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Compile Data Set for Download or QSAR

Found 62 hits Enz. Inhib. hit(s) with Target = 'Glutamate carboxypeptidase II' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM17659
PNG
((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Show SMILES OC(=O)CCC(CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
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0.275n/an/an/an/an/an/an/an/a



ZENECA Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of the Folate hydrolase


J Med Chem 39: 619-22 (1996)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50048694
PNG
(2-[(2-Carboxy-ethyl)-hydroxy-phosphinoylmethyl]-pe...)
Show SMILES OC(=O)CCC(CP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C9H15O8P/c10-7(11)2-1-6(9(14)15)5-18(16,17)4-3-8(12)13/h6H,1-5H2,(H,10,11)(H,12,13)(H,14,15)(H,16,17)
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1.90n/an/an/an/an/an/an/an/a



ZENECA Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of the Folate hydrolase


J Med Chem 39: 619-22 (1996)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50014185
PNG
(2-(3-Carboxy-acryloylamino)-pentanedioic acid | CH...)
Show SMILES OC(=O)CC[C@H](NC(=O)\C=C\C(O)=O)C(O)=O
Show InChI InChI=1S/C9H11NO7/c11-6(2-4-8(14)15)10-5(9(16)17)1-3-7(12)13/h2,4-5H,1,3H2,(H,10,11)(H,12,13)(H,14,15)(H,16,17)/b4-2+/t5-/m0/s1
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400n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Tested for Ac-Asp-[3,4-3H]-Glu-OH hydrolysis inhibitory activity against rat fore-brain N-acetylated-alpha-linked acidic dipeptidase


J Med Chem 33: 2734-44 (1990)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50048693
PNG
(2-Phosphonomethyl-succinic acid | 2-Phosphonomethy...)
Show SMILES OC(=O)CC(CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H9O7P/c6-4(7)1-3(5(8)9)2-13(10,11)12/h3H,1-2H2,(H,6,7)(H,8,9)(H2,10,11,12)
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700n/an/an/an/an/an/an/an/a



ZENECA Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of the Folate hydrolase


J Med Chem 39: 619-22 (1996)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50014184
PNG
(2-(2-Carboxy-acetylamino)-pentanedioic acid | CHEM...)
Show SMILES OC(=O)CC[C@H](NC(=O)CC(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO7/c10-5(3-7(13)14)9-4(8(15)16)1-2-6(11)12/h4H,1-3H2,(H,9,10)(H,11,12)(H,13,14)(H,15,16)/t4-/m0/s1
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900n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Tested for Ac-Asp-[3,4-3H]-Glu-OH hydrolysis inhibitory activity against rat fore-brain N-acetylated-alpha-linked acidic dipeptidase


J Med Chem 33: 2734-44 (1990)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50014188
PNG
(2-(3-Carboxy-2-methoxycarbonylamino-acryloylamino)...)
Show SMILES COC(=O)N=C(CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C11H14N2O9/c1-22-11(21)13-6(4-8(16)17)9(18)12-5(10(19)20)2-3-7(14)15/h5H,2-4H2,1H3,(H,12,18)(H,14,15)(H,16,17)(H,19,20)/t5-/m0/s1
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1.40E+3n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Tested for Ac-Asp-[3,4-3H]-Glu-OH hydrolysis inhibitory activity against rat fore-brain N-acetylated-alpha-linked acidic dipeptidase


J Med Chem 33: 2734-44 (1990)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50014187
PNG
(2-(3-Acetylamino-4-carboxy-butyrylamino)-pentanedi...)
Show SMILES CC(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C12H18N2O8/c1-6(15)13-7(5-11(19)20)4-9(16)14-8(12(21)22)2-3-10(17)18/h7-8H,2-5H2,1H3,(H,13,15)(H,14,16)(H,17,18)(H,19,20)(H,21,22)/t7-,8+/m1/s1
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3.20E+3n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Tested for Ac-Asp-[3,4-3H]-Glu-OH hydrolysis inhibitory activity against rat fore-brain N-acetylated-alpha-linked acidic dipeptidase


J Med Chem 33: 2734-44 (1990)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50014182
PNG
(2-(2-Acetylamino-4-carboxy-butyrylamino)-pentanedi...)
Show SMILES CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C12H18N2O8/c1-6(15)13-7(2-4-9(16)17)11(20)14-8(12(21)22)3-5-10(18)19/h7-8H,2-5H2,1H3,(H,13,15)(H,14,20)(H,16,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1
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3.50E+3n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Tested for Ac-Asp-[3,4-3H]-Glu-OH hydrolysis inhibitory activity against rat fore-brain N-Acetylated alpha-linked Dipeptidase (NAALA Dipeptidase)


J Med Chem 33: 2734-44 (1990)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50014180
PNG
(2-(2-Acetylamino-3-carboxy-propionylamino)-pentane...)
Show SMILES CC(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7+/m0/s1
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8.50E+3n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Tested for Ac-Asp-[3,4-3H]-Glu-OH hydrolysis inhibitory activity against rat fore-brain N-acetylated-alpha-linked acidic dipeptidase


J Med Chem 33: 2734-44 (1990)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50014181
PNG
(2-(3-Carboxy-acryloylamino)-pentanedioic acid | CH...)
Show SMILES OC(=O)CC[C@H](NC(=O)\C=C/C(O)=O)C(O)=O
Show InChI InChI=1S/C9H11NO7/c11-6(2-4-8(14)15)10-5(9(16)17)1-3-7(12)13/h2,4-5H,1,3H2,(H,10,11)(H,12,13)(H,14,15)(H,16,17)/b4-2-/t5-/m0/s1
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4.10E+4n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Tested for Ac-Asp-[3,4-3H]-Glu-OH hydrolysis inhibitory activity against rat fore-brain N-acetylated-alpha-linked acidic dipeptidase


J Med Chem 33: 2734-44 (1990)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM17659
PNG
((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Show SMILES OC(=O)CCC(CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
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n/an/a 0.300n/an/an/an/an/an/a



Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50085699
PNG
((S,S / R,R)4-Carboxy-5-[(2,4-dicarboxy-butyl)-hydr...)
Show SMILES OC(=O)CCC(CP(O)(=O)CC(CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C12H19O10P/c13-9(14)3-1-7(11(17)18)5-23(21,22)6-8(12(19)20)2-4-10(15)16/h7-8H,1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)(H,21,22)
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n/an/a 0.5n/an/an/an/an/an/a



Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106576
PNG
(2-[(2-Carboxy-propyl)-hydroxy-phosphinoylmethyl]-p...)
Show SMILES CC(CP(O)(=O)CC(CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17O8P/c1-6(9(13)14)4-19(17,18)5-7(10(15)16)2-3-8(11)12/h6-7H,2-5H2,1H3,(H,11,12)(H,13,14)(H,15,16)(H,17,18)
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n/an/a 1.5n/an/an/an/an/an/a



Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106577
PNG
(2-[(2-Carboxy-3-phenyl-propyl)-hydroxy-phosphinoyl...)
Show SMILES OC(=O)CCC(CP(O)(=O)CC(Cc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C16H21O8P/c17-14(18)7-6-12(15(19)20)9-25(23,24)10-13(16(21)22)8-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
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n/an/a 2n/an/an/an/an/an/a



Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50116251
PNG
(2-{[3-(4-Amino-benzoylamino)-3-carboxy-propyl]-hyd...)
Show SMILES Nc1ccc(cc1)C(=O)N[C@@H](CCP(O)(=O)O[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C16H21N2O10P/c17-10-3-1-9(2-4-10)14(21)18-11(15(22)23)7-8-29(26,27)28-12(16(24)25)5-6-13(19)20/h1-4,11-12H,5-8,17H2,(H,18,21)(H,19,20)(H,22,23)(H,24,25)(H,26,27)/t11-,12-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate


Bioorg Med Chem Lett 12: 2189-92 (2002)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106570
PNG
(2-{Hydroxy-[(4-methoxy-phenylamino)-methyl]-phosph...)
Show SMILES COc1ccc(NCP(O)(=O)CC(CCC(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C14H20NO7P/c1-22-12-5-3-11(4-6-12)15-9-23(20,21)8-10(14(18)19)2-7-13(16)17/h3-6,10,15H,2,7-9H2,1H3,(H,16,17)(H,18,19)(H,20,21)
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n/an/a 3n/an/an/an/an/an/a



Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106566
PNG
(2-(Hydroxy-phenylaminomethyl-phosphinoylmethyl)-pe...)
Show SMILES OC(=O)CCC(CP(O)(=O)CNc1ccccc1)C(O)=O
Show InChI InChI=1S/C13H18NO6P/c15-12(16)7-6-10(13(17)18)8-21(19,20)9-14-11-4-2-1-3-5-11/h1-5,10,14H,6-9H2,(H,15,16)(H,17,18)(H,19,20)
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n/an/a 4n/an/an/an/an/an/a



Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50116250
PNG
(2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...)
Show SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCP(O)(=O)O[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C24H29N8O10P/c1-32(11-13-10-27-20-18(28-13)19(25)30-24(26)31-20)14-4-2-12(3-5-14)21(35)29-15(22(36)37)8-9-43(40,41)42-16(23(38)39)6-7-17(33)34/h2-5,10,15-16H,6-9,11H2,1H3,(H,29,35)(H,33,34)(H,36,37)(H,38,39)(H,40,41)(H4,25,26,27,30,31)/t15-,16-/m0/s1
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate


Bioorg Med Chem Lett 12: 2189-92 (2002)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50116253
PNG
(2-{[3-Carboxy-3-(4-methylamino-benzoylamino)-propy...)
Show SMILES CNc1ccc(cc1)C(=O)N[C@@H](CCP(O)(=O)O[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C17H23N2O10P/c1-18-11-4-2-10(3-5-11)15(22)19-12(16(23)24)8-9-30(27,28)29-13(17(25)26)6-7-14(20)21/h2-5,12-13,18H,6-9H2,1H3,(H,19,22)(H,20,21)(H,23,24)(H,25,26)(H,27,28)/t12-,13-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate


Bioorg Med Chem Lett 12: 2189-92 (2002)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50116252
PNG
(2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...)
Show SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCP(O)(=O)OC(CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C24H29N8O10P/c1-32(11-13-10-27-20-18(28-13)19(25)30-24(26)31-20)14-4-2-12(3-5-14)21(35)29-15(22(36)37)8-9-43(40,41)42-16(23(38)39)6-7-17(33)34/h2-5,10,15-16H,6-9,11H2,1H3,(H,29,35)(H,33,34)(H,36,37)(H,38,39)(H,40,41)(H4,25,26,27,30,31)
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n/an/a 5n/an/an/an/an/an/a



Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate


Bioorg Med Chem Lett 12: 2189-92 (2002)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM17659
PNG
((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Show SMILES OC(=O)CCC(CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against expressed rat Glutamate carboxypeptidase II, using a substrate concentration of 5 microM


J Med Chem 44: 298-301 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50102256
PNG
(2-[3-(1-Carboxy-2-mercapto-ethyl)-ureido]-pentaned...)
Show SMILES OC(=O)CC[C@H](NC(=O)N[C@@H](CS)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H14N2O7S/c12-6(13)2-1-4(7(14)15)10-9(18)11-5(3-19)8(16)17/h4-5,19H,1-3H2,(H,12,13)(H,14,15)(H,16,17)(H2,10,11,18)/t4-,5-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against expressed rat Glutamate carboxypeptidase II, using a substrate concentration of 5 microM


J Med Chem 44: 298-301 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106575
PNG
(2-[Hydroxy-(hydroxy-pyridin-4-yl-methyl)-phosphino...)
Show SMILES OC(=O)CCC(CP(O)(O)C(=O)c1ccncc1)C(O)=O
Show InChI InChI=1S/C12H16NO7P/c14-10(15)2-1-9(11(16)17)7-21(19,20)12(18)8-3-5-13-6-4-8/h3-6,9,19-21H,1-2,7H2,(H,14,15)(H,16,17)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106567
PNG
(2-{[(3-Fluoro-phenyl)-hydroxy-methyl]-hydroxy-phos...)
Show SMILES OC(=O)CCC(CP(O)(O)C(=O)c1cccc(F)c1)C(O)=O
Show InChI InChI=1S/C13H16FO7P/c14-10-3-1-2-8(6-10)13(19)22(20,21)7-9(12(17)18)4-5-11(15)16/h1-3,6,9,20-22H,4-5,7H2,(H,15,16)(H,17,18)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50102259
PNG
(2-[(2,4-Dicarboxy-butyl)-hydroxy-phosphinoylmethyl...)
Show SMILES OC(=O)CC[C@H](CP(O)(=O)C[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C12H19O10P/c13-9(14)3-1-7(11(17)18)5-23(21,22)6-8(12(19)20)2-4-10(15)16/h7-8H,1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)(H,21,22)/t7-,8-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against expressed rat Glutamate carboxypeptidase II, using a substrate concentration of 5 microM


