BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 115 hits Enz. Inhib. hit(s) with Target = 'Glycine receptor (alpha-1/beta)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50411311
PNG
(CHEMBL2113267)
Show SMILES C[C@H]1[C@H]2[C@@H](OC1=O)[C@H](O)[C@]13C4OC(=O)[C@]21OC1OC(=O)[C@H](O)C31[C@@H]([C@H]4O)C(C)(C)C
Show InChI InChI=1S/C20H24O10/c1-5-6-8(27-13(5)24)10(22)19-12-7(21)9(17(2,3)4)18(19)11(23)14(25)29-16(18)30-20(6,19)15(26)28-12/h5-12,16,21-23H,1-4H3/t5-,6?,7+,8+,9-,10-,11-,12?,16?,18?,19+,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 560n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50411311
PNG
(CHEMBL2113267)
Show SMILES C[C@H]1[C@H]2[C@@H](OC1=O)[C@H](O)[C@]13C4OC(=O)[C@]21OC1OC(=O)[C@H](O)C31[C@@H]([C@H]4O)C(C)(C)C
Show InChI InChI=1S/C20H24O10/c1-5-6-8(27-13(5)24)10(22)19-12-7(21)9(17(2,3)4)18(19)11(23)14(25)29-16(18)30-20(6,19)15(26)28-12/h5-12,16,21-23H,1-4H3/t5-,6?,7+,8+,9-,10-,11-,12?,16?,18?,19+,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 650n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 300 uM glycine-induced current by whole-cell patch clamp experiment


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50292287
PNG
(CHEMBL465161 | GINKGOLIDE A | ginkgolide-A)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18+,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 690n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50411311
PNG
(CHEMBL2113267)
Show SMILES C[C@H]1[C@H]2[C@@H](OC1=O)[C@H](O)[C@]13C4OC(=O)[C@]21OC1OC(=O)[C@H](O)C31[C@@H]([C@H]4O)C(C)(C)C
Show InChI InChI=1S/C20H24O10/c1-5-6-8(27-13(5)24)10(22)19-12-7(21)9(17(2,3)4)18(19)11(23)14(25)29-16(18)30-20(6,19)15(26)28-12/h5-12,16,21-23H,1-4H3/t5-,6?,7+,8+,9-,10-,11-,12?,16?,18?,19+,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 780n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 300 uM glycine-induced current by whole-cell patch clamp experiment


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50251276
PNG
(BN 52021 | CHEMBL514432 | GINKOLIDE B | Gingkolide...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11+,15+,17+,18+,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 300 uM glycine-induced current by whole-cell patch clamp experiment


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50292287
PNG
(CHEMBL465161 | GINKGOLIDE A | ginkgolide-A)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18+,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50251276
PNG
(BN 52021 | CHEMBL514432 | GINKOLIDE B | Gingkolide...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11+,15+,17+,18+,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.10E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 30 uM glycine-induced current by whole-cell patch clamp experiment


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50251276
PNG
(BN 52021 | CHEMBL514432 | GINKOLIDE B | Gingkolide...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11+,15+,17+,18+,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208076
PNG
(3,14-didehydroginkgolide A | CHEMBL373969)
Show SMILES CC1=C2[C@H](C[C@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@]24OC5=O)OC1=O
Show InChI InChI=1S/C20H22O8/c1-7-11-9(25-13(7)22)6-18-8-5-10(17(2,3)4)19(18)12(21)15(24)26-16(19)28-20(11,18)27-14(8)23/h8-10,12,16,21H,5-6H2,1-4H3/t8-,9-,10-,12-,16-,18-,19-,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208068
