BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 43 hits Enz. Inhib. hit(s) with Target = 'Glutamate Carboxypeptidase II (GCPII)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17759
PNG
((2S)-2-(phosphonomethyl)pentanedioic acid | (S)-2-...)
Show SMILES OC(=O)CC[C@H](CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)/t4-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
MMDB
PDB
Article
PubMed
n/an/a 0.100n/an/an/an/a7.437



Guilford



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17659
PNG
((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Show SMILES OC(=O)CCC(CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PDB
Article
PubMed
n/an/a 0.300n/an/an/an/a7.437



Guilford



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17659
PNG
((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Show SMILES OC(=O)CCC(CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PDB
Article
PubMed
n/an/a 0.300n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17659
PNG
((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Show SMILES OC(=O)CCC(CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PDB
Article
PubMed
n/an/a 0.300n/an/an/an/a7.437



NCI-FCRDC



Assay Description
The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17775
PNG
(3-(1-carboxy-4-sulfanylbutoxy)benzoic acid | Thiol...)
Show SMILES OC(=O)C(CCCS)Oc1cccc(c1)C(O)=O
Show InChI InChI=1S/C12H14O5S/c13-11(14)8-3-1-4-9(7-8)17-10(12(15)16)5-2-6-18/h1,3-4,7,10,18H,2,5-6H2,(H,13,14)(H,15,16)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 14n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17762
PNG
(3-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Show SMILES OC(=O)C(CCCS)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C13H16O4S/c14-12(15)10-4-1-3-9(7-10)8-11(13(16)17)5-2-6-18/h1,3-4,7,11,18H,2,5-6,8H2,(H,14,15)(H,16,17)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 15n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17758
PNG
((2R)-2-(phosphonomethyl)pentanedioic acid | (R)-2-...)
Show SMILES OC(=O)CC[C@@H](CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)/t4-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 30n/an/an/an/a7.437



Guilford



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17776
PNG
(3-[(1-carboxy-4-sulfanylbutyl)sulfanyl]benzoic aci...)
Show SMILES OC(=O)C(CCCS)Sc1cccc(c1)C(O)=O
Show InChI InChI=1S/C12H14O4S2/c13-11(14)8-3-1-4-9(7-8)18-10(12(15)16)5-2-6-17/h1,3-4,7,10,17H,2,5-6H2,(H,13,14)(H,15,16)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 32n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17754
PNG
((2S)-2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)meth...)
Show SMILES OC(=O)CC[C@H](CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O
Show InChI InChI=1S/C13H12F5O6P/c14-8-6(9(15)11(17)12(18)10(8)16)4-25(23,24)3-5(13(21)22)1-2-7(19)20/h5H,1-4H2,(H,19,20)(H,21,22)(H,23,24)/t5-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 34n/an/an/an/a7.437



Guilford



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17763
PNG
(4-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Show SMILES OC(=O)C(CCCS)Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C13H16O4S/c14-12(15)10-5-3-9(4-6-10)8-11(13(16)17)2-1-7-18/h3-6,11,18H,1-2,7-8H2,(H,14,15)(H,16,17)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 63n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17757
PNG
((2S)-2-(3-sulfanylpropyl)pentanedioic acid | (S)-2...)
Show SMILES OC(=O)CC[C@@H](CCCS)C(O)=O
Show InChI InChI=1S/C8H14O4S/c9-7(10)4-3-6(8(11)12)2-1-5-13/h6,13H,1-5H2,(H,9,10)(H,11,12)/t6-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 67n/an/an/an/a7.437



Guilford



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17752
PNG
(2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...)
Show SMILES OC(=O)CCC(CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O
Show InChI InChI=1S/C13H12F5O6P/c14-8-6(9(15)11(17)12(18)10(8)16)4-25(23,24)3-5(13(21)22)1-2-7(19)20/h5H,1-4H2,(H,19,20)(H,21,22)(H,23,24)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 82n/an/an/an/a7.437



