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Compile Data Set for Download or QSAR

Found 74 hits Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, AMPA 3' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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0.00220n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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PubMed
0.0210n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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0.0450n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50211399
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazo...)
Show SMILES NC(Cc1c(o[nH]c1=O)-c1nnn(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1S/C14H14N6O4/c15-10(14(22)23)6-9-11(24-18-13(9)21)12-16-19-20(17-12)7-8-4-2-1-3-5-8/h1-5,10H,6-7,15H2,(H,18,21)(H,22,23)
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0.390n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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1.20n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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3.70n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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20.6n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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Article
21n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50060635
PNG
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)
Show SMILES N[C@@H](Cn1cc(F)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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70n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50126764
PNG
((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Show SMILES N[C@@H](CC1=CCCCc2o[nH]c(=O)c12)C(O)=O
Show InChI InChI=1S/C11H14N2O4/c12-7(11(15)16)5-6-3-1-2-4-8-9(6)10(14)13-17-8/h3,7H,1-2,4-5,12H2,(H,13,14)(H,15,16)/t7-/m0/s1
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173n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 flop isoform expressed in baculovirus infected Sf9 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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249n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50252920
PNG
((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Show SMILES N[C@@H](Cn1c2CSCc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C9H11N3O4S/c10-5(8(14)15)1-12-6-3-17-2-4(6)7(13)11-9(12)16/h5H,1-3,10H2,(H,14,15)(H,11,13,16)/t5-/m0/s1
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311n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50197103
PNG
((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1
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330n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to full length rat GluA3


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50252873
PNG
(2-amino-3-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-...)
Show SMILES NC(Cn1cc(Br)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8BrN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)
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434n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50060632
PNG
((S)-2-Amino-3-(5-chloro-2,4-dioxo-3,4-dihydro-2H-p...)
Show SMILES N[C@@H](Cn1cc(Cl)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8ClN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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451n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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500n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to full length rat GluA3


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/m1/s1
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900n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to rat GluA3-LBD (GluK3-S1S2)


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50252922
PNG
((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Show SMILES N[C@@H](Cn1c2ccsc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C9H9N3O4S/c10-4(8(14)15)3-12-5-1-2-17-6(5)7(13)11-9(12)16/h1-2,4H,3,10H2,(H,14,15)(H,11,13,16)/t4-/m0/s1
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936n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50060627
PNG
((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...)
Show SMILES N[C@@H](Cn1cc(I)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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976n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50295042
PNG
((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Show SMILES CC1CCC=C(C[C@H](N)C(O)=O)c2c1o[nH]c2=O
Show InChI InChI=1S/C12H16N2O4/c1-6-3-2-4-7(5-8(13)12(16)17)9-10(6)18-14-11(9)15/h4,6,8H,2-3,5,13H2,1H3,(H,14,15)(H,16,17)/t6?,8-/m0/s1
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1.11E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 flop isoform expressed in baculovirus infected Sf9 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50252921
PNG
((S)-1-(2'-Amino-2'-carboxyethyl)-6,6-dimethyl-2,3,...)
Show SMILES CC1(C)Cc2c(C1)c(=O)[nH]c(=O)n2C[C@H](N)C(O)=O
Show InChI InChI=1S/C12H17N3O4/c1-12(2)3-6-8(4-12)15(5-7(13)10(17)18)11(19)14-9(6)16/h7H,3-5,13H2,1-2H3,(H,17,18)(H,14,16,19)/t7-/m0/s1
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1.51E+3n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50107595
PNG
((S)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cycl...)
Show SMILES N[C@@H](Cn1c2CCCc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C10H13N3O4/c11-6(9(15)16)4-13-7-3-1-2-5(7)8(14)12-10(13)17/h6H,1-4,11H2,(H,15,16)(H,12,14,17)/t6-/m0/s1
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1.89E+3n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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1.98E+3n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50126763
PNG
((S)-2-amino-3-(3-hydroxy-5-tert-butyl-4-isoxazolyl...)
Show SMILES CC(C)(C)c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C10H16N2O4/c1-10(2,3)7-5(8(13)12-16-7)4-6(11)9(14)15/h6H,4,11H2,1-3H3,(H,12,13)(H,14,15)/t6-/m0/s1
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2.04E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 flop isoform expressed in baculovirus infected Sf9 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50107595
PNG
((S)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cycl...)
Show SMILES N[C@@H](Cn1c2CCCc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C10H13N3O4/c11-6(9(15)16)4-13-7-3-1-2-5(7)8(14)12-10(13)17/h6H,1-4,11H2,(H,15,16)(H,12,14,17)/t6-/m0/s1
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2.14E+3n/an/an/an/an/an/an/an/a



Universita' degli Studi di Siena

Curated by ChEMBL


Assay Description
Binding affinity towards Ionotropic glutamate receptor AMPA 3 from rat brain


J Med Chem 44: 4501-4 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50197103
PNG
((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1
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4.20E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to rat GluA3-LBD (GluK3-S1S2)


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50027828
PNG
((7S)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]p...)
Show SMILES [O-]C(=O)C1[NH2+]CCc2c1o[nH]c2=O
Show InChI InChI=1S/C7H8N2O4/c10-6-3-1-2-8-4(7(11)12)5(3)13-9-6/h4,8H,1-2H2,(H,9,10)(H,11,12)
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4.52E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50252923
PNG
((S)-1-(2'-Amino-2'-carboxyethyl)quinazoline-2,4(1H...)
Show SMILES N[C@@H](Cn1c2ccccc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C11H11N3O4/c12-7(10(16)17)5-14-8-4-2-1-3-6(8)9(15)13-11(14)18/h1-4,7H,5,12H2,(H,16,17)(H,13,15,18)/t7-/m0/s1
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6.91E+3n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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7.40E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to rat GluA3-LBD (GluK3-S1S2)


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50061058
PNG
(2-Amino-3-(2,4-dihydroxy-pyrimidin-1-yl)-propionic...)
Show SMILES NC(Cn1ccc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H9N3O4/c8-4(6(12)13)3-10-2-1-5(11)9-7(10)14/h1-2,4H,3,8H2,(H,12,13)(H,9,11,14)
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1.90E+4n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50355329
PNG
(CHEMBL1835336)
Show SMILES NC(Cc1cc(Cl)c(cc1CCC(O)=O)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C12H13ClN2O6/c13-8-3-7(4-9(14)12(18)19)6(1-2-11(16)17)5-10(8)15(20)21/h3,5,9H,1-2,4,14H2,(H,16,17)(H,18,19)
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2.27E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from recombinant rat GluA3 flop isoform receptor expressed in Sf9 insect cell membrane


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50128264
PNG
((R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)p...)
Show SMILES NC(Cc1o[nH]c(=O)c1Cl)C(O)=O
Show InChI InChI=1S/C6H7ClN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)
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2.75E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50252719
PNG
((S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimid...)
Show SMILES N[C@@H](Cn1c2cocc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C9H9N3O5/c10-5(8(14)15)1-12-6-3-17-2-4(6)7(13)11-9(12)16/h2-3,5H,1,10H2,(H,14,15)(H,11,13,16)/t5-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50252917
PNG
((R)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cycl...)
Show SMILES N[C@H](Cn1c2CCCc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C10H13N3O4/c11-6(9(15)16)4-13-7-3-1-2-5(7)8(14)12-10(13)17/h6H,1-4,11H2,(H,15,16)(H,12,14,17)/t6-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50252918
PNG
((S)-1-(3'-Amino-3'-carboxypropyl)-6,7-dihydro-1H-c...)
Show SMILES N[C@@H](CCn1c2CCCc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C11H15N3O4/c12-7(10(16)17)4-5-14-8-3-1-2-6(8)9(15)13-11(14)18/h7H,1-5,12H2,(H,16,17)(H,13,15,18)/t7-/m0/s1
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1.00E+5n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50252919
PNG
((S,S)-1,3-Di(3'-amino-3'-carboxypropyl)-6,7-dihydr...)
Show SMILES N[C@@H](CCn1c2CCCc2c(=O)n(CC[C@H](N)C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C15H22N4O6/c16-9(13(21)22)4-6-18-11-3-1-2-8(11)12(20)19(15(18)25)7-5-10(17)14(23)24/h9-10H,1-7,16-17H2,(H,21,22)(H,23,24)/t9-,10-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50034501
PNG
((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Show SMILES N[C@H](C(O)=O)c1cc(=O)[nH]o1
Show InChI InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)/t4-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50316374
PNG
(CHEMBL1096289 | N-(4-hydroxyphenylpropanyl)-spermi...)
Show SMILES NCCCNCCCCNCCCNC(=O)CCc1ccccc1
Show InChI InChI=1S/C19H34N4O/c20-12-6-15-21-13-4-5-14-22-16-7-17-23-19(24)11-10-18-8-2-1-3-9-18/h1-3,8-9,21-22H,4-7,10-17,20H2,(H,23,24)
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n/an/a 64n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant GluA3 receptor expressed in Xenopus oocytes assessed as inhibition of 300 uM kainate-induced current


