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Compile Data Set for Download or QSAR

Found 208 hits Enz. Inhib. hit(s) with Target = 'Glutamate NMDA receptor; Grin1/Grin2c' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015743
PNG
(Acetic acid 3-[1-(3,6-dihydro-2H-pyridin-1-yl)-cyc...)
Show SMILES CC(=O)Oc1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C19H25NO2/c1-16(21)22-18-10-8-9-17(15-18)19(11-4-2-5-12-19)20-13-6-3-7-14-20/h3,6,8-10,15H,2,4-5,7,11-14H2,1H3
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6n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015738
PNG
(3-[1-(3,6-Dihydro-2H-pyridin-1-yl)-cyclohexyl]-phe...)
Show SMILES Oc1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C17H23NO/c19-16-9-7-8-15(14-16)17(10-3-1-4-11-17)18-12-5-2-6-13-18/h2,5,7-9,14,19H,1,3-4,6,10-13H2
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7n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015734
PNG
(1-(1-Thiophen-2-yl-cyclohexyl)-1,2,3,6-tetrahydro-...)
Show SMILES C1CCC(CC1)(N1CCC=CC1)c1cccs1
Show InChI InChI=1S/C15H21NS/c1-3-9-15(10-4-1,14-8-7-13-17-14)16-11-5-2-6-12-16/h2,5,7-8,13H,1,3-4,6,9-12H2
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12n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015741
PNG
(1-[1-(3-Methoxy-phenyl)-cyclohexyl]-1,2,3,6-tetrah...)
Show SMILES COc1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C18H25NO/c1-20-17-10-8-9-16(15-17)18(11-4-2-5-12-18)19-13-6-3-7-14-19/h3,6,8-10,15H,2,4-5,7,11-14H2,1H3
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33n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015732
PNG
(1-(1-Phenyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin...)
Show SMILES C1CCC(CC1)(N1CCC=CC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,3-5,8,10-11H,2,6-7,9,12-15H2
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37n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015733
PNG
(3-[1-(3,6-Dihydro-2H-pyridin-1-yl)-cyclohexyl]-ben...)
Show SMILES O=NCc1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C18H24N2O/c21-19-15-16-8-7-9-17(14-16)18(10-3-1-4-11-18)20-12-5-2-6-13-20/h2,5,7-9,14H,1,3-4,6,10-13,15H2
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56n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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60n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015735
PNG
(1-(1-m-Tolyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridi...)
Show SMILES Cc1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C18H25N/c1-16-9-8-10-17(15-16)18(11-4-2-5-12-18)19-13-6-3-7-14-19/h3,6,8-10,15H,2,4-5,7,11-14H2,1H3
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81n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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91n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity of compound against Phencyclidine receptor by displacement of [3H]TCP


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015744
PNG
(1-[1-(3-Methoxymethoxy-phenyl)-cyclohexyl]-1,2,3,6...)
Show SMILES COCOc1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C19H27NO2/c1-21-16-22-18-10-8-9-17(15-18)19(11-4-2-5-12-19)20-13-6-3-7-14-20/h3,6,8-10,15H,2,4-5,7,11-14,16H2,1H3
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92n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015740
PNG
(1-[1-(3-Vinyl-phenyl)-cyclohexyl]-1,2,3,6-tetrahyd...)
Show SMILES C=Cc1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C19H25N/c1-2-17-10-9-11-18(16-17)19(12-5-3-6-13-19)20-14-7-4-8-15-20/h2,4,7,9-11,16H,1,3,5-6,8,12-15H2
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114n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018933
PNG
(1-(3-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES C[C@H]1CCC[C@@](C1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-12-18(15-16,17-10-4-2-5-11-17)19-13-6-3-7-14-19/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3/t16-,18-/m0/s1
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170n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015731
PNG
(1-[1-(3-Methylsulfanyl-phenyl)-cyclohexyl]-1,2,3,6...)
Show SMILES CSc1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C18H25NS/c1-20-17-10-8-9-16(15-17)18(11-4-2-5-12-18)19-13-6-3-7-14-19/h3,6,8-10,15H,2,4-5,7,11-14H2,1H3
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231n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015736
PNG
(1-[1-(3-Fluoro-phenyl)-cyclohexyl]-1,2,3,6-tetrahy...)
Show SMILES Fc1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C17H22FN/c18-16-9-7-8-15(14-16)17(10-3-1-4-11-17)19-12-5-2-6-13-19/h2,5,7-9,14H,1,3-4,6,10-13H2
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281n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015739
PNG
(3-[1-(3,6-Dihydro-2H-pyridin-1-yl)-cyclohexyl]-ben...)
Show SMILES O=Cc1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C18H23NO/c20-15-16-8-7-9-17(14-16)18(10-3-1-4-11-18)19-12-5-2-6-13-19/h2,5,7-9,14-15H,1,3-4,6,10-13H2
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324n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50368882
PNG
(CHEMBL147585 | SK&F-10047 | SK-10047)
Show SMILES CC1C2Cc3ccc(O)cc3C1CCN2CC=C
Show InChI InChI=1S/C16H21NO/c1-3-7-17-8-6-14-11(2)16(17)9-12-4-5-13(18)10-15(12)14/h3-5,10-11,14,16,18H,1,6-9H2,2H3
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370n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested on Phencyclidine binding assay.