J Med Chem 44: 298-301 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50102255
PNG
(2-[3-(2-tert-Butylsulfanyl-1-carboxy-ethyl)-ureido...)
Show SMILES CC(C)(C)SCC(NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H22N2O7S/c1-13(2,3)23-6-8(11(20)21)15-12(22)14-7(10(18)19)4-5-9(16)17/h7-8H,4-6H2,1-3H3,(H,16,17)(H,18,19)(H,20,21)(H2,14,15,22)/t7-,8?/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against expressed rat Glutamate carboxypeptidase II, using a substrate concentration of 5 microM


J Med Chem 44: 298-301 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50102257
PNG
(2-[3-(1,2-Dicarboxy-ethyl)-ureido]-pentanedioic ac...)
Show SMILES OC(=O)CC[C@H](NC(=O)N[C@@H](CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H14N2O9/c13-6(14)2-1-4(8(17)18)11-10(21)12-5(9(19)20)3-7(15)16/h4-5H,1-3H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)(H2,11,12,21)/t4-,5-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against expressed rat Glutamate carboxypeptidase IIusing a substrate concentration of 5 microM


J Med Chem 44: 298-301 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50102258
PNG
((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Show SMILES OC(=O)CC[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H16N2O9/c14-7(15)3-1-5(9(18)19)12-11(22)13-6(10(20)21)2-4-8(16)17/h5-6H,1-4H2,(H,14,15)(H,16,17)(H,18,19)(H,20,21)(H2,12,13,22)/t5-,6-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against expressed rat Glutamate carboxypeptidase II, using a substrate concentration of 5 microM