PNG
((1R,3R,6R,7S,8S,9S,10R,11R,12R,13S,16S,17R)-8-tert...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5[C@@H](F)[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@]4(OC5=O)[C@@]12O
Show InChI InChI=1S/C20H23FO10/c1-5-12(24)28-11-9(22)18-6-7(21)8(16(2,3)4)17(18)10(23)14(26)29-15(17)31-20(18,19(5,11)27)30-13(6)25/h5-11,15,22-23,27H,1-4H3/t5-,6+,7-,8+,9+,10+,11+,15+,17+,18+,19-,20+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208081
PNG
((1R,3R,6R,7S,8S,9S,10R,11R,12R,13S,16S,17R)-8-tert...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5[C@@H](Cl)[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@]4(OC5=O)[C@@]12O
Show InChI InChI=1S/C20H23ClO10/c1-5-12(24)28-11-9(22)18-6-7(21)8(16(2,3)4)17(18)10(23)14(26)29-15(17)31-20(18,19(5,11)27)30-13(6)25/h5-11,15,22-23,27H,1-4H3/t5-,6+,7-,8+,9+,10+,11+,15+,17+,18+,19-,20+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50292287
PNG
(CHEMBL465161 | GINKGOLIDE A | ginkgolide-A)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18+,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.80E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 300 uM glycine-induced current by whole-cell patch clamp experiment


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208074
PNG
(CHEMBL374004 | ginkgolide J)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O10/c1-6-12(23)27-7-5-17-14(25)28-11-8(21)9(16(2,3)4)18(20(11,17)19(6,7)26)10(22)13(24)29-15(18)30-17/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8+,9+,10+,11?,15+,17-,18+,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208060
PNG
(10-methoxy-ginkgolide C | CHEMBL221823)
Show SMILES CO[C@H]1C(=O)O[C@H]2O[C@@]34OC(=O)[C@@H]5[C@H](O)[C@@H](C(C)(C)C)[C@]12[C@]35[C@@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C21H26O11/c1-6-13(24)29-11-10(23)19-7-8(22)9(17(2,3)4)18(19)12(28-5)15(26)30-16(18)32-21(19,20(6,11)27)31-14(7)25/h6-12,16,22-23,27H,1-5H3/t6-,7+,8+,9+,10+,11+,12+,16+,18+,19+,20-,21+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.90E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 3000 uM glycine-induced current by whole-cell patch clamp experiment


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208076
PNG
(3,14-didehydroginkgolide A | CHEMBL373969)
Show SMILES CC1=C2[C@H](C[C@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@]24OC5=O)OC1=O
Show InChI InChI=1S/C20H22O8/c1-7-11-9(25-13(7)22)6-18-8-5-10(17(2,3)4)19(18)12(21)15(24)26-16(19)28-20(11,18)27-14(8)23/h8-10,12,16,21H,5-6H2,1-4H3/t8-,9-,10-,12-,16-,18-,19-,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 6.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208074
PNG
(CHEMBL374004 | ginkgolide J)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O10/c1-6-12(23)27-7-5-17-14(25)28-11-8(21)9(16(2,3)4)18(20(11,17)19(6,7)26)10(22)13(24)29-15(18)30-17/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8+,9+,10+,11?,15+,17-,18+,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 6.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 300 uM glycine-induced current by whole-cell patch clamp experiment


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208074
PNG
