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Compile Data Set for Download or QSAR

Found 53 hits Enz. Inhib. hit(s) with Target = 'Glutamate [NMDA] receptor subunit epsilon 4' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440060
PNG
(CHEMBL2426081)
Show SMILES OC(=O)CCC(=O)N1N=C(C[C@H]1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21Cl2N3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)/t23-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440067
PNG
(CHEMBL2426072 | CHEMBL2426073)
Show SMILES OC(=O)C=CC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H19BrClN3O4/c29-18-9-5-17(6-10-18)26-20-3-1-2-4-21(20)31-28(37)27(26)22-15-23(16-7-11-19(30)12-8-16)33(32-22)24(34)13-14-25(35)36/h1-14,23H,15H2,(H,31,37)(H,35,36)
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n/an/a 190n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440084
PNG
(CHEMBL2426093)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21BrClN3O4/c29-18-9-5-17(6-10-18)26-20-3-1-2-4-21(20)31-28(37)27(26)22-15-23(16-7-11-19(30)12-8-16)33(32-22)24(34)13-14-25(35)36/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
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n/an/a 290n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440065
PNG
(CHEMBL2426075)
Show SMILES OC(=O)CCCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C29H23BrClN3O4/c30-19-12-8-18(9-13-19)27-21-4-1-2-5-22(21)32-29(38)28(27)23-16-24(17-10-14-20(31)15-11-17)34(33-23)25(35)6-3-7-26(36)37/h1-2,4-5,8-15,24H,3,6-7,16H2,(H,32,38)(H,36,37)
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n/an/a 320n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440085
PNG
(CHEMBL2426092)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21Br2N3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
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n/an/a 390n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440057
PNG
(CHEMBL2426097)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21Cl2N3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
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n/an/a 440n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440081
PNG
(CHEMBL2426096)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21BrClN3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
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n/an/a 510n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440077
PNG
(CHEMBL2425977)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)c(F)c2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H20Cl2FN3O4/c29-17-8-5-15(6-9-17)23-14-22(33-34(23)24(35)11-12-25(36)37)27-26(16-7-10-19(30)20(31)13-16)18-3-1-2-4-21(18)32-28(27)38/h1-10,13,23H,11-12,14H2,(H,32,38)(H,36,37)
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n/an/a 530n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440067
PNG
(CHEMBL2426072 | CHEMBL2426073)
Show SMILES OC(=O)C=CC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H19BrClN3O4/c29-18-9-5-17(6-10-18)26-20-3-1-2-4-21(20)31-28(37)27(26)22-15-23(16-7-11-19(30)12-8-16)33(32-22)24(34)13-14-25(35)36/h1-14,23H,15H2,(H,31,37)(H,35,36)
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n/an/a 570n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440058
PNG
(CHEMBL2426100)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(F)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21ClFN3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
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n/an/a 580n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440074
PNG
(CHEMBL2426065)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(F)c(F)c2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H20ClF2N3O4/c29-17-8-5-15(6-9-17)23-14-22(33-34(23)24(35)11-12-25(36)37)27-26(16-7-10-19(30)20(31)13-16)18-3-1-2-4-21(18)32-28(27)38/h1-10,13,23H,11-12,14H2,(H,32,38)(H,36,37)
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n/an/a 660n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440063
PNG
(CHEMBL2426077)
Show SMILES OC(=O)CCCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C29H23Cl2N3O4/c30-19-12-8-17(9-13-19)24-16-23(33-34(24)25(35)6-3-7-26(36)37)28-27(18-10-14-20(31)15-11-18)21-4-1-2-5-22(21)32-29(28)38/h1-2,4-5,8-15,24H,3,6-7,16H2,(H,32,38)(H,36,37)
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n/an/a 690n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440052
PNG
(CHEMBL2426105)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cccc(F)c2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21ClFN3O4/c29-18-10-8-16(9-11-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-3-5-19(30)14-17)20-6-1-2-7-21(20)31-28(27)37/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
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n/an/a 690n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440072
PNG
(CHEMBL2426067)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cc(Cl)cc(Cl)c2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H20Cl3N3O4/c29-17-7-5-15(6-8-17)23-14-22(33-34(23)24(35)9-10-25(36)37)27-26(16-11-18(30)13-19(31)12-16)20-3-1-2-4-21(20)32-28(27)38/h1-8,11-13,23H,9-10,14H2,(H,32,38)(H,36,37)
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n/an/a 700n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440073
PNG
(CHEMBL2426066)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cc(F)cc(F)c2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H20ClF2N3O4/c29-17-7-5-15(6-8-17)23-14-22(33-34(23)24(35)9-10-25(36)37)27-26(16-11-18(30)13-19(31)12-16)20-3-1-2-4-21(20)32-28(27)38/h1-8,11-13,23H,9-10,14H2,(H,32,38)(H,36,37)
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n/an/a 810n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440075
PNG
(CHEMBL2425979)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)c(Cl)c2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H20Cl3N3O4/c29-17-8-5-15(6-9-17)23-14-22(33-34(23)24(35)11-12-25(36)37)27-26(16-7-10-19(30)20(31)13-16)18-3-1-2-4-21(18)32-28(27)38/h1-10,13,23H,11-12,14H2,(H,32,38)(H,36,37)
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n/an/a 910n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440076
PNG
(CHEMBL2425978)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(F)c(Cl)c2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H20Cl2FN3O4/c29-17-8-5-15(6-9-17)23-14-22(33-34(23)24(35)11-12-25(36)37)27-26(16-7-10-20(31)19(30)13-16)18-3-1-2-4-21(18)32-28(27)38/h1-10,13,23H,11-12,14H2,(H,32,38)(H,36,37)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440051
PNG
(CHEMBL2425972)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cccc(Cl)c2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21Cl2N3O4/c29-18-10-8-16(9-11-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-3-5-19(30)14-17)20-6-1-2-7-21(20)31-28(27)37/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50242446
PNG
(2-[(2S)-2-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(1S,2S)-1...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)C(O)=O
Show InChI InChI=1S/C101H150N26O39/c1-10-46(6)76(125-73(133)43-110-81(140)66(36-55(94(153)154)95(155)156)117-79(138)49(9)112-86(145)63(33-50-18-22-53(128)23-19-50)119-89(148)68(38-57(98(161)162)99(163)164)122-90(149)69(39-75(136)137)123-83(142)60(27-29-74(134)135)113-71(131)40-103)92(151)116-59(17-15-31-108-101(105)106)82(141)121-67(37-56(96(157)158)97(159)160)88(147)120-64(34-51-20-24-54(129)25-21-51)87(146)115-61(26-28-70(104)130)84(143)118-62(32-45(4)5)91(150)126-77(47(7)11-2)93(152)124-65(35-52-41-107-44-111-52)80(139)109-42-72(132)114-58(16-13-14-30-102)85(144)127-78(100(165)166)48(8)12-3/h18-25,41,44-49,55-69,76-78,128-129H,10-17,26-40,42-43,102-103H2,1-9H3,(H2,104,130)(H,107,111)(H,109,139)(H,110,140)(H,112,145)(H,113,131)(H,114,132)(H,115,146)(H,116,151)(H,117,138)(H,118,143)(H,119,148)(H,120,147)(H,121,141)(H,122,149)(H,123,142)(H,124,152)(H,125,133)(H,126,150)(H,127,144)(H,134,135)(H,136,137)(H,153,154)(H,155,156)(H,157,158)(H,159,160)(H,161,162)(H,163,164)(H,165,166)(H4,105,106,108)/t46-,47-,48-,49-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,76-,77-,78-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA NR2D receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50242447
PNG
(2-[(2S)-2-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)CC)C(O)=O
Show InChI InChI=1S/C108H159N25O41/c1-9-50(5)82(131-85(145)53(8)118-93(153)74(43-61(101(161)162)102(163)164)124-84(144)52(7)117-92(152)72(40-55-21-27-58(135)28-22-55)127-97(157)76(45-63(105(169)170)106(171)172)130-98(158)77-42-60(137)48-133(77)100(160)69(32-34-80(140)141)123-86(146)64(111)46-81(142)143)99(159)122-67(18-15-37-115-108(113)114)89(149)129-75(44-62(103(165)166)104(167)168)96(156)128-73(41-56-23-29-59(136)30-24-56)95(155)121-68(31-33-78(112)138)90(150)125-70(38-49(3)4)94(154)120-66(17-12-14-36-110)88(148)126-71(39-54-19-25-57(134)26-20-54)87(147)116-47-79(139)119-65(16-11-13-35-109)91(151)132-83(107(173)174)51(6)10-2/h19-30,49-53,60-77,82-83,134-137H,9-18,31-48,109-111H2,1-8H3,(H2,112,138)(H,116,147)(H,117,152)(H,118,153)(H,119,139)(H,120,154)(H,121,155)(H,122,159)(H,123,146)(H,124,144)(H,125,150)(H,126,148)(H,127,157)(H,128,156)(H,129,149)(H,130,158)(H,131,145)(H,132,151)(H,140,141)(H,142,143)(H,161,162)(H,163,164)(H,165,166)(H,167,168)(H,169,170)(H,171,172)(H,173,174)(H4,113,114,115)/t50-,51-,52-,53-,60+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,82-,83-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA NR2D receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50242449
PNG
(CHEMBL525025 | conantokin-G)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(N)=O
Show InChI InChI=1S/C88H138N26O44/c1-7-34(6)61(77(138)103-41(12-10-20-98-88(96)97)63(124)107-48(23-35(78(139)140)79(141)142)69(130)100-40(11-8-9-19-89)64(125)113-54(31-115)76(137)104-45(62(95)123)28-57(93)118)114-75(136)47(22-33(4)5)106-70(131)49(24-36(80(143)144)81(145)146)109-67(128)44(14-17-56(92)117)102-74(135)53(29-58(94)119)112-73(134)51(26-38(84(151)152)85(153)154)110-66(127)43(13-16-55(91)116)101-68(129)46(21-32(2)3)105-71(132)52(27-39(86(155)156)87(157)158)111-72(133)50(25-37(82(147)148)83(149)150)108-65(126)42(15-18-60(121)122)99-59(120)30-90/h32-54,61,115H,7-31,89-90H2,1-6H3,(H2,91,116)(H2,92,117)(H2,93,118)(H2,94,119)(H2,95,123)(H,99,120)(H,100,130)(H,101,129)(H,102,135)(H,103,138)(H,104,137)(H,105,132)(H,106,131)(H,107,124)(H,108,126)(H,109,128)(H,110,127)(H,111,133)(H,112,134)(H,113,125)(H,114,136)(H,121,122)(H,139,140)(H,141,142)(H,143,144)(H,145,146)(H,147,148)(H,149,150)(H,151,152)(H,153,154)(H,155,156)(H,157,158)(H4,96,97,98)/t34-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,61-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA NR2D receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440091
PNG
(CHEMBL2426086)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(cc1)[N+]([O-])=O)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C28H21ClN4O6/c29-18-8-11-21-20(14-18)26(17-4-2-1-3-5-17)27(28(37)30-21)22-15-23(16-6-9-19(10-7-16)33(38)39)32(31-22)24(34)12-13-25(35)36/h1-11,14,23H,12-13,15H2,(H,30,37)(H,35,36)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440062
PNG
(CHEMBL2426078)
Show SMILES NC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H22Cl2N4O3/c29-18-9-5-16(6-10-18)23-15-22(33-34(23)25(36)14-13-24(31)35)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)32-28(27)37/h1-12,23H,13-15H2,(H2,31,35)(H,32,37)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440070
PNG
(CHEMBL2426068 | CHEMBL2426069)
Show SMILES OC(=O)C=CC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C28H19BrClN3O4/c29-18-8-6-16(7-9-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-2-1-3-5-17)20-14-19(30)10-11-21(20)31-28(27)37/h1-14,23H,15H2,(H,31,37)(H,35,36)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440078
PNG
(CHEMBL2426101)
Show SMILES Cc1ccc(cc1)-c1c(C2=NN(C(C2)c2ccc(Cl)cc2)C(=O)CCC(O)=O)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C29H24ClN3O4/c1-17-6-8-19(9-7-17)27-21-4-2-3-5-22(21)31-29(37)28(27)23-16-24(18-10-12-20(30)13-11-18)33(32-23)25(34)14-15-26(35)36/h2-13,24H,14-16H2,1H3,(H,31,37)(H,35,36)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440061
PNG
(CHEMBL2424674)
Show SMILES OC(=O)CCCN1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H23Cl2N3O3/c29-19-11-7-17(8-12-19)24-16-23(32-33(24)15-3-6-25(34)35)27-26(18-9-13-20(30)14-10-18)21-4-1-2-5-22(21)31-28(27)36/h1-2,4-5,7-14,24H,3,6,15-16H2,(H,31,36)(H,34,35)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440050
PNG
(CHEMBL2425973)
Show SMILES Cc1cccc(c1)-c1c(C2=NN(C(C2)c2ccc(Cl)cc2)C(=O)CCC(O)=O)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C29H24ClN3O4/c1-17-5-4-6-19(15-17)27-21-7-2-3-8-22(21)31-29(37)28(27)23-16-24(18-9-11-20(30)12-10-18)33(32-23)25(34)13-14-26(35)36/h2-12,15,24H,13-14,16H2,1H3,(H,31,37)(H,35,36)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440059
PNG
(CHEMBL2426082)
Show SMILES OC(=O)CCC(=O)N1N=C(C[C@@H]1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21Cl2N3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)/t23-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440055
PNG
(CHEMBL2426102)
Show SMILES COc1ccc(cc1)-c1c(C2=NN(C(C2)c2ccc(Cl)cc2)C(=O)CCC(O)=O)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C29H24ClN3O5/c1-38-20-12-8-18(9-13-20)27-21-4-2-3-5-22(21)31-29(37)28(27)23-16-24(17-6-10-19(30)11-7-17)33(32-23)25(34)14-15-26(35)36/h2-13,24H,14-16H2,1H3,(H,31,37)(H,35,36)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440047
PNG
(CHEMBL2425976)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cccc(c2)C(F)(F)F)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C29H21ClF3N3O4/c30-19-10-8-16(9-11-19)23-15-22(35-36(23)24(37)12-13-25(38)39)27-26(17-4-3-5-18(14-17)29(31,32)33)20-6-1-2-7-21(20)34-28(27)40/h1-11,14,23H,12-13,15H2,(H,34,40)(H,38,39)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440053
PNG
(CHEMBL2426104)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(cc2)C(F)(F)F)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C29H21ClF3N3O4/c30-19-11-7-16(8-12-19)23-15-22(35-36(23)24(37)13-14-25(38)39)27-26(17-5-9-18(10-6-17)29(31,32)33)20-3-1-2-4-21(20)34-28(27)40/h1-12,23H,13-15H2,(H,34,40)(H,38,39)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440083
PNG
(CHEMBL2426094)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(F)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21BrFN3O4/c29-18-9-5-17(6-10-18)26-20-3-1-2-4-21(20)31-28(37)27(26)22-15-23(16-7-11-19(30)12-8-16)33(32-22)24(34)13-14-25(35)36/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440092
PNG
(CHEMBL2426085)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C28H21BrClN3O4/c29-18-8-6-16(7-9-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-2-1-3-5-17)20-14-19(30)10-11-21(20)31-28(27)37/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440080
PNG
(CHEMBL2426098)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(F)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H21ClFN3O4/c29-18-9-5-17(6-10-18)26-20-3-1-2-4-21(20)31-28(37)27(26)22-15-23(16-7-11-19(30)12-8-16)33(32-22)24(34)13-14-25(35)36/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440069
PNG
(CHEMBL2426071)
Show SMILES OC(=O)CCCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C29H23BrClN3O4/c30-19-11-9-17(10-12-19)24-16-23(33-34(24)25(35)7-4-8-26(36)37)28-27(18-5-2-1-3-6-18)21-15-20(31)13-14-22(21)32-29(28)38/h1-3,5-6,9-15,24H,4,7-8,16H2,(H,32,38)(H,36,37)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440089
PNG
(CHEMBL2426089)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C29H21ClF3N3O4/c30-19-10-11-21-20(14-19)26(17-4-2-1-3-5-17)27(28(40)34-21)22-15-23(36(35-22)24(37)12-13-25(38)39)16-6-8-18(9-7-16)29(31,32)33/h1-11,14,23H,12-13,15H2,(H,34,40)(H,38,39)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440049
PNG
(CHEMBL2425974)
Show SMILES COc1cccc(c1)-c1c(C2=NN(C(C2)c2ccc(Cl)cc2)C(=O)CCC(O)=O)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C29H24ClN3O5/c1-38-20-6-4-5-18(15-20)27-21-7-2-3-8-22(21)31-29(37)28(27)23-16-24(17-9-11-19(30)12-10-17)33(32-23)25(34)13-14-26(35)36/h2-12,15,24H,13-14,16H2,1H3,(H,31,37)(H,35,36)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440093
PNG
(CHEMBL2426084)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C28H21Cl2N3O4/c29-18-8-6-16(7-9-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-2-1-3-5-17)20-14-19(30)10-11-21(20)31-28(27)37/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440070
PNG
(CHEMBL2426068 | CHEMBL2426069)
Show SMILES OC(=O)C=CC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C28H19BrClN3O4/c29-18-8-6-16(7-9-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-2-1-3-5-17)20-14-19(30)10-11-21(20)31-28(27)37/h1-14,23H,15H2,(H,31,37)(H,35,36)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440054
PNG
(CHEMBL2426103)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(cc2)C#N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C29H21ClN4O4/c30-20-11-9-18(10-12-20)24-15-23(33-34(24)25(35)13-14-26(36)37)28-27(19-7-5-17(16-31)6-8-19)21-3-1-2-4-22(21)32-29(28)38/h1-12,24H,13-15H2,(H,32,38)(H,36,37)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50242448
PNG
(2-[(2S)-2-[({[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-am...)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](CCC(O)=O)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(N)=O
Show InChI InChI=1S/C91H141N27O36/c1-38(2)26-56(78(136)110-53(20-15-25-99-91(97)98)76(134)114-59(30-48(87(147)148)88(149)150)79(137)109-51(18-11-13-23-92)74(132)103-40(5)69(127)102-41(6)72(130)116-61(37-119)81(139)111-55(68(96)126)32-63(95)121)107-65(123)35-101-73(131)58(29-47(85(143)144)86(145)146)112-71(129)42(7)104-77(135)57(27-44-34-100-50-17-10-9-16-46(44)50)113-75(133)52(19-12-14-24-93)108-70(128)43(8)105-83(141)67(39(3)4)117-80(138)60(31-49(89(151)152)90(153)154)115-82(140)62-28-45(120)36-118(62)84(142)54(21-22-66(124)125)106-64(122)33-94/h9-10,16-17,34,38-43,45,47-49,51-62,67,100,119-120H,11-15,18-33,35-37,92-94H2,1-8H3,(H2,95,121)(H2,96,126)(H,101,131)(H,102,127)(H,103,132)(H,104,135)(H,105,141)(H,106,122)(H,107,123)(H,108,128)(H,109,137)(H,110,136)(H,111,139)(H,112,129)(H,113,133)(H,114,134)(H,115,140)(H,116,130)(H,117,138)(H,124,125)(H,143,144)(H,145,146)(H,147,148)(H,149,150)(H,151,152)(H,153,154)(H4,97,98,99)/t40-,41-,42-,43-,45+,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,67-/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA NR2D receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440082
PNG
(CHEMBL2426095)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccccc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H22BrN3O4/c29-19-12-10-18(11-13-19)26-20-8-4-5-9-21(20)30-28(36)27(26)22-16-23(17-6-2-1-3-7-17)32(31-22)24(33)14-15-25(34)35/h1-13,23H,14-16H2,(H,30,36)(H,34,35)
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n/an/a 9.10E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50242450
PNG
(CHEMBL524886 | conantokin-R)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)C(CC(C(O)=O)C(O)=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CN)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C126H202N34O48S3/c1-15-57(8)93(115(189)141-62(13)96(170)145-71(24-16-19-36-127)100(174)136-51-89(165)143-83(52-209)111(185)147-73(26-18-21-38-129)104(178)157-92(56(6)7)114(188)154-80(48-86(131)162)108(182)156-84(53-210)112(186)155-82(43-63-29-31-64(161)32-30-63)116(190)160-40-23-28-85(160)125(207)208)159-110(184)81(49-87(132)163)150-99(173)65(44-66(117(191)192)118(193)194)70(27-22-39-135-126(133)134)144-95(169)60(11)139-105(179)76(42-54(2)3)151-106(180)77(45-67(119(195)196)120(197)198)149-98(172)59(10)137-94(168)58(9)138-101(175)75(35-41-211-14)148-102(176)72(25-17-20-37-128)146-97(171)61(12)140-113(187)91(55(4)5)158-109(183)79(47-69(123(203)204)124(205)206)153-107(181)78(46-68(121(199)200)122(201)202)152-103(177)74(33-34-90(166)167)142-88(164)50-130/h29-32,54-62,65-85,91-93,161,209-210H,15-28,33-53,127-130H2,1-14H3,(H2,131,162)(H2,132,163)(H,136,174)(H,137,168)(H,138,175)(H,139,179)(H,140,187)(H,141,189)(H,142,164)(H,143,165)(H,144,169)(H,145,170)(H,146,171)(H,147,185)(H,148,176)(H,149,172)(H,150,173)(H,151,180)(H,152,177)(H,153,181)(H,154,188)(H,155,186)(H,156,182)(H,157,178)(H,158,183)(H,159,184)(H,166,167)(H,191,192)(H,193,194)(H,195,196)(H,197,198)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H4,133,134,135)/t57-,58-,59-,60-,61-,62-,65?,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,91-,92-,93-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA NR2D receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440079
PNG
(CHEMBL2426099)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccccc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C28H22ClN3O4/c29-19-12-10-18(11-13-19)26-20-8-4-5-9-21(20)30-28(36)27(26)22-16-23(17-6-2-1-3-7-17)32(31-22)24(33)14-15-25(34)35/h1-13,23H,14-16H2,(H,30,36)(H,34,35)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440064
PNG
(CHEMBL2426076)
Show SMILES OC(=O)CCCC(=O)N1N=C(CC1c1ccc(cc1)[N+]([O-])=O)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C29H23ClN4O6/c30-19-11-14-22-21(15-19)27(18-5-2-1-3-6-18)28(29(38)31-22)23-16-24(17-9-12-20(13-10-17)34(39)40)33(32-23)25(35)7-4-8-26(36)37/h1-3,5-6,9-15,24H,4,7-8,16H2,(H,31,38)(H,36,37)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440048
PNG
(CHEMBL2425975)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cccc(c2)C#N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C29H21ClN4O4/c30-20-10-8-18(9-11-20)24-15-23(33-34(24)25(35)12-13-26(36)37)28-27(19-5-3-4-17(14-19)16-31)21-6-1-2-7-22(21)32-29(28)38/h1-11,14,24H,12-13,15H2,(H,32,38)(H,36,37)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440094
PNG
(CHEMBL2426083)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(F)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C28H21ClFN3O4/c29-18-8-11-21-20(14-18)26(17-4-2-1-3-5-17)27(28(37)31-21)22-15-23(16-6-9-19(30)10-7-16)33(32-22)24(34)12-13-25(35)36/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440087
PNG
(CHEMBL2426090)
Show SMILES CN(C)c1ccc(cc1)C1CC(=NN1C(=O)CCC(O)=O)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C30H27ClN4O4/c1-34(2)21-11-8-18(9-12-21)25-17-24(33-35(25)26(36)14-15-27(37)38)29-28(19-6-4-3-5-7-19)22-16-20(31)10-13-23(22)32-30(29)39/h3-13,16,25H,14-15,17H2,1-2H3,(H,32,39)(H,37,38)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


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Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM53950
PNG
(4-[(3Z)-3-(6-chloranyl-2-oxidanylidene-4-phenyl-qu...)
Show SMILES COc1ccc(cc1)C1CC(=NN1C(=O)CCC(O)=O)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C29H24ClN3O5/c1-38-20-10-7-17(8-11-20)24-16-23(32-33(24)25(34)13-14-26(35)36)28-27(18-5-3-2-4-6-18)21-15-19(30)9-12-22(21)31-29(28)37/h2-12,15,24H,13-14,16H2,1H3,(H,31,37)(H,35,36)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 4


(Rattus norvegicus)
BDBM50440086
PNG
(CHEMBL2426091)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc2OCOc2c1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C29H22ClN3O6/c30-18-7-8-20-19(13-18)27(16-4-2-1-3-5-16)28(29(37)31-20)21-14-22(33(32-21)25(34)10-11-26(35)36)17-6-9-23-24(12-17)39-15-38-23/h1-9,12-13,22H,10-11,14-15H2,(H,31,37)(H,35,36)
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n/an/a 2.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


Citation and Details
More data for this
Ligand-Target Pair
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