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Found 60 hits Enz. Inhib. hit(s) with Target = 'Glutaminase kidney isoform, mitochondrial' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM108460
PNG
(CHEMBL2178393 | US8604016, 17)
Show SMILES Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1
Show InChI InChI=1S/C16H18N6OS3/c17-15-21-19-13(25-15)6-8-24-9-7-14-20-22-16(26-14)18-12(23)10-11-4-2-1-3-5-11/h1-5H,6-10H2,(H2,17,21)(H,18,22,23)
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2.00E+3n/an/an/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of human kidney glutaminase (124 to 669) assessed as reduction of glutamine hydrolysis by double-reciprocal plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150108
PNG
(CHEMBL3770617)
PDB
MMDB

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n/an/a 29n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149986
PNG
(CHEMBL3770889)
Show SMILES CN(C)CC(=O)NC(CC(=O)Nc1ccc(Br)cn1)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C25H27BrN6O5S/c1-32(2)15-24(34)30-20(13-23(33)31-22-12-9-17(26)14-28-22)25(35)29-18-10-7-16(8-11-18)19-5-3-4-6-21(19)38(27,36)37/h3-12,14,20H,13,15H2,1-2H3,(H,29,35)(H,30,34)(H2,27,36,37)(H,28,31,33)
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n/an/a 30n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150109
PNG
(CHEMBL3770355)
PDB
MMDB

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n/an/a 30n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149988
PNG
(CHEMBL3770945)
Show SMILES CNCCNC(=O)C(CC(=O)Nc1ccc(Br)cn1)NC(=O)c1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C25H27BrN6O5S/c1-28-12-13-29-25(35)20(14-23(33)32-22-11-10-18(26)15-30-22)31-24(34)17-8-6-16(7-9-17)19-4-2-3-5-21(19)38(27,36)37/h2-11,15,20,28H,12-14H2,1H3,(H,29,35)(H,31,34)(H2,27,36,37)(H,30,32,33)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150062
PNG
(CHEMBL3769896)
PDB
MMDB

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n/an/a 30n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150066
PNG
(CHEMBL3771319)
PDB
MMDB

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n/an/a 36n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149985
PNG
(CHEMBL3769701)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)CCC(=O)Nc2ccc(Cl)cn2)cc1
Show InChI InChI=1S/C21H19ClN4O4S/c22-15-7-10-19(24-13-15)26-21(28)12-11-20(27)25-16-8-5-14(6-9-16)17-3-1-2-4-18(17)31(23,29)30/h1-10,13H,11-12H2,(H,25,27)(H2,23,29,30)(H,24,26,28)
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n/an/a 36n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149984
PNG
(CHEMBL3769593)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NC(CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCNCC1
Show InChI InChI=1S/C26H27BrN6O5S/c27-19-9-10-23(30-16-19)32-24(34)15-21(26(36)33-13-11-29-12-14-33)31-25(35)18-7-5-17(6-8-18)20-3-1-2-4-22(20)39(28,37)38/h1-10,16,21,29H,11-15H2,(H,31,35)(H2,28,37,38)(H,30,32,34)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150111
PNG
(CHEMBL3771020)
PDB
MMDB

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TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149983
PNG
(CHEMBL3769936)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NC(CC(=O)Nc1ccc(Br)cn1)C(=O)NC1CCCC1
Show InChI InChI=1S/C27H28BrN5O5S/c28-19-13-14-24(30-16-19)33-25(34)15-22(27(36)31-20-5-1-2-6-20)32-26(35)18-11-9-17(10-12-18)21-7-3-4-8-23(21)39(29,37)38/h3-4,7-14,16,20,22H,1-2,5-6,15H2,(H,31,36)(H,32,35)(H2,29,37,38)(H,30,33,34)
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Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150110
PNG
(CHEMBL3771098)
PDB
MMDB

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n/an/a 70n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150705
PNG
(CHEMBL3770102)
PDB
MMDB

