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Found 13 hits Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic kainate 5' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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15n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to rat cloned KA2 receptor


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50178141
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(4-carboxybenzyl)...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccc(cc2)C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C15H15N3O6/c16-11(14(22)23)8-17-6-5-12(19)18(15(17)24)7-9-1-3-10(4-2-9)13(20)21/h1-6,11H,7-8,16H2,(H,20,21)(H,22,23)/t11-/m0/s1
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n/an/an/a 9.25E+3n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50178138
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxyethyl)p...)
Show SMILES N[C@@H](Cn1ccc(=O)n(CCC(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C10H13N3O6/c11-6(9(17)18)5-12-3-1-7(14)13(10(12)19)4-2-8(15)16/h1,3,6H,2,4-5,11H2,(H,15,16)(H,17,18)/t6-/m0/s1
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n/an/an/a 7.31E+4n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50207594
PNG
(2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...)
Show SMILES NS(=O)(=O)c1cccc2c1c(cc1[nH]c(=O)c(=O)[nH]c21)[N+]([O-])=O
Show InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
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n/an/an/a 1.78E+3n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50185323
PNG
((RS)-1-(2-amino-2-carboxyethyl)-3-(4-phosphonobenz...)
Show SMILES NC(Cn1ccc(=O)n(Cc2ccc(cc2)P(O)(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C14H16N3O7P/c15-11(13(19)20)8-16-6-5-12(18)17(14(16)21)7-9-1-3-10(4-2-9)25(22,23)24/h1-6,11H,7-8,15H2,(H,19,20)(H2,22,23,24)
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n/an/an/a 5.80E+3n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50185324
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-phosphonobenzy...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccccc2P(O)(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C14H16N3O7P/c15-10(13(19)20)8-16-6-5-12(18)17(14(16)21)7-9-3-1-2-4-11(9)25(22,23)24/h1-6,10H,7-8,15H2,(H,19,20)(H2,22,23,24)/t10-/m0/s1
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n/an/an/a 1.05E+4n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50185318
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccsc2C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C13H13N3O6S/c14-8(11(18)19)6-15-3-1-9(17)16(13(15)22)5-7-2-4-23-10(7)12(20)21/h1-4,8H,5-6,14H2,(H,18,19)(H,20,21)/t8-/m0/s1
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n/an/an/a 105n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50185328
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(tetrazol-5-ylmet...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2nnn[nH]2)c1=O)C(O)=O
Show InChI InChI=1S/C9H11N7O4/c10-5(8(18)19)3-15-2-1-7(17)16(9(15)20)4-6-11-13-14-12-6/h1-2,5H,3-4,10H2,(H,18,19)(H,11,12,13,14)/t5-/m0/s1
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n/an/an/a 6.02E+4n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50185322
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-tetrazol-5-yle...)
Show SMILES N[C@@H](Cn1ccc(=O)n(CCc2nnn[nH]2)c1=O)C(O)=O
Show InChI InChI=1S/C10H13N7O4/c11-6(9(19)20)5-16-3-2-8(18)17(10(16)21)4-1-7-12-14-15-13-7/h2-3,6H,1,4-5,11H2,(H,19,20)(H,12,13,14,15)/t6-/m0/s1
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n/an/an/a 5.37E+4n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50185319
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(4-sulfobenzyl)py...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccc(cc2)S(O)(=O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C14H15N3O7S/c15-11(13(19)20)8-16-6-5-12(18)17(14(16)21)7-9-1-3-10(4-2-9)25(22,23)24/h1-6,11H,7-8,15H2,(H,19,20)(H,22,23,24)/t11-/m0/s1
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n/an/an/a 4.68E+3n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50178136
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccccc2C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C15H15N3O6/c16-11(14(22)23)8-17-6-5-12(19)18(15(17)24)7-9-3-1-2-4-10(9)13(20)21/h1-6,11H,7-8,16H2,(H,20,21)(H,22,23)/t11-/m0/s1
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n/an/an/a 402n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50185320
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxyfuran-3...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccoc2C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C13H13N3O7/c14-8(11(18)19)6-15-3-1-9(17)16(13(15)22)5-7-2-4-23-10(7)12(20)21/h1-4,8H,5-6,14H2,(H,18,19)(H,20,21)/t8-/m0/s1
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n/an/an/a 1.88E+3n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic kainate 5


(Rattus norvegicus)
BDBM50185321
PNG
(6-cyano-7-nitroquinoxaline-2,3-dione | 7-nitro-2,3...)
Show SMILES [O-][N+](=O)c1cc2=NC(=O)C(=O)N=c2cc1C#N
Show InChI InChI=1S/C9H2N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H
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n/an/an/a 1.66E+3n/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers


Citation and Details
More data for this
Ligand-Target Pair