(CHEMBL374004 | ginkgolide J)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O10/c1-6-12(23)27-7-5-17-14(25)28-11-8(21)9(16(2,3)4)18(20(11,17)19(6,7)26)10(22)13(24)29-15(18)30-17/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8+,9+,10+,11?,15+,17-,18+,19-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.10E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208068
PNG
((1R,3R,6R,7S,8S,9S,10R,11R,12R,13S,16S,17R)-8-tert...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5[C@@H](F)[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@]4(OC5=O)[C@@]12O
Show InChI InChI=1S/C20H23FO10/c1-5-12(24)28-11-9(22)18-6-7(21)8(16(2,3)4)17(18)10(23)14(26)29-15(17)31-20(18,19(5,11)27)30-13(6)25/h5-11,15,22-23,27H,1-4H3/t5-,6+,7-,8+,9+,10+,11+,15+,17+,18+,19-,20+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.30E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208082
PNG
((1R,3R,6R,7S,8S,9S,10S,11R,12R,13S,16S,17R)-9-azid...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5[C@@H](N=[N+]=[N-])[C@@H](C(C)(C)C)[C@]33[C@@H](OC(=O)[C@@H]3O)O[C@]4(OC5=O)[C@@]12O
Show InChI InChI=1S/C20H23N3O10/c1-5-12(26)30-11-9(24)18-6-7(22-23-21)8(16(2,3)4)17(18)10(25)14(28)31-15(17)33-20(18,19(5,11)29)32-13(6)27/h5-11,15,24-25,29H,1-4H3/t5-,6+,7-,8+,9+,10+,11+,15+,17+,18+,19-,20+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 7.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208081
PNG
((1R,3R,6R,7S,8S,9S,10R,11R,12R,13S,16S,17R)-8-tert...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5[C@@H](Cl)[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@]4(OC5=O)[C@@]12O
Show InChI InChI=1S/C20H23ClO10/c1-5-12(24)28-11-9(22)18-6-7(21)8(16(2,3)4)17(18)10(23)14(26)29-15(17)31-20(18,19(5,11)27)30-13(6)25/h5-11,15,22-23,27H,1-4H3/t5-,6+,7-,8+,9+,10+,11+,15+,17+,18+,19-,20+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 7.60E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50436164
PNG
(CHEMBL2398352)
Show SMILES CN1C(=O)NC(=O)\C1=C/c1c[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O2/c1-16-11(12(17)15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-7,14H,1H3,(H,15,17,18)/b11-6+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.80E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Modulation of recombinant GlyR-alpha1 (unknown origin) expressed in HEK293 cells assessed as inhibition of glycine-induced current by automated plana...


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208085
PNG
((3S,8R,12R,16S,17R,21S)-3-tert-butyl-17-hydroxy-16...)
Show SMILES C[C@@H]1C(=O)OC2[C@@H]3OCO[C@H]4C(=O)OC5OC6(C(=O)OC7C[C@@H](C(C)(C)C)C45[C@]367)[C@@]12O
Show InChI InChI=1S/C21H24O10/c1-7-13(22)29-11-10-19-9-5-8(17(2,3)4)18(19)12(27-6-26-10)14(23)30-16(18)31-21(19,15(24)28-9)20(7,11)25/h7-12,16,25H,5-6H2,1-4H3/t7-,8+,9?,10+,11?,12?,16?,18?,19+,20-,21?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.90E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208060
PNG
(10-methoxy-ginkgolide C | CHEMBL221823)
Show SMILES CO[C@H]1C(=O)O[C@H]2O[C@@]34OC(=O)[C@@H]5[C@H](O)[C@@H](C(C)(C)C)[C@]12[C@]35[C@@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C21H26O11/c1-6-13(24)29-11-10(23)19-7-8(22)9(17(2,3)4)18(19)12(28-5)15(26)30-16(18)32-21(19,20(6,11)27)31-14(7)25/h6-12,16,22-23,27H,1-5H3/t6-,7+,8+,9+,10+,11+,12+,16+,18+,19+,20-,21+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 9.80E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208085
PNG
((3S,8R,12R,16S,17R,21S)-3-tert-butyl-17-hydroxy-16...)
