H2,1-6H3,(H,38,43)(H,41,42)/t25-,28-,35-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075763
PNG
(4-[5-(4-Chloro-phenyl)-3-(2,6-dipropoxy-phenyl)-1H...)
Show SMILES CCCOc1cccc(OCCC)c1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H27ClN2O2/c1-3-16-31-24-6-5-7-25(32-17-4-2)26(24)22-18-23(19-8-10-21(28)11-9-19)30-27(22)20-12-14-29-15-13-20/h5-15,18,30H,3-4,16-17H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075790
PNG
(4-[5-(4-Chloro-phenyl)-1H-pyrrol-2-yl]-pyridine | ...)
Show SMILES Clc1ccc(cc1)-c1ccc([nH]1)-c1ccncc1
Show InChI InChI=1S/C15H11ClN2/c16-13-3-1-11(2-4-13)14-5-6-15(18-14)12-7-9-17-10-8-12/h1-10,18H
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075755
PNG
(4-[5-(4-Chloro-phenyl)-3-(2-isopropoxy-phenyl)-1H-...)
Show SMILES CC(C)Oc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H21ClN2O/c1-16(2)28-23-6-4-3-5-20(23)21-15-22(17-7-9-19(25)10-8-17)27-24(21)18-11-13-26-14-12-18/h3-16,27H,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Mus musculus)
BDBM50075766
PNG
(4-[5-(4-Chloro-phenyl)-3-(2-propoxy-phenyl)-1H-pyr...)
Show SMILES CCCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H21ClN2O/c1-2-15-28-23-6-4-3-5-20(23)21-16-22(17-7-9-19(25)10-8-17)27-24(21)18-11-13-26-14-12-18/h3-14,16,27H,2,15H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on ...


Bioorg Med Chem Lett 9: 641-6 (1999)

More data for this
Ligand-Target Pair
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