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Found 238 hits Enz. Inhib. hit(s) with Target = 'Glucose-dependent insulinotropic receptor' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50433861
PNG
(CHEMBL2382409)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)c1ncc(OCc2ccc(cc2)S(C)(=O)=O)cn1
Show InChI InChI=1S/C23H30N4O5S/c1-23(2,3)32-22(28)27-17-7-8-18(27)14-26(13-17)21-24-11-19(12-25-21)31-15-16-5-9-20(10-6-16)33(4,29)30/h5-6,9-12,17-18H,7-8,13-15H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50433856
PNG
(CHEMBL2382410)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)c1ncc(OCc2ccncc2C#N)cn1
Show InChI InChI=1S/C22H26N6O3/c1-22(2,3)31-21(29)28-17-4-5-18(28)13-27(12-17)20-25-10-19(11-26-20)30-14-15-6-7-24-9-16(15)8-23/h6-7,9-11,17-18H,4-5,12-14H2,1-3H3
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n/an/a 9n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50433853
PNG
(CHEMBL2382413)
Show SMILES FC1(F)CC(OC(=O)N2C3CCC2CN(C3)c2ncc(OCc3ccncc3C#N)cn2)C1(F)F
Show InChI InChI=1S/C22H20F4N6O3/c23-21(24)5-18(22(21,25)26)35-20(33)32-15-1-2-16(32)11-31(10-15)19-29-8-17(9-30-19)34-12-13-3-4-28-7-14(13)6-27/h3-4,7-9,15-16,18H,1-2,5,10-12H2
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n/an/a 65n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50433862
PNG
(CHEMBL2382408)
Show SMILES CC(C)(C)OC(=O)N1CC2CCC(C1)N2c1ncc(OCc2ccc(cc2)S(C)(=O)=O)cn1
Show InChI InChI=1S/C23H30N4O5S/c1-23(2,3)32-22(28)26-13-17-7-8-18(14-26)27(17)21-24-11-19(12-25-21)31-15-16-5-9-20(10-6-16)33(4,29)30/h5-6,9-12,17-18H,7-8,13-15H2,1-4H3
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n/an/a 72n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50420842
PNG
(CHEMBL2086684)
Show SMILES C[C@@H]1CN(CCN1c1ncc(OCc2ccncc2C#N)cn1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H26N6O3/c1-15-13-26(20(28)30-21(2,3)4)7-8-27(15)19-24-11-18(12-25-19)29-14-16-5-6-23-10-17(16)9-22/h5-6,10-12,15H,7-8,13-14H2,1-4H3/t15-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50433859
PNG
(CHEMBL2382415)
Show SMILES FC(F)(F)COC(=O)N1C2CCC1CN(C2)c1ncc(OCc2ccncc2C#N)cn1
Show InChI InChI=1S/C20H19F3N6O3/c21-20(22,23)12-32-19(30)29-15-1-2-16(29)10-28(9-15)18-26-7-17(8-27-18)31-11-13-3-4-25-6-14(13)5-24/h3-4,6-8,15-16H,1-2,9-12H2
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n/an/a 104n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50433857
PNG
(CHEMBL2382417)
Show SMILES CC(C)c1nc(no1)N1C2CCC1CN(C2)c1ncc(OCc2ccncc2C#N)cn1
Show InChI InChI=1S/C22H24N8O2/c1-14(2)20-27-22(28-32-20)30-17-3-4-18(30)12-29(11-17)21-25-9-19(10-26-21)31-13-15-5-6-24-8-16(15)7-23/h5-6,8-10,14,17-18H,3-4,11-13H2,1-2H3
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n/an/a 122n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50420863
PNG
(CHEMBL2086660)
Show SMILES C[C@@H]1CN(CCN1c1ncc(OCc2ccc(cc2)S(C)(=O)=O)cn1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H30N4O5S/c1-16-14-25(21(27)31-22(2,3)4)10-11-26(16)20-23-12-18(13-24-20)30-15-17-6-8-19(9-7-17)32(5,28)29/h6-9,12-13,16H,10-11,14-15H2,1-5H3/t16-/m1/s1
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n/an/a 129n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50420845
