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Compile Data Set for Download or QSAR

Found 31 hits Enz. Inhib. hit(s) with Target = 'Glutamate-Kainate 7' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate-Kainate 7


(HUMAN)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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10n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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PubMed
10n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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42n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 3 in HEK293 cells using [3H]-kainate as radio...


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50116040
PNG
((7-{3-[3-(4-Nitro-phenyl)-ureidomethyl]-pyrrol-1-y...)
Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)C(F)(F)F)-n1ccc(CNC(=O)Nc2ccc(cc2)[N+]([O-])=O)c1
Show InChI InChI=1S/C23H17F3N6O7/c24-23(25,26)15-7-16-18(31(11-19(33)34)21(36)20(35)29-16)8-17(15)30-6-5-12(10-30)9-27-22(37)28-13-1-3-14(4-2-13)32(38)39/h1-8,10H,9,11H2,(H,29,35)(H,33,34)(H2,27,28,37)
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46n/an/an/an/an/an/an/an/a



Abbott GmbH & Co. KG

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand


Bioorg Med Chem Lett 12: 2113-6 (2002)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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423n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50091474
PNG
((2S,4E)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3+/t7-/m0/s1
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518n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50116044
PNG
(CHEMBL416685 | {6-Nitro-2,3-dioxo-7-[3-(4-phenyl-p...)
Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CN2CCC(CC2)c2ccccc2)c1
Show InChI InChI=1S/C26H25N5O6/c32-24(33)16-30-21-13-22(23(31(36)37)12-20(21)27-25(34)26(30)35)29-11-6-17(15-29)14-28-9-7-19(8-10-28)18-4-2-1-3-5-18/h1-6,11-13,15,19H,7-10,14,16H2,(H,27,34)(H,32,33)
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530n/an/an/an/an/an/an/an/a



Abbott GmbH & Co. KG

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand


Bioorg Med Chem Lett 12: 2113-6 (2002)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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617n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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617n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50116042
PNG
(CHEMBL63861 | {7-[3-(4-Benzyl-piperazin-1-ylmethyl...)
Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CN2CCN(Cc3ccccc3)CC2)c1
Show InChI InChI=1S/C26H26N6O6/c33-24(34)17-31-21-13-22(23(32(37)38)12-20(21)27-25(35)26(31)36)30-7-6-19(16-30)15-29-10-8-28(9-11-29)14-18-4-2-1-3-5-18/h1-7,12-13,16H,8-11,14-15,17H2,(H,27,35)(H,33,34)
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680n/an/an/an/an/an/an/an/a



Abbott GmbH & Co. KG

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand


Bioorg Med Chem Lett 12: 2113-6 (2002)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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PubMed
789n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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789n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50116048
PNG
(CHEMBL67828 | {6-Nitro-2,3-dioxo-7-[3-(4-phenethyl...)
Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CN2CCN(CCc3ccccc3)CC2)c1
Show InChI InChI=1S/C27H28N6O6/c34-25(35)18-32-22-15-23(24(33(38)39)14-21(22)28-26(36)27(32)37)31-9-7-20(17-31)16-30-12-10-29(11-13-30)8-6-19-4-2-1-3-5-19/h1-5,7,9,14-15,17H,6,8,10-13,16,18H2,(H,28,36)(H,34,35)
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1.40E+3n/an/an/an/an/an/an/an/a



Abbott GmbH & Co. KG

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand


Bioorg Med Chem Lett 12: 2113-6 (2002)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50116047
PNG
((6-Nitro-2,3-dioxo-7-{3-[(3-phenyl-propylamino)-me...)
Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CNCCCc2ccccc2)c1
Show InChI InChI=1S/C24H23N5O6/c30-22(31)15-28-19-12-20(21(29(34)35)11-18(19)26-23(32)24(28)33)27-10-8-17(14-27)13-25-9-4-7-16-5-2-1-3-6-16/h1-3,5-6,8,10-12,14,25H,4,7,9,13,15H2,(H,26,32)(H,30,31)
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1.40E+3n/an/an/an/an/an/an/an/a



Abbott GmbH & Co. KG

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand


Bioorg Med Chem Lett 12: 2113-6 (2002)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50116043
PNG
(3-(6-Nitro-2,3-dioxo-7-pyrrol-1-yl-3,4-dihydro-2H-...)
Show SMILES OC(=O)CCn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1cccc1
Show InChI InChI=1S/C15H12N4O6/c20-13(21)3-6-18-10-8-11(17-4-1-2-5-17)12(19(24)25)7-9(10)16-14(22)15(18)23/h1-2,4-5,7-8H,3,6H2,(H,16,22)(H,20,21)
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2.50E+3n/an/an/an/an/an/an/an/a



