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Compile Data Set for Download or QSAR

Found 260 hits Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, AMPA 1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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0.00520n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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0.0220n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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0.150n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50060635
PNG
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)
Show SMILES N[C@@H](Cn1cc(F)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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2.90n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194124
PNG
((S)-N-(1-(5-(6-aminohexylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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5.20n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50211399
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazo...)
Show SMILES NC(Cc1c(o[nH]c1=O)-c1nnn(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1S/C14H14N6O4/c15-10(14(22)23)6-9-11(24-18-13(9)21)12-16-19-20(17-12)7-8-4-2-1-3-5-8/h1-5,10H,6-7,15H2,(H,18,21)(H,22,23)
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7.70n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194124
PNG
((S)-N-(1-(5-(6-aminohexylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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10n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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10n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194127
PNG
((S)-N-(1-(5-(7-aminoheptylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCN
Show InChI InChI=1S/C25H44N4O3/c1-2-11-24(31)29-23(20-21-12-14-22(30)15-13-21)25(32)28-19-10-6-9-18-27-17-8-5-3-4-7-16-26/h12-15,23,27,30H,2-11,16-20,26H2,1H3,(H,28,32)(H,29,31)/t23-/m0/s1
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10n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194113
PNG
((S)-N-(1-(5-(4-aminobutylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-6-3-5-14-24-15-7-4-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
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13n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194123
PNG
((S)-N-(1-(5-(5-aminopentylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-4-7-16-25-15-6-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
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13n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194118
PNG
((S)-N-(1-(5-(3-aminopropylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-5-3-4-13-23-14-6-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
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14n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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21.9n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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22n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA1o expressed in sS9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194111
PNG
((S)-N-(1-(5-(10-aminodecylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-9-12-21-30-20-11-8-6-4-3-5-7-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
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26n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50252873
PNG
(2-amino-3-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-...)
Show SMILES NC(Cn1cc(Br)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8BrN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)
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35n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50060632
PNG
((S)-2-Amino-3-(5-chloro-2,4-dioxo-3,4-dihydro-2H-p...)
Show SMILES N[C@@H](Cn1cc(Cl)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8ClN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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37n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194109
PNG
((S)-N-(1-(5-(8-aminooctylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-11-7-10-19-28-18-9-6-4-3-5-8-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)/t24-/m0/s1
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37n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194114
PNG
((S)-N-(1-(9-(6-aminohexylamino)nonylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCNCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-8-5-3-4-7-11-20-30-21-12-9-6-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
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37n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194119
PNG
((S)-N-(1-(4-(7-aminoheptylamino)butylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-8-17-26-16-7-5-3-4-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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38n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50252922
PNG
((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Show SMILES N[C@@H](Cn1c2ccsc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C9H9N3O4S/c10-4(8(14)15)3-12-5-1-2-17-6(5)7(13)11-9(12)16/h1-2,4H,3,10H2,(H,14,15)(H,11,13,16)/t4-/m0/s1
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50n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194120
PNG
((S)-N-(1-(4-(6-aminohexylamino)butylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-7-16-25-15-6-4-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
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53n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50252920
PNG
((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Show SMILES N[C@@H](Cn1c2CSCc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C9H11N3O4S/c10-5(8(14)15)1-12-6-3-17-2-4(6)7(13)11-9(12)16/h5H,1-3,10H2,(H,14,15)(H,11,13,16)/t5-/m0/s1
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58n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194118
PNG
((S)-N-(1-(5-(3-aminopropylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-5-3-4-13-23-14-6-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
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63n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194122
PNG
((S)-N-(1-(8-(3-aminopropylamino)octylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-6-4-3-5-7-16-26-17-9-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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65n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194117
PNG
((S)-N-(1-(5-(9-aminononylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCN
Show InChI InChI=1S/C27H48N4O3/c1-2-13-26(33)31-25(22-23-14-16-24(32)17-15-23)27(34)30-21-12-8-11-20-29-19-10-7-5-3-4-6-9-18-28/h14-17,25,29,32H,2-13,18-22,28H2,1H3,(H,30,34)(H,31,33)/t25-/m0/s1
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65n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194113
PNG
((S)-N-(1-(5-(4-aminobutylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-6-3-5-14-24-15-7-4-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
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68n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194126
PNG
((S)-N-(1-(8-(6-aminohexylamino)octylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCCCCN
Show InChI InChI=1S/C27H48N4O3/c1-2-13-26(33)31-25(22-23-14-16-24(32)17-15-23)27(34)30-21-12-7-4-3-6-10-19-29-20-11-8-5-9-18-28/h14-17,25,29,32H,2-13,18-22,28H2,1H3,(H,30,34)(H,31,33)/t25-/m0/s1
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77n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194112
PNG
((S)-N-(1-(5-(12-aminododecylamino)pentylamino)-3-(...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCCCN
Show InChI InChI=1S/C30H54N4O3/c1-2-16-29(36)34-28(25-26-17-19-27(35)20-18-26)30(37)33-24-15-11-14-23-32-22-13-10-8-6-4-3-5-7-9-12-21-31/h17-20,28,32,35H,2-16,21-25,31H2,1H3,(H,33,37)(H,34,36)/t28-/m0/s1
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77n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50060627
PNG
((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...)
Show SMILES N[C@@H](Cn1cc(I)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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83n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194123
PNG
((S)-N-(1-(5-(5-aminopentylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-4-7-16-25-15-6-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
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95n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50252921
PNG
((S)-1-(2'-Amino-2'-carboxyethyl)-6,6-dimethyl-2,3,...)
Show SMILES CC1(C)Cc2c(C1)c(=O)[nH]c(=O)n2C[C@H](N)C(O)=O
Show InChI InChI=1S/C12H17N3O4/c1-12(2)3-6-8(4-12)15(5-7(13)10(17)18)11(19)14-9(6)16/h7H,3-5,13H2,1-2H3,(H,17,18)(H,14,16,19)/t7-/m0/s1
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102n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50107595
PNG
((S)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cycl...)
Show SMILES N[C@@H](Cn1c2CCCc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C10H13N3O4/c11-6(9(15)16)4-13-7-3-1-2-5(7)8(14)12-10(13)17/h6H,1-4,11H2,(H,15,16)(H,12,14,17)/t6-/m0/s1
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109n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194127
PNG
((S)-N-(1-(5-(7-aminoheptylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCN
Show InChI InChI=1S/C25H44N4O3/c1-2-11-24(31)29-23(20-21-12-14-22(30)15-13-21)25(32)28-19-10-6-9-18-27-17-8-5-3-4-7-16-26/h12-15,23,27,30H,2-11,16-20,26H2,1H3,(H,28,32)(H,29,31)/t23-/m0/s1
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110n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194116
PNG
((S)-N-(1-(3-(6-aminohexylamino)propylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-7-15-24-14-6-4-3-5-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
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126n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50128264
PNG
((R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)p...)
Show SMILES NC(Cc1o[nH]c(=O)c1Cl)C(O)=O
Show InChI InChI=1S/C6H7ClN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)
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130n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA1o expressed in sS9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194115
PNG
((S)-N-(1-(5-(2-aminoethylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCN
Show InChI InChI=1S/C20H34N4O3/c1-2-6-19(26)24-18(15-16-7-9-17(25)10-8-16)20(27)23-13-5-3-4-12-22-14-11-21/h7-10,18,22,25H,2-6,11-15,21H2,1H3,(H,23,27)(H,24,26)/t18-/m0/s1
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140n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194110
PNG
((S)-N-(1-(7-(4-aminobutylamino)heptylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCNCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-5-3-4-7-16-26-17-9-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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168n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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169n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194111
PNG
((S)-N-(1-(5-(10-aminodecylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-9-12-21-30-20-11-8-6-4-3-5-7-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
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180n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50027828
PNG
((7S)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]p...)
Show SMILES [O-]C(=O)C1[NH2+]CCc2c1o[nH]c2=O
Show InChI InChI=1S/C7H8N2O4/c10-6-3-1-2-8-4(7(11)12)5(3)13-9-6/h4,8H,1-2H2,(H,9,10)(H,11,12)
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180n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA1o expressed in sS9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194108
PNG
((S)-N-(1-(2-(6-aminohexylamino)ethylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCNCCCCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-14-23-13-6-4-3-5-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
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208n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194107
PNG
((S)-N-(1-(7-(6-aminohexylamino)heptylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCNCCCCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-11-6-3-5-9-18-28-19-10-7-4-8-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)/t24-/m0/s1
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208n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50126764
PNG
((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Show SMILES N[C@@H](CC1=CCCCc2o[nH]c(=O)c12)C(O)=O
Show InChI InChI=1S/C11H14N2O4/c12-7(11(15)16)5-6-3-1-2-4-8-9(6)10(14)13-17-8/h3,7H,1-2,4-5,12H2,(H,13,14)(H,15,16)/t7-/m0/s1
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232n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 flop isoform expressed in baculovirus infected Sf9 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194118
PNG
((S)-N-(1-(5-(3-aminopropylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-5-3-4-13-23-14-6-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
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270n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194109
PNG
((S)-N-(1-(5-(8-aminooctylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-11-7-10-19-28-18-9-6-4-3-5-8-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)/t24-/m0/s1
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330n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194125
PNG
((S)-N-(1-(3-(8-aminooctylamino)propylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-17-26-16-8-6-4-3-5-7-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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350n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50061058
PNG
(2-Amino-3-(2,4-dihydroxy-pyrimidin-1-yl)-propionic...)
Show SMILES NC(Cn1ccc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H9N3O4/c8-4(6(12)13)3-10-2-1-5(11)9-7(10)14/h1-2,4H,3,8H2,(H,12,13)(H,9,11,14)
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410n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 1


(Rattus norvegicus)
BDBM50194115
PNG
((S)-N-(1-(5-(2-aminoethylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCN
Show InChI InChI=1S/C20H34N4O3/c1-2-6-19(26)24-18(15-16-7-9-17(25)10-8-16)20(27)23-13-5-3-4-12-22-14-11-21/h7-10,18,22,25H,2-6,11-15,21H2,1H3,(H,23,27)(H,24,26)/t18-/m0/s1
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410n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


Citation and Details
More data for this
Ligand-Target Pair
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