J Med Chem 44: 298-301 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106564
PNG
(2-[(3,5-Difluoro-benzyl)-hydroxy-phosphinoylmethyl...)
Show SMILES OC(=O)CCC(CP(O)(=O)Cc1cc(F)cc(F)c1)C(O)=O
Show InChI InChI=1S/C13H15F2O6P/c14-10-3-8(4-11(15)5-10)6-22(20,21)7-9(13(18)19)1-2-12(16)17/h3-5,9H,1-2,6-7H2,(H,16,17)(H,18,19)(H,20,21)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106568
PNG
(2-(Benzyl-hydroxy-phosphinoylmethyl)-pentanedioic ...)
Show SMILES OC(=O)CCC(CP(O)(=O)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C13H17O6P/c14-12(15)7-6-11(13(16)17)9-20(18,19)8-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H,14,15)(H,16,17)(H,18,19)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106557
PNG
(2-[Hydroxy-(hydroxy-phenyl-methyl)-phosphinoylmeth...)
Show SMILES OC(=O)CCC(CP(O)(O)C(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C13H17O7P/c14-11(15)7-6-10(12(16)17)8-21(19,20)13(18)9-4-2-1-3-5-9/h1-5,10,19-21H,6-8H2,(H,14,15)(H,16,17)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106560
PNG
(2-[(3,5-Bis-trifluoromethyl-benzyl)-hydroxy-phosph...)
Show SMILES OC(=O)CCC(CP(O)(=O)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C15H15F6O6P/c16-14(17,18)10-3-8(4-11(5-10)15(19,20)21)6-28(26,27)7-9(13(24)25)1-2-12(22)23/h3-5,9H,1-2,6-7H2,(H,22,23)(H,24,25)(H,26,27)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106571
PNG
(2-[(Benzylamino-methyl)-hydroxy-phosphinoylmethyl]...)
Show SMILES OC(=O)CCC(CP(O)(O)C=NCc1ccccc1)C(O)=O
Show InChI InChI=1S/C14H20NO6P/c16-13(17)7-6-12(14(18)19)9-22(20,21)10-15-8-11-4-2-1-3-5-11/h1-5,10,12,20-22H,6-9H2,(H,16,17)(H,18,19)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106555
PNG
(2-[Hydroxy-(4-methyl-benzyl)-phosphinoylmethyl]-pe...)
Show SMILES Cc1ccc(CP(O)(=O)CC(CCC(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C14H19O6P/c1-10-2-4-11(5-3-10)8-21(19,20)9-12(14(17)18)6-7-13(15)16/h2-5,12H,6-9H2,1H3,(H,15,16)(H,17,18)(H,19,20)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM17752
PNG
(2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...)
Show SMILES OC(=O)CCC(CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O
Show InChI InChI=1S/C13H12F5O6P/c14-8-6(9(15)11(17)12(18)10(8)16)4-25(23,24)3-5(13(21)22)1-2-7(19)20/h5H,1-4H2,(H,19,20)(H,21,22)(H,23,24)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106572
PNG
(2-[Hydroxy-(4-methoxy-benzyl)-phosphinoylmethyl]-p...)
Show SMILES COc1ccc(CP(O)(=O)CC(CCC(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C14H19O7P/c1-21-12-5-2-10(3-6-12)8-22(19,20)9-11(14(17)18)4-7-13(15)16/h2-3,5-6,11H,4,7-9H2,1H3,(H,15,16)(H,17,18)(H,19,20)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106558
PNG
(2-[(2-Benzyloxycarbonyl-propyl)-hydroxy-phosphinoy...)
Show SMILES CC(CP(O)(=O)CC(CCC(O)=O)C(O)=O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C17H23O8P/c1-12(17(22)25-9-13-5-3-2-4-6-13)10-26(23,24)11-14(16(20)21)7-8-15(18)19/h2-6,12,14H,7-11H2,1H3,(H,18,19)(H,20,21)(H,23,24)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106563
PNG
(2-[(3-Amino-benzyl)-hydroxy-phosphinoylmethyl]-pen...)
Show SMILES Nc1cccc(CP(O)(=O)CC(CCC(O)=O)C(O)=O)c1
Show InChI InChI=1S/C13H18NO6P/c14-11-3-1-2-9(6-11)7-21(19,20)8-10(13(17)18)4-5-12(15)16/h1-3,6,10H,4-5,7-8,14H2,(H,15,16)(H,17,18)(H,19,20)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106578
PNG
(2-(Hydroxy-phenethyl-phosphinoylmethyl)-pentanedio...)
Show SMILES OC(=O)CCC(CP(O)(=O)CCc1ccccc1)C(O)=O
Show InChI InChI=1S/C14H19O6P/c15-13(16)7-6-12(14(17)18)10-21(19,20)9-8-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H,15,16)(H,17,18)(H,19,20)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106565
PNG
(2-[(2-Fluoro-benzyl)-hydroxy-phosphinoylmethyl]-pe...)
Show SMILES OC(=O)CCC(CP(O)(=O)Cc1ccccc1F)C(O)=O
Show InChI InChI=1S/C13H16FO6P/c14-11-4-2-1-3-9(11)7-21(19,20)8-10(13(17)18)5-6-12(15)16/h1-4,10H,5-8H2,(H,15,16)(H,17,18)(H,19,20)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106554
PNG
(2-Phosphonomethyl-4-(5H-tetrazol-5-yl)-butyric aci...)
Show SMILES OC(=O)C(CCc1nnn[nH]1)CP(O)(O)=O
Show InChI InChI=1S/C6H11N4O5P/c11-6(12)4(3-16(13,14)15)1-2-5-7-9-10-8-5/h4H,1-3H2,(H,11,12)(H2,13,14,15)(H,7,8,9,10)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106556
PNG
(2-Phosphonomethyl-hexanedioic acid | CHEMBL334737)
Show SMILES OC(=O)CCCC(CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C7H13O7P/c8-6(9)3-1-2-5(7(10)11)4-15(12,13)14/h5H,1-4H2,(H,8,9)(H,10,11)(H2,12,13,14)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106562
PNG
(4-Phenyl-2-phosphonomethyl-butyric acid | CHEMBL13...)
Show SMILES OC(=O)C(CCc1ccccc1)CP(O)(O)=O
Show InChI InChI=1S/C11H15O5P/c12-11(13)10(8-17(14,15)16)7-6-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H,12,13)(H2,14,15,16)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106559
PNG
(4-Cyano-2-phosphonomethyl-butyric acid | CHEMBL334...)
Show SMILES OC(=O)C(CCC#N)CP(O)(O)=O
Show InChI InChI=1S/C6H10NO5P/c7-3-1-2-5(6(8)9)4-13(10,11)12/h5H,1-2,4H2,(H,8,9)(H2,10,11,12)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106561
PNG
(2-(Hydroxy-propyl-phosphinoylmethyl)-pentanedioic ...)
Show SMILES CCCP(O)(=O)CC(CCC(O)=O)C(O)=O
Show InChI InChI=1S/C9H17O6P/c1-2-5-16(14,15)6-7(9(12)13)3-4-8(10)11/h7H,2-6H2,1H3,(H,10,11)(H,12,13)(H,14,15)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106574
PNG
(2-(3-Hydroxy-benzyl)-3-phosphono-propionic acid | ...)
Show SMILES OC(=O)C(Cc1cccc(O)c1)CP(O)(O)=O
Show InChI InChI=1S/C10H13O6P/c11-9-3-1-2-7(5-9)4-8(10(12)13)6-17(14,15)16/h1-3,5,8,11H,4,6H2,(H,12,13)(H2,14,15,16)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50106569
PNG
(2-Benzyl-3-phosphono-propionic acid | CHEMBL132313)
Show SMILES OC(=O)C(Cc1ccccc1)CP(O)(O)=O
Show InChI InChI=1S/C10H13O5P/c11-10(12)9(7-16(13,14)15)6-8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,11,12)(H2,13,14,15)
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Guilford Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat brain NAALADase (Folate hydrolase)