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50355329
PNG
(CHEMBL1835336)
Show SMILES NC(Cc1cc(Cl)c(cc1CCC(O)=O)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C12H13ClN2O6/c13-8-3-7(4-9(14)12(18)19)6(1-2-11(16)17)5-10(8)15(20)21/h3,5,9H,1-2,4,14H2,(H,16,17)(H,18,19)
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluA3 flip isoform receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced cu...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50137125
PNG
(2-(3-(3-bromophenyl)ureido)-4-chlorobenzoic acid |...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C14H10BrClN2O3/c15-8-2-1-3-10(6-8)17-14(21)18-12-7-9(16)4-5-11(12)13(19)20/h1-7H,(H,19,20)(H2,17,18,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at rat homomeric recombinant GluR3 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLI...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50137124
PNG
(4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1
Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at rat homomeric recombinant GluR3 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLI...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50158554
PNG
(CHEMBL224688 | {2-[3-(3-bromophenyl)ureido]-4-chlo...)
Show SMILES OC(=O)Cc1ccc(Cl)cc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C15H12BrClN2O3/c16-10-2-1-3-12(7-10)18-15(22)19-13-8-11(17)5-4-9(13)6-14(20)21/h1-5,7-8H,6H2,(H,20,21)(H2,18,19,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at rat homomeric recombinant GluR3 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLI...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50158556
PNG
(1-(3-bromophenyl)-3-[5-chloro-2-(1H-tetrazol-5-yl-...)
Show SMILES Clc1ccc(-c2nnn[nH]2)c(NC(=O)Nc2cccc(Br)c2)c1
Show InChI InChI=1S/C14H10BrClN6O/c15-8-2-1-3-10(6-8)17-14(23)18-12-7-9(16)4-5-11(12)13-19-21-22-20-13/h1-7H,(H2,17,18,23)(H,19,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at rat homomeric recombinant GluR3 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLI...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50158555
PNG
(1-[5-chloro-2-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-...)
Show SMILES Clc1ccc(-c2nc(=O)o[nH]2)c(NC(=O)Nc2cccc(Br)c2)c1
Show InChI InChI=1S/C15H10BrClN4O3/c16-8-2-1-3-10(6-8)18-14(22)19-12-7-9(17)4-5-11(12)13-20-15(23)24-21-13/h1-7H,(H2,18,19,22)(H,20,21,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at rat homomeric recombinant GluR3 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLI...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50158561
PNG
(2-[3-(3-bromophenyl)ureido]-4-chlorobenzenesulfoni...)
Show SMILES OS(=O)(=O)c1ccc(Cl)cc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C13H10BrClN2O4S/c14-8-2-1-3-10(6-8)16-13(18)17-11-7-9(15)4-5-12(11)22(19,20)21/h1-7H,(H2,16,17,18)(H,19,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at rat homomeric recombinant GluR3 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLI...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50002368
PNG
((R,S)-2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)p...)
Show SMILES Cc1onc(C(O)=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c1-3-4(2-5(9)7(11)12)6(8(13)14)10-15-3/h5H,2,9H2,1H3,(H,11,12)(H,13,14)
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n/an/an/an/a 100n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant GluA3 receptor flop isoform expressed in Xenopus oocytes


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/an/an/a 5.20E+4n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant GluA3 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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n/an/an/an/a 1.40E+3n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant GluA3 receptor flop isoform expressed in Xenopus oocytes


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/an/an/a 1.30E+3n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant GluA3 receptor flop isoform expressed in Xenopus oocytes


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 3


(Rattus norvegicus)
BDBM50002368
PNG
((R,S)-2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)p...)
Show SMILES Cc1onc(C(O)=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c1-3-4(2-5(9)7(11)12)6(8(13)14)10-15-3/h5H,2,9H2,1H3,(H,11,12)(H,13,14)
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n/an/an/an/a 100n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant GluA3 receptor expressed in Xenopus oocytes


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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