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Compile Data Set for Download or QSAR

Found 65 hits Enz. Inhib. hit(s) with Target = 'Glucokinase regulatory protein' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucokinase regulatory protein


(Homo sapiens)
BDBM50447275
PNG
(CHEMBL3114185)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C21H20F6N4O3S/c1-2-3-16-13-30(35(33,34)17-8-9-18(28)29-12-17)10-11-31(16)15-6-4-14(5-7-15)19(32,20(22,23)24)21(25,26)27/h4-9,12,16,32H,10-11,13H2,1H3,(H2,28,29)/t16-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009124
PNG
(CHEMBL3237987)
Show SMILES CC#CCC(O)(c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O3S/c1-3-5-13-23(32,24(25,26)27)18-7-9-19(10-8-18)31-15-14-30(17-20(31)6-4-2)35(33,34)21-11-12-22(28)29-16-21/h7-12,16,20,32H,13-15,17H2,1-2H3,(H2,28,29)/t20-,23?/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009122
PNG
(CHEMBL3237986)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(O)(CC#C)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C23H23F3N4O3S/c1-3-5-19-16-29(34(32,33)20-10-11-21(27)28-15-20)13-14-30(19)18-8-6-17(7-9-18)22(31,12-4-2)23(24,25)26/h2,6-11,15,19,31H,12-14,16H2,1H3,(H2,27,28)/t19-,22?/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009116
PNG
(CHEMBL3237981)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C21H23F3N4O4S/c1-2-3-17-13-27(33(31,32)18-8-9-19(25)26-12-18)10-11-28(17)16-6-4-15(5-7-16)20(30,14-29)21(22,23)24/h4-9,12,17,29-30H,10-11,13-14H2,1H3,(H2,25,26)/t17-,20-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50447271
PNG
(CHEMBL3114187)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C21H23F3N4O3S/c1-3-4-17-14-27(32(30,31)18-9-10-19(25)26-13-18)11-12-28(17)16-7-5-15(6-8-16)20(2,29)21(22,23)24/h5-10,13,17,29H,11-12,14H2,1-2H3,(H2,25,26)/t17-,20+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448558
PNG
(CHEMBL3127349)
Show SMILES C[C@H]1COCCN1C[C@H]1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C23H27F6N3O4S2/c1-16-15-36-11-10-30(16)13-19-14-31(38(34,35)20-3-2-12-37-20)8-9-32(19)18-6-4-17(5-7-18)21(33,22(24,25)26)23(27,28)29/h2-7,12,16,19,33H,8-11,13-15H2,1H3/t16-,19-/m0/s1
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n/an/a 9.70n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009107
PNG
(CHEMBL3238309)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C20H19F6N5O3S/c1-2-3-14-12-30(35(33,34)15-5-6-16(27)28-11-15)8-9-31(14)17-7-4-13(10-29-17)18(32,19(21,22)23)20(24,25)26/h4-7,10-11,14,32H,8-9,12H2,1H3,(H2,27,28)/t14-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009155
PNG
(CHEMBL3238310)
Show SMILES CC#C[C@H]1CN(CCN1c1ncc(cn1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C19H18F6N6O3S/c1-2-3-13-11-30(35(33,34)14-4-5-15(26)27-10-14)6-7-31(13)16-28-8-12(9-29-16)17(32,18(20,21)22)19(23,24)25/h4-5,8-10,13,32H,6-7,11H2,1H3,(H2,26,27)/t13-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448559
PNG
(CHEMBL3127352)
Show SMILES C[C@H]1COCCN1C[C@H]1CN(CCN1c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C23H30F3N3O4S2/c1-17-16-33-12-11-27(17)14-20-15-28(35(31,32)21-4-3-13-34-21)9-10-29(20)19-7-5-18(6-8-19)22(2,30)23(24,25)26/h3-8,13,17,20,30H,9-12,14-16H2,1-2H3/t17-,20-,22-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009110
PNG
(CHEMBL3238307)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-7-17(24)25-12-16)9-10-28(15)18-8-5-14(11-26-18)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,25)/t15-,19+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009111
PNG
(CHEMBL3238308)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-7-17(24)25-12-16)9-10-28(15)18-8-5-14(11-26-18)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,25)/t15-,19-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009118
PNG
(CHEMBL3238313)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C20H22F3N5O4S/c1-2-3-15-12-27(33(31,32)16-5-6-17(24)25-11-16)8-9-28(15)18-7-4-14(10-26-18)19(30,13-29)20(21,22)23/h4-7,10-11,15,29-30H,8-9,12-13H2,1H3,(H2,24,25)/t15-,19+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009121
PNG
(CHEMBL3237985)
Show SMILES COCC(O)(c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N4O4S/c1-3-4-18-14-28(34(31,32)19-9-10-20(26)27-13-19)11-12-29(18)17-7-5-16(6-8-17)21(30,15-33-2)22(23,24)25/h5-10,13,18,30H,11-12,14-15H2,1-2H3,(H2,26,27)/t18-,21?/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009104
PNG
(CHEMBL3238303)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[S@](=N)(=O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C19H20F3N5O3S2/c1-2-3-15-13-26(32(29,30)17-8-9-18(23)25-12-17)10-11-27(15)14-4-6-16(7-5-14)31(24,28)19(20,21)22/h4-9,12,15,24H,10-11,13H2,1H3,(H2,23,25)/t15-,31-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009109
PNG
(CHEMBL3238306)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-7-17(24)25-12-16)9-10-28(15)18-8-5-14(11-26-18)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,25)/t15-,19?/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50447292
PNG
(CHEMBL3113979)
Show SMILES C[C@H]1COCCN1C[C@H]1CN(CCN1c1ccc(cc1)[C@@](C)(O)C(F)(F)F)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C23H30F3N3O4S2/c1-17-16-33-12-11-27(17)14-20-15-28(35(31,32)21-4-3-13-34-21)9-10-29(20)19-7-5-18(6-8-19)22(2,30)23(24,25)26/h3-8,13,17,20,30H,9-12,14-16H2,1-2H3/t17-,20-,22+/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009117
PNG
(CHEMBL3238312)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)C(O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C20H22F3N5O4S/c1-2-3-15-12-27(33(31,32)16-5-6-17(24)25-11-16)8-9-28(15)18-7-4-14(10-26-18)19(30,13-29)20(21,22)23/h4-7,10-11,15,29-30H,8-9,12-13H2,1H3,(H2,24,25)/t15-,19?/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009120
PNG
(CHEMBL3237984)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(O)(CC#N)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C22H22F3N5O3S/c1-2-3-18-15-29(34(32,33)19-8-9-20(27)28-14-19)12-13-30(18)17-6-4-16(5-7-17)21(31,10-11-26)22(23,24)25/h4-9,14,18,31H,10,12-13,15H2,1H3,(H2,27,28)/t18-,21?/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009115
PNG
(CHEMBL3237980)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C21H23F3N4O4S/c1-2-3-17-13-27(33(31,32)18-8-9-19(25)26-12-18)10-11-28(17)16-6-4-15(5-7-16)20(30,14-29)21(22,23)24/h4-9,12,17,29-30H,10-11,13-14H2,1H3,(H2,25,26)/t17-,20+/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009094
PNG
(CHEMBL3237993)
Show SMILES CNS(=O)(=O)c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C19H23N5O4S2/c1-3-4-16-14-23(30(27,28)18-9-10-19(20)22-13-18)11-12-24(16)15-5-7-17(8-6-15)29(25,26)21-2/h5-10,13,16,21H,11-12,14H2,1-2H3,(H2,20,22)/t16-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448562
PNG
(CHEMBL3127348)
Show SMILES OC(c1ccc(cc1)N1CCN(C[C@@H]1CN1CCOCC1)S(=O)(=O)c1cccs1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H25F6N3O4S2/c23-21(24,25)20(32,22(26,27)28)16-3-5-17(6-4-16)31-8-7-30(37(33,34)19-2-1-13-36-19)15-18(31)14-29-9-11-35-12-10-29/h1-6,13,18,32H,7-12,14-15H2/t18-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009102
PNG
(CHEMBL3238301)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=N)(=O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C19H20F3N5O3S2/c1-2-3-15-13-26(32(29,30)17-8-9-18(23)25-12-17)10-11-27(15)14-4-6-16(7-5-14)31(24,28)19(20,21)22/h4-9,12,15,24H,10-11,13H2,1H3,(H2,23,25)/t15-,31?/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009128
PNG
