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Compile Data Set for Download or QSAR

Found 311 hits Enz. Inhib. hit(s) with Target = 'Glutamate [NMDA] receptor subunit epsilon 1/zeta 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50111396
PNG
(CHEMBL273636 | [[(S)-1-(4-Bromo-phenyl)-ethylamino...)
Show SMILES C[C@H](NC(c1cccc2[nH]c(=O)c(=O)[nH]c12)P(O)(O)=O)c1ccc(Br)cc1
Show InChI InChI=1S/C17H17BrN3O5P/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26)/t9-,17?/m0/s1
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5.40n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50050704
PNG
((R)-4-(3-Phosphono-propyl)-piperazine-2-carboxylic...)
Show SMILES OC(=O)[C@H]1CN(CCCP(O)(O)=O)CCN1
Show InChI InChI=1/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)/t7-/s2
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41n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419775
PNG
(CHEMBL1950808)
Show SMILES OC(=O)[C@@H]1NCCN([C@@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1
Show InChI InChI=1/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/s2
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210n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50004897
PNG
((APV)2-Amino-5-phosphono-pentanoic acid | (R)-2-Am...)
Show SMILES NC(CCCP(O)(O)=O)C(O)=O
Show InChI InChI=1/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
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280n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164549
PNG
((2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-pipera...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3cc(Br)ccc23)c1
Show InChI InChI=1S/C21H17BrN2O5/c22-14-4-6-16-12(10-14)2-1-11-9-13(3-5-15(11)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1
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320n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164549
PNG
((2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-pipera...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3cc(Br)ccc23)c1
Show InChI InChI=1S/C21H17BrN2O5/c22-14-4-6-16-12(10-14)2-1-11-9-13(3-5-15(11)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1
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320n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM81977
PNG
(CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV)
Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O
Show InChI InChI=1/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/s2
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390n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...


J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50017226
PNG
((R)-2-Amino-7-phosphono-heptanoic acid | 2-Amino-7...)
Show SMILES N[C@H](CCCCCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)/t6-/m1/s1
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490n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164540
PNG
((2R,3S)-1-(Phenanthrene-2-carbonyl)-piperazine-2,3...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1
Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1
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550n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164540
PNG
((2R,3S)-1-(Phenanthrene-2-carbonyl)-piperazine-2,3...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1
Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1
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550n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164556
PNG
((2R,3S)-1-((E)-3-Naphthalen-2-yl-acryloyl)-piperaz...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)\C=C\c1ccc2ccccc2c1
Show InChI InChI=1S/C19H18N2O5/c22-15(21-10-9-20-16(18(23)24)17(21)19(25)26)8-6-12-5-7-13-3-1-2-4-14(13)11-12/h1-8,11,16-17,20H,9-10H2,(H,23,24)(H,25,26)/b8-6+/t16-,17+/m0/s1
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840n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164555
PNG
((2R,3S)-1-(9,10-Dihydro-phenanthrene-2-carbonyl)-p...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc-2c(CCc3ccccc-23)c1
Show InChI InChI=1S/C21H20N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-4,7-8,11,17-18,22H,5-6,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1
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1.50E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164555
PNG
((2R,3S)-1-(9,10-Dihydro-phenanthrene-2-carbonyl)-p...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc-2c(CCc3ccccc-23)c1
Show InChI InChI=1S/C21H20N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-4,7-8,11,17-18,22H,5-6,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1
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1.54E+3n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419786
PNG
(CHEMBL1950795)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(I)ccc2c1
Show InChI InChI=1/C17H15IN2O5/c18-12-4-3-9-7-11(2-1-10(9)8-12)15(21)20-6-5-19-13(16(22)23)14(20)17(24)25/h1-4,7-8,13-14,19H,5-6H2,(H,22,23)(H,24,25)/t13-,14+/s2
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3.00E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164548
PNG
((2R,3S)-1-(7-Bromo-9,10-dihydro-phenanthrene-2-car...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc-2c(CCc3cc(Br)ccc-23)c1
Show InChI InChI=1S/C21H19BrN2O5/c22-14-4-6-16-12(10-14)2-1-11-9-13(3-5-15(11)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h3-6,9-10,17-18,23H,1-2,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1
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3.88E+3n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164548
PNG
((2R,3S)-1-(7-Bromo-9,10-dihydro-phenanthrene-2-car...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc-2c(CCc3cc(Br)ccc-23)c1
Show InChI InChI=1S/C21H19BrN2O5/c22-14-4-6-16-12(10-14)2-1-11-9-13(3-5-15(11)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h3-6,9-10,17-18,23H,1-2,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1
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3.90E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419787
PNG
(CHEMBL1950794)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(Br)ccc2c1
Show InChI InChI=1/C17H15BrN2O5/c18-12-4-3-9-7-11(2-1-10(9)8-12)15(21)20-6-5-19-13(16(22)23)14(20)17(24)25/h1-4,7-8,13-14,19H,5-6H2,(H,22,23)(H,24,25)/t13-,14+/s2
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4.10E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/s2
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4.70E+3n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...


J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419784
PNG
(CHEMBL1950797)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)CCc1ccc2ccccc2c1
Show InChI InChI=1/C19H20N2O5/c22-15(21-10-9-20-16(18(23)24)17(21)19(25)26)8-6-12-5-7-13-3-1-2-4-14(13)11-12/h1-5,7,11,16-17,20H,6,8-10H2,(H,23,24)(H,25,26)/t16-,17+/s2
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5.10E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419778
PNG
(CHEMBL1950803)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(Cl)c3ccccc3c2c1
Show InChI InChI=1/C21H17ClN2O5/c22-16-10-11-5-6-12(9-15(11)13-3-1-2-4-14(13)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/s2
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7.20E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419788
PNG
(CHEMBL1950793)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(F)ccc2c1
Show InChI InChI=1/C17H15FN2O5/c18-12-4-3-9-7-11(2-1-10(9)8-12)15(21)20-6-5-19-13(16(22)23)14(20)17(24)25/h1-4,7-8,13-14,19H,5-6H2,(H,22,23)(H,24,25)/t13-,14+/s2
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7.40E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50364074
PNG
(CHEMBL1950805)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(I)c3ccccc3c2c1
Show InChI InChI=1/C21H17IN2O5/c22-16-10-11-5-6-12(9-15(11)13-3-1-2-4-14(13)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/s2
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7.40E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164545
PNG
((2R,3S)-1-(9-Oxo-9H-fluorene-2-carbonyl)-piperazin...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2-c3ccccc3C(=O)c2c1
Show InChI InChI=1S/C20H16N2O6/c23-17-13-4-2-1-3-11(13)12-6-5-10(9-14(12)17)18(24)22-8-7-21-15(19(25)26)16(22)20(27)28/h1-6,9,15-16,21H,7-8H2,(H,25,26)(H,27,28)/t15-,16+/m0/s1
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7.97E+3n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164550
PNG
((2R,3S)-1-(4'-Fluoro-biphenyl-4-carbonyl)-piperazi...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN2O5/c20-14-7-5-12(6-8-14)11-1-3-13(4-2-11)17(23)22-10-9-21-15(18(24)25)16(22)19(26)27/h1-8,15-16,21H,9-10H2,(H,24,25)(H,26,27)/t15-,16+/m0/s1
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8.78E+3n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164551
PNG
((2R,3S)-1-(Naphthalene-2-carbonyl)-piperazine-2,3-...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H16N2O5/c20-15(12-6-5-10-3-1-2-4-11(10)9-12)19-8-7-18-13(16(21)22)14(19)17(23)24/h1-6,9,13-14,18H,7-8H2,(H,21,22)(H,23,24)/t13-,14+/m0/s1
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9.60E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164551
PNG
((2R,3S)-1-(Naphthalene-2-carbonyl)-piperazine-2,3-...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H16N2O5/c20-15(12-6-5-10-3-1-2-4-11(10)9-12)19-8-7-18-13(16(21)22)14(19)17(23)24/h1-6,9,13-14,18H,7-8H2,(H,21,22)(H,23,24)/t13-,14+/m0/s1
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9.60E+3n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164543
PNG
((2R,3R)-1-(Phenanthrene-2-carbonyl)-piperazine-2,3...)
Show SMILES OC(=O)[C@@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1
Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18-/m1/s1
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1.05E+4n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419776
PNG
(CHEMBL1950806)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc3ccccc3cc2c1
Show InChI InChI=1/C21H18N2O5/c24-19(23-8-7-22-17(20(25)26)18(23)21(27)28)15-6-5-14-9-12-3-1-2-4-13(12)10-16(14)11-15/h1-6,9-11,17-18,22H,7-8H2,(H,25,26)(H,27,28)/t17-,18+/s2
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1.05E+4n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164543
PNG
((2R,3R)-1-(Phenanthrene-2-carbonyl)-piperazine-2,3...)
Show SMILES OC(=O)[C@@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1
Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18-/m1/s1
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1.05E+4n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164541
PNG
((2R,3S)-1-Phenanthren-2-ylmethyl-piperazine-2,3-di...)