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n/an/a 98n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149992
PNG
(CHEMBL3769897)
Show SMILES CC(=O)NC(CNC(=O)c1ccc(cc1)-c1ccccc1S(N)(=O)=O)C(=O)Nc1ccc(Br)cn1
Show InChI InChI=1S/C23H22BrN5O5S/c1-14(30)28-19(23(32)29-21-11-10-17(24)12-26-21)13-27-22(31)16-8-6-15(7-9-16)18-4-2-3-5-20(18)35(25,33)34/h2-12,19H,13H2,1H3,(H,27,31)(H,28,30)(H2,25,33,34)(H,26,29,32)
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n/an/a 157n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM109086
PNG
(US8604016, 670)
Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)c1
Show InChI InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149990
PNG
(CHEMBL3770229)
Show SMILES CN(C)CCN(C)C(=O)C(CC(=O)Nc1ccc(Br)cn1)NC(=O)c1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C27H31BrN6O5S/c1-33(2)14-15-34(3)27(37)22(16-25(35)32-24-13-12-20(28)17-30-24)31-26(36)19-10-8-18(9-11-19)21-6-4-5-7-23(21)40(29,38)39/h4-13,17,22H,14-16H2,1-3H3,(H,31,36)(H2,29,38,39)(H,30,32,35)
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n/an/a 190n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150018
PNG
(CHEMBL3769551)
PDB
MMDB

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TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150019
PNG
(CHEMBL3769973)
PDB
MMDB

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TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400050
PNG
(CHEMBL2177757 | US8604016, 1)
Show SMILES O=C(Cc1ccccc1)Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1
Show InChI InChI=1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149987
PNG
(CHEMBL3770357)
Show SMILES CN(C)Cc1nccn1-c1ccc(cc1)C(=O)N[C@@H](CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C27H32BrN7O3/c1-33(2)18-24-29-12-15-35(24)21-9-6-19(7-10-21)26(37)31-22(27(38)34-13-4-3-5-14-34)16-25(36)32-23-11-8-20(28)17-30-23/h6-12,15,17,22H,3-5,13-14,16,18H2,1-2H3,(H,31,37)(H,30,32,36)/t22-/m0/s1
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n/an/a 490n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150015
PNG
(CHEMBL3770218)
PDB
MMDB

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TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149982
PNG
(CHEMBL3769558)
Show SMILES Brc1ccc(NC(=O)C[C@H](NC(=O)c2ccc(cc2)-c2ccccc2CN2CCOCC2)C(=O)N2CCCCC2)nc1
Show InChI InChI=1S/C32H36BrN5O4/c33-26-12-13-29(34-21-26)36-30(39)20-28(32(41)38-14-4-1-5-15-38)35-31(40)24-10-8-23(9-11-24)27-7-3-2-6-25(27)22-37-16-18-42-19-17-37/h2-3,6-13,21,28H,1,4-5,14-20,22H2,(H,35,40)(H,34,36,39)/t28-/m0/s1
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149989
PNG
(CHEMBL3770066)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NCCNS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClN3O5S2/c22-17-9-11-18(12-10-17)32(29,30)25-14-13-24-21(26)16-7-5-15(6-8-16)19-3-1-2-4-20(19)31(23,27)28/h1-12,25H,13-14H2,(H,24,26)(H2,23,27,28)
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n/an/a 790n/an/an/an/an/an/a


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Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50149991
PNG
(CHEMBL3771046)
Show SMILES NC(CNC(=O)c1ccc(cc1)-c1ccccc1S(N)(=O)=O)C(=O)Nc1ccc(Br)cn1
Show InChI InChI=1S/C21H20BrN5O4S/c22-15-9-10-19(25-11-15)27-21(29)17(23)12-26-20(28)14-7-5-13(6-8-14)16-3-1-2-4-18(16)32(24,30)31/h1-11,17H,12,23H2,(H,26,28)(H2,24,30,31)(H,25,27,29)
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n/an/a 1.01E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150017
PNG
(CHEMBL3771176)
PDB
MMDB

