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Compile Data Set for Download or QSAR

Found 484 hits Enz. Inhib. hit(s) with Target = 'Glycine transporter 2' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 2


(HUMAN)
BDBM50122872
PNG
(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Show SMILES COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(N)c2CCOc12
Show InChI InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



Janssen Research Foundation

Curated by PDSP Ki Database




Eur J Pharmacol 423: 71-83 (2001)


BindingDB Entry DOI: 10.7270/Q23T9FSX
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023929
PNG
(CHEMBL3325502)
Show SMILES CN(C)CCCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H32F3N3O2/c1-30(2)14-3-15-31-16-12-22(13-17-31)29-24(32)20-6-4-19(5-7-20)18-33-23-10-8-21(9-11-23)25(26,27)28/h4-11,22H,3,12-18H2,1-2H3,(H,29,32)
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n/an/a 15n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50102692
PNG
(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)
Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCC1)N(C)C
Show InChI InChI=1S/C24H32N2O4/c1-26(2)24(12-8-9-13-24)17-25-23(27)19-14-20(28-3)22(21(15-19)29-4)30-16-18-10-6-5-7-11-18/h5-7,10-11,14-15H,8-9,12-13,16-17H2,1-4H3,(H,25,27)
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n/an/a 16n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Glycine Transporter type-2


J Med Chem 44: 2679-82 (2001)


Article DOI: 10.1021/jm0011272
BindingDB Entry DOI: 10.7270/Q2DN44BJ
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138590
PNG
(2-(7-Hydroxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl...)
Show SMILES Oc1ccc2CCN(Cc3ccccc3C(=O)NCC\C=C\c3ccccc3)Cc2c1
Show InChI InChI=1S/C27H28N2O2/c30-25-14-13-22-15-17-29(20-24(22)18-25)19-23-11-4-5-12-26(23)27(31)28-16-7-6-10-21-8-2-1-3-9-21/h1-6,8-14,18,30H,7,15-17,19-20H2,(H,28,31)/b10-6+
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n/an/a 24n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138578
PNG
(2-(7-Hydroxy-1-methyl-3,4-dihydro-1H-isoquinolin-2...)
Show SMILES CC1N(Cc2ccccc2C(=O)NCC\C=C\c2ccccc2)CCc2ccc(O)cc12
Show InChI InChI=1S/C28H30N2O2/c1-21-27-19-25(31)15-14-23(27)16-18-30(21)20-24-12-5-6-13-26(24)28(32)29-17-8-7-11-22-9-3-2-4-10-22/h2-7,9-15,19,21,31H,8,16-18,20H2,1H3,(H,29,32)/b11-7+
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n/an/a 30n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50203568
PNG
((1-(4-(6-((5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl...)
Show SMILES OCC1(CCCC1)N1CCN(CC1)C1CCc2ccc(OCc3noc(n3)-c3ccccc3F)cc12
Show InChI InChI=1S/C28H33FN4O3/c29-24-6-2-1-5-22(24)27-30-26(31-36-27)18-35-21-9-7-20-8-10-25(23(20)17-21)32-13-15-33(16-14-32)28(19-34)11-3-4-12-28/h1-2,5-7,9,17,25,34H,3-4,8,10-16,18-19H2
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n/an/a 32n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 1675-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.109
BindingDB Entry DOI: 10.7270/Q25H7FXG
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138594
PNG
(2-(5-Hydroxy-1,3-dihydro-isoindol-2-ylmethyl)-N-(4...)
Show SMILES Oc1ccc2CN(Cc3ccccc3C(=O)NCC\C=C\c3ccccc3)Cc2c1
Show InChI InChI=1S/C26H26N2O2/c29-24-14-13-21-17-28(19-23(21)16-24)18-22-11-4-5-12-25(22)26(30)27-15-7-6-10-20-8-2-1-3-9-20/h1-6,8-14,16,29H,7,15,17-19H2,(H,27,30)/b10-6+
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n/an/a 33n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138558
PNG
(2-[(6-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylam...)
Show SMILES Oc1ccc2CC(CCc2c1)NCc1ccccc1C(=O)NCC\C=C\c1ccccc1
Show InChI InChI=1S/C28H30N2O2/c31-26-16-14-22-18-25(15-13-23(22)19-26)30-20-24-11-4-5-12-27(24)28(32)29-17-7-6-10-21-8-2-1-3-9-21/h1-6,8-12,14,16,19,25,30-31H,7,13,15,17-18,20H2,(H,29,32)/b10-6+
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n/an/a 43n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023797
PNG
(CHEMBL3325511)
Show SMILES FC(F)(F)c1ccc(OCc2ccc(cc2)C(=O)NC2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C26H26F3N3O2/c27-26(28,29)22-7-9-24(10-8-22)34-18-19-3-5-21(6-4-19)25(33)31-23-11-14-32(15-12-23)17-20-2-1-13-30-16-20/h1-10,13,16,23H,11-12,14-15,17-18H2,(H,31,33)
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n/an/a 52n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138584
PNG
(2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-((E...)
Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCC\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C26H28N2O2/c29-24-15-13-22(14-16-24)17-19-27-20-23-11-4-5-12-25(23)26(30)28-18-7-6-10-21-8-2-1-3-9-21/h1-6,8-16,27,29H,7,17-20H2,(H,28,30)/b10-6+
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n/an/a 56n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138559
PNG
(2-(7-Hydroxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-y...)
Show SMILES Oc1ccc2CCN(Cc3ccccc3C(=O)NCC\C=C\c3ccccc3)CCc2c1
Show InChI InChI=1S/C28H30N2O2/c31-26-14-13-23-15-18-30(19-16-24(23)20-26)21-25-11-4-5-12-27(25)28(32)29-17-7-6-10-22-8-2-1-3-9-22/h1-6,8-14,20,31H,7,15-19,21H2,(H,29,32)/b10-6+
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n/an/a 58n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023926
PNG
(CHEMBL3325505)
Show SMILES FC(F)(F)c1ccc(OCc2ccc(cc2)C(=O)NC2CCN(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C27H27F3N2O2/c28-27(29,30)23-10-12-25(13-11-23)34-19-21-6-8-22(9-7-21)26(33)31-24-14-16-32(17-15-24)18-20-4-2-1-3-5-20/h1-13,24H,14-19H2,(H,31,33)
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n/an/a 62n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023866
PNG
(CHEMBL3325509)
Show SMILES OCCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H25F3N2O3/c23-22(24,25)18-5-7-20(8-6-18)30-15-16-1-3-17(4-2-16)21(29)26-19-9-11-27(12-10-19)13-14-28/h1-8,19,28H,9-15H2,(H,26,29)
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n/an/a 66n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138556
PNG
(2-(7-Hydroxy-3-methyl-3,4-dihydro-1H-isoquinolin-2...)
Show SMILES CC1Cc2ccc(O)cc2CN1Cc1ccccc1C(=O)NCC\C=C\c1ccccc1
Show InChI InChI=1S/C28H30N2O2/c1-21-17-23-14-15-26(31)18-25(23)20-30(21)19-24-12-5-6-13-27(24)28(32)29-16-8-7-11-22-9-3-2-4-10-22/h2-7,9-15,18,21,31H,8,16-17,19-20H2,1H3,(H,29,32)/b11-7+
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n/an/a 67n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023928
PNG
(CHEMBL3325503)
Show SMILES CN(C)CCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C24H30F3N3O2/c1-29(2)15-16-30-13-11-21(12-14-30)28-23(31)19-5-3-18(4-6-19)17-32-22-9-7-20(8-10-22)24(25,26)27/h3-10,21H,11-17H2,1-2H3,(H,28,31)
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n/an/a 71n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50102687
PNG
(4-Butoxy-N-(1-dimethylamino-cyclopentylmethyl)-3,5...)
Show SMILES CCCCOc1c(OC)cc(cc1OC)C(=O)NCC1(CCCC1)N(C)C
Show InChI InChI=1S/C21H34N2O4/c1-6-7-12-27-19-17(25-4)13-16(14-18(19)26-5)20(24)22-15-21(23(2)3)10-8-9-11-21/h13-14H,6-12,15H2,1-5H3,(H,22,24)
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n/an/a 77n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Glycine Transporter type-2


J Med Chem 44: 2679-82 (2001)


Article DOI: 10.1021/jm0011272
BindingDB Entry DOI: 10.7270/Q2DN44BJ
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138565
PNG
(CHEMBL348200 | N-[4-(4-Chloro-phenyl)-butyl]-2-{[2...)
Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCCCCc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C26H29ClN2O2/c27-23-12-8-20(9-13-23)5-3-4-17-29-26(31)25-7-2-1-6-22(25)19-28-18-16-21-10-14-24(30)15-11-21/h1-2,6-15,28,30H,3-5,16-19H2,(H,29,31)
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n/an/a 77n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023930
PNG
(CHEMBL3325501)
Show SMILES CN1CCC(CC1)N1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H32F3N3O2/c1-31-14-12-23(13-15-31)32-16-10-22(11-17-32)30-25(33)20-4-2-19(3-5-20)18-34-24-8-6-21(7-9-24)26(27,28)29/h2-9,22-23H,10-18H2,1H3,(H,30,33)
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n/an/a 80n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138555
PNG
(2-[(6-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylam...)
Show SMILES Oc1ccc2CC(CCc2c1)NCc1ccccc1C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C28H32N2O2/c31-26-16-14-22-18-25(15-13-23(22)19-26)30-20-24-11-4-5-12-27(24)28(32)29-17-7-6-10-21-8-2-1-3-9-21/h1-5,8-9,11-12,14,16,19,25,30-31H,6-7,10,13,15,17-18,20H2,(H,29,32)
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n/an/a 81n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50102688
PNG
(4-Benzyloxy-N-(1-dimethylamino-cyclohexylmethyl)-3...)
Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCCC1)N(C)C
Show InChI InChI=1S/C25H34N2O4/c1-27(2)25(13-9-6-10-14-25)18-26-24(28)20-15-21(29-3)23(22(16-20)30-4)31-17-19-11-7-5-8-12-19/h5,7-8,11-12,15-16H,6,9-10,13-14,17-18H2,1-4H3,(H,26,28)
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n/an/a 84n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Glycine Transporter type-2


J Med Chem 44: 2679-82 (2001)


Article DOI: 10.1021/jm0011272
BindingDB Entry DOI: 10.7270/Q2DN44BJ
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138561
PNG
(2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-(4-...)
Show SMILES Cc1ccc(CCCCNC(=O)c2ccccc2CNCCc2ccc(O)cc2)cc1
Show InChI InChI=1S/C27H32N2O2/c1-21-9-11-22(12-10-21)6-4-5-18-29-27(31)26-8-3-2-7-24(26)20-28-19-17-23-13-15-25(30)16-14-23/h2-3,7-16,28,30H,4-6,17-20H2,1H3,(H,29,31)
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n/an/a 86n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138569
PNG
(2-(7-Hydroxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl...)
Show SMILES Oc1ccc2CCN(Cc3ccccc3C(=O)NCCCCc3ccccc3)Cc2c1
Show InChI InChI=1S/C27H30N2O2/c30-25-14-13-22-15-17-29(20-24(22)18-25)19-23-11-4-5-12-26(23)27(31)28-16-7-6-10-21-8-2-1-3-9-21/h1-5,8-9,11-14,18,30H,6-7,10,15-17,19-20H2,(H,28,31)
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n/an/a 89n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138572
PNG
(CHEMBL153410 | N-[4-(3-Chloro-phenyl)-butyl]-2-{[2...)
Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCCCCc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C26H29ClN2O2/c27-23-9-5-7-21(18-23)6-3-4-16-29-26(31)25-10-2-1-8-22(25)19-28-17-15-20-11-13-24(30)14-12-20/h1-2,5,7-14,18,28,30H,3-4,6,15-17,19H2,(H,29,31)
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n/an/a 99n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023874
PNG
(CHEMBL3325508)
Show SMILES FCCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H24F4N2O2/c23-11-14-28-12-9-19(10-13-28)27-21(29)17-3-1-16(2-4-17)15-30-20-7-5-18(6-8-20)22(24,25)26/h1-8,19H,9-15H2,(H,27,29)
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n/an/a 99n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023924
PNG
(CHEMBL3325507)
Show SMILES CN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N2O2/c1-26-12-10-18(11-13-26)25-20(27)16-4-2-15(3-5-16)14-28-19-8-6-17(7-9-19)21(22,23)24/h2-9,18H,10-14H2,1H3,(H,25,27)
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n/an/a 105n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023925
PNG
(CHEMBL3325506)
Show SMILES CCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H25F3N2O2/c1-2-27-13-11-19(12-14-27)26-21(28)17-5-3-16(4-6-17)15-29-20-9-7-18(8-10-20)22(23,24)25/h3-10,19H,2,11-15H2,1H3,(H,26,28)
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n/an/a 107n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023993
PNG
(CHEMBL3325495)
Show SMILES CN1CCC(CC1)N1CCC(C1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H30F3N3O2/c1-30-13-11-22(12-14-30)31-15-10-21(16-31)29-24(32)19-4-2-18(3-5-19)17-33-23-8-6-20(7-9-23)25(26,27)28/h2-9,21-22H,10-17H2,1H3,(H,29,32)
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n/an/a 112n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023932
PNG
(CHEMBL3325499)
Show SMILES CN1CCC(CC1)N1CC[C@@H](C1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H30F3N3O2/c1-30-13-11-22(12-14-30)31-15-10-21(16-31)29-24(32)19-4-2-18(3-5-19)17-33-23-8-6-20(7-9-23)25(26,27)28/h2-9,21-22H,10-17H2,1H3,(H,29,32)/t21-/m0/s1
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n/an/a 115n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138587
PNG
(CHEMBL348211 | N-[4-(3,4-Dichloro-phenyl)-butyl]-2...)
Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCCCCc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C26H28Cl2N2O2/c27-24-13-10-20(17-25(24)28)5-3-4-15-30-26(32)23-7-2-1-6-21(23)18-29-16-14-19-8-11-22(31)12-9-19/h1-2,6-13,17,29,31H,3-5,14-16,18H2,(H,30,32)
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n/an/a 120n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138575
PNG
(2-[(2-Hydroxy-6,7,8,9-tetrahydro-5H-benzocyclohept...)
Show SMILES Oc1ccc2CC(CCCc2c1)NCc1ccccc1C(=O)NCC\C=C\c1ccccc1
Show InChI InChI=1S/C29H32N2O2/c32-27-17-16-24-19-26(14-8-13-23(24)20-27)31-21-25-12-4-5-15-28(25)29(33)30-18-7-6-11-22-9-2-1-3-10-22/h1-6,9-12,15-17,20,26,31-32H,7-8,13-14,18-19,21H2,(H,30,33)/b11-6+
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n/an/a 130n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138576
PNG
(2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-[4-...)
Show SMILES COc1ccc(CCCCNC(=O)c2ccccc2CNCCc2ccc(O)cc2)cc1
Show InChI InChI=1S/C27H32N2O3/c1-32-25-15-11-21(12-16-25)6-4-5-18-29-27(31)26-8-3-2-7-23(26)20-28-19-17-22-9-13-24(30)14-10-22/h2-3,7-16,28,30H,4-6,17-20H2,1H3,(H,29,31)
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n/an/a 130n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138592
PNG
(2-(6-Hydroxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl...)
Show SMILES Oc1ccc2CN(Cc3ccccc3C(=O)NCC\C=C\c3ccccc3)CCc2c1
Show InChI InChI=1S/C27H28N2O2/c30-25-14-13-23-19-29(17-15-22(23)18-25)20-24-11-4-5-12-26(24)27(31)28-16-7-6-10-21-8-2-1-3-9-21/h1-6,8-14,18,30H,7,15-17,19-20H2,(H,28,31)/b10-6+
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n/an/a 130n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138564
PNG
(2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-(4-...)
Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCCC#Cc2ccccc2)cc1
Show InChI InChI=1S/C26H26N2O2/c29-24-15-13-22(14-16-24)17-19-27-20-23-11-4-5-12-25(23)26(30)28-18-7-6-10-21-8-2-1-3-9-21/h1-5,8-9,11-16,27,29H,7,17-20H2,(H,28,30)
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n/an/a 140n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138562
PNG
(2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-[4-...)
Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCCCCc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H29F3N2O2/c28-27(29,30)23-12-8-20(9-13-23)5-3-4-17-32-26(34)25-7-2-1-6-22(25)19-31-18-16-21-10-14-24(33)15-11-21/h1-2,6-15,31,33H,3-5,16-19H2,(H,32,34)
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n/an/a 140n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138596
PNG
(2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-(4-...)
Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCCCCc2ccccc2)cc1
Show InChI InChI=1S/C26H30N2O2/c29-24-15-13-22(14-16-24)17-19-27-20-23-11-4-5-12-25(23)26(30)28-18-7-6-10-21-8-2-1-3-9-21/h1-5,8-9,11-16,27,29H,6-7,10,17-20H2,(H,28,30)
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n/an/a 170n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023824
PNG
(CHEMBL3325510)
Show SMILES OCCCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H27F3N2O3/c24-23(25,26)19-6-8-21(9-7-19)31-16-17-2-4-18(5-3-17)22(30)27-20-10-13-28(14-11-20)12-1-15-29/h2-9,20,29H,1,10-16H2,(H,27,30)
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n/an/a 181n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50102685
PNG
(4-Butoxy-N-(1-dimethylamino-cyclohexylmethyl)-3,5-...)
Show SMILES CCCCOc1c(OC)cc(cc1OC)C(=O)NCC1(CCCCC1)N(C)C
Show InChI InChI=1S/C22H36N2O4/c1-6-7-13-28-20-18(26-4)14-17(15-19(20)27-5)21(25)23-16-22(24(2)3)11-9-8-10-12-22/h14-15H,6-13,16H2,1-5H3,(H,23,25)
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n/an/a 214n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Glycine Transporter type-2


J Med Chem 44: 2679-82 (2001)


Article DOI: 10.1021/jm0011272
BindingDB Entry DOI: 10.7270/Q2DN44BJ
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50024121
PNG
(CHEMBL3325490)
Show SMILES CN1CCC(CC1)N1CCC(C1)NC(=O)c1ccc(COc2ccc(cc2)C(C)(C)C)cc1
Show InChI InChI=1S/C28H39N3O2/c1-28(2,3)23-9-11-26(12-10-23)33-20-21-5-7-22(8-6-21)27(32)29-24-13-18-31(19-24)25-14-16-30(4)17-15-25/h5-12,24-25H,13-20H2,1-4H3,(H,29,32)
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n/an/a 250n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138586
PNG
(2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-((Z...)
Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCC\C=C/c2ccccc2)cc1
Show InChI InChI=1S/C26H28N2O2/c29-24-15-13-22(14-16-24)17-19-27-20-23-11-4-5-12-25(23)26(30)28-18-7-6-10-21-8-2-1-3-9-21/h1-6,8-16,27,29H,7,17-20H2,(H,28,30)/b10-6-
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n/an/a 300n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50203566
PNG
((1-(3-(7-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Show SMILES OCC1CCCN(CCCC2CCCc3ccc(OCc4noc(n4)-c4ccc(Cl)cc4)cc23)C1
Show InChI InChI=1S/C28H34ClN3O3/c29-24-11-8-23(9-12-24)28-30-27(31-35-28)19-34-25-13-10-22-6-1-5-21(26(22)16-25)7-3-15-32-14-2-4-20(17-32)18-33/h8-13,16,20-21,33H,1-7,14-15,17-19H2
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n/an/a 319n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 1675-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.109
BindingDB Entry DOI: 10.7270/Q25H7FXG
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138579
PNG
(2-(7-Hydroxy-1,3,4,5-tetrahydro-benzo[c]azepin-2-y...)
Show SMILES Oc1ccc2CN(Cc3ccccc3C(=O)NCC\C=C\c3ccccc3)CCCc2c1
Show InChI InChI=1S/C28H30N2O2/c31-26-16-15-24-20-30(18-8-13-23(24)19-26)21-25-12-4-5-14-27(25)28(32)29-17-7-6-11-22-9-2-1-3-10-22/h1-6,9-12,14-16,19,31H,7-8,13,17-18,20-21H2,(H,29,32)/b11-6+
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n/an/a 320n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138566
PNG
(2-{[2-(3-Hydroxy-phenyl)-ethylamino]-methyl}-N-(4-...)
Show SMILES Oc1cccc(CCNCc2ccccc2C(=O)NCCCCc2ccccc2)c1
Show InChI InChI=1S/C26H30N2O2/c29-24-14-8-12-22(19-24)16-18-27-20-23-13-4-5-15-25(23)26(30)28-17-7-6-11-21-9-2-1-3-10-21/h1-5,8-10,12-15,19,27,29H,6-7,11,16-18,20H2,(H,28,30)
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n/an/a 330n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023927
PNG
(CHEMBL3325504)
Show SMILES CCCCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C24H29F3N2O2/c1-2-3-14-29-15-12-21(13-16-29)28-23(30)19-6-4-18(5-7-19)17-31-22-10-8-20(9-11-22)24(25,26)27/h4-11,21H,2-3,12-17H2,1H3,(H,28,30)
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n/an/a 330n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023935
PNG
(CHEMBL3325498)
Show SMILES CN1CCC(CC1)N1CCC(C1)NC(=O)c1ccc(COc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C24H29Cl2N3O2/c1-28-11-9-20(10-12-28)29-13-8-19(15-29)27-24(30)18-4-2-17(3-5-18)16-31-21-6-7-22(25)23(26)14-21/h2-7,14,19-20H,8-13,15-16H2,1H3,(H,27,30)
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n/an/a 361n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023931
PNG
(CHEMBL3325500)
Show SMILES CN1CCC(CC1)N1CC[C@H](C1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H30F3N3O2/c1-30-13-11-22(12-14-30)31-15-10-21(16-31)29-24(32)19-4-2-18(3-5-19)17-33-23-8-6-20(7-9-23)25(26,27)28/h2-9,21-22H,10-17H2,1H3,(H,29,32)/t21-/m1/s1
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n/an/a 363n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50138554
PNG
(2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-[4-...)
Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCCCCc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C27H29F3N2O3/c28-27(29,30)35-24-14-10-20(11-15-24)5-3-4-17-32-26(34)25-7-2-1-6-22(25)19-31-18-16-21-8-12-23(33)13-9-21/h1-2,6-15,31,33H,3-5,16-19H2,(H,32,34)
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n/an/a 370n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line


Bioorg Med Chem Lett 14: 545-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.080
BindingDB Entry DOI: 10.7270/Q2M9083Z
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50203575
PNG
((1-(3-(7-((5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl...)
Show SMILES OCC1CCCN(CCCC2CCCc3ccc(OCc4noc(n4)-c4ccccc4F)cc23)C1
Show InChI InChI=1S/C28H34FN3O3/c29-26-11-2-1-10-24(26)28-30-27(31-35-28)19-34-23-13-12-22-8-3-7-21(25(22)16-23)9-5-15-32-14-4-6-20(17-32)18-33/h1-2,10-13,16,20-21,33H,3-9,14-15,17-19H2
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n/an/a 385n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 1675-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.109
BindingDB Entry DOI: 10.7270/Q25H7FXG
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50203569
PNG
((1-(3-(7-((5-(2-fluorophenyl)pyridin-2-yl)methoxy)...)
Show SMILES OCC1CCCN(CCCC2CCCc3ccc(OCc4ccc(cn4)-c4ccccc4F)cc23)C1
Show InChI InChI=1S/C31H37FN2O2/c32-31-11-2-1-10-29(31)26-12-14-27(33-19-26)22-36-28-15-13-25-8-3-7-24(30(25)18-28)9-5-17-34-16-4-6-23(20-34)21-35/h1-2,10-15,18-19,23-24,35H,3-9,16-17,20-22H2
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n/an/a 401n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 1675-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.109
BindingDB Entry DOI: 10.7270/Q25H7FXG
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50023973
PNG
(CHEMBL3325496)
Show SMILES CN1CCC(CC1)N1CCC(C1)NC(=O)c1ccc(COc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C24H29Cl2N3O2/c1-28-11-9-21(10-12-28)29-13-8-20(15-29)27-24(30)18-4-2-17(3-5-18)16-31-23-7-6-19(25)14-22(23)26/h2-7,14,20-21H,8-13,15-16H2,1H3,(H,27,30)
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n/an/a 431n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50024017
PNG
(CHEMBL3325494)
Show SMILES CN1CCC(CC1)N1CCC(C1)NC(=O)c1ccc(COc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C24H30ClN3O2/c1-27-13-11-22(12-14-27)28-15-10-21(16-28)26-24(29)19-4-2-18(3-5-19)17-30-23-8-6-20(25)7-9-23/h2-9,21-22H,10-17H2,1H3,(H,26,29)
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n/an/a 440n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs


Bioorg Med Chem Lett 24: 4603-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1
More data for this
Ligand-Target Pair
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