Show SMILES OC(=O)[C@H]1NCCN(Cc2ccc3c(ccc4ccccc34)c2)[C@H]1C(O)=O
Show InChI InChI=1S/C21H20N2O4/c24-20(25)18-19(21(26)27)23(10-9-22-18)12-13-5-8-17-15(11-13)7-6-14-3-1-2-4-16(14)17/h1-8,11,18-19,22H,9-10,12H2,(H,24,25)(H,26,27)/t18-,19+/m0/s1
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1.12E+4n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164541
PNG
((2R,3S)-1-Phenanthren-2-ylmethyl-piperazine-2,3-di...)
Show SMILES OC(=O)[C@H]1NCCN(Cc2ccc3c(ccc4ccccc34)c2)[C@H]1C(O)=O
Show InChI InChI=1S/C21H20N2O4/c24-20(25)18-19(21(26)27)23(10-9-22-18)12-13-5-8-17-15(11-13)7-6-14-3-1-2-4-16(14)17/h1-8,11,18-19,22H,9-10,12H2,(H,24,25)(H,26,27)/t18-,19+/m0/s1
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1.12E+4n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419777
PNG
(CHEMBL1950804)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(Br)c3ccccc3c2c1
Show InChI InChI=1/C21H17BrN2O5/c22-16-10-11-5-6-12(9-15(11)13-3-1-2-4-14(13)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/s2
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1.15E+4n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164554
PNG
((2R,3S)-1-[(E)-(3-Phenyl-acryloyl)]-piperazine-2,3...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C15H16N2O5/c18-11(7-6-10-4-2-1-3-5-10)17-9-8-16-12(14(19)20)13(17)15(21)22/h1-7,12-13,16H,8-9H2,(H,19,20)(H,21,22)/b7-6+/t12-,13+/m0/s1
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1.32E+4n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164544
PNG
((2R,3S)-1-(Biphenyl-4-sulfonyl)-piperazine-2,3-dic...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H18N2O6S/c21-17(22)15-16(18(23)24)20(11-10-19-15)27(25,26)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15-16,19H,10-11H2,(H,21,22)(H,23,24)/t15-,16+/m0/s1
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1.36E+4n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164544
PNG
((2R,3S)-1-(Biphenyl-4-sulfonyl)-piperazine-2,3-dic...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H18N2O6S/c21-17(22)15-16(18(23)24)20(11-10-19-15)27(25,26)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15-16,19H,10-11H2,(H,21,22)(H,23,24)/t15-,16+/m0/s1
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1.36E+4n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164553
PNG
((2R,3S)-1-(Phenanthrene-3-carbonyl)-piperazine-2,3...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2ccc3ccccc3c2c1
Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-8-7-13-6-5-12-3-1-2-4-15(12)16(13)11-14/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1
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1.42E+4n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164552
PNG
((2R,3S)-1-(Biphenyl-4-carbonyl)-piperazine-2,3-dic...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H18N2O5/c22-17(21-11-10-20-15(18(23)24)16(21)19(25)26)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15-16,20H,10-11H2,(H,23,24)(H,25,26)/t15-,16+/m0/s1
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1.57E+4n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164552
PNG
((2R,3S)-1-(Biphenyl-4-carbonyl)-piperazine-2,3-dic...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H18N2O5/c22-17(21-11-10-20-15(18(23)24)16(21)19(25)26)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15-16,20H,10-11H2,(H,23,24)(H,25,26)/t15-,16+/m0/s1
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1.58E+4n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164540
PNG
((2R,3S)-1-(Phenanthrene-2-carbonyl)-piperazine-2,3...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1
Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1
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1.76E+4n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164553
PNG
((2R,3S)-1-(Phenanthrene-3-carbonyl)-piperazine-2,3...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2ccc3ccccc3c2c1
Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-8-7-13-6-5-12-3-1-2-4-15(12)16(13)11-14/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1
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2.20E+4n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164542
PNG
((2R,3S)-1-(2'-Bromo-biphenyl-4-carbonyl)-piperazin...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccccc1Br
Show InChI InChI=1S/C19H17BrN2O5/c20-14-4-2-1-3-13(14)11-5-7-12(8-6-11)17(23)22-10-9-21-15(18(24)25)16(22)19(26)27/h1-8,15-16,21H,9-10H2,(H,24,25)(H,26,27)/t15-,16+/m0/s1
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4.29E+4n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419780
PNG
(CHEMBL1950801)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)\N=N\c1ccccc1
Show InChI InChI=1/C19H18N4O5/c24-17(23-11-10-20-15(18(25)26)16(23)19(27)28)12-6-8-14(9-7-12)22-21-13-4-2-1-3-5-13/h1-9,15-16,20H,10-11H2,(H,25,26)(H,27,28)/b22-21+/t15-,16+/s2
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9.93E+4n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419783
PNG
(CHEMBL1950798)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1/C18H16N2O7/c21-15(20-6-5-19-13(17(24)25)14(20)18(26)27)11-3-1-10-8-12(16(22)23)4-2-9(10)7-11/h1-4,7-8,13-14,19H,5-6H2,(H,22,23)(H,24,25)(H,26,27)/t13-,14+/s2
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419785
PNG
(CHEMBL1950796)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(ccc2c1)-c1ccccc1
Show InChI InChI=1/C23H20N2O5/c26-21(25-11-10-24-19(22(27)28)20(25)23(29)30)18-9-8-16-12-15(6-7-17(16)13-18)14-4-2-1-3-5-14/h1-9,12-13,19-20,24H,10-11H2,(H,27,28)(H,29,30)/t19-,20+/s2
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419779
PNG
(CHEMBL1950802)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(CCc2ccccc2)cc1
Show InChI InChI=1/C21H22N2O5/c24-19(23-13-12-22-17(20(25)26)18(23)21(27)28)16-10-8-15(9-11-16)7-6-14-4-2-1-3-5-14/h1-5,8-11,17-18,22H,6-7,12-13H2,(H,25,26)(H,27,28)/t17-,18+/s2
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50164547
PNG
((2R,3S)-1-Benzoyl-piperazine-2,3-dicarboxylic acid...)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccccc1
Show InChI InChI=1S/C13H14N2O5/c16-11(8-4-2-1-3-5-8)15-7-6-14-9(12(17)18)10(15)13(19)20/h1-5,9-10,14H,6-7H2,(H,17,18)(H,19,20)/t9-,10+/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50419781
PNG
(CHEMBL1950800)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)C#Cc1ccccc1
Show InChI InChI=1/C21H18N2O5/c24-19(23-13-12-22-17(20(25)26)18(23)21(27)28)16-10-8-15(9-11-16)7-6-14-4-2-1-3-5-14/h1-5,8-11,17-18,22H,12-13H2,(H,25,26)(H,27,28)/t17-,18+/s2
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1.38E+5n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...


J Med Chem 55: 327-41 (2012)


Article DOI: 10.1021/jm201230z
BindingDB Entry DOI: 10.7270/Q2TD9XTJ
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50426000
PNG
(CHEMBL2311573)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1/C31H52N10O4/c32-24(13-18-39-31(34)35)29(44)37-16-10-4-8-15-36-14-7-2-1-3-9-17-38-30(45)26(20-27(33)42)41-28(43)19-22-21-40-25-12-6-5-11-23(22)25/h5-6,11-12,21,24,26,36,40H,1-4,7-10,13-20,32H2,(H2,33,42)(H,37,44)(H,38,45)(H,41,43)(H4,34,35,39)/t24-,26+/s2
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n/an/a 5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluN1/2A receptor expressed in Xenopus laevis oocyte assessed as glutamate and glycine-induced current at holding potentials from -...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50425996
PNG
(CHEMBL2314718)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)[C@@H](NC(=O)Cc1ccc(O)cc1O)c1c[nH]c2ccccc12
Show InChI InChI=1/C35H53N9O5/c36-28(15-20-42-35(37)38)33(48)40-18-10-4-8-17-39-16-7-2-1-3-9-19-41-34(49)32(27-23-43-29-12-6-5-11-26(27)29)44-31(47)21-24-13-14-25(45)22-30(24)46/h5-6,11-14,22-23,28,32,39,43,45-46H,1-4,7-10,15-21,36H2,(H,40,48)(H,41,49)(H,44,47)(H4,37,38,42)/t28-,32+/s2
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n/an/a 5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluN1/2A receptor expressed in Xenopus laevis oocyte assessed as glutamate and glycine-induced current at holding potentials from -...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50426009
PNG
(CHEMBL2314938)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCCNCCCCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1/C30H53N9O6/c31-23(10-9-17-38-30(33)34)28(44)36-16-8-7-14-35-13-5-3-1-2-4-6-15-37-29(45)24(20-26(32)42)39-27(43)18-21-11-12-22(40)19-25(21)41/h11-12,19,23-24,35,40-41H,1-10,13-18,20,31H2,(H2,32,42)(H,36,44)(H,37,45)(H,39,43)(H4,33,34,38)/t23-,24-/s2
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n/an/a 8n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluN1/2A receptor expressed in Xenopus laevis oocyte assessed as glutamate and glycine-induced current at holding potentials from -...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
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