Show SMILES C[C@@H]1C(=O)OC2[C@@H]3OCO[C@H]4C(=O)OC5OC6(C(=O)OC7C[C@@H](C(C)(C)C)C45[C@]367)[C@@]12O
Show InChI InChI=1S/C21H24O10/c1-7-13(22)29-11-10-19-9-5-8(17(2,3)4)18(19)12(27-6-26-10)14(23)30-16(18)31-21(19,15(24)28-9)20(7,11)25/h7-12,16,25H,5-6H2,1-4H3/t7-,8+,9?,10+,11?,12?,16?,18?,19+,20-,21?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50208082
PNG
((1R,3R,6R,7S,8S,9S,10S,11R,12R,13S,16S,17R)-9-azid...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5[C@@H](N=[N+]=[N-])[C@@H](C(C)(C)C)[C@]33[C@@H](OC(=O)[C@@H]3O)O[C@]4(OC5=O)[C@@]12O
Show InChI InChI=1S/C20H23N3O10/c1-5-12(26)30-11-9(24)18-6-7(22-23-21)8(16(2,3)4)17(18)10(25)14(28)31-15(17)33-20(18,19(5,11)29)32-13(6)27/h5-11,15,24-25,29H,1-4H3/t5-,6+,7-,8+,9+,10+,11+,15+,17+,18+,19-,20+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50436165
PNG
(CHEMBL2398351)
Show SMILES CN1C(=[NH2+])N(C)[C@]2(Cc3c([nH]c4ccccc34)[C@@]3([C@H]2c2c[nH]c4ccccc24)N(C)C(=[NH2+])N(C)C3=O)C1=O
Show InChI InChI=1S/C28H28N8O2/c1-33-23(37)27(35(3)25(33)29)13-17-15-9-6-8-12-20(15)32-22(17)28(24(38)34(2)26(30)36(28)4)21(27)18-14-31-19-11-7-5-10-16(18)19/h5-12,14,21,29-32H,13H2,1-4H3/p+2/t21-,27-,28+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 2.59E+4n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Modulation of recombinant GlyR-alpha1 (unknown origin) expressed in HEK293 cells assessed as inhibition of glycine-induced current by automated plana...


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220049
PNG
((1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15...)
Show SMILES C[N+]12CC[C@H]3[C@@H]1C[C@@H]1[C@@H]4[C@@H]3N([C@@H]3OCC=C5C[N+]6(C)CC[C@@]78[C@@H]6C[C@@H]5[C@@H]3[C@@H]7N([C@@H]4OCC=C1C2)c1ccccc81)c1ccccc1
Show InChI InChI=1S/C40H48N4O2/c1-43-16-12-27-32(43)20-28-24(22-43)13-18-45-38-34(28)36(27)41(26-8-4-3-5-9-26)39-35-29-21-33-40(15-17-44(33,2)23-25(29)14-19-46-39)30-10-6-7-11-31(30)42(38)37(35)40/h3-11,13-14,27-29,32-39H,12,15-23H2,1-2H3/q+2/t27-,28-,29-,32-,33-,34+,35+,36+,37-,38+,39+,40+,43?,44?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220046
PNG
(CHEMBL382243 | trimethyl({20-[(trimethylazaniumyl)...)
Show SMILES C[N+](C)(C)Cc1c2Cn3c(Cn2c2ccccc12)c(C[N+](C)(C)C)c1ccccc31
Show InChI InChI=1S/C26H34N4/c1-29(2,3)17-21-19-11-7-9-13-23(19)27-16-26-22(18-30(4,5)6)20-12-8-10-14-24(20)28(26)15-25(21)27/h7-14H,15-18H2,1-6H3/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220050
PNG
((1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15...)
Show SMILES C1C[N+]2(CC3=CCO[C@@H]4[C@@H]5[C@H]3C[C@H]2[C@H]1[C@H]5N([C@@H]1OCC=C2C[N+]3(CC[C@@]56[C@@H]3C[C@@H]2[C@@H]1[C@@H]5N4c1ccccc61)C1CCCC=C1)c1ccccc1)C1CCCC=C1
Show InChI InChI=1S/C50H60N4O2/c1-4-12-34(13-5-1)51-46-37-20-24-53(35-14-6-2-7-15-35)30-32-21-26-55-48(44(46)38(32)28-42(37)53)52-41-19-11-10-18-40(41)50-23-25-54(36-16-8-3-9-17-36)31-33-22-27-56-49(51)45(47(50)52)39(33)29-43(50)54/h1,4-6,8,10-14,16,18-19,21-22,35-39,42-49H,2-3,7,9,15,17,20,23-31H2/q+2/t35?,36?,37-,38-,39-,42-,43-,44+,45+,46+,47-,48+,49+,50+,53?,54?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220056
PNG
((1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-24...)
Show SMILES C=CC[N+]12CC[C@H]3[C@@H]1C[C@@H]1[C@@H]4[C@@H]3N([C@@H]3OCC=C5C[N+]6(CC=C)CC[C@@]78[C@@H]6C[C@@H]5[C@@H]3[C@@H]7N([C@@H]4OCC=C1C2)c1ccccc81)c1ccccc1
Show InChI InChI=1S/C44H52N4O2/c1-3-18-47-20-14-31-36(47)24-32-28(26-47)15-22-49-42-38(32)40(31)45(30-10-6-5-7-11-30)43-39-33-25-37-44(34-12-8-9-13-35(34)46(42)41(39)44)17-21-48(37,19-4-2)27-29(33)16-23-50-43/h3-13,15-16,31-33,36-43H,1-2,14,17-27H2/q+2/t31-,32-,33-,36-,37-,38+,39+,40+,41-,42+,43+,44+,47?,48?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220054
PNG
((1R,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-24...)
Show SMILES C=CC[N+]12CC[C@H]3[C@@H]1C[C@@H]1[C@@H]4[C@@H]3N([C@@H]3OCC=C5CN6CC[C@@]78[C@@H]6C[C@@H]5[C@@H]3[C@@H]7N([C@@H]4OCC=C1C2)c1ccccc81)c1ccccc1
Show InChI InChI=1S/C41H47N4O2/c1-2-17-45-18-12-28-33(45)21-29-26(24-45)14-20-46-39-35(29)37(28)43(27-8-4-3-5-9-27)40-36-30-22-34-41(15-16-42(34)23-25(30)13-19-47-40)31-10-6-7-11-32(31)44(39)38(36)41/h2-11,13-14,28-30,33-40H,1,12,15-24H2/q+1/t28-,29-,30-,33-,34-,35+,36+,37+,38-,39+,40+,41+,45?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220058
PNG
(CHEMBL231047 | toxiferine)
Show SMILES C[N+]12CCC34[C@@H]1C[C@@H](\C(C2)=C/CO)\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(C)C\C1=C\CO)c1ccccc21
Show InChI InChI=1S/C40H46N4O2/c1-43-15-13-39-31-7-3-5-9-33(31)41-22-30-28-20-36-40(14-16-44(36,2)24-26(28)12-18-46)32-8-4-6-10-34(32)42(38(30)40)21-29(37(39)41)27(19-35(39)43)25(23-43)11-17-45/h3-12,21-22,27-28,35-38,45-46H,13-20,23-24H2,1-2H3/q+2/b25-11-,26-12-,29-21-,30-22-/t27-,28?,35?,36?,37-,38-,39+,40?,43?,44?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220061
PNG
((1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15...)
Show SMILES C(c1ccccc1)[N+]12CC[C@H]3[C@@H]1C[C@@H]1[C@@H]4[C@@H]3N([C@@H]3OCC=C5C[N+]6(Cc7ccccc7)CC[C@@]78[C@@H]6C[C@@H]5[C@@H]3[C@@H]7N([C@@H]4OCC=C1C2)c1ccccc81)c1ccccc1
Show InChI InChI=1S/C52H56N4O2/c1-4-12-34(13-5-1)30-55-24-20-39-44(55)28-40-36(32-55)21-26-57-50-46(40)48(39)53(38-16-8-3-9-17-38)51-47-41-29-45-52(42-18-10-11-19-43(42)54(50)49(47)52)23-25-56(45,33-37(41)22-27-58-51)31-35-14-6-2-7-15-35/h1-19,21-22,39-41,44-51H,20,23-33H2/q+2/t39-,40-,41-,44-,45-,46+,47+,48+,49-,50+,51+,52+,55?,56?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220047
PNG
((1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15...)
Show SMILES Brc1ccc(C[N+]23CC[C@H]4[C@@H]2C[C@@H]2[C@@H]5[C@@H]4N([C@@H]4OCC=C6C[N+]7(Cc8ccc(Br)cc8)CC[C@@]89[C@@H]7C[C@@H]6[C@@H]4[C@@H]8N([C@@H]5OCC=C2C3)c2ccccc92)c2ccccc2)cc1
Show InChI InChI=1S/C52H54Br2N4O2/c53-36-14-10-32(11-15-36)28-57-22-18-39-44(57)26-40-34(30-57)19-24-59-50-46(40)48(39)55(38-6-2-1-3-7-38)51-47-41-27-45-52(42-8-4-5-9-43(42)56(50)49(47)52)21-23-58(45,31-35(41)20-25-60-51)29-33-12-16-37(54)17-13-33/h1-17,19-20,39-41,44-51H,18,21-31H2/q+2/t39-,40-,41-,44-,45-,46+,47+,48+,49-,50+,51+,52+,57?,58?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220045
PNG
(CHEMBL206666 | [(20-{[dimethyl(prop-2-en-1-yl)azan...)
Show SMILES C[N+](C)(CC=C)Cc1c2Cn3c(Cn2c2ccccc12)c(C[N+](C)(C)CC=C)c1ccccc31
Show InChI InChI=1S/C30H38N4/c1-7-17-33(3,4)21-25-23-13-9-11-15-27(23)31-20-30-26(22-34(5,6)18-8-2)24-14-10-12-16-28(24)32(30)19-29(25)31/h7-16H,1-2,17-22H2,3-6H3/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220041
PNG
(CHEMBL229999 | {[20-({dimethyl[(4-nitrophenyl)meth...)
Show SMILES C[N+](C)(Cc1c2Cn3c(Cn2c2ccccc12)c(C[N+](C)(C)Cc1ccc(cc1)[N+]([O-])=O)c1ccccc31)Cc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C38H40N6O4/c1-43(2,23-27-13-17-29(18-14-27)41(45)46)25-33-31-9-5-7-11-35(31)39-22-38-34(32-10-6-8-12-36(32)40(38)21-37(33)39)26-44(3,4)24-28-15-19-30(20-16-28)42(47)48/h5-20H,21-26H2,1-4H3/q+2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220044
PNG
((1S,11S,13S,18R,20R,27S,29R,30R,31S,35E)-35-(2-hyd...)
Show SMILES OC\C=C1\C[N+]2(Cc3ccc(cc3)[N+]([O-])=O)CCC3[C@@H]2C[C@@H]1\C1=C\N2[C@H]4[C@H]5[C@H]6C[C@H]7[C@@]4(CC[N+]7(Cc4ccc(cc4)[N+]([O-])=O)CC6=CCO[C@H]5N([C@H]31)c1ccccc1)c1ccccc21
Show InChI InChI=1S/C52H54N6O6/c59-24-19-35-31-57(29-33-10-14-38(15-11-33)55(60)61)22-18-40-46(57)26-41(35)43-28-53-45-9-5-4-8-44(45)52-21-23-58(30-34-12-16-39(17-13-34)56(62)63)32-36-20-25-64-51(48(50(52)53)42(36)27-47(52)58)54(49(40)43)37-6-2-1-3-7-37/h1-17,19-20,28,40-42,46-51,59H,18,21-27,29-32H2/q+2/b35-19-,43-28-/t40?,41?,42-,46-,47-,48+,49+,50-,51+,52+,57?,58?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220040
PNG
((1R,9R,18S,19S,21R,22R,23R,25R,32S,34R,35R,36S)-24...)
Show SMILES C1CN2CC3=CCO[C@@H]4[C@@H]5[C@H]3C[C@H]2[C@H]1[C@H]5N([C@@H]1OCC=C2CN3CC[C@@]56[C@@H]3C[C@@H]2[C@@H]1[C@@H]5N4c1ccccc61)c1ccccc1
Show InChI InChI=1S/C38H42N4O2/c1-2-6-24(7-3-1)41-34-25-10-14-39-20-22-11-16-43-36(32(34)26(22)18-30(25)39)42-29-9-5-4-8-28(29)38-13-15-40-21-23-12-17-44-37(41)33(35(38)42)27(23)19-31(38)40/h1-9,11-12,25-27,30-37H,10,13-21H2/t25-,26-,27-,30-,31-,32+,33+,34+,35-,36+,37+,38+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220043
PNG
((1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15...)
Show SMILES [O-][N+](=O)c1ccc(C[N+]23CC[C@H]4[C@@H]2C[C@@H]2[C@@H]5[C@@H]4N([C@@H]4OCC=C6C[N+]7(Cc8ccc(cc8)[N+]([O-])=O)CC[C@@]89[C@@H]7C[C@@H]6[C@@H]4[C@@H]8N([C@@H]5OCC=C2C3)c2ccccc92)c2ccccc2)cc1
Show InChI InChI=1S/C52H54N6O6/c59-55(60)37-14-10-32(11-15-37)28-57-22-18-39-44(57)26-40-34(30-57)19-24-63-50-46(40)48(39)53(36-6-2-1-3-7-36)51-47-41-27-45-52(42-8-4-5-9-43(42)54(50)49(47)52)21-23-58(45,31-35(41)20-25-64-51)29-33-12-16-38(17-13-33)56(61)62/h1-17,19-20,39-41,44-51H,18,21-31H2/q+2/t39-,40-,41-,44-,45-,46+,47+,48+,49-,50+,51+,52+,57?,58?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220042
PNG
((1S,11S,13S,17R,18R,20R,27S,29R,30R,31S,35E)-14,26...)
Show SMILES COc1ccc(C[N+]23CC[C@H]4[C@@H]2C[C@@H](\C(C3)=C/CO)\C2=C\N3[C@H]5[C@H]6[C@H]7C[C@H]8[C@@]5(CC[N+]8(Cc5ccc(OC)c(OC)c5)CC7=CCO[C@H]6N([C@H]42)c2ccccc2)c2ccccc32)cc1OC
Show InChI InChI=1S/C56H64N4O6/c1-62-47-16-14-35(26-49(47)64-3)31-59-22-18-40-46(59)28-41(37(33-59)19-24-61)43-30-57-45-13-9-8-12-44(45)56-21-23-60(32-36-15-17-48(63-2)50(27-36)65-4)34-38-20-25-66-55(52(54(56)57)42(38)29-51(56)60)58(53(40)43)39-10-6-5-7-11-39/h5-17,19-20,26-27,30,40-42,46,51-55,61H,18,21-25,28-29,31-34H2,1-4H3/q+2/b37-19-,43-30-/t40-,41?,42-,46-,51-,52+,53+,54-,55+,56+,59?,60?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220055
PNG
((1S,11S,13S,17R,18R,20R,27S,29R,30R,31S,35E)-14,26...)
Show SMILES OC\C=C1\C[N+]2(CC[C@H]3[C@@H]2C[C@@H]1\C1=C\N2[C@H]4[C@H]5[C@H]6C[C@H]7[C@@]4(CC[N+]7(CC6=CCO[C@H]5N([C@H]31)c1ccccc1)C1CCCC=C1)c1ccccc21)C1CCCC=C1
Show InChI InChI=1S/C50H60N4O2/c55-26-21-33-31-53(36-14-6-2-7-15-36)24-20-38-44(53)28-39(33)41-30-51-43-19-11-10-18-42(43)50-23-25-54(37-16-8-3-9-17-37)32-34-22-27-56-49(46(48(50)51)40(34)29-45(50)54)52(47(38)41)35-12-4-1-5-13-35/h1,4-6,8,10-14,16,18-19,21-22,30,36-40,44-49,55H,2-3,7,9,15,17,20,23-29,31-32H2/q+2/b33-21-,41-30-/t36?,37?,38-,39?,40-,44-,45-,46+,47+,48-,49+,50+,53?,54?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220057
PNG
((1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15...)
Show SMILES COc1ccc(C[N+]23CC[C@H]4[C@@H]2C[C@@H]2[C@@H]5[C@@H]4N([C@@H]4OCC=C6C[N+]7(Cc8ccc(OC)c(OC)c8)CC[C@@]89[C@@H]7C[C@@H]6[C@@H]4[C@@H]8N([C@@H]5OCC=C2C3)c2ccccc92)c2ccccc2)cc1OC
Show InChI InChI=1S/C56H64N4O6/c1-61-45-16-14-34(26-47(45)63-3)30-59-22-18-39-44(59)28-40-36(32-59)19-24-65-54-50(40)52(39)57(38-10-6-5-7-11-38)55-51-41-29-49-56(42-12-8-9-13-43(42)58(54)53(51)56)21-23-60(49,33-37(41)20-25-66-55)31-35-15-17-46(62-2)48(27-35)64-4/h5-17,19-20,26-27,39-41,44,49-55H,18,21-25,28-33H2,1-4H3/q+2/t39-,40-,41-,44-,49-,50+,51+,52+,53-,54+,55+,56+,59?,60?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220051
PNG
((1S,11S,13S,17R,18R,20R,27S,29R,30R,31S,35E)-35-(2...)
Show SMILES C[N+]12CC[C@H]3[C@@H]1C[C@@H](\C(C2)=C/CO)\C1=C\N2[C@H]4[C@H]5[C@H]6C[C@H]7[C@@]4(CC[N+]7(C)CC6=CCO[C@H]5N([C@H]31)c1ccccc1)c1ccccc21
Show InChI InChI=1S/C40H48N4O2/c1-43-16-12-28-34(43)20-29(25(23-43)13-18-45)31-22-41-33-11-7-6-10-32(33)40-15-17-44(2)24-26-14-19-46-39(36(38(40)41)30(26)21-35(40)44)42(37(28)31)27-8-4-3-5-9-27/h3-11,13-14,22,28-30,34-39,45H,12,15-21,23-24H2,1-2H3/q+2/b25-13-,31-22-/t28-,29?,30-,34-,35-,36+,37+,38-,39+,40+,43?,44?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220053
PNG
((1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15...)
Show SMILES C\C=C\C[N+]12CC[C@H]3[C@@H]1C[C@@H]1[C@@H]4[C@@H]3N([C@@H]3OCC=C5C[N+]6(C\C=C\C)CC[C@@]78[C@@H]6C[C@@H]5[C@@H]3[C@@H]7N([C@@H]4OCC=C1C2)c1ccccc81)c1ccccc1
Show InChI InChI=1S/C46H56N4O2/c1-3-5-20-49-22-16-33-38(49)26-34-30(28-49)17-24-51-44-40(34)42(33)47(32-12-8-7-9-13-32)45-41-35-27-39-46(36-14-10-11-15-37(36)48(44)43(41)46)19-23-50(39,21-6-4-2)29-31(35)18-25-52-45/h3-15,17-18,33-35,38-45H,16,19-29H2,1-2H3/q+2/b5-3+,6-4+/t33-,34-,35-,38-,39-,40+,41+,42+,43-,44+,45+,46+,49?,50?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Glycine receptor (alpha-1/beta)


(Homo sapiens)
BDBM50220052
PNG
((alcuronium)(1R,11S,18S,20R,21R,22S)-12-oxa-17-azo...)
Show SMILES OC\C=C1\C[N+]2(CC=C)CCC34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(CC=C)C\C1=C\CO)c1ccccc21
Show InChI InChI=1S/C44H50N4O2/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2/q+2/b29-13-,30-14-,33-25-,34-26-/t31-,32?,39?,40?,41-,42-,43+,44?,47?,48?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 115 total )  |  Next  |  Last  >>
Jump to: