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Found 120 hits Enz. Inhib. hit(s) with Target = 'Glucose-dependent insulinotropic receptor' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341310
PNG
(CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...)
Show SMILES CC(C)OC(=O)N1CC2COCC(C1)C2Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C22H28N4O5/c1-13(2)29-22(27)26-8-16-10-28-11-17(9-26)19(16)31-21-14(3)20(24-12-25-21)30-18-6-5-7-23-15(18)4/h5-7,12-13,16-17,19H,8-11H2,1-4H3
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32n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341310
PNG
(CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...)
Show SMILES CC(C)OC(=O)N1CC2COCC(C1)C2Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C22H28N4O5/c1-13(2)29-22(27)26-8-16-10-28-11-17(9-26)19(16)31-21-14(3)20(24-12-25-21)30-18-6-5-7-23-15(18)4/h5-7,12-13,16-17,19H,8-11H2,1-4H3
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125n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341309
PNG
(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-10-7-16(8-11-24)27-18-14(3)19(23-12-22-18)28-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3
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140n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341310
PNG
(CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...)
Show SMILES CC(C)OC(=O)N1CC2COCC(C1)C2Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C22H28N4O5/c1-13(2)29-22(27)26-8-16-10-28-11-17(9-26)19(16)31-21-14(3)20(24-12-25-21)30-18-6-5-7-23-15(18)4/h5-7,12-13,16-17,19H,8-11H2,1-4H3
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n/an/an/an/a 228n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 expressed in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341310
PNG
(CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...)
Show SMILES CC(C)OC(=O)N1CC2COCC(C1)C2Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C22H28N4O5/c1-13(2)29-22(27)26-8-16-10-28-11-17(9-26)19(16)31-21-14(3)20(24-12-25-21)30-18-6-5-7-23-15(18)4/h5-7,12-13,16-17,19H,8-11H2,1-4H3
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n/an/an/an/a 227n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 expressed in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341309
PNG
(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-10-7-16(8-11-24)27-18-14(3)19(23-12-22-18)28-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3
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n/an/an/an/a 84n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 expressed in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343443
PNG
(CHEMBL1773283 | tert-butyl 4-(1-(2-fluoro-4-(methy...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Sc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H26FN5O4S2/c1-22(2,3)32-21(29)27-9-7-14(8-10-27)33-20-16-12-26-28(19(16)24-13-25-20)18-6-5-15(11-17(18)23)34(4,30)31/h5-6,11-14H,7-10H2,1-4H3
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n/an/an/an/a 7.30n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343447
PNG
(CHEMBL1775169 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O5S/c1-22(2,3)32-21(28)26-11-9-16(10-12-26)31-20-18-13-25-27(19(18)23-14-24-20)15-5-7-17(8-6-15)33(4,29)30/h5-8,13-14,16H,9-12H2,1-4H3
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n/an/an/an/a 9.80n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343452
PNG
(CHEMBL1773282 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Sc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O4S2/c1-22(2,3)31-21(28)26-11-9-16(10-12-26)32-20-18-13-25-27(19(18)23-14-24-20)15-5-7-17(8-6-15)33(4,29)30/h5-8,13-14,16H,9-12H2,1-4H3
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n/an/an/an/a 15.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343445
PNG
(CHEMBL1773293 | tert-butyl 4-(3-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2c(noc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O6S/c1-22(2,3)31-21(27)26-11-9-15(10-12-26)30-20-19-18(23-13-24-20)17(25-32-19)14-5-7-16(8-6-14)33(4,28)29/h5-8,13,15H,9-12H2,1-4H3
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n/an/an/an/a 17n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343446
PNG
(CHEMBL1775178 | tert-butyl 4-(1-(2-fluoro-4-(methy...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H26FN5O5S/c1-22(2,3)33-21(29)27-9-7-14(8-10-27)32-20-16-12-26-28(19(16)24-13-25-20)18-6-5-15(11-17(18)23)34(4,30)31/h5-6,11-14H,7-10H2,1-4H3
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n/an/an/an/a 19.6n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343459
PNG
(CHEMBL1775174 | cyclopentyl 4-(1-(4-(methylsulfony...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1ncc2c(OC3CCN(CC3)C(=O)OC3CCCC3)ncnc12
Show InChI InChI=1S/C23H27N5O5S/c1-34(30,31)19-8-6-16(7-9-19)28-21-20(14-26-28)22(25-15-24-21)32-18-10-12-27(13-11-18)23(29)33-17-4-2-3-5-17/h6-9,14-15,17-18H,2-5,10-13H2,1H3
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n/an/an/an/a 21n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343442
PNG
(CHEMBL1775179 | isopropyl 4-(1-(2-fluoro-4-(methyl...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3
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n/an/an/an/a 33n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343458
PNG
(CHEMBL1773294 | isopropyl 4-(3-(4-(methylsulfonyl)...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2c(noc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H24N4O6S/c1-13(2)29-21(26)25-10-8-15(9-11-25)30-20-19-18(22-12-23-20)17(24-31-19)14-4-6-16(7-5-14)32(3,27)28/h4-7,12-13,15H,8-11H2,1-3H3
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n/an/an/an/a 40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343460
PNG
(CHEMBL1773288 | tert-butyl 4-(3-methyl-1-(4-(methy...)
Show SMILES Cc1nn(-c2ccc(cc2)S(C)(=O)=O)c2ncnc(OC3CCN(CC3)C(=O)OC(C)(C)C)c12
Show InChI InChI=1S/C23H29N5O5S/c1-15-19-20(28(26-15)16-6-8-18(9-7-16)34(5,30)31)24-14-25-21(19)32-17-10-12-27(13-11-17)22(29)33-23(2,3)4/h6-9,14,17H,10-13H2,1-5H3
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n/an/an/an/a 42n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343454
PNG
(CHEMBL1773291 | tert-butyl 4-(3-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(nnc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H26N6O5S/c1-21(2,3)32-20(28)26-11-9-15(10-12-26)31-19-17-18(22-13-23-19)27(25-24-17)14-5-7-16(8-6-14)33(4,29)30/h5-8,13,15H,9-12H2,1-4H3
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n/an/an/an/a 42n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343450
PNG
(CHEMBL1775170 | ethyl 4-(1-(4-(methylsulfonyl)phen...)
Show SMILES CCOC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H23N5O5S/c1-3-29-20(26)24-10-8-15(9-11-24)30-19-17-12-23-25(18(17)21-13-22-19)14-4-6-16(7-5-14)31(2,27)28/h4-7,12-13,15H,3,8-11H2,1-2H3
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n/an/an/an/a 53n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343456
PNG
(CHEMBL1775176 | neopentyl 4-(1-(4-(methylsulfonyl)...)
Show SMILES CC(C)(C)COC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H29N5O5S/c1-23(2,3)14-32-22(29)27-11-9-17(10-12-27)33-21-19-13-26-28(20(19)24-15-25-21)16-5-7-18(8-6-16)34(4,30)31/h5-8,13,15,17H,9-12,14H2,1-4H3
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n/an/an/an/a 65n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343448
PNG
(CHEMBL1773287 | tert-butyl 4-((1-(2-fluoro-4-(meth...)
Show SMILES CC(C)(C)OC(=O)N1CCC(Cc2ncnc3n(ncc23)-c2ccc(cc2F)S(C)(=O)=O)CC1
Show InChI InChI=1S/C23H28FN5O4S/c1-23(2,3)33-22(30)28-9-7-15(8-10-28)11-19-17-13-27-29(21(17)26-14-25-19)20-6-5-16(12-18(20)24)34(4,31)32/h5-6,12-15H,7-11H2,1-4H3
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n/an/an/an/a 88n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343434
PNG
(CHEMBL1773286 | tert-butyl 4-((1-(4-(methylsulfony...)
Show SMILES CC(C)(C)OC(=O)N1CCC(Cc2ncnc3n(ncc23)-c2ccc(cc2)S(C)(=O)=O)CC1
Show InChI InChI=1S/C23H29N5O4S/c1-23(2,3)32-22(29)27-11-9-16(10-12-27)13-20-19-14-26-28(21(19)25-15-24-20)17-5-7-18(8-6-17)33(4,30)31/h5-8,14-16H,9-13H2,1-4H3
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n/an/an/an/a 120n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343436
PNG
(CHEMBL1773281 | isopropyl 4-((ethyl(1-(2-fluoro-4-...)