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50368882
PNG
(CHEMBL147585 | SK&F-10047 | SK-10047)
Show SMILES CC1C2Cc3ccc(O)cc3C1CCN2CC=C
Show InChI InChI=1S/C16H21NO/c1-3-7-17-8-6-14-11(2)16(17)9-12-4-5-13(18)10-15(12)14/h3-5,10-11,14,16,18H,1,6-9H2,2H3
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370n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 M


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015730
PNG
(1-[1-(3-Trifluoromethyl-phenyl)-cyclohexyl]-1,2,3,...)
Show SMILES FC(F)(F)c1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C18H22F3N/c19-18(20,21)16-9-7-8-15(14-16)17(10-3-1-4-11-17)22-12-5-2-6-13-22/h2,5,7-9,14H,1,3-4,6,10-13H2
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422n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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530n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015742
PNG
(1-[1-(3-[1,3]Dioxolan-2-yl-phenyl)-cyclohexyl]-1,2...)
Show SMILES C1COC(O1)c1cccc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C20H27NO2/c1-3-10-20(11-4-1,21-12-5-2-6-13-21)18-9-7-8-17(16-18)19-22-14-15-23-19/h2,5,7-9,16,19H,1,3-4,6,10-15H2
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601n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50405724
PNG
(CHEMBL1169565)
Show SMILES C1C2CC(CC12)[C@H](N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H25N/c1-3-7-14(8-4-1)18(19-9-5-2-6-10-19)17-12-15-11-16(15)13-17/h1,3-4,7-8,15-18H,2,5-6,9-13H2/t15?,16?,17?,18-/m1/s1
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630n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity of compound against Phencyclidine receptor by displacement of [3H]TCP


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50038169
PNG
((3R,4R)-3-Amino-1-hydroxy-4-methyl-pyrrolidin-2-on...)
Show SMILES C[C@@H]1CN(O)C(=O)[C@@H]1N
Show InChI InChI=1S/C5H10N2O2/c1-3-2-7(9)5(8)4(3)6/h3-4,9H,2,6H2,1H3/t3-,4-/m1/s1
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650n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for in vitro inhibition of cortical neuron at NMDA receptor


J Med Chem 37: 4053-67 (1995)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50405723
PNG
(CHEMBL1169564)
Show SMILES C1C2CC(CC12)[C@@H](N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H25N/c1-3-7-14(8-4-1)18(19-9-5-2-6-10-19)17-12-15-11-16(15)13-17/h1,3-4,7-8,15-18H,2,5-6,9-13H2/t15?,16?,17?,18-/m0/s1
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680n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity of compound against Phencyclidine receptor by displacement of [3H]TCP


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50062599
PNG
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | MEM...)
Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2
Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
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700n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Compound with the N-methyl-D-aspartate glutamate receptor blocking activity


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015745
PNG
(1-[1-(3-Benzyloxy-phenyl)-cyclohexyl]-1,2,3,6-tetr...)
Show SMILES C(Oc1cccc(c1)C1(CCCCC1)N1CCC=CC1)c1ccccc1
Show InChI InChI=1S/C24H29NO/c1-4-11-21(12-5-1)20-26-23-14-10-13-22(19-23)24(15-6-2-7-16-24)25-17-8-3-9-18-25/h1,3-5,8,10-14,19H,2,6-7,9,15-18,20H2
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733n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50038175
PNG
((3R,4R)-3-Amino-1,4-dihydroxy-pyrrolidin-2-one | C...)
Show SMILES N[C@@H]1[C@H](O)CN(O)C1=O
Show InChI InChI=1S/C4H8N2O3/c5-3-2(7)1-6(9)4(3)8/h2-3,7,9H,1,5H2/t2-,3-/m1/s1
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750n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for in vitro inhibition of cortical neuron at NMDA receptor


J Med Chem 37: 4053-67 (1995)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018932
PNG
(1-(3-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES C[C@@H]1CCC[C@@](C1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-12-18(15-16,17-10-4-2-5-11-17)19-13-6-3-7-14-19/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3/t16-,18+/m1/s1
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820n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50288367
PNG
(3-(2,3-Dioxo-7-pyrrol-1-yl-6-trifluoromethyl-3,4-d...)
Show SMILES OC(=O)CCn1c2cc(c(cc2[nH]c(=O)c1=O)C(F)(F)F)-n1cccc1
Show InChI InChI=1S/C16H12F3N3O4/c17-16(18,19)9-7-10-12(8-11(9)21-4-1-2-5-21)22(6-3-13(23)24)15(26)14(25)20-10/h1-2,4-5,7-8H,3,6H2,(H,20,25)(H,23,24)
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1.20E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against glycine site of NMDA receptor using [3H]-glycine as a radioligand.


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50048875
PNG
(CHEMBL431343 | N-[3-(5-Methoxy-1,2,3,4-tetrahydro-...)
Show SMILES COc1cccc2C(CCCNCCNc3ccccc3)CCCc12
Show InChI InChI=1S/C22H30N2O/c1-25-22-14-6-12-20-18(8-5-13-21(20)22)9-7-15-23-16-17-24-19-10-3-2-4-11-19/h2-4,6,10-12,14,18,23-24H,5,7-9,13,15-17H2,1H3
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2.13E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 M


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018929
PNG
(3-Methyl-1-(1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES CC1CCCN(C1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-14-19(15-16)18(12-6-3-7-13-18)17-10-4-2-5-11-17/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3
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2.15E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018929
PNG
(3-Methyl-1-(1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES CC1CCCN(C1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-14-19(15-16)18(12-6-3-7-13-18)17-10-4-2-5-11-17/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3
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2.15E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50038159
PNG
((R)-3-Amino-1-hydroxy-pyrrolidin-2-one | CHEMBL335...)
Show SMILES N[C@@H]1CCN(O)C1=O
Show InChI InChI=1S/C4H8N2O2/c5-3-1-2-6(8)4(3)7/h3,8H,1-2,5H2/t3-/m1/s1
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2.50E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for in vitro inhibition of cortical neuron at NMDA receptor


J Med Chem 37: 4053-67 (1995)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50405723
PNG
(CHEMBL1169564)
Show SMILES C1C2CC(CC12)[C@@H](N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H25N/c1-3-7-14(8-4-1)18(19-9-5-2-6-10-19)17-12-15-11-16(15)13-17/h1,3-4,7-8,15-18H,2,5-6,9-13H2/t15?,16?,17?,18-/m0/s1
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2.60E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50405724
PNG
(CHEMBL1169565)
Show SMILES C1C2CC(CC12)[C@H](N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H25N/c1-3-7-14(8-4-1)18(19-9-5-2-6-10-19)17-12-15-11-16(15)13-17/h1,3-4,7-8,15-18H,2,5-6,9-13H2/t15?,16?,17?,18-/m1/s1
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3.20E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018931
PNG
(1-(3-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES C[C@H]1CCC[C@](C1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-12-18(15-16,17-10-4-2-5-11-17)19-13-6-3-7-14-19/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3/t16-,18+/m0/s1
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3.30E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50038157
PNG
(6-Hydroxy-2,6-diaza-bicyclo[3.2.1]octan-7-one | CH...)
Show SMILES ON1C2CC(NCC2)C1=O
Show InChI InChI=1S/C6H10N2O2/c9-6-5-3-4(8(6)10)1-2-7-5/h4-5,7,10H,1-3H2
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3.50E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for in vitro inhibition of cortical neuron at NMDA receptor


J Med Chem 37: 4053-67 (1995)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50048867
PNG
(1-Benzyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphth...)
Show SMILES COc1cccc2C(CCCN3CCN(Cc4ccccc4)CC3)CCCc12
Show InChI InChI=1S/C25H34N2O/c1-28-25-14-6-12-23-22(10-5-13-24(23)25)11-7-15-26-16-18-27(19-17-26)20-21-8-3-2-4-9-21/h2-4,6,8-9,12,14,22H,5,7,10-11,13,15-20H2,1H3
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3.89E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 M


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018930
PNG
(1-(3-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES C[C@@H]1CCC[C@](C1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-12-18(15-16,17-10-4-2-5-11-17)19-13-6-3-7-14-19/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3/t16-,18-/m1/s1
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6.80E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50007314
PNG
(CHEMBL104834 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Show SMILES Clc1ccc(CCN[C@@H]2CCCC[C@@H]2N2CCCC2)cc1Cl
Show InChI InChI=1S/C18H26Cl2N2/c19-15-8-7-14(13-16(15)20)9-10-21-17-5-1-2-6-18(17)22-11-3-4-12-22/h7-8,13,17-18,21H,1-6,9-12H2/t17-,18+/m1/s1
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6.88E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was tested for the inhibitory concentration against phencyclidine by using [3H]-TCP as radioligand at PCP receptor in guinea pig brain


J Med Chem 34: 3058-65 (1991)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50288358
PNG
((2,3-Dioxo-7-pyrrol-1-yl-6-trifluoromethyl-3,4-dih...)
Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)C(F)(F)F)-n1cccc1
Show InChI InChI=1S/C15H10F3N3O4/c16-15(17,18)8-5-9-11(6-10(8)20-3-1-2-4-20)21(7-12(22)23)14(25)13(24)19-9/h1-6H,7H2,(H,19,24)(H,22,23)
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8.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against glycine site of NMDA receptor using [3H]-glycine as a radioligand.


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50048871
PNG
(1-[4-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)C3=NCCCC3)CCCc12
Show InChI InChI=1S/C24H37N3O/c1-28-23-12-7-10-21-20(9-6-11-22(21)23)8-3-5-15-26-16-18-27(19-17-26)24-13-2-4-14-25-24/h7,10,12,20H,2-6,8-9,11,13-19H2,1H3
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8.33E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 M


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50048873
PNG
(1-Benzyl-4-[3-(3,4-dihydro-naphthalen-1-yl)-propyl...)
Show SMILES C(CN1CCN(Cc2ccccc2)CC1)CC1=CCCc2ccccc12
Show InChI InChI=1S/C24H30N2/c1-2-8-21(9-3-1)20-26-18-16-25(17-19-26)15-7-13-23-12-6-11-22-10-4-5-14-24(22)23/h1-5,8-10,12,14H,6-7,11,13,15-20H2
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8.43E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 M


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50015737
PNG
(1-[1-(3,5-Dimethoxy-phenyl)-cyclohexyl]-1,2,3,6-te...)
Show SMILES COc1cc(OC)cc(c1)C1(CCCCC1)N1CCC=CC1
Show InChI InChI=1S/C19H27NO2/c1-21-17-13-16(14-18(15-17)22-2)19(9-5-3-6-10-19)20-11-7-4-8-12-20/h4,7,13-15H,3,5-6,8-12H2,1-2H3
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8.60E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.


J Med Chem 33: 2211-5 (1990)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50037480
PNG
((6R,11S)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m1/s1
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9.04E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity against PCP receptor from guinea pig brain, using [3H]TCP as radioligand.


J Med Chem 35: 2221-30 (1992)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on NMDA receptor using [3H]- CGS-19,755 as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on NMDA receptor using [3H]- CGS-19,755 as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50064173
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1(=O)c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NO2S/c22-24(23)19-9-5-4-8-18(19)10-11-20(24)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brain


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50288361
PNG
(6-Nitro-7-pyrrol-1-yl-1,4-dihydro-quinoxaline-2,3-...)
Show SMILES [O-][N+](=O)c1cc2[n-]c(=[OH+])c(=[OH+])[n-]c2cc1-n1cccc1
Show InChI InChI=1S/C12H8N4O4/c17-11-12(18)14-8-6-10(16(19)20)9(5-7(8)13-11)15-3-1-2-4-15/h1-6H,(H2,13,14,17,18)
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1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against glycine site of NMDA receptor using [3H]-glycine as a radioligand.


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Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50064175
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NOS/c22-23-19-9-5-4-8-18(19)10-11-20(23)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brain


Citation and Details
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brain


Citation and Details
More data for this
Ligand-Target Pair
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