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n/an/a 1.40E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400058
PNG
(CHEMBL2177749)
Show SMILES O=C(CCCCc1nnc(NC(=O)Cc2ccccc2)s1)NCCN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C28H35N5O2S/c34-25(29-17-20-33-18-15-24(16-19-33)23-11-5-2-6-12-23)13-7-8-14-27-31-32-28(36-27)30-26(35)21-22-9-3-1-4-10-22/h1-6,9-12,24H,7-8,13-21H2,(H,29,34)(H,30,32,35)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400072
PNG
(CHEMBL2178396)
Show SMILES Nc1nnc(CCCCc2nnc(NC(=O)Cc3ccccc3)s2)s1
Show InChI InChI=1S/C16H18N6OS2/c17-15-21-19-13(24-15)8-4-5-9-14-20-22-16(25-14)18-12(23)10-11-6-2-1-3-7-11/h1-3,6-7H,4-5,8-10H2,(H2,17,21)(H,18,22,23)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400067
PNG
(CHEMBL2177740)
Show SMILES Nc1nnc(CCCCc2nnc(NC(=O)Cc3ccc(F)cc3)s2)s1
Show InChI InChI=1S/C16H17FN6OS2/c17-11-7-5-10(6-8-11)9-12(24)19-16-23-21-14(26-16)4-2-1-3-13-20-22-15(18)25-13/h5-8H,1-4,9H2,(H2,18,22)(H,19,23,24)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM108460
PNG
(CHEMBL2178393 | US8604016, 17)
Show SMILES Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1
Show InChI InChI=1S/C16H18N6OS3/c17-15-21-19-13(25-15)6-8-24-9-7-14-20-22-16(26-14)18-12(23)10-11-4-2-1-3-5-11/h1-5H,6-10H2,(H2,17,21)(H,18,22,23)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150067
PNG
(CHEMBL3771225)
PDB
MMDB

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n/an/a 3.07E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400050
PNG
(CHEMBL2177757 | US8604016, 1)
Show SMILES O=C(Cc1ccccc1)Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1
Show InChI InChI=1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400059
PNG
(CHEMBL2177748)
Show SMILES OC1CCN(CCNC(=O)CCCCc2nnc(NC(=O)Cc3ccccc3)s2)CC1
Show InChI InChI=1S/C22H31N5O3S/c28-18-10-13-27(14-11-18)15-12-23-19(29)8-4-5-9-21-25-26-22(31-21)24-20(30)16-17-6-2-1-3-7-17/h1-3,6-7,18,28H,4-5,8-16H2,(H,23,29)(H,24,26,30)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400068
PNG
(CHEMBL2177739)
Show SMILES Cc1ccc(CC(=O)Nc2nnc(CCCCc3nnc(N)s3)s2)cc1
Show InChI InChI=1S/C17H20N6OS2/c1-11-6-8-12(9-7-11)10-13(24)19-17-23-21-15(26-17)5-3-2-4-14-20-22-16(18)25-14/h6-9H,2-5,10H2,1H3,(H2,18,22)(H,19,23,24)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400063
PNG
(CHEMBL2177744)
Show SMILES O=C(CCCCc1nnc(NC(=O)Cc2ccccc2)s1)NCCN1CCCC1
Show InChI InChI=1S/C21H29N5O2S/c27-18(22-12-15-26-13-6-7-14-26)10-4-5-11-20-24-25-21(29-20)23-19(28)16-17-8-2-1-3-9-17/h1-3,8-9H,4-7,10-16H2,(H,22,27)(H,23,25,28)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150658
PNG
(CHEMBL3769544)
PDB
MMDB

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n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150659
PNG
(CHEMBL3770563)
PDB
MMDB

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n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150703
PNG
(CHEMBL3770921)
PDB
MMDB

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TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150660
PNG
(CHEMBL3769604)
PDB
MMDB

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TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150065
PNG
(CHEMBL3770713)
PDB
MMDB