Guilford



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17752
PNG
(2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...)
Show SMILES OC(=O)CCC(CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O
Show InChI InChI=1S/C13H12F5O6P/c14-8-6(9(15)11(17)12(18)10(8)16)4-25(23,24)3-5(13(21)22)1-2-7(19)20/h5H,1-4H2,(H,19,20)(H,21,22)(H,23,24)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 82n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17756
PNG
((2R)-2-(3-sulfanylpropyl)pentanedioic acid | (R)-2...)
Show SMILES OC(=O)CC[C@H](CCCS)C(O)=O
Show InChI InChI=1S/C8H14O4S/c9-7(10)4-3-6(8(11)12)2-1-5-13/h6,13H,1-5H2,(H,9,10)(H,11,12)/t6-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 85n/an/an/an/a7.437



Guilford



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17755
PNG
(2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...)
Show SMILES OC(=O)CCC(CCCS)C(O)=O
Show InChI InChI=1S/C8H14O4S/c9-7(10)4-3-6(8(11)12)2-1-5-13/h6,13H,1-5H2,(H,9,10)(H,11,12)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 90n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17755
PNG
(2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...)
Show SMILES OC(=O)CCC(CCCS)C(O)=O
Show InChI InChI=1S/C8H14O4S/c9-7(10)4-3-6(8(11)12)2-1-5-13/h6,13H,1-5H2,(H,9,10)(H,11,12)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 90n/an/an/an/a7.437



Guilford



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17777
PNG
(3-[2-carboxy-2-(phosphonomethyl)ethyl]benzoic acid...)
Show SMILES OC(=O)C(Cc1cccc(c1)C(O)=O)CP(O)(O)=O
Show InChI InChI=1S/C11H13O7P/c12-10(13)8-3-1-2-7(4-8)5-9(11(14)15)6-19(16,17)18/h1-4,9H,5-6H2,(H,12,13)(H,14,15)(H2,16,17,18)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 120n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17767
PNG
(3-[2-carboxy-2-(5-sulfanylpentyl)ethyl]benzoic aci...)
Show SMILES OC(=O)C(CCCCCS)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C15H20O4S/c16-14(17)12(6-2-1-3-8-20)9-11-5-4-7-13(10-11)15(18)19/h4-5,7,10,12,20H,1-3,6,8-9H2,(H,16,17)(H,18,19)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 190n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17779
PNG
(2-[(hydroxycarbamoyl)methyl]pentanedioic acid | CH...)
Show SMILES ONC(=O)CC(CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO6/c9-5(8-14)3-4(7(12)13)1-2-6(10)11/h4,14H,1-3H2,(H,8,9)(H,10,11)(H,12,13)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 220n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17766
PNG
(3-[2-carboxy-2-(4-sulfanylbutyl)ethyl]benzoic acid...)
Show SMILES OC(=O)C(CCCCS)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C14H18O4S/c15-13(16)11(5-1-2-7-19)8-10-4-3-6-12(9-10)14(17)18/h3-4,6,9,11,19H,1-2,5,7-8H2,(H,15,16)(H,17,18)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 390n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17764
PNG
(3-[2-carboxy-2-(sulfanylmethyl)ethyl]benzoic acid ...)
Show SMILES OC(=O)C(CS)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C11H12O4S/c12-10(13)8-3-1-2-7(4-8)5-9(6-16)11(14)15/h1-4,9,16H,5-6H2,(H,12,13)(H,14,15)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 440n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17771
PNG
(3-[2-carbamoyl-2-(3-sulfanylpropyl)ethyl]benzoic a...)
Show SMILES NC(=O)C(CCCS)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C13H17NO3S/c14-12(15)10(5-2-6-18)7-9-3-1-4-11(8-9)13(16)17/h1,3-4,8,10,18H,2,5-7H2,(H2,14,15)(H,16,17)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 640n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17770
PNG
(3-[3-methoxy-3-oxo-2-(3-sulfanylpropyl)propyl]benz...)
Show SMILES COC(=O)C(CCCS)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C14H18O4S/c1-18-14(17)12(6-3-7-19)9-10-4-2-5-11(8-10)13(15)16/h2,4-5,8,12,19H,3,6-7,9H2,1H3,(H,15,16)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 730n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17765
PNG
(3-[2-carboxy-2-(2-sulfanylethyl)ethyl]benzoic acid...)
Show SMILES OC(=O)C(CCS)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C12H14O4S/c13-11(14)9-3-1-2-8(6-9)7-10(4-5-17)12(15)16/h1-3,6,10,17H,4-5,7H2,(H,13,14)(H,15,16)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.10E+3n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17753
PNG
((2R)-2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)meth...)
Show SMILES OC(=O)CC[C@@H](CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O
Show InChI InChI=1S/C13H12F5O6P/c14-8-6(9(15)11(17)12(18)10(8)16)4-25(23,24)3-5(13(21)22)1-2-7(19)20/h5H,1-4H2,(H,19,20)(H,21,22)(H,23,24)/t5-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.40E+3n/an/an/an/a7.437



Guilford



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17760
PNG
(2-benzyl-5-sulfanylpentanoic acid | Thiol-Based In...)
Show SMILES OC(=O)C(CCCS)Cc1ccccc1
Show InChI InChI=1S/C12H16O2S/c13-12(14)11(7-4-8-15)9-10-5-2-1-3-6-10/h1-3,5-6,11,15H,4,7-9H2,(H,13,14)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1.40E+3n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17761
PNG
(2-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Show SMILES OC(=O)C(CCCS)Cc1ccccc1C(O)=O
Show InChI InChI=1S/C13H16O4S/c14-12(15)10(5-3-7-18)8-9-4-1-2-6-11(9)13(16)17/h1-2,4,6,10,18H,3,5,7-8H2,(H,14,15)(H,16,17)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 1.70E+3n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17774
PNG
(2-[(3-cyanophenyl)methyl]-5-sulfanylpentanoic acid...)
Show SMILES OC(=O)C(CCCS)Cc1cccc(c1)C#N
Show InChI InChI=1S/C13H15NO2S/c14-9-11-4-1-3-10(7-11)8-12(13(15)16)5-2-6-17/h1,3-4,7,12,17H,2,5-6,8H2,(H,15,16)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.80E+3n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17773
PNG
(2-[(3-carbamoylphenyl)methyl]-5-sulfanylpentanoic ...)
Show SMILES NC(=O)c1cccc(CC(CCCS)C(O)=O)c1
Show InChI InChI=1S/C13H17NO3S/c14-12(15)10-4-1-3-9(7-10)8-11(13(16)17)5-2-6-18/h1,3-4,7,11,18H,2,5-6,8H2,(H2,14,15)(H,16,17)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 2.20E+3n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17778
PNG
(3-[2-carboxy-2-({hydroxy[(2,3,4,5,6-pentafluorophe...)
Show SMILES OC(=O)C(Cc1cccc(c1)C(O)=O)CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C18H14F5O6P/c19-12-11(13(20)15(22)16(23)14(12)21)7-30(28,29)6-10(18(26)27)5-8-2-1-3-9(4-8)17(24)25/h1-4,10H,5-7H2,(H,24,25)(H,26,27)(H,28,29)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 2.40E+3n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17772
PNG
(2-{[3-(methoxycarbonyl)phenyl]methyl}-5-sulfanylpe...)
Show SMILES COC(=O)c1cccc(CC(CCCS)C(O)=O)c1
Show InChI InChI=1S/C14H18O4S/c1-18-14(17)12-5-2-4-10(9-12)8-11(13(15)16)6-3-7-19/h2,4-5,9,11,19H,3,6-8H2,1H3,(H,15,16)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.70E+3n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17660
PNG
((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Show SMILES N[C@@H](Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PDB
Article
PubMed
n/an/a 9.50E+3n/an/an/an/a7.437



NCI-FCRDC



Assay Description
The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17782
PNG
(2-[(3-carboxyphenyl)methyl]butanedioic acid | carb...)
Show SMILES OC(=O)CC(Cc1cccc(c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C12H12O6/c13-10(14)6-9(12(17)18)5-7-2-1-3-8(4-7)11(15)16/h1-4,9H,5-6H2,(H,13,14)(H,15,16)(H,17,18)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.50E+4n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17780
PNG
(3-{2-carboxy-2-[(hydroxycarbamoyl)methyl]ethyl}ben...)
Show SMILES ONC(=O)CC(Cc1cccc(c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C12H13NO6/c14-10(13-19)6-9(12(17)18)5-7-2-1-3-8(4-7)11(15)16/h1-4,9,19H,5-6H2,(H,13,14)(H,15,16)(H,17,18)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 1.50E+4n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17768
PNG
(3-{2-carboxy-2-[3-(methylsulfanyl)propyl]ethyl}ben...)
Show SMILES CSCCCC(Cc1cccc(c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H18O4S/c1-19-7-3-6-12(14(17)18)9-10-4-2-5-11(8-10)13(15)16/h2,4-5,8,12H,3,6-7,9H2,1H3,(H,15,16)(H,17,18)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17769
PNG
(3-(2-carboxy-2-{3-[(triphenylmethyl)sulfanyl]propy...)
Show SMILES OC(=O)C(CCCSC(c1ccccc1)(c1ccccc1)c1ccccc1)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C32H30O4S/c33-30(34)25-13-10-12-24(22-25)23-26(31(35)36)14-11-21-37-32(27-15-4-1-5-16-27,28-17-6-2-7-18-28)29-19-8-3-9-20-29/h1-10,12-13,15-20,22,26H,11,14,21,23H2,(H,33,34)(H,35,36)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17781
PNG
(CHEMBL65860 | butane-1,2,4-tricarboxylic acid | ca...)
Show SMILES OC(=O)CCC(CC(O)=O)C(O)=O
Show InChI InChI=1S/C7H10O6/c8-5(9)2-1-4(7(12)13)3-6(10)11/h4H,1-3H2,(H,8,9)(H,10,11)(H,12,13)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 2.00E+4n/an/an/an/a7.437



MGI Pharma



Assay Description
GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17661
PNG
((2S)-2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimi...)
Show SMILES N[C@@H](Cn1ccc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H9N3O4/c8-4(6(12)13)3-10-2-1-5(11)9-7(10)14/h1-2,4H,3,8H2,(H,12,13)(H,9,11,14)/t4-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 6.70E+4n/an/an/an/a7.437



NCI-FCRDC



Assay Description
The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM107672
PNG
((S)-2-((N-((S)-2-benzamido-2-carboxyethyl) sulfamo...)
Show SMILES OC(=O)CC[C@H](NS(=O)(=O)NC[C@H](NC(=O)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19N3O9S/c19-12(20)7-6-10(14(22)23)18-28(26,27)16-8-11(15(24)25)17-13(21)9-4-2-1-3-5-9/h1-5,10-11,16,18H,6-8H2,(H,17,21)(H,19,20)(H,22,23)(H,24,25)/t10-,11-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Washington State University, Pullman, WA, 99164-4630, USA



Assay Description
Inhibitors were made in TRIS buffer (50mM Tris pH 7.4 containing 1% Triton X-100). Working solutions of purified GCPII (50ug/mL) were diluted in TRI...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
DrugBank
Article
PubMed
n/an/a 4.28E+5n/an/an/an/a7.437



NCI-FCRDC



Assay Description
The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17663
PNG
((2S)-2-amino-3-(sulfooxy)propanoic acid | L-SOS | ...)
Show SMILES N[C@@H](COS(O)(=O)=O)C(O)=O
Show InChI InChI=1S/C3H7NO6S/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/t2-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

AffyNet 
MMDB
PDB
Article
PubMed
n/an/a 4.38E+5n/an/an/an/a7.437



NCI-FCRDC



Assay Description
The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17664
PNG
((2S)-2-amino-3-(phosphonooxy)propanoic acid | CHEM...)
Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 5.23E+5n/an/an/an/a7.437



NCI-FCRDC



Assay Description
The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate Carboxypeptidase II (GCPII)


(Homo sapiens (human))
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+7n/an/an/an/a7.437



NCI-FCRDC



Assay Description
The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...


Citation and Details
More data for this
Ligand-Target Pair