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Compile Data Set for Download or QSAR

Found 9 hits Enz. Inhib. hit(s) with Target = 'Glutamate (NMDA) receptor subunit zeta 1' AND taxid = 9823   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate (NMDA) receptor subunit zeta 1


(Sus scrofa)
BDBM50089759
PNG
((R)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Show SMILES O[C@@H](CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2/t20-/m0/s1
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MMDB

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PubMed
n/an/a 50n/an/an/an/an/an/a



Zentrum für Pharmaforschung

Curated by ChEMBL


Assay Description
Displacement of [3H]-ifendropil from binding site of N-methyl-D-aspartate glutamate receptor was evaluated employing synaptosomal fraction of porcine...


Bioorg Med Chem Lett 10: 1377-80 (2000)

More data for this
Ligand-Target Pair
Glutamate (NMDA) receptor subunit zeta 1


(Sus scrofa)
BDBM50079387
PNG
(1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...)
Show SMILES OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2
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PubMed
n/an/a 83n/an/an/an/an/an/a



Zentrum für Pharmaforschung

Curated by ChEMBL


Assay Description
Displacement of [3H]-ifendropil from binding site of N-methyl-D-aspartate glutamate receptor was evaluated employing synaptosomal fraction of porcine...


Bioorg Med Chem Lett 10: 1377-80 (2000)

More data for this
Ligand-Target Pair
Glutamate (NMDA) receptor subunit zeta 1


(Sus scrofa)
BDBM50089759
PNG
((R)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Show SMILES O[C@@H](CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2/t20-/m0/s1
PDB
MMDB

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CHEMBL
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PC sid
UniChem

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PubMed
n/an/a 213n/an/an/an/an/an/a



Zentrum für Pharmaforschung

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor at NR2B subunit in high affinity fraction of por...


Bioorg Med Chem Lett 10: 1377-80 (2000)

More data for this
Ligand-Target Pair
Glutamate (NMDA) receptor subunit zeta 1


(Sus scrofa)
BDBM50079387
PNG
(1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...)
Show SMILES OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2
PDB
MMDB

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CHEMBL
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PC sid
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PubMed
n/an/a 277n/an/an/an/an/an/a



Zentrum für Pharmaforschung

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor at NR2B subunit in high affinity fraction of por...


Bioorg Med Chem Lett 10: 1377-80 (2000)

More data for this
Ligand-Target Pair
Glutamate (NMDA) receptor subunit zeta 1


(Sus scrofa)
BDBM50089760
PNG
((S)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Show SMILES O[C@H](CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2/t20-/m1/s1
PDB
MMDB

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CHEMBL
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PC sid
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PubMed
n/an/a 545n/an/an/an/an/an/a



Zentrum für Pharmaforschung

Curated by ChEMBL


Assay Description
Displacement of [3H]-ifendropil from binding site of N-methyl-D-aspartate glutamate receptor was evaluated employing synaptosomal fraction of porcine...


Bioorg Med Chem Lett 10: 1377-80 (2000)

More data for this
Ligand-Target Pair
Glutamate (NMDA) receptor subunit zeta 1


(Sus scrofa)
BDBM50089760
PNG
((S)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Show SMILES O[C@H](CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2/t20-/m1/s1
PDB
MMDB

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CHEMBL
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PC sid
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PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



Zentrum für Pharmaforschung

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor at NR2B subunit in high affinity fraction of por...


Bioorg Med Chem Lett 10: 1377-80 (2000)

More data for this
Ligand-Target Pair
Glutamate (NMDA) receptor subunit zeta 1


(Sus scrofa)
BDBM50089760
PNG
((S)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Show SMILES O[C@H](CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2/t20-/m1/s1
PDB
MMDB

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CHEMBL
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PC sid
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PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



Zentrum für Pharmaforschung

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor lacking NR2B subunit in low affinity fraction of...


Bioorg Med Chem Lett 10: 1377-80 (2000)

More data for this
Ligand-Target Pair
Glutamate (NMDA) receptor subunit zeta 1


(Sus scrofa)
BDBM50079387
PNG
(1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...)
Show SMILES OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2
PDB
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CHEMBL
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PubMed
n/an/a 1.13E+4n/an/an/an/an/an/a



Zentrum für Pharmaforschung

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor lacking NR2B subunit in low affinity fraction of...


Bioorg Med Chem Lett 10: 1377-80 (2000)

More data for this
Ligand-Target Pair
Glutamate (NMDA) receptor subunit zeta 1


(Sus scrofa)
BDBM50089759
PNG
((R)-1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-pip...)
Show SMILES O[C@@H](CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2/t20-/m0/s1
PDB
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CHEMBL
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PubMed
n/an/a 2.37E+4n/an/an/an/an/an/a



Zentrum für Pharmaforschung

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor lacking NR2B subunit in low affinity fraction of...


Bioorg Med Chem Lett 10: 1377-80 (2000)

More data for this
Ligand-Target Pair