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TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400054
PNG
(CHEMBL2177753)
Show SMILES CN(C(=O)CCCCc1nnc(NC(=O)Cc2ccccc2)s1)C(C)(C)C
Show InChI InChI=1S/C20H28N4O2S/c1-20(2,3)24(4)18(26)13-9-8-12-17-22-23-19(27-17)21-16(25)14-15-10-6-5-7-11-15/h5-7,10-11H,8-9,12-14H2,1-4H3,(H,21,23,25)
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n/an/a 5.20E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400070
PNG
(CHEMBL2178398)
Show SMILES Nc1nnc(CCCCc2nnc(NC(=O)c3ccccc3)s2)s1
Show InChI InChI=1S/C15H16N6OS2/c16-14-20-18-11(23-14)8-4-5-9-12-19-21-15(24-12)17-13(22)10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2,(H2,16,20)(H,17,21,22)
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n/an/a 7.20E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150661
PNG
(CHEMBL3770033)
PDB
MMDB

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n/an/a 7.70E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400061
PNG
(CHEMBL2177746)
Show SMILES CN1CCCC1CCNC(=O)CCCCc1nnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C22H31N5O2S/c1-27-15-7-10-18(27)13-14-23-19(28)11-5-6-12-21-25-26-22(30-21)24-20(29)16-17-8-3-2-4-9-17/h2-4,8-9,18H,5-7,10-16H2,1H3,(H,23,28)(H,24,26,29)
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n/an/a 8.10E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50150016
PNG
(CHEMBL3769448)
PDB
MMDB

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n/an/a 9.70E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400060
PNG
(CHEMBL2177747)
Show SMILES O=C(CCCCc1nnc(NC(=O)Cc2ccccc2)s1)NCCN1CCCCC1
Show InChI InChI=1S/C22H31N5O2S/c28-19(23-13-16-27-14-7-2-8-15-27)11-5-6-12-21-25-26-22(30-21)24-20(29)17-18-9-3-1-4-10-18/h1,3-4,9-10H,2,5-8,11-17H2,(H,23,28)(H,24,26,29)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400055
PNG
(CHEMBL2177752)
Show SMILES CC(C)(C)NC(=O)CCCCc1nnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C19H26N4O2S/c1-19(2,3)21-15(24)11-7-8-12-17-22-23-18(26-17)20-16(25)13-14-9-5-4-6-10-14/h4-6,9-10H,7-8,11-13H2,1-3H3,(H,21,24)(H,20,23,25)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400066
PNG
(CHEMBL2177741)
Show SMILES CC(C(=O)Nc1nnc(CCCCc2nnc(N)s2)s1)c1ccccc1
Show InChI InChI=1S/C17H20N6OS2/c1-11(12-7-3-2-4-8-12)15(24)19-17-23-21-14(26-17)10-6-5-9-13-20-22-16(18)25-13/h2-4,7-8,11H,5-6,9-10H2,1H3,(H2,18,22)(H,19,23,24)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400073
PNG
(CHEMBL2178395)
Show SMILES Nc1nnc(CCCc2nnc(NC(=O)Cc3ccccc3)s2)s1
Show InChI InChI=1S/C15H16N6OS2/c16-14-20-18-12(23-14)7-4-8-13-19-21-15(24-13)17-11(22)9-10-5-2-1-3-6-10/h1-3,5-6H,4,7-9H2,(H2,16,20)(H,17,21,22)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400069
PNG
(CHEMBL2177738)
Show SMILES Nc1nnc(CCCCc2nnc(NC(=O)CC3CCCCC3)s2)s1
Show InChI InChI=1S/C16H24N6OS2/c17-15-21-19-13(24-15)8-4-5-9-14-20-22-16(25-14)18-12(23)10-11-6-2-1-3-7-11/h11H,1-10H2,(H2,17,21)(H,18,22,23)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50400056
PNG
(CHEMBL2177751)
Show SMILES CCN(CC)CCNC(=O)CCCCc1nnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C21H31N5O2S/c1-3-26(4-2)15-14-22-18(27)12-8-9-13-20-24-25-21(29-20)23-19(28)16-17-10-6-5-7-11-17/h5-7,10-11H,3-4,8-9,12-16H2,1-2H3,(H,22,27)(H,23,25,28)
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n/an/a 2.60E+4n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay


Citation and Details
More data for this
Ligand-Target Pair
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