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Found 10 hits Enz. Inhib. hit(s) with Target = 'Glutaminyl Cyclase' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminyl Cyclase


(Mus musculus (mouse))
BDBM7887
PNG
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
Show SMILES C(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C10H10N2/c1-2-4-10(5-3-1)8-12-7-6-11-9-12/h1-7,9H,8H2
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PubMed
6.40E+3 -30.1n/an/an/an/an/a8.030



Probiodrug AG



Assay Description
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...


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More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutaminyl Cyclase


(Mus musculus (mouse))
BDBM7970
PNG
(N-diethylcysteamine | diethyl(2-sulfanylethyl)amin...)
Show SMILES CCN(CC)CCS
Show InChI InChI=1S/C6H15NS/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3
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1.09E+4 -28.8n/an/an/an/an/a8.030



Probiodrug AG



Assay Description
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Mus musculus (mouse))
BDBM7884
PNG
(1-methyl-1H-imidazole | US9138393, 1-Methylimidazo...)
Show SMILES Cn1ccnc1
Show InChI InChI=1S/C4H6N2/c1-6-3-2-5-4-6/h2-4H,1H3
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2.30E+4 -26.9n/an/an/an/an/a8.030



Probiodrug AG



Assay Description
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Mus musculus (mouse))
BDBM7969
PNG
(N-dimethylcysteamine | dimethyl(2-sulfanylethyl)am...)
Show SMILES CN(C)CCS
Show InChI InChI=1S/C4H11NS/c1-5(2)3-4-6/h6H,3-4H2,1-2H3
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2.90E+4 -26.3n/an/an/an/an/a8.030



Probiodrug AG



Assay Description
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Mus musculus (mouse))
BDBM7968
PNG
(2-aminoethane-1-thiol | Cysteamine)
Show InChI InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2
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4.20E+4 -25.4n/an/an/an/an/a8.030



Probiodrug AG



Assay Description
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Mus musculus (mouse))
BDBM7882
PNG
(1H-imidazole | CHEMBL540 | US9138393, Imidazole | ...)
Show SMILES c1c[nH]cn1
Show InChI InChI=1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
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1.60E+5 -22.0n/an/an/an/an/a8.030



Probiodrug AG



Assay Description
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Mus musculus (mouse))
BDBM7939
PNG
(1H-1,3-benzodiazole | Benzimidazole | US9138393, B...)
Show SMILES c1nc2ccccc2[nH]1
Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)8-5-9-7/h1-5H,(H,8,9)
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1.92E+5 -21.6n/an/an/an/an/a8.030



Probiodrug AG



Assay Description
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Mus musculus (mouse))
BDBM7971
PNG
(2-sulfanylethan-1-ol | Mercaptoethanol)
Show InChI InChI=1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2
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2.58E+6 -15.0n/an/an/an/an/a8.030



Probiodrug AG



Assay Description
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Mus musculus (mouse))
BDBM7973
PNG
(2-aminoethan-1-ol | CHEMBL104943 | ethanolamine)
Show InChI InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2
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PubMed
1.93E+7 -9.95n/an/an/an/an/a8.030



Probiodrug AG



Assay Description
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Mus musculus (mouse))
BDBM7972
PNG
(CHEMBL816 | ethane-1,2-diamine | ethylenediamine)
Show InChI InChI=1S/C2H8N2/c3-1-2-4/h1-4H2
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2.20E+7 -9.62n/an/an/an/an/a8.030



Probiodrug AG



Assay Description
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...


Citation and Details
More data for this
Ligand-Target Pair