Abbott GmbH & Co. KG

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand


Bioorg Med Chem Lett 12: 2113-6 (2002)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50116050
PNG
(1-(4-Carboxymethyl-7-nitro-2,3-dioxo-1,2,3,4-tetra...)
Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(c1)C(O)=O
Show InChI InChI=1S/C15H10N4O8/c20-12(21)6-18-9-4-10(17-2-1-7(5-17)15(24)25)11(19(26)27)3-8(9)16-13(22)14(18)23/h1-5H,6H2,(H,16,22)(H,20,21)(H,24,25)
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4.10E+3n/an/an/an/an/an/an/an/a



Abbott GmbH & Co. KG

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand


Bioorg Med Chem Lett 12: 2113-6 (2002)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50116041
PNG
(CHEMBL303415 | [6-Nitro-2,3-dioxo-7-(3-piperidin-1...)
Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H21N5O6/c26-18(27)12-24-15-9-16(17(25(30)31)8-14(15)21-19(28)20(24)29)23-7-4-13(11-23)10-22-5-2-1-3-6-22/h4,7-9,11H,1-3,5-6,10,12H2,(H,21,28)(H,26,27)
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5.70E+3n/an/an/an/an/an/an/an/a



Abbott GmbH & Co. KG

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand


Bioorg Med Chem Lett 12: 2113-6 (2002)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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PubMed
5.73E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM86754
PNG
(LY 466195 | LY-466195)
Show SMILES OC(=O)C1CC(F)(F)CN1C[C@H]1CC[C@H]2CN[C@@H](C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C16H24F2N2O4/c17-16(18)5-13(15(23)24)20(8-16)7-9-1-2-10-6-19-12(14(21)22)4-11(10)3-9/h9-13,19H,1-8H2,(H,21,22)(H,23,24)/t9-,10-,11+,12-,13?/m0/s1
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Article
PubMed
8.90E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50168962
PNG
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)
Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1
Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM86751
PNG
(CHEMBL14935 | LY 293558 | LY-293558)
Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](CCc3nnn[nH]3)CC[C@H]2CN1
Show InChI InChI=1S/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50091475
PNG
((2S,4Z)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3-/t7-/m0/s1
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PubMed
1.05E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50091473
PNG
((S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic a...)
Show SMILES CCC(CC)=C(C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-3-6(4-2)7(9(12)13)5-8(11)10(14)15/h8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t8-/m0/s1
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1.24E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)

More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50207594
PNG
(2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...)
Show SMILES NS(=O)(=O)c1cccc2c1c(cc1[nH]c(=O)c(=O)[nH]c21)[N+]([O-])=O
Show InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
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1.80E+4n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM86751
PNG
(CHEMBL14935 | LY 293558 | LY-293558)
Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](CCc3nnn[nH]3)CC[C@H]2CN1
Show InChI InChI=1S/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Binding affinity to GluR7


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50185318
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccsc2C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C13H13N3O6S/c14-8(11(18)19)6-15-3-1-9(17)16(13(15)22)5-7-2-4-23-10(7)12(20)21/h1-4,8H,5-6,14H2,(H,18,19)(H,20,21)/t8-/m0/s1
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1.11E+5n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human GLUK7 expressed in HEK293 cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50178148
PNG
((RS)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl...)
Show SMILES NC(Cn1ccc(=O)n(Cc2ccccc2C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C15H15N3O6/c16-11(14(22)23)8-17-6-5-12(19)18(15(17)24)7-9-3-1-2-4-10(9)13(20)21/h1-6,11H,7-8,16H2,(H,20,21)(H,22,23)
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3.74E+5n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50207594
PNG
(2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...)
Show SMILES NS(=O)(=O)c1cccc2c1c(cc1[nH]c(=O)c(=O)[nH]c21)[N+]([O-])=O
Show InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
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n/an/a 4.40E+4n/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50364074
PNG
(CHEMBL1950805)
Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(I)c3ccccc3c2c1
Show InChI InChI=1S/C21H17IN2O5/c22-16-10-11-5-6-12(9-15(11)13-3-1-2-4-14(13)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1
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n/an/a 8.13E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GluK3 receptor expressed in human HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50185318
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccsc2C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C13H13N3O6S/c14-8(11(18)19)6-15-3-1-9(17)16(13(15)22)5-7-2-4-23-10(7)12(20)21/h1-4,8H,5-6,14H2,(H,18,19)(H,20,21)/t8-/m0/s1
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n/an/a 2.64E+5n/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human GLUK7 expressed in HEK293 cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(HUMAN)
BDBM50178148
PNG
((RS)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl...)
Show SMILES NC(Cn1ccc(=O)n(Cc2ccccc2C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C15H15N3O6/c16-11(14(22)23)8-17-6-5-12(19)18(15(17)24)7-9-3-1-2-4-10(9)13(20)21/h1-6,11H,7-8,16H2,(H,20,21)(H,22,23)
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n/an/a 8.80E+5n/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair