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Found 246 hits Enz. Inhib. hit(s) with Target = 'Glycine' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine, strychnine


(RAT)
BDBM50022784
PNG
((R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine...)
Show SMILES CNCCC(Oc1ccccc1C)c1ccccc1
Show InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3
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PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Glycine, strychnine


(RAT)
BDBM82071
PNG
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
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1.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Glycine, strychnine


(RAT)
BDBM84745
PNG
(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Show SMILES CNCC[C@H](Oc1cccc2ccccc12)c1cccs1
Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Glycine, non-strychnine


(RAT)
BDBM82071
PNG
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
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1.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Glycine, non-strychnine


(RAT)
BDBM84745
PNG
(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Show SMILES CNCC[C@H](Oc1cccc2ccccc12)c1cccs1
Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM81790
PNG
(Amisulpride | CAS_71675-85-9 | NSC_2159)
Show SMILES CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC
Show InChI InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Synthélabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 280: 83-97 (1997)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM22869
PNG
(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Show SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Synthélabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 280: 83-97 (1997)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Synthélabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 280: 83-97 (1997)

More data for this
Ligand-Target Pair
Glycine, strychnine


(RAT)
BDBM81790
PNG
(Amisulpride | CAS_71675-85-9 | NSC_2159)
Show SMILES CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC
Show InChI InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Synthélabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 280: 83-97 (1997)

More data for this
Ligand-Target Pair
Glycine, strychnine


(RAT)
BDBM22869
PNG
(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Show SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Synthélabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 280: 83-97 (1997)

More data for this
Ligand-Target Pair
Glycine, strychnine


(RAT)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Synthélabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 280: 83-97 (1997)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Glaxo Group Research Ltd.

Curated by PDSP Ki Database




Br J Pharmacol 111: 332-8 (1994)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pudue Pharma Discovery Research

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Glycine, strychnine


(RAT)
BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pudue Pharma Discovery Research

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM22913
PNG
(CHEMBL1237146 | CHEMBL498770 | Iodophenpropit | {[...)
Show SMILES NC(SCCCc1cnc[nH]1)=NCCc1ccc(I)cc1
Show InChI InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20)
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Vrije Universiteit

Curated by PDSP Ki Database




Br J Pharmacol 116: 2315-21 (1995)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by PDSP Ki Database




Br J Pharmacol 116: 2315-21 (1995)

More data for this
Ligand-Target Pair
Glycine, non-strychnine


(RAT)
BDBM22913
PNG
(CHEMBL1237146 | CHEMBL498770 | Iodophenpropit | {[...)
Show SMILES NC(SCCCc1cnc[nH]1)=NCCc1ccc(I)cc1
Show InChI InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20)
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Vrije Universiteit

Curated by PDSP Ki Database




Br J Pharmacol 116: 2315-21 (1995)

More data for this
Ligand-Target Pair
Glycine, non-strychnine


(RAT)
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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Vrije Universiteit

Curated by PDSP Ki Database




Br J Pharmacol 116: 2315-21 (1995)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM50035057
PNG
((eltoprazine)1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)...)
Show SMILES C1CN(CCN1)c1cccc2OCCOc12
Show InChI InChI=1S/C12H16N2O2/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12/h1-3,13H,4-9H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Duphar B.V.

Curated by PDSP Ki Database




Drug Metabol Drug Interact 8: 85-114 (1990)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM81818
PNG
(CAS_1794 | CHEMBL1909810 | HMA | NSC_1794)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1
Show InChI InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Center for Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database




J Recept Res 11: 891-907 (1991)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM81819
PNG
(Benzamil | CAS_1937-37-7 | CHEMBL212579 | NSC_1081...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCc1ccccc1
Show InChI InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22)
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Center for Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database




J Recept Res 11: 891-907 (1991)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM16173
PNG
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
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Center for Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database




J Recept Res 11: 891-907 (1991)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM50010685
PNG
((+/-)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahyd...)
Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@H]3c2cc1O
Show InChI InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



University of North Carolina

Curated by PDSP Ki Database




J Pharmacol Exp Ther 262: 383-93 (1992)

More data for this
Ligand-Target Pair
Glycine


(RAT)
BDBM50010685
PNG
((+/-)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahyd...)
Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@H]3c2cc1O
Show InChI InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17+/m1/s1
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University of North Carolina

Curated by PDSP Ki Database




J Pharmacol Exp Ther 262: 383-93 (1992)

More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50304335
PNG
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)
Show SMILES Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2
Show InChI InChI=1S/C17H20N2O2/c1-19-15-5-3-2-4-11(15)8-16(19)17(20)21-14-9-12-6-7-13(10-14)18-12/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1
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n/an/a 1.07n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry in presence of 10 uM glycine


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50195169
PNG
(2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(prop...)
Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H29Cl2N3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(22)14-18(17)23/h3-4,14H,2,5-13,15H2,1H3,(H,24,27)
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n/an/a 3.20n/an/an/an/an/an/a



Merck and Co.

