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Found 63 hits Enz. Inhib. hit(s) with Target = 'Glycine transporter 2' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 2


(Rattus norvegicus)
BDBM50335008
PNG
(5-Biphenyl-4-yl-4-(2-fluorophenyl)-N-methyl-4H-1,2...)
Show SMILES CNc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4/c1-23-21-25-24-20(26(21)19-10-6-5-9-18(19)22)17-13-11-16(12-14-17)15-7-3-2-4-8-15/h2-14H,1H3,(H,23,25)
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TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099875
PNG
((E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl...)
Show SMILES CC(C)c1ccc(cc1)C(=C/C[C@H](N)C([O-])=O)\c1ccc(F)cc1F
Show InChI InChI=1S/C20H21F2NO2/c1-12(2)13-3-5-14(6-4-13)16(9-10-19(23)20(24)25)17-8-7-15(21)11-18(17)22/h3-9,11-12,19H,10,23H2,1-2H3,(H,24,25)/p-1/b16-9+/t19-/m0/s1
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NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335010
PNG
(3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-t...)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C22H18FN3/c1-2-21-24-25-22(26(21)20-11-7-6-10-19(20)23)18-14-12-17(13-15-18)16-8-4-3-5-9-16/h3-15H,2H2,1H3
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n/an/a 230n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335010
PNG
(3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-t...)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C22H18FN3/c1-2-21-24-25-22(26(21)20-11-7-6-10-19(20)23)18-14-12-17(13-15-18)16-8-4-3-5-9-16/h3-15H,2H2,1H3
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n/an/a 230n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335010
PNG
(3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-t...)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C22H18FN3/c1-2-21-24-25-22(26(21)20-11-7-6-10-19(20)23)18-14-12-17(13-15-18)16-8-4-3-5-9-16/h3-15H,2H2,1H3
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Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335006
PNG
(2-(3-Biphenyl-4-yl-5-methyl-4H-1,2,4-triazole-4-yl...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1C#N
Show InChI InChI=1S/C22H16N4/c1-16-24-25-22(26(16)21-10-6-5-9-20(21)15-23)19-13-11-18(12-14-19)17-7-3-2-4-8-17/h2-14H,1H3
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TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335004
PNG
(3-Biphenyl-4-yl-4-(2-chlorophenyl)-5-methyl-4H-1,2...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1Cl
Show InChI InChI=1S/C21H16ClN3/c1-15-23-24-21(25(15)20-10-6-5-9-19(20)22)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14H,1H3
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TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099886
PNG
((E)-2-Amino-5-(3,4-diethyl-phenyl)-5-(2,4-difluoro...)
Show SMILES CCc1ccc(cc1CC)C(=C/C[C@H](N)C([O-])=O)\c1ccc(F)cc1F
Show InChI InChI=1S/C21H23F2NO2/c1-3-13-5-6-15(11-14(13)4-2)17(9-10-20(24)21(25)26)18-8-7-16(22)12-19(18)23/h5-9,11-12,20H,3-4,10,24H2,1-2H3,(H,25,26)/p-1/b17-9+/t20-/m0/s1
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NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099859
PNG
(CHEMBL29220 | Sodium; (E)-2-amino-5-(2-fluoro-phen...)
Show SMILES CC(C)c1ccc(cc1)C(=C/CC(N)C([O-])=O)\c1ccccc1F
Show InChI InChI=1S/C20H22FNO2/c1-13(2)14-7-9-15(10-8-14)16(11-12-19(22)20(23)24)17-5-3-4-6-18(17)21/h3-11,13,19H,12,22H2,1-2H3,(H,23,24)/p-1/b16-11+
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NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099862
PNG
(CHEMBL28746 | Sodium; (E)-2-amino-5-(2,4-difluoro-...)
Show SMILES CC(C)c1ccc(cc1)C(=C/CC(N)C([O-])=O)\c1ccc(F)cc1F
Show InChI InChI=1S/C20H21F2NO2/c1-12(2)13-3-5-14(6-4-13)16(9-10-19(23)20(24)25)17-8-7-15(21)11-18(17)22/h3-9,11-12,19H,10,23H2,1-2H3,(H,24,25)/p-1/b16-9+
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NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50439743
PNG
(CHEMBL2419425)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(N)c1C
Show InChI InChI=1S/C23H22N4/c1-3-22-25-26-23(27(22)21-11-7-10-20(24)16(21)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15H,3,24H2,1-2H3
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n/an/a 340n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335001
PNG
(3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C21H16FN3/c1-15-23-24-21(25(15)20-10-6-5-9-19(20)22)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14H,1H3
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TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335001
PNG
(3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C21H16FN3/c1-15-23-24-21(25(15)20-10-6-5-9-19(20)22)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14H,1H3
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Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099878
PNG
((E)-2-Amino-5-(2,4-difluoro-phenyl)-5-naphthalen-2...)
Show SMILES N[C@@H](C\C=C(/c1ccc2ccccc2c1)c1ccc(F)cc1F)C([O-])=O
Show InChI InChI=1S/C21H17F2NO2/c22-16-7-8-18(19(23)12-16)17(9-10-20(24)21(25)26)15-6-5-13-3-1-2-4-14(13)11-15/h1-9,11-12,20H,10,24H2,(H,25,26)/p-1/b17-9+/t20-/m0/s1
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NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50360102
PNG
(CHEMBL1928735)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2cccnc12
Show InChI InChI=1S/C25H20N4/c1-2-23-27-28-25(21-15-13-19(14-16-21)18-8-4-3-5-9-18)29(23)22-12-6-10-20-11-7-17-26-24(20)22/h3-17H,2H2,1H3
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Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099882
PNG
(CHEMBL29958 | Sodium; (Z)-2-amino-5-(4-isopropyl-p...)
Show SMILES CC(C)c1ccc(cc1)C(=C/CC(N)C([O-])=O)\c1ccccc1
Show InChI InChI=1S/C20H23NO2/c1-14(2)15-8-10-17(11-9-15)18(12-13-19(21)20(22)23)16-6-4-3-5-7-16/h3-12,14,19H,13,21H2,1-2H3,(H,22,23)/p-1/b18-12-
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NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099879
PNG
(CHEMBL28601 | Sodium; (E)-2-amino-5-(2,4-difluoro-...)
Show SMILES CCc1ccc(cc1)C(=C/CC(N)C([O-])=O)\c1ccc(F)cc1F
Show InChI InChI=1S/C19H19F2NO2/c1-2-12-3-5-13(6-4-12)15(9-10-18(22)19(23)24)16-8-7-14(20)11-17(16)21/h3-9,11,18H,2,10,22H2,1H3,(H,23,24)/p-1/b15-9+
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NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335005
PNG
(3-Biphenyl-4-yl-5-methyl-4-[2-(trifluoromethyl)phe...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H16F3N3/c1-15-26-27-21(28(15)20-10-6-5-9-19(20)22(23,24)25)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14H,1H3
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TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099866
PNG
(CHEMBL418388 | Sodium; (E)-2-amino-5-(3,4-diethyl-...)
Show SMILES CCc1ccc(cc1CC)C(=C/CC(N)C([O-])=O)\c1ccc(F)cc1F
Show InChI InChI=1S/C21H23F2NO2/c1-3-13-5-6-15(11-14(13)4-2)17(9-10-20(24)21(25)26)18-8-7-16(22)12-19(18)23/h5-9,11-12,20H,3-4,10,24H2,1-2H3,(H,25,26)/p-1/b17-9+
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NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50439737
PNG
(CHEMBL2419431)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(F)c1C
Show InChI InChI=1S/C23H20FN3/c1-3-22-25-26-23(27(22)21-11-7-10-20(24)16(21)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15H,3H2,1-2H3
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Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335007
PNG
(2-(3-(biphenyl-4-yl)-5-methyl-4H-1,2,4-triazol-4-y...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1O
Show InChI InChI=1S/C21H17N3O/c1-15-22-23-21(24(15)19-9-5-6-10-20(19)25)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14,25H,1H3
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TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50439745
PNG
(CHEMBL2419423)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1C
Show InChI InChI=1S/C23H21N3/c1-3-22-24-25-23(26(22)21-12-8-7-9-17(21)2)20-15-13-19(14-16-20)18-10-5-4-6-11-18/h4-16H,3H2,1-2H3
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Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099883
PNG
(CHEMBL28577 | Sodium; (E)-2-amino-5-(2,4-difluoro-...)
Show SMILES NC(C\C=C(/c1ccc2ccccc2c1)c1ccc(F)cc1F)C([O-])=O
Show InChI InChI=1S/C21H17F2NO2/c22-16-7-8-18(19(23)12-16)17(9-10-20(24)21(25)26)15-6-5-13-3-1-2-4-14(13)11-15/h1-9,11-12,20H,10,24H2,(H,25,26)/p-1/b17-9+
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NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335012
PNG
(3-Biphenyl-4-yl-5-methyl-4-(2-methylphenyl)-4H-1,2...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1C
Show InChI InChI=1S/C22H19N3/c1-16-8-6-7-11-21(16)25-17(2)23-24-22(25)20-14-12-19(13-15-20)18-9-4-3-5-10-18/h3-15H,1-2H3
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n/an/a 780n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50439750
PNG
(CHEMBL2419441)
Show SMILES CCc1nnc(-c2ccc(nc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4/c1-2-20-24-25-21(26(20)19-11-7-6-10-17(19)22)16-12-13-18(23-14-16)15-8-4-3-5-9-15/h3-14H,2H2,1H3
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n/an/a 790n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50439749
PNG
(CHEMBL2417571)
Show SMILES CCc1nnc(-c2ccc(cn2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4/c1-2-20-24-25-21(26(20)19-11-7-6-10-17(19)22)18-13-12-16(14-23-18)15-8-4-3-5-9-15/h3-14H,2H2,1H3
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n/an/a 890n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335009
PNG
(3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methoxy-4H-1,...)
Show SMILES COc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C21H16FN3O/c1-26-21-24-23-20(25(21)19-10-6-5-9-18(19)22)17-13-11-16(12-14-17)15-7-3-2-4-8-15/h2-14H,1H3
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n/an/a 990n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099858
PNG
(CHEMBL285370 | Sodium; (E)-2-amino-5-(4-isopropyl-...)
Show SMILES CC(C)c1ccc(cc1)C(=C/CC(N)C([O-])=O)\c1ccsc1
Show InChI InChI=1S/C18H21NO2S/c1-12(2)13-3-5-14(6-4-13)16(15-9-10-22-11-15)7-8-17(19)18(20)21/h3-7,9-12,17H,8,19H2,1-2H3,(H,20,21)/p-1/b16-7+
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n/an/a 1.03E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099873
PNG
(CHEMBL29964 | Sodium; (E)-2-amino-5-(4-isopropyl-p...)
Show SMILES COc1ccc(cc1)C(=C\CC(N)C([O-])=O)\c1ccc(cc1)C(C)C
Show InChI InChI=1S/C21H25NO3/c1-14(2)15-4-6-16(7-5-15)19(12-13-20(22)21(23)24)17-8-10-18(25-3)11-9-17/h4-12,14,20H,13,22H2,1-3H3,(H,23,24)/p-1/b19-12+
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n/an/a 1.16E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099863
PNG
(CHEMBL29023 | Sodium; (E)-2-amino-5-(2,4-difluoro-...)
Show SMILES Cc1ccc(cc1)C(=C/CC(N)C([O-])=O)\c1ccc(F)cc1F
Show InChI InChI=1S/C18H17F2NO2/c1-11-2-4-12(5-3-11)14(8-9-17(21)18(22)23)15-7-6-13(19)10-16(15)20/h2-8,10,17H,9,21H2,1H3,(H,22,23)/p-1/b14-8+
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n/an/a 1.17E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50439744
PNG
(CHEMBL2419424)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(C)c1C
Show InChI InChI=1S/C24H23N3/c1-4-23-25-26-24(27(23)22-12-8-9-17(2)18(22)3)21-15-13-20(14-16-21)19-10-6-5-7-11-19/h5-16H,4H2,1-3H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50439741
PNG
(CHEMBL2419427)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(O)c1C
Show InChI InChI=1S/C23H21N3O/c1-3-22-24-25-23(26(22)20-10-7-11-21(27)16(20)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15,27H,3H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099868
PNG
(CHEMBL27914 | Sodium; (E)-2-amino-5-biphenyl-3-yl-...)
Show SMILES NC(C\C=C(/c1cccc(c1)-c1ccccc1)c1ccc(F)cc1F)C([O-])=O
Show InChI InChI=1S/C23H19F2NO2/c24-18-9-10-20(21(25)14-18)19(11-12-22(26)23(27)28)17-8-4-7-16(13-17)15-5-2-1-3-6-15/h1-11,13-14,22H,12,26H2,(H,27,28)/p-1/b19-11+
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n/an/a 1.34E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50334998
PNG
(3-Biphenyl-4-yl-5-methyl-4-phenyl-4H-1,2,4-triazol...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1
Show InChI InChI=1S/C21H17N3/c1-16-22-23-21(24(16)20-10-6-3-7-11-20)19-14-12-18(13-15-19)17-8-4-2-5-9-17/h2-15H,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099861
PNG
(CHEMBL28549 | Sodium; (E)-2-amino-5-(2,4-difluoro-...)
Show SMILES CC(C)c1cccc(c1)C(=C/CC(N)C([O-])=O)\c1ccc(F)cc1F
Show InChI InChI=1S/C20H21F2NO2/c1-12(2)13-4-3-5-14(10-13)16(8-9-19(23)20(24)25)17-7-6-15(21)11-18(17)22/h3-8,10-12,19H,9,23H2,1-2H3,(H,24,25)/p-1/b16-8+
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n/an/a 1.59E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50439751
PNG
(CHEMBL2419444)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccn2)n1-c1ccccc1F
Show InChI InChI=1S/C20H15FN4/c1-14-23-24-20(25(14)19-8-3-2-6-17(19)21)16-11-9-15(10-12-16)18-7-4-5-13-22-18/h2-13H,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50114035
PNG
(3-Biphenyl-4-yl-4-(2-methoxy-phenyl)-5-methyl-4H-[...)
Show SMILES COc1ccccc1-n1c(C)nnc1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H19N3O/c1-16-23-24-22(25(16)20-10-6-7-11-21(20)26-2)19-14-12-18(13-15-19)17-8-4-3-5-9-17/h3-15H,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099881
PNG
((E)-2-Amino-5-(4-tert-butyl-phenyl)-5-(2,4-difluor...)
Show SMILES CC(C)(C)c1ccc(cc1)C(=C/CC(N)C([O-])=O)\c1ccc(F)cc1F
Show InChI InChI=1S/C21H23F2NO2/c1-21(2,3)14-6-4-13(5-7-14)16(10-11-19(24)20(25)26)17-9-8-15(22)12-18(17)23/h4-10,12,19H,11,24H2,1-3H3,(H,25,26)/p-1/b16-10+
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n/an/a 1.74E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099880
PNG
(CHEMBL29279 | Sodium; (E)-2-amino-5-(2,4-difluoro-...)
Show SMILES COc1ccc(cc1)C(=C/CC(N)C([O-])=O)\c1ccc(F)cc1F
Show InChI InChI=1S/C18H17F2NO3/c1-24-13-5-2-11(3-6-13)14(8-9-17(21)18(22)23)15-7-4-12(19)10-16(15)20/h2-8,10,17H,9,21H2,1H3,(H,22,23)/p-1/b14-8+
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n/an/a 2.03E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099865
PNG
(CHEMBL283017 | Sodium; 2-amino-5,5-bis-(4-isopropy...)
Show SMILES CC(C)c1ccc(cc1)C(=CCC(N)C([O-])=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C23H29NO2/c1-15(2)17-5-9-19(10-6-17)21(13-14-22(24)23(25)26)20-11-7-18(8-12-20)16(3)4/h5-13,15-16,22H,14,24H2,1-4H3,(H,25,26)/p-1
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n/an/a 2.03E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099885
PNG
(CHEMBL281450 | Sodium; (E)-2-amino-5-biphenyl-4-yl...)
Show SMILES CC(C)c1ccc(cc1)C(=C/CC(N)C([O-])=O)\c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H27NO2/c1-18(2)19-8-12-22(13-9-19)24(16-17-25(27)26(28)29)23-14-10-21(11-15-23)20-6-4-3-5-7-20/h3-16,18,25H,17,27H2,1-2H3,(H,28,29)/p-1/b24-16+
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n/an/a 2.06E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099864
PNG
(CHEMBL27850 | Sodium; (Z)-2-amino-5-biphenyl-4-yl-...)
Show SMILES NC(C\C=C(\c1ccc(cc1)-c1ccccc1)c1ccc(F)cc1F)C([O-])=O
Show InChI InChI=1S/C23H19F2NO2/c24-18-10-11-20(21(25)14-18)19(12-13-22(26)23(27)28)17-8-6-16(7-9-17)15-4-2-1-3-5-15/h1-12,14,22H,13,26H2,(H,27,28)/p-1/b19-12-
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n/an/a 2.40E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099872
PNG
(CHEMBL285592 | Sodium; (E)-2-amino-5-(4-cyano-phen...)
Show SMILES CC(C)c1ccc(cc1)C(=C/CC(N)C([O-])=O)\c1ccc(cc1)C#N
Show InChI InChI=1S/C21H22N2O2/c1-14(2)16-7-9-18(10-8-16)19(11-12-20(23)21(24)25)17-5-3-15(13-22)4-6-17/h3-11,14,20H,12,23H2,1-2H3,(H,24,25)/p-1/b19-11-
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n/an/a 2.64E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50360091
PNG
(CHEMBL1928738)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2ncccc12
Show InChI InChI=1S/C25H20N4/c1-2-24-27-28-25(20-15-13-19(14-16-20)18-8-4-3-5-9-18)29(24)23-12-6-11-22-21(23)10-7-17-26-22/h3-17H,2H2,1H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099870
PNG
(CHEMBL29022 | Sodium; (E)-2-amino-5-biphenyl-2-yl-...)
Show SMILES NC(C\C=C(\c1ccc(F)cc1F)c1ccccc1-c1ccccc1)C([O-])=O
Show InChI InChI=1S/C23H19F2NO2/c24-16-10-11-20(21(25)14-16)19(12-13-22(26)23(27)28)18-9-5-4-8-17(18)15-6-2-1-3-7-15/h1-12,14,22H,13,26H2,(H,27,28)/p-1/b19-12+
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n/an/a 2.75E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50439740
PNG
(CHEMBL2419428)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(CO)c1C
Show InChI InChI=1S/C24H23N3O/c1-3-23-25-26-24(27(23)22-11-7-10-21(16-28)17(22)2)20-14-12-19(13-15-20)18-8-5-4-6-9-18/h4-15,28H,3,16H2,1-2H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335011
PNG
(3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-...)
Show SMILES CC(C)c1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C23H20FN3/c1-16(2)22-25-26-23(27(22)21-11-7-6-10-20(21)24)19-14-12-18(13-15-19)17-8-4-3-5-9-17/h3-16H,1-2H3
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n/an/a 3.30E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50335011
PNG
(3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-...)
Show SMILES CC(C)c1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F
Show InChI InChI=1S/C23H20FN3/c1-16(2)22-25-26-23(27(22)21-11-7-6-10-20(21)24)19-14-12-18(13-15-19)17-8-4-3-5-9-17/h3-16H,1-2H3
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n/an/a 3.30E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50099877
PNG
(CHEMBL29396 | Sodium; (E)-2-amino-5-biphenyl-4-yl-...)
Show SMILES NC(C\C=C(/c1ccc(cc1)-c1ccccc1)c1ccc(F)cc1F)C([O-])=O
Show InChI InChI=1S/C23H19F2NO2/c24-18-10-11-20(21(25)14-18)19(12-13-22(26)23(27)28)17-8-6-16(7-9-17)15-4-2-1-3-5-15/h1-12,14,22H,13,26H2,(H,27,28)/p-1/b19-12+
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n/an/a 3.66E+3n/an/an/an/an/an/a



NPS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...


Bioorg Med Chem Lett 11: 1371-3 (2001)

More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50360092
PNG
(CHEMBL1928736)
Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2ccncc12
Show InChI InChI=1S/C25H20N4/c1-2-24-27-28-25(21-13-11-19(12-14-21)18-7-4-3-5-8-18)29(24)23-10-6-9-20-15-16-26-17-22(20)23/h3-17H,2H2,1H3
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n/an/a 4.20E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
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