(CHEMBL3237983)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@@](O)(CN)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C21H24F3N5O3S/c1-2-3-17-13-28(33(31,32)18-8-9-19(26)27-12-18)10-11-29(17)16-6-4-15(5-7-16)20(30,14-25)21(22,23)24/h4-9,12,17,30H,10-11,13-14,25H2,1H3,(H2,26,27)/t17-,20-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009147
PNG
(CHEMBL3238316)
Show SMILES CC#C[C@H]1CN(CCN1c1ncc(s1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C18H20F3N5O3S2/c1-3-4-12-11-25(31(28,29)13-5-6-15(22)23-9-13)7-8-26(12)16-24-10-14(30-16)17(2,27)18(19,20)21/h5-6,9-10,12,27H,7-8,11H2,1-2H3,(H2,22,23)/t12-,17?/m0/s1
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n/an/a 49n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448563
PNG
(CHEMBL3127347)
Show SMILES OC(c1ccc(cc1)N1CCN(C[C@@H]1CC1CCOCC1)S(=O)(=O)c1cccs1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H26F6N2O4S2/c24-22(25,26)21(32,23(27,28)29)17-3-5-18(6-4-17)31-10-9-30(37(33,34)20-2-1-13-36-20)15-19(31)14-16-7-11-35-12-8-16/h1-6,13,16,19,32H,7-12,14-15H2/t19-/m0/s1
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n/an/a 58n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009114
PNG
(CHEMBL3237992)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(N)(=O)=O)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C18H21N5O4S2/c1-2-3-15-13-22(29(26,27)17-8-9-18(19)21-12-17)10-11-23(15)14-4-6-16(7-5-14)28(20,24)25/h4-9,12,15H,10-11,13H2,1H3,(H2,19,21)(H2,20,24,25)/t15-/m0/s1
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n/an/a 61n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009108
PNG
(CHEMBL3238311)
Show SMILES CNS(=O)(=O)c1ccc(nc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C18H22N6O4S2/c1-3-4-14-13-23(30(27,28)16-5-7-17(19)21-12-16)9-10-24(14)18-8-6-15(11-22-18)29(25,26)20-2/h5-8,11-12,14,20H,9-10,13H2,1-2H3,(H2,19,21)/t14-/m0/s1
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n/an/a 68n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009105
PNG
(CHEMBL3238305)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(nc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-8-18(24)26-12-16)9-10-28(15)14-5-7-17(25-11-14)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,26)/t15-,19?/m0/s1
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n/an/a 69n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009119
PNG
(CHEMBL3238314)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C20H22F3N5O4S/c1-2-3-15-12-27(33(31,32)16-5-6-17(24)25-11-16)8-9-28(15)18-7-4-14(10-26-18)19(30,13-29)20(21,22)23/h4-7,10-11,15,29-30H,8-9,12-13H2,1H3,(H2,24,25)/t15-,19-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009143
PNG
(CHEMBL3238315)
Show SMILES CC#C[C@H]1CN(CCN1c1ncc(s1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C18H17F6N5O3S2/c1-2-3-11-10-28(34(31,32)12-4-5-14(25)26-8-12)6-7-29(11)15-27-9-13(33-15)16(30,17(19,20)21)18(22,23)24/h4-5,8-9,11,30H,6-7,10H2,1H3,(H2,25,26)/t11-/m0/s1
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n/an/a 81n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448561
PNG
(CHEMBL3127350)
Show SMILES C[C@@](O)(c1ccc(cc1)N1CCN(C[C@@H]1CC1CCOCC1)S(=O)(=O)c1cccs1)C(F)(F)F
Show InChI InChI=1S/C23H29F3N2O4S2/c1-22(29,23(24,25)26)18-4-6-19(7-5-18)28-11-10-27(34(30,31)21-3-2-14-33-21)16-20(28)15-17-8-12-32-13-9-17/h2-7,14,17,20,29H,8-13,15-16H2,1H3/t20-,22+/m0/s1
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n/an/a 95n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448560
PNG
(CHEMBL3127351)
Show SMILES C[C@](O)(c1ccc(cc1)N1CCN(C[C@@H]1CC1CCOCC1)S(=O)(=O)c1cccs1)C(F)(F)F
Show InChI InChI=1S/C23H29F3N2O4S2/c1-22(29,23(24,25)26)18-4-6-19(7-5-18)28-11-10-27(34(30,31)21-3-2-14-33-21)16-20(28)15-17-8-12-32-13-9-17/h2-7,14,17,20,29H,8-13,15-16H2,1H3/t20-,22-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009095
PNG
(CHEMBL3237994)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)NC1CC1)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C21H25N5O4S2/c1-2-3-18-15-25(32(29,30)20-10-11-21(22)23-14-20)12-13-26(18)17-6-8-19(9-7-17)31(27,28)24-16-4-5-16/h6-11,14,16,18,24H,4-5,12-13,15H2,1H3,(H2,22,23)/t18-/m0/s1
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n/an/a 101n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009103
PNG
(CHEMBL3238302)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[S@@](=N)(=O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C19H20F3N5O3S2/c1-2-3-15-13-26(32(29,30)17-8-9-18(23)25-12-17)10-11-27(15)14-4-6-16(7-5-14)31(24,28)19(20,21)22/h4-9,12,15,24H,10-11,13H2,1H3,(H2,23,25)/t15-,31+/m0/s1
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n/an/a 182n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448571
PNG
(CHEMBL3127361)
Show SMILES Oc1ccccc1CC1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C24H22F6N2O4S2/c25-23(26,27)22(34,24(28,29)30)17-7-9-18(10-8-17)32-12-11-31(38(35,36)21-6-3-13-37-21)15-19(32)14-16-4-1-2-5-20(16)33/h1-10,13,19,33-34H,11-12,14-15H2
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n/an/a 215n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009100
PNG
(CHEMBL3238296)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)NC(C)C)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C21H27N5O4S2/c1-4-5-18-15-25(32(29,30)20-10-11-21(22)23-14-20)12-13-26(18)17-6-8-19(9-7-17)31(27,28)24-16(2)3/h6-11,14,16,18,24H,12-13,15H2,1-3H3,(H2,22,23)/t18-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009112
PNG
(CHEMBL3238300)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=N)(=O)C1CC1)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C21H25N5O3S2/c1-2-3-17-15-25(31(28,29)20-10-11-21(22)24-14-20)12-13-26(17)16-4-6-18(7-5-16)30(23,27)19-8-9-19/h4-7,10-11,14,17,19,23H,8-9,12-13,15H2,1H3,(H2,22,24)/t17-,30?/m0/s1
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n/an/a 256n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009098
PNG
(CHEMBL3238304)
Show SMILES CN=S(=O)(c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S2/c1-3-4-16-14-27(33(30,31)18-9-10-19(24)26-13-18)11-12-28(16)15-5-7-17(8-6-15)32(29,25-2)20(21,22)23/h5-10,13,16H,11-12,14H2,1-2H3,(H2,24,26)/t16-,32?/m0/s1
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n/an/a 266n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448578
PNG
(CHEMBL3127354)
Show SMILES C[C@H]1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C18H18F6N2O3S2/c1-12-11-25(31(28,29)15-3-2-10-30-15)8-9-26(12)14-6-4-13(5-7-14)16(27,17(19,20)21)18(22,23)24/h2-7,10,12,27H,8-9,11H2,1H3/t12-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009113
PNG
(CHEMBL3238299)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(C)(=N)=O)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C19H23N5O3S2/c1-3-4-16-14-23(29(26,27)18-9-10-19(20)22-13-18)11-12-24(16)15-5-7-17(8-6-15)28(2,21)25/h5-10,13,16,21H,11-12,14H2,1-2H3,(H2,20,22)/t16-,28?/m0/s1
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n/an/a 310n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009096
PNG
(CHEMBL3238297)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)NCC1CC1)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C22H27N5O4S2/c1-2-3-19-16-26(33(30,31)21-10-11-22(23)24-15-21)12-13-27(19)18-6-8-20(9-7-18)32(28,29)25-14-17-4-5-17/h6-11,15,17,19,25H,4-5,12-14,16H2,1H3,(H2,23,24)/t19-/m0/s1
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n/an/a 320n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009125
PNG