Show SMILES CCN(CC1CCN(CC1)C(=O)OC(C)C)c1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C24H31FN6O4S/c1-5-29(14-17-8-10-30(11-9-17)24(32)35-16(2)3)22-19-13-28-31(23(19)27-15-26-22)21-7-6-18(12-20(21)25)36(4,33)34/h6-7,12-13,15-17H,5,8-11,14H2,1-4H3
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n/an/an/an/a 264n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343435
PNG
(CHEMBL1773277 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Nc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H28N6O4S/c1-22(2,3)32-21(29)27-11-9-15(10-12-27)26-19-18-13-25-28(20(18)24-14-23-19)16-5-7-17(8-6-16)33(4,30)31/h5-8,13-15H,9-12H2,1-4H3,(H,23,24,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343439
PNG
(CHEMBL1773284 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)S(=O)c1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O5S2/c1-22(2,3)32-21(28)26-11-9-16(10-12-26)33(29)20-18-13-25-27(19(18)23-14-24-20)15-5-7-17(8-6-15)34(4,30)31/h5-8,13-14,16H,9-12H2,1-4H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343441
PNG
(CHEMBL1773285 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)S(=O)(=O)c1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O6S2/c1-22(2,3)33-21(28)26-11-9-17(10-12-26)35(31,32)20-18-13-25-27(19(18)23-14-24-20)15-5-7-16(8-6-15)34(4,29)30/h5-8,13-14,17H,9-12H2,1-4H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364541
PNG
(CHEMBL1951011)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(cc2F)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H26FN3O6S/c1-13(2)29-21(26)25-9-7-15(8-10-25)30-19-14(3)20(24-12-23-19)31-18-6-5-16(11-17(18)22)32(4,27)28/h5-6,11-13,15H,7-10H2,1-4H3
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n/an/an/an/a 55n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364542
PNG
(CHEMBL1951012)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H27FN4O5S/c1-13(2)30-21(27)26-9-7-15(8-10-26)31-20-14(3)19(23-12-24-20)25-18-6-5-16(11-17(18)22)32(4,28)29/h5-6,11-13,15H,7-10H2,1-4H3,(H,23,24,25)
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n/an/an/an/a 200n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364543
PNG
(CHEMBL1951013)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ncc(cc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-8-6-16(7-9-26)31-20-15(4)19(23-12-24-20)25-18-14(3)10-17(11-22-18)32(5,28)29/h10-13,16H,6-9H2,1-5H3,(H,22,23,24,25)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364544
PNG
(CHEMBL1951014)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(c(C)n2)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-10-8-16(9-11-26)31-20-14(3)19(22-12-23-20)25-18-7-6-17(15(4)24-18)32(5,28)29/h6-7,12-13,16H,8-11H2,1-5H3,(H,22,23,24,25)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341309
PNG
(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-10-7-16(8-11-24)27-18-14(3)19(23-12-22-18)28-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3
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n/an/an/an/a 83n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364545
PNG
(CHEMBL1951015)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2cccnc2C)c1C
Show InChI InChI=1S/C20H27N5O3/c1-13(2)27-20(26)25-10-7-16(8-11-25)28-19-14(3)18(22-12-23-19)24-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3,(H,22,23,24)
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n/an/an/an/a 700n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364546
PNG
(CHEMBL1951016)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2cccnc2)c1C
Show InChI InChI=1S/C19H25N5O3/c1-13(2)26-19(25)24-9-6-16(7-10-24)27-18-14(3)17(21-12-22-18)23-15-5-4-8-20-11-15/h4-5,8,11-13,16H,6-7,9-10H2,1-3H3,(H,21,22,23)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364547
PNG
(CHEMBL1951017)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cnccc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-9-6-16(7-10-24)27-18-15(4)19(23-12-22-18)28-17-11-21-8-5-14(17)3/h5,8,11-13,16H,6-7,9-10H2,1-4H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364548
PNG
(CHEMBL1949674)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(C)nc2C)c1C
Show InChI InChI=1S/C21H28N4O4/c1-13(2)27-21(26)25-10-8-17(9-11-25)28-19-15(4)20(23-12-22-19)29-18-7-6-14(3)24-16(18)5/h6-7,12-13,17H,8-11H2,1-5H3
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n/an/an/an/a 270n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364549
PNG
(CHEMBL1951018)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cncc(F)c2)c1C
Show InChI InChI=1S/C19H23FN4O4/c1-12(2)26-19(25)24-6-4-15(5-7-24)27-17-13(3)18(23-11-22-17)28-16-8-14(20)9-21-10-16/h8-12,15H,4-7H2,1-3H3
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n/an/an/an/a 530n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364550
PNG
(CHEMBL1951019)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cncc(c2)C#N)c1C
Show InChI InChI=1S/C20H23N5O4/c1-13(2)27-20(26)25-6-4-16(5-7-25)28-18-14(3)19(24-12-23-18)29-17-8-15(9-21)10-22-11-17/h8,10-13,16H,4-7H2,1-3H3
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n/an/an/an/a 1.75E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364551