PNG
(CHEMBL2086680)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ncc(OCc2ccncc2C#N)cn1
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)29-19(27)26-8-6-25(7-9-26)18-23-12-17(13-24-18)28-14-15-4-5-22-11-16(15)10-21/h4-5,11-13H,6-9,14H2,1-3H3
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n/an/a 507n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50420871
PNG
(CHEMBL2086650)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ncc(OCc2ccc(cc2)S(C)(=O)=O)cn1
Show InChI InChI=1S/C21H28N4O5S/c1-21(2,3)30-20(26)25-11-9-24(10-12-25)19-22-13-17(14-23-19)29-15-16-5-7-18(8-6-16)31(4,27)28/h5-8,13-14H,9-12,15H2,1-4H3
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n/an/a 543n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50420836
PNG
(CHEMBL2086690)
Show SMILES CC(C)c1nc(no1)N1CCN([C@H](C)C1)c1ncc(OCc2ccncc2C#N)cn1
Show InChI InChI=1S/C21H24N8O2/c1-14(2)19-26-21(27-31-19)28-6-7-29(15(3)12-28)20-24-10-18(11-25-20)30-13-16-4-5-23-9-17(16)8-22/h4-5,9-11,14-15H,6-7,12-13H2,1-3H3/t15-/m1/s1
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n/an/a 568n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50433854
PNG
(CHEMBL2382412)
Show SMILES C[C@@H]1CN(CCN1c1ncc(OCc2ccncc2C#N)cn1)C(=O)OC1CC(F)(F)C1(F)F
Show InChI InChI=1S/C21H20F4N6O3/c1-13-11-30(19(32)34-17-6-20(22,23)21(17,24)25)4-5-31(13)18-28-9-16(10-29-18)33-12-14-2-3-27-8-15(14)7-26/h2-3,8-10,13,17H,4-6,11-12H2,1H3/t13-,17?/m1/s1
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n/an/a 694n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50433855
PNG
(CHEMBL2382411)
Show SMILES FC1(F)CC(OC(=O)N2CCN(CC2)c2ncc(OCc3ccncc3C#N)cn2)C1(F)F
Show InChI InChI=1S/C20H18F4N6O3/c21-19(22)7-16(20(19,23)24)33-18(31)30-5-3-29(4-6-30)17-27-10-15(11-28-17)32-12-13-1-2-26-9-14(13)8-25/h1-2,9-11,16H,3-7,12H2
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n/an/a 758n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50420839
PNG
(CHEMBL2086687)
Show SMILES C[C@@H]1CN(CCN1c1ncc(OCc2ccncc2C#N)cn1)C(=O)OCC(F)(F)F
Show InChI InChI=1S/C19H19F3N6O3/c1-13-10-27(18(29)31-12-19(20,21)22)4-5-28(13)17-25-8-16(9-26-17)30-11-14-2-3-24-7-15(14)6-23/h2-3,7-9,13H,4-5,10-12H2,1H3/t13-/m1/s1
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n/an/a 1.83E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50433858
PNG
(CHEMBL2382416)
Show SMILES CC(C)c1nc(no1)N1CCN(CC1)c1ncc(OCc2ccncc2C#N)cn1
Show InChI InChI=1S/C20H22N8O2/c1-14(2)18-25-20(26-30-18)28-7-5-27(6-8-28)19-23-11-17(12-24-19)29-13-15-3-4-22-10-16(15)9-21/h3-4,10-12,14H,5-8,13H2,1-2H3
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n/an/a 2.72E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50433860
PNG
(CHEMBL2382414)
Show SMILES FC(F)(F)COC(=O)N1CCN(CC1)c1ncc(OCc2ccncc2C#N)cn1
Show InChI InChI=1S/C18H17F3N6O3/c19-18(20,21)12-30-17(28)27-5-3-26(4-6-27)16-24-9-15(10-25-16)29-11-13-1-2-23-8-14(13)7-22/h1-2,8-10H,3-6,11-12H2
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n/an/a 4.99E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342667
PNG
(CHEMBL1771067 | tert-butyl 1'-p-tolyl-4,4'-bipiper...)