(CHEMBL3237982)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@](O)(CN)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C21H24F3N5O3S/c1-2-3-17-13-28(33(31,32)18-8-9-19(26)27-12-18)10-11-29(17)16-6-4-15(5-7-16)20(30,14-25)21(22,23)24/h4-9,12,17,30H,10-11,13-14,25H2,1H3,(H2,26,27)/t17-,20+/m0/s1
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n/an/a 374n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009099
PNG
(CHEMBL3237991)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(C)(=O)=O)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C19H22N4O4S2/c1-3-4-16-14-22(29(26,27)18-9-10-19(20)21-13-18)11-12-23(16)15-5-7-17(8-6-15)28(2,24)25/h5-10,13,16H,11-12,14H2,1-2H3,(H2,20,21)/t16-/m0/s1
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n/an/a 401n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448572
PNG
(CHEMBL3127360)
Show SMILES OC(c1ccc(cc1)N1CCN(C[C@@H]1Cc1ccccc1)S(=O)(=O)c1cccs1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C24H22F6N2O3S2/c25-23(26,27)22(33,24(28,29)30)18-8-10-19(11-9-18)32-13-12-31(37(34,35)21-7-4-14-36-21)16-20(32)15-17-5-2-1-3-6-17/h1-11,14,20,33H,12-13,15-16H2/t20-/m0/s1
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n/an/a 701n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448569
PNG
(CHEMBL3127341)
Show SMILES Oc1ccc(CC2CN(CCN2c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2cccs2)cc1
Show InChI InChI=1S/C24H22F6N2O4S2/c25-23(26,27)22(34,24(28,29)30)17-5-7-18(8-6-17)32-12-11-31(38(35,36)21-2-1-13-37-21)15-19(32)14-16-3-9-20(33)10-4-16/h1-10,13,19,33-34H,11-12,14-15H2
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n/an/a 850n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448567
PNG
(CHEMBL3127343)
Show SMILES Cc1cccc(CC2CN(CCN2c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2cccs2)c1
Show InChI InChI=1S/C25H24F6N2O3S2/c1-17-4-2-5-18(14-17)15-21-16-32(38(35,36)22-6-3-13-37-22)11-12-33(21)20-9-7-19(8-10-20)23(34,24(26,27)28)25(29,30)31/h2-10,13-14,21,34H,11-12,15-16H2,1H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009089
PNG
(CHEMBL3237979)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(C)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C21H23F3N4O2S/c1-3-4-18-14-27(31(29,30)19-9-10-20(25)26-13-19)11-12-28(18)17-7-5-16(6-8-17)15(2)21(22,23)24/h5-10,13,15,18H,11-12,14H2,1-2H3,(H2,25,26)/t15?,18-/m0/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50009088
PNG
(CHEMBL3237988)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(C)=O)S(=O)(=O)c1ccc(N)nc1
Show InChI InChI=1S/C20H22N4O3S/c1-3-4-18-14-23(28(26,27)19-9-10-20(21)22-13-19)11-12-24(18)17-7-5-16(6-8-17)15(2)25/h5-10,13,18H,11-12,14H2,1-2H3,(H2,21,22)/t18-/m0/s1
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n/an/a 1.09E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50448568
PNG
(CHEMBL3127342)
Show SMILES Cc1ccccc1CC1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C25H24F6N2O3S2/c1-17-5-2-3-6-18(17)15-21-16-32(38(35,36)22-7-4-14-37-22)12-13-33(21)20-10-8-19(9-11-20)23(34,24(26,27)28)25(29,30)31/h2-11,14,21,34H,12-13,15-16H2,1H3
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n/an/a 1.23E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens)
BDBM50447286
PNG
(CHEMBL3113992)
Show SMILES OC(c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1cccs1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H16F6N2O3S2/c18-16(19,20)15(26,17(21,22)23)12-3-5-13(6-4-12)24-7-9-25(10-8-24)30(27,28)14-2-1-11-29-14/h1-6,11,26H,7-10H2
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n/an/a 1.42E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addit...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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