PNG
(CHEMBL1951020)
Show SMILES COc1ccc(Oc2ncnc(OC3CCN(CC3)C(=O)OC(C)C)c2C)c(C)n1
Show InChI InChI=1S/C21H28N4O5/c1-13(2)28-21(26)25-10-8-16(9-11-25)29-19-14(3)20(23-12-22-19)30-17-6-7-18(27-5)24-15(17)4/h6-7,12-13,16H,8-11H2,1-5H3
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n/an/an/an/a 800n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364552
PNG
(CHEMBL1951021)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H28N4O6S/c1-13(2)29-21(26)25-10-8-16(9-11-25)30-19-14(3)20(23-12-22-19)31-17-6-7-18(24-15(17)4)32(5,27)28/h6-7,12-13,16H,8-11H2,1-5H3
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n/an/an/an/a 190n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364553
PNG
(CHEMBL1951022)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-10-8-16(9-11-26)31-20-14(3)19(22-12-23-20)25-17-6-7-18(24-15(17)4)32(5,28)29/h6-7,12-13,16H,8-11H2,1-5H3,(H,22,23,25)
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n/an/an/an/a 920n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364537
PNG
(CHEMBL1951023)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2)S(C)(=O)=O)c1C
Show InChI InChI=1S/C20H27N5O5S/c1-13(2)29-20(26)25-9-7-16(8-10-25)30-19-14(3)18(22-12-23-19)24-15-5-6-17(21-11-15)31(4,27)28/h5-6,11-13,16H,7-10H2,1-4H3,(H,22,23,24)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364538
PNG
(CHEMBL1951024)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cnc(cc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H28N4O6S/c1-13(2)29-21(26)25-8-6-16(7-9-25)30-19-15(4)20(24-12-23-19)31-17-11-22-18(10-14(17)3)32(5,27)28/h10-13,16H,6-9H2,1-5H3
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n/an/an/an/a 140n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364539
PNG
(CHEMBL1951025)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2cnc(cc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-8-6-16(7-9-26)31-20-15(4)19(23-12-24-20)25-17-11-22-18(10-14(17)3)32(5,28)29/h10-13,16H,6-9H2,1-5H3,(H,23,24,25)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364540
PNG
(CHEMBL1951026)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccncc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-9-6-16(7-10-24)27-18-15(4)19(23-12-22-18)28-17-5-8-21-11-14(17)3/h5,8,11-13,16H,6-7,9-10H2,1-4H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364555
PNG
(CHEMBL1951028)
Show SMILES CCc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C22H31N5O5S/c1-6-17-20(26-18-7-8-19(25-15(18)4)33(5,29)30)23-13-24-21(17)32-16-9-11-27(12-10-16)22(28)31-14(2)3/h7-8,13-14,16H,6,9-12H2,1-5H3,(H,23,24,26)
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n/an/an/an/a 688n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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n/an/an/an/a 421n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364560
PNG
(CHEMBL1951033)
Show SMILES CCOc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C22H31N5O6S/c1-6-31-19-20(26-17-7-8-18(25-15(17)4)34(5,29)30)23-13-24-21(19)33-16-9-11-27(12-10-16)22(28)32-14(2)3/h7-8,13-14,16H,6,9-12H2,1-5H3,(H,23,24,26)
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n/an/an/an/a 486n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364565
PNG
(CHEMBL1949688)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1cc(Nc2ccc(nc2[N+]([O-])=O)S(C)(=O)=O)ncn1
Show InChI InChI=1S/C19H24N6O7S/c1-12(2)31-19(26)24-8-6-13(7-9-24)32-16-10-15(20-11-21-16)22-14-4-5-17(33(3,29)30)23-18(14)25(27)28/h4-5,10-13H,6-9H2,1-3H3,(H,20,21,22)
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n/an/an/an/a>5.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50445481
PNG
(CHEMBL3104879)
Show SMILES CC(C)N1C(=O)c2cc(C)nc(Oc3cc(NS(=O)(=O)c4ccc(Cl)cc4)ccc3F)c2C1=O
Show InChI InChI=1S/C23H19ClFN3O5S/c1-12(2)28-22(29)17-10-13(3)26-21(20(17)23(28)30)33-19-11-15(6-9-18(19)25)27-34(31,32)16-7-4-14(24)5-8-16/h4-12,27H,1-3H3
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n/an/an/an/a 2.05E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 assessed as cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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n/an/an/an/a 421n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50055992
PNG
(CHEMBL3325842)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H26FN5O5S/c1-12(2)30-20(27)26-9-7-14(8-10-26)31-19-17(21)18(22-11-23-19)25-15-5-6-16(24-13(15)3)32(4,28)29/h5-6,11-12,14H,7-10H2,1-4H3,(H,22,23,25)
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n/an/an/an/a 265n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Citation and Details
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50055993
PNG
(CHEMBL3325843)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H25FN4O6S/c1-12(2)29-20(26)25-9-7-14(8-10-25)30-18-17(21)19(23-11-22-18)31-15-5-6-16(24-13(15)3)32(4,27)28/h5-6,11-12,14H,7-10H2,1-4H3
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n/an/an/an/a 142n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Citation and Details
More data for this
Ligand-Target Pair
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