Curated by ChEMBL


Assay Description
Inhibition of rat GlyT1


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50195181
PNG
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)
Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28)
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n/an/a 7.40n/an/an/an/an/an/a



Merck and Co.

Curated by ChEMBL


Assay Description
Inhibition of rat GlyT1


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50149871
PNG
((R)-2-((3-(biphenyl-4-yloxy)-3-(4-fluorophenyl)pro...)
Show SMILES CN(CC[C@@H](Oc1ccc(cc1)-c1ccccc1)c1ccc(F)cc1)CC(O)=O
Show InChI InChI=1S/C24H24FNO3/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18/h2-14,23H,15-17H2,1H3,(H,27,28)/t23-/m1/s1
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n/an/a 8.90n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50195173
PNG
(2-chloro-4-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)
Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2Cl)(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(23)14-18(17)22/h3-4,14H,2,5-13,15H2,1H3,(H,24,27)
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n/an/a 10n/an/an/an/an/an/a



Merck and Co.

Curated by ChEMBL


Assay Description
Inhibition of rat GlyT1


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50304334
PNG
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-tropane | ...)
Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cc2ccccc2n1C
Show InChI InChI=1S/C18H22N2O2/c1-19-13-7-8-14(19)11-15(10-13)22-18(21)17-9-12-5-3-4-6-16(12)20(17)2/h3-6,9,13-15H,7-8,10-11H2,1-2H3/t13-,14-/m1/s1
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n/an/a 10.2n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50304335
PNG
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)
Show SMILES Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2
Show InChI InChI=1S/C17H20N2O2/c1-19-15-5-3-2-4-11(15)8-16(19)17(20)21-14-9-12-6-7-13(10-14)18-12/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1
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n/an/a 11.5n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50195170
PNG
(2-chloro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)
Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H30ClN3O5S/c1-2-15-31(28,29)25-9-7-21(8-10-25,20(27)24-11-13-30-14-12-24)16-23-19(26)17-5-3-4-6-18(17)22/h3-6H,2,7-16H2,1H3,(H,23,26)
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n/an/a 18n/an/an/an/an/an/a



Merck and Co.

Curated by ChEMBL


Assay Description
Inhibition of rat GlyT1


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50195166
PNG
(3-chloro-2,6-difluoro-N-((4-(morpholine-4-carbonyl...)
Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)ccc(Cl)c2F)(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H28ClF2N3O5S/c1-2-13-33(30,31)27-7-5-21(6-8-27,20(29)26-9-11-32-12-10-26)14-25-19(28)17-16(23)4-3-15(22)18(17)24/h3-4H,2,5-14H2,1H3,(H,25,28)
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n/an/a 20n/an/an/an/an/an/a



Merck and Co.

Curated by ChEMBL


Assay Description
Inhibition of rat GlyT1


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50195178
PNG
(2-chloro-6-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)
Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2Cl)(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-14-32(29,30)26-8-6-21(7-9-26,20(28)25-10-12-31-13-11-25)15-24-19(27)18-16(22)4-3-5-17(18)23/h3-5H,2,6-15H2,1H3,(H,24,27)
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n/an/a 22n/an/an/an/an/an/a



Merck and Co.