Show SMILES Cc1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N2O2/c1-17-5-7-20(8-6-17)23-13-9-18(10-14-23)19-11-15-24(16-12-19)21(25)26-22(2,3)4/h5-8,18-19H,9-16H2,1-4H3
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n/an/an/an/a 1.90E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342668
PNG
(CHEMBL1771068 | tert-butyl 1'-(4-(methylsulfonyl)p...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H34N2O4S/c1-22(2,3)28-21(25)24-15-11-18(12-16-24)17-9-13-23(14-10-17)19-5-7-20(8-6-19)29(4,26)27/h5-8,17-18H,9-16H2,1-4H3
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n/an/an/an/a 36n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342670
PNG
(CHEMBL1771070 | tert-butyl 1'-(4-(methylsulfinyl)p...)
Show SMILES CS(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N2O3S/c1-22(2,3)27-21(25)24-15-11-18(12-16-24)17-9-13-23(14-10-17)19-5-7-20(8-6-19)28(4)26/h5-8,17-18H,9-16H2,1-4H3
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n/an/an/an/a 132n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342671
PNG
(CHEMBL1771071 | tert-butyl 1'-(4-acetylphenyl)-4,4...)
Show SMILES CC(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C23H34N2O3/c1-17(26)18-5-7-21(8-6-18)24-13-9-19(10-14-24)20-11-15-25(16-12-20)22(27)28-23(2,3)4/h5-8,19-20H,9-16H2,1-4H3
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n/an/an/an/a 341n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342672
PNG
(CHEMBL1771072 | tert-butyl 1'-(4-(methylthio)pheny...)
Show SMILES CSc1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N2O2S/c1-22(2,3)26-21(25)24-15-11-18(12-16-24)17-9-13-23(14-10-17)19-5-7-20(27-4)8-6-19/h5-8,17-18H,9-16H2,1-4H3
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n/an/an/an/a 513n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342673
PNG
(CHEMBL1771073 | tert-butyl 1'-(4-carbamoylphenyl)-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C22H33N3O3/c1-22(2,3)28-21(27)25-14-10-17(11-15-25)16-8-12-24(13-9-16)19-6-4-18(5-7-19)20(23)26/h4-7,16-17H,8-15H2,1-3H3,(H2,23,26)
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n/an/an/an/a 165n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342674
PNG
(CHEMBL1771075 | tert-butyl 1'-(pyridin-2-yl)-4,4'-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C20H31N3O2/c1-20(2,3)25-19(24)23-14-9-17(10-15-23)16-7-12-22(13-8-16)18-6-4-5-11-21-18/h4-6,11,16-17H,7-10,12-15H2,1-3H3
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n/an/an/an/a 2.50E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342675
PNG
(CHEMBL1771076 | tert-butyl 1'-(pyrimidin-4-yl)-4,4...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccncn1
Show InChI InChI=1S/C19H30N4O2/c1-19(2,3)25-18(24)23-12-7-16(8-13-23)15-5-10-22(11-6-15)17-4-9-20-14-21-17/h4,9,14-16H,5-8,10-13H2,1-3H3
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n/an/an/an/a 379n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342676
PNG
(CHEMBL1771077 | tert-butyl 1'-(pyrimidin-2-yl)-4,4...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C19H30N4O2/c1-19(2,3)25-18(24)23-13-7-16(8-14-23)15-5-11-22(12-6-15)17-20-9-4-10-21-17/h4,9-10,15-16H,5-8,11-14H2,1-3H3
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n/an/an/an/a 523n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342677
PNG
(CHEMBL1771078 | tert-butyl 1'-(pyrazin-2-yl)-4,4'-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1cnccn1
Show InChI InChI=1S/C19H30N4O2/c1-19(2,3)25-18(24)23-12-6-16(7-13-23)15-4-10-22(11-5-15)17-14-20-8-9-21-17/h8-9,14-16H,4-7,10-13H2,1-3H3
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n/an/an/an/a 142n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342678
PNG
(CHEMBL1771079 | tert-butyl 1'-(2-cyanopyrimidin-4-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccnc(n1)C#N
Show InChI InChI=1S/C20H29N5O2/c1-20(2,3)27-19(26)25-12-7-16(8-13-25)15-5-10-24(11-6-15)18-4-9-22-17(14-21)23-18/h4,9,15-16H,5-8,10-13H2,1-3H3
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n/an/an/an/a 11n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342679
PNG
(CHEMBL1771080 | tert-butyl 1'-(6-cyanopyrimidin-4-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1cc(ncn1)C#N
Show InChI InChI=1S/C20H29N5O2/c1-20(2,3)27-19(26)25-10-6-16(7-11-25)15-4-8-24(9-5-15)18-12-17(13-21)22-14-23-18/h12,14-16H,4-11H2,1-3H3
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n/an/an/an/a 31n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342680
PNG
(CHEMBL1771081 | tert-butyl 1'-(2-cyano-6-methylpyr...)
Show SMILES Cc1cc(nc(n1)C#N)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H31N5O2/c1-15-13-19(24-18(14-22)23-15)25-9-5-16(6-10-25)17-7-11-26(12-8-17)20(27)28-21(2,3)4/h13,16-17H,5-12H2,1-4H3
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n/an/an/an/a 2n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342681
PNG
(CHEMBL1771082 | tert-butyl 1'-(6-cyano-2-methylpyr...)
Show SMILES Cc1nc(cc(n1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C)C#N
Show InChI InChI=1S/C21H31N5O2/c1-15-23-18(14-22)13-19(24-15)25-9-5-16(6-10-25)17-7-11-26(12-8-17)20(27)28-21(2,3)4/h13,16-17H,5-12H2,1-4H3
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n/an/an/an/a 2n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342682
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(pyridin-2-yl)-4,4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C22H29N3O2S/c1-28(26,27)21-7-5-20(6-8-21)24-14-9-18(10-15-24)19-11-16-25(17-12-19)22-4-2-3-13-23-22/h2-8,13,18-19H,9-12,14-17H2,1H3
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n/an/an/an/a 682n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342683
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(pyrazin-2-yl)-4,4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1cnccn1
Show InChI InChI=1S/C21H28N4O2S/c1-28(26,27)20-4-2-19(3-5-20)24-12-6-17(7-13-24)18-8-14-25(15-9-18)21-16-22-10-11-23-21/h2-5,10-11,16-18H,6-9,12-15H2,1H3
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n/an/an/an/a 239n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342684
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(pyrimidin-2-yl)-4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H28N4O2S/c1-28(26,27)20-5-3-19(4-6-20)24-13-7-17(8-14-24)18-9-15-25(16-10-18)21-22-11-2-12-23-21/h2-6,11-12,17-18H,7-10,13-16H2,1H3
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n/an/an/an/a 887n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342685
PNG
(1-(5-methylpyrimidin-2-yl)-1'-(4-(methylsulfonyl)p...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H30N4O2S/c1-17-15-23-22(24-16-17)26-13-9-19(10-14-26)18-7-11-25(12-8-18)20-3-5-21(6-4-20)29(2,27)28/h3-6,15-16,18-19H,7-14H2,1-2H3
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n/an/an/an/a 45n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342686
PNG
(1-(5-chloropyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(Cl)cn1
Show InChI InChI=1S/C22H28ClN3O2S/c1-29(27,28)21-5-3-20(4-6-21)25-12-8-17(9-13-25)18-10-14-26(15-11-18)22-7-2-19(23)16-24-22/h2-7,16-18H,8-15H2,1H3
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n/an/an/an/a 131n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342687
PNG
(1-(5-fluoropyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(F)cn1
Show InChI InChI=1S/C22H28FN3O2S/c1-29(27,28)21-5-3-20(4-6-21)25-12-8-17(9-13-25)18-10-14-26(15-11-18)22-7-2-19(23)16-24-22/h2-7,16-18H,8-15H2,1H3
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n/an/an/an/a 206n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342688
PNG
(1-(5-methylpyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Show SMILES Cc1ccc(nc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H31N3O2S/c1-18-3-8-23(24-17-18)26-15-11-20(12-16-26)19-9-13-25(14-10-19)21-4-6-22(7-5-21)29(2,27)28/h3-8,17,19-20H,9-16H2,1-2H3
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n/an/an/an/a 73n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342689
PNG
(6-(1'-(4-(methylsulfonyl)phenyl)-4,4'-bipiperidin-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C23H28N4O2S/c1-30(28,29)22-5-3-21(4-6-22)26-12-8-19(9-13-26)20-10-14-27(15-11-20)23-7-2-18(16-24)17-25-23/h2-7,17,19-20H,8-15H2,1H3
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n/an/an/an/a 41n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342690
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(5-(trifluoromethy...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O2S/c1-32(30,31)21-5-3-20(4-6-21)28-12-8-17(9-13-28)18-10-14-29(15-11-18)22-7-2-19(16-27-22)23(24,25)26/h2-7,16-18H,8-15H2,1H3
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n/an/an/an/a 8n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342691
PNG
(1-(5-chloropyrimidin-2-yl)-1'-(4-(methylsulfonyl)p...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H27ClN4O2S/c1-29(27,28)20-4-2-19(3-5-20)25-10-6-16(7-11-25)17-8-12-26(13-9-17)21-23-14-18(22)15-24-21/h2-5,14-17H,6-13H2,1H3
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n/an/an/an/a 8n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342692
PNG
(4-(1'-(5-chloropyrimidin-2-yl)-4,4'-bipiperidin-1-...)
Show SMILES Cc1cc(nc(n1)C#N)N1CCC(CC1)C1CCN(CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClN7/c1-14-10-19(26-18(11-22)25-14)27-6-2-15(3-7-27)16-4-8-28(9-5-16)20-23-12-17(21)13-24-20/h10,12-13,15-16H,2-9H2,1H3
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n/an/an/an/a 11n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342693
PNG
(2-methyl-6-(1'-(5-methylpyrimidin-2-yl)-4,4'-bipip...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)C1CCN(CC1)c1cc(nc(C)n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-13-23-21(24-14-15)28-9-5-18(6-10-28)17-3-7-27(8-4-17)20-11-19(12-22)25-16(2)26-20/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/an/an/a 10n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342694
PNG
(2-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Show SMILES Cc1cnc(cn1)N1CCC(CC1)C1CCN(CC1)c1cc(nc(C)n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-13-24-21(14-23-15)28-9-5-18(6-10-28)17-3-7-27(8-4-17)20-11-19(12-22)25-16(2)26-20/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/an/an/a 82n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342695
PNG
(4-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Show SMILES Cc1cnc(cn1)N1CCC(CC1)C1CCN(CC1)c1cc(C)nc(n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-11-20(26-19(12-22)25-15)27-7-3-17(4-8-27)18-5-9-28(10-6-18)21-14-23-16(2)13-24-21/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/an/an/a 64n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342703
PNG
(CHEMBL1771104 | rac-4-(3-(2-(3-(1-(5-chloropyrimid...)
Show SMILES Fc1cc(OCCCC2CC2CCCC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C28H36ClFN4O2/c29-22-17-31-28(32-18-22)34-12-10-19(11-13-34)3-1-4-20-15-21(20)5-2-14-36-24-8-9-25(26(30)16-24)27(35)33-23-6-7-23/h8-9,16-21,23H,1-7,10-15H2,(H,33,35)
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n/an/an/an/a 0.800n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342696
PNG
((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Show SMILES Fc1cc(OCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C23H26ClFN4O2/c24-16-11-26-23(27-12-16)29-7-5-14(6-8-29)20-9-15(20)13-31-18-3-4-19(21(25)10-18)22(30)28-17-1-2-17/h3-4,10-12,14-15,17,20H,1-2,5-9,13H2,(H,28,30)
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n/an/an/an/a 9n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342696
PNG
((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Show SMILES Fc1cc(OCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C23H26ClFN4O2/c24-16-11-26-23(27-12-16)29-7-5-14(6-8-29)20-9-15(20)13-31-18-3-4-19(21(25)10-18)22(30)28-17-1-2-17/h3-4,10-12,14-15,17,20H,1-2,5-9,13H2,(H,28,30)
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n/an/an/an/a 23n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/an/an/a 0.400n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/an/an/a 5n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/an/an/a 2n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Citation and Details
More data for this
Ligand-Target Pair
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