J Med Chem 44: 4170-5 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50102260
PNG
(2-(2-Amino-4-carboxy-butyrylamino)-pentanedioic ac...)
Show SMILES N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C10H16N2O7/c11-5(1-3-7(13)14)9(17)12-6(10(18)19)2-4-8(15)16/h5-6H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against expressed rat Glutamate carboxypeptidase II, using a substrate concentration of 5 microM


J Med Chem 44: 298-301 (2001)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50014185
PNG
(2-(3-Carboxy-acryloylamino)-pentanedioic acid | CH...)
Show SMILES OC(=O)CC[C@H](NC(=O)\C=C\C(O)=O)C(O)=O
Show InChI InChI=1S/C9H11NO7/c11-6(2-4-8(14)15)10-5(9(16)17)1-3-7(12)13/h2,4-5H,1,3H2,(H,10,11)(H,12,13)(H,14,15)(H,16,17)/b4-2+/t5-/m0/s1
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University of Minnesota

Curated by ChEMBL


Assay Description
Concentration required for 50%inhibition of Ac-Asp-[3,4-3H]-Glu-OH hydrolysis against rat fore-brain N-acetylated-alpha-linked acidic dipeptidase


J Med Chem 33: 2734-44 (1990)

More data for this
Ligand-Target Pair
Glutamate carboxypeptidase II


(Rattus norvegicus)
BDBM50014188
PNG
(2-(3-Carboxy-2-methoxycarbonylamino-acryloylamino)...)
Show SMILES COC(=O)N=C(CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C11H14N2O9/c1-22-11(21)13-6(4-8(16)17)9(18)12-5(10(19)20)2-3-7(14)15/h5H,2-4H2,1H3,(H,12,18)(H,14,15)(H,16,17)(H,19,20)/t5-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Concentration required for 50%inhibition of Ac-Asp-[3,4-3H]-Glu-OH hydrolysis against rat fore-brain N-acetylated-alpha-linked acidic dipeptidase


J Med Chem 33: 2734-44 (1990)

More data for this
Ligand-Target Pair
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