Curated by ChEMBL


Assay Description
Inhibition of rat GlyT1


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50102692
PNG
(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)
Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCC1)N(C)C
Show InChI InChI=1S/C24H32N2O4/c1-26(2)24(12-8-9-13-24)17-25-23(27)19-14-20(28-3)22(21(15-19)29-4)30-16-18-10-6-5-7-11-18/h5-7,10-11,14-15H,8-9,12-13,16-17H2,1-4H3,(H,25,27)
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n/an/a 22n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50415201
PNG
(CHEMBL611364)
Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1ccc[nH]1
Show InChI InChI=1S/C13H18N2O2/c1-15-9-4-5-10(15)8-11(7-9)17-13(16)12-3-2-6-14-12/h2-3,6,9-11,14H,4-5,7-8H2,1H3/t9-,10-/m1/s1
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n/an/a 33.9n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50304335
PNG
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)
Show SMILES Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2
Show InChI InChI=1S/C17H20N2O2/c1-19-15-5-3-2-4-11(15)8-16(19)17(20)21-14-9-12-6-7-13(10-14)18-12/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1
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n/an/a 33.9n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50415204
PNG
(CHEMBL596443)
Show SMILES O=C(OC1C[C@H]2CC[C@H](C1)N2)c1cccs1
Show InChI InChI=1S/C12H15NO2S/c14-12(11-2-1-5-16-11)15-10-6-8-3-4-9(7-10)13-8/h1-2,5,8-10,13H,3-4,6-7H2/t8-,9-/m1/s1
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n/an/a 41.7n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50415205
PNG
(CHEMBL595797)
Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1ccco1
Show InChI InChI=1S/C13H17NO3/c1-14-9-4-5-10(14)8-11(7-9)17-13(15)12-3-2-6-16-12/h2-3,6,9-11H,4-5,7-8H2,1H3/t9-,10-/m1/s1
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n/an/a 50.1n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50415208
PNG
(CHEMBL608418)
Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cccnc1
Show InChI InChI=1S/C14H18N2O2/c1-16-11-4-5-12(16)8-13(7-11)18-14(17)10-3-2-6-15-9-10/h2-3,6,9,11-13H,4-5,7-8H2,1H3/t11-,12-/m1/s1
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n/an/a 58.9n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50415210
PNG
(CHEMBL608417)
Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H20N2O2/c1-19-12-6-7-13(19)10-14(9-12)21-17(20)16-8-11-4-2-3-5-15(11)18-16/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1
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n/an/a 60.3n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50439754
PNG
(CHEMBL2419440)
Show SMILES CCc1nnc(-c2ccc(nc2)-c2ccccc2)n1-c1cccc(C#N)c1C
Show InChI InChI=1S/C23H19N5/c1-3-22-26-27-23(28(22)21-11-7-10-18(14-24)16(21)2)19-12-13-20(25-15-19)17-8-5-4-6-9-17/h4-13,15H,3H2,1-2H3
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n/an/a 64n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50304335
PNG
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)
Show SMILES Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2
Show InChI InChI=1S/C17H20N2O2/c1-19-15-5-3-2-4-11(15)8-16(19)17(20)21-14-9-12-6-7-13(10-14)18-12/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1
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n/an/a 70.8n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry in presence of 10 uM glycine


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50415211
PNG
(CHEMBL595791)
Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C18H20N2O2/c1-20-14-6-7-15(20)10-16(9-14)22-18(21)13-8-12-4-2-3-5-17(12)19-11-13/h2-5,8,11,14-16H,6-7,9-10H2,1H3/t14-,15-/m1/s1
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n/an/a 72.4n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50415206
PNG
(CHEMBL596257)
Show SMILES O=C(OC1C[C@H]2CC[C@H](C1)N2)c1ccco1
Show InChI InChI=1S/C12H15NO3/c14-12(11-2-1-5-15-11)16-10-6-8-3-4-9(7-10)13-8/h1-2,5,8-10,13H,3-4,6-7H2/t8-,9-/m1/s1
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n/an/a 79.4n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50335008
PNG
(5-Biphenyl-4-yl-4-(2-fluorophenyl)-N-methyl-4H-1,2...)
Show SMILES CNc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4/c1-23-21-25-24-20(26(21)19-10-6-5-9-18(19)22)17-13-11-16(12-14-17)15-7-3-2-4-8-15/h2-14H,1H3,(H,23,25)
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n/an/a 83n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT1 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50415203
PNG
(CHEMBL595116)
Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cccs1
Show InChI InChI=1S/C13H17NO2S/c1-14-9-4-5-10(14)8-11(7-9)16-13(15)12-3-2-6-17-12/h2-3,6,9-11H,4-5,7-8H2,1H3/t9-,10-/m1/s1
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n/an/a 89.1n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor alpha-1 chain


(Rattus norvegicus)
BDBM50415209
PNG
(CHEMBL596237)
Show SMILES O=C(OC1C[C@H]2CC[C@H](C1)N2)c1cccnc1
Show InChI InChI=1S/C13H16N2O2/c16-13(9-2-1-5-14-8-9)17-12-6-10-3-4-11(7-12)15-10/h1-2,5,8,10-12,15H,3-4,6-7H2/t10-,11-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry


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Ligand-Target Pair
Glycine transporter 1


(Rattus norvegicus)
BDBM50335006
PNG
(2-(3-Biphenyl-4-yl-5-methyl-4H-1,2,4-triazole-4-yl...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1C#N
Show InChI InChI=1S/C22H16N4/c1-16-24-25-22(26(16)21-10-6-5-9-20(21)15-23)19-13-11-18(12-14-19)17-7-3-2-4-8-17/h2-14H,1H3
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TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT1 in rat C6 cells


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More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335008
PNG
(5-Biphenyl-4-yl-4-(2-fluorophenyl)-N-methyl-4H-1,2...)
Show SMILES CNc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4/c1-23-21-25-24-20(26(21)19-10-6-5-9-18(19)22)17-13-11-16(12-14-17)15-7-3-2-4-8-15/h2-14H,1H3,(H,23,25)
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TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


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Ligand-Target Pair
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