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Found 696 hits Enz. Inhib. hit(s) with Target = 'Glycogen Phosphorylase (PYGL)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50031485
PNG
((2R,3R,4R)-2-Hydroxymethyl-pyrrolidine-3,4-diol | ...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5-/m1/s1
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PubMed
400n/an/an/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Inhibitory activity against pig Liver glycogen phosphorylase a


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50211296
PNG
((7R,8S,9S,10R)-8,9,10-trihydroxy-7-hydroxymethyl-6...)
Show SMILES OC[C@H]1OC2(NC(=O)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2-,3-,4+,5-,8?/m1/s1
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4.20E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of liver glycogen phosphorylase B


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50211294
PNG
((7R,8S,9S,10R)-8,9,10-trihydroxy-7-hydroxymethyl-2...)
Show SMILES OC[C@H]1OC2(NC(=S)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O6S/c11-1-2-3(12)4(13)5(14)8(16-2)6(15)9-7(17)10-8/h2-5,11-14H,1H2,(H2,9,10,15,17)/t2-,3-,4+,5-,8?/m1/s1
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5.10E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of liver glycogen phosphorylase B


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50263769
PNG
((5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethy...)
Show SMILES OC[C@H]1O[C@@]2(NC(=S)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O6S/c11-1-2-3(12)4(13)5(14)8(16-2)6(15)9-7(17)10-8/h2-5,11-14H,1H2,(H2,9,10,15,17)/t2-,3-,4+,5-,8+/m1/s1
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1.09E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against muscle Glycogen Phosphorylase a


J Med Chem 44: 2843-8 (2001)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50211289
PNG
(5-[4-(6,7-dibromo-2,3-dihydrobenzo[1,4]dioxin-2-yl...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2COc3cc(Br)c(Br)cc3O2)cc1
Show InChI InChI=1S/C19H13Br2NO5S/c20-13-6-15-16(7-14(13)21)27-12(9-26-15)8-25-11-3-1-10(2-4-11)5-17-18(23)22-19(24)28-17/h1-7,12H,8-9H2,(H,22,23,24)
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1.20E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of liver glycogen phosphorylase B


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50263769
PNG
((5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethy...)
Show SMILES OC[C@H]1O[C@@]2(NC(=S)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O6S/c11-1-2-3(12)4(13)5(14)8(16-2)6(15)9-7(17)10-8/h2-5,11-14H,1H2,(H2,9,10,15,17)/t2-,3-,4+,5-,8+/m1/s1
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2.98E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against liver Glycogen Phosphorylase a


J Med Chem 44: 2843-8 (2001)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50211288
PNG
(5-[4-(6,7-dibromo-2,3-dihydrobenzo[1,4]dioxin-2-yl...)
Show SMILES COc1cc(C=C2SC(O)=NC2=O)ccc1OCC1COc2cc(Br)c(Br)cc2O1
Show InChI InChI=1S/C20H15Br2NO6S/c1-26-15-4-10(5-18-19(24)23-20(25)30-18)2-3-14(15)27-8-11-9-28-16-6-12(21)13(22)7-17(16)29-11/h2-7,11H,8-9H2,1H3,(H,23,24,25)
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3.00E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of liver glycogen phosphorylase B


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50211286
PNG
(5-[4-(6-bromo-2,3-dihydrobenzo[1,4]dioxin-2-ylmeth...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2COc3cc(Br)ccc3O2)cc1
Show InChI InChI=1S/C19H14BrNO5S/c20-12-3-6-15-16(8-12)25-10-14(26-15)9-24-13-4-1-11(2-5-13)7-17-18(22)21-19(23)27-17/h1-8,14H,9-10H2,(H,21,22,23)
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8.00E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of liver glycogen phosphorylase B


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50351158
PNG
(CHEMBL423707)
Show SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
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4.90E+6n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase a (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50135554
PNG
(4-{3-[(4-Nitro-pyridine-2-carbonyl)-amino]-naphtha...)
Show SMILES OC(=O)c1ccc(Oc2cc3ccccc3cc2NC(=O)c2cc(ccn2)[N+]([O-])=O)cc1C(O)=O
Show InChI InChI=1S/C24H15N3O8/c28-22(20-11-15(27(33)34)7-8-25-20)26-19-9-13-3-1-2-4-14(13)10-21(19)35-16-5-6-17(23(29)30)18(12-16)24(31)32/h1-12H,(H,26,28)(H,29,30)(H,31,32)
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n/an/a 1n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HLGP(human liver glycogen phosphorylase)


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50135558
PNG
(4-{3-Fluoro-2-[(4-nitro-pyridine-2-carbonyl)-amino...)
Show SMILES OC(=O)c1ccc(Oc2cccc(F)c2NC(=O)c2cc(ccn2)[N+]([O-])=O)cc1C(O)=O
Show InChI InChI=1S/C20H12FN3O8/c21-14-2-1-3-16(32-11-4-5-12(19(26)27)13(9-11)20(28)29)17(14)23-18(25)15-8-10(24(30)31)6-7-22-15/h1-9H,(H,23,25)(H,26,27)(H,28,29)
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n/an/a 1n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HLGP(human liver glycogen phosphorylase)


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50133440
PNG
(1-(4-Chloro-benzyl)-4-(2-chloro-phenyl)-6-methyl-1...)
Show SMILES CC(C)OC(=O)C1=C(C)N(Cc2ccc(Cl)cc2)C(C(O)=O)=C(C1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H23Cl2NO6/c1-13(2)34-25(33)19-14(3)28(12-15-8-10-16(26)11-9-15)22(24(31)32)21(23(29)30)20(19)17-6-4-5-7-18(17)27/h4-11,13,20H,12H2,1-3H3,(H,29,30)(H,31,32)
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n/an/a 2n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)


Bioorg Med Chem Lett 13: 3405-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50135553
PNG
(4-{3-[(4-Chloro-pyridine-2-carbonyl)-amino]-naphth...)
Show SMILES OC(=O)c1ccc(Oc2cc3ccccc3cc2NC(=O)c2cc(Cl)ccn2)cc1C(O)=O
Show InChI InChI=1S/C24H15ClN2O6/c25-15-7-8-26-20(11-15)22(28)27-19-9-13-3-1-2-4-14(13)10-21(19)33-16-5-6-17(23(29)30)18(12-16)24(31)32/h1-12H,(H,27,28)(H,29,30)(H,31,32)
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n/an/a 2n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HLGP(human liver glycogen phosphorylase)


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24393
PNG
(2,3-dichloro-N-{1-[(2R)-2,3-dihydroxypropyl]-2-oxo...)
Show SMILES OC[C@H](O)CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1
Show InChI InChI=1S/C19H17Cl2N3O4S/c20-15-16-14(29-17(15)21)6-11(22-16)18(27)23-12-5-9-3-1-2-4-13(9)24(19(12)28)7-10(26)8-25/h1-4,6,10,12,22,25-26H,5,7-8H2,(H,23,27)/t10-,12?/m1/s1
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n/an/a 2n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50135565
PNG
(4-{3-[(4-Methoxy-pyridine-2-carbonyl)-amino]-napht...)
Show SMILES COc1ccnc(c1)C(=O)Nc1cc2ccccc2cc1Oc1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C25H18N2O7/c1-33-16-8-9-26-21(13-16)23(28)27-20-10-14-4-2-3-5-15(14)11-22(20)34-17-6-7-18(24(29)30)19(12-17)25(31)32/h2-13H,1H3,(H,27,28)(H,29,30)(H,31,32)
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n/an/a 2n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HLGP(human liver glycogen phosphorylase)


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27730
PNG
((2S,3R)-3-(tert-butoxy)-2-{[4-(4-methoxyphenyl)-2-...)
Show SMILES COc1ccc(cc1)-c1ccc(C(=O)N[C@@H]([C@@H](C)OC(C)(C)C)C(O)=O)c(NC(=O)Nc2c(C)cc(C)cc2C)c1
Show InChI InChI=1S/C32H39N3O6/c1-18-15-19(2)27(20(3)16-18)35-31(39)33-26-17-23(22-9-12-24(40-8)13-10-22)11-14-25(26)29(36)34-28(30(37)38)21(4)41-32(5,6)7/h9-17,21,28H,1-8H3,(H,34,36)(H,37,38)(H2,33,35,39)/t21-,28+/m1/s1
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n/an/a 3n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27747
PNG
((2S,3R)-3-(tert-butoxy)-2-{[2-({[4-(cyclopropylmet...)
Show SMILES C[C@@H](OC(C)(C)C)[C@H](NC(=O)c1ccc(cc1NC(=O)Nc1c(C)cc(CC2CC2)cc1C)-c1cccc(F)c1)C(O)=O
Show InChI InChI=1S/C34H40FN3O5/c1-19-14-23(16-22-10-11-22)15-20(2)29(19)38-33(42)36-28-18-25(24-8-7-9-26(35)17-24)12-13-27(28)31(39)37-30(32(40)41)21(3)43-34(4,5)6/h7-9,12-15,17-18,21-22,30H,10-11,16H2,1-6H3,(H,37,39)(H,40,41)(H2,36,38,42)/t21-,30+/m1/s1
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n/an/a 3n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50135562
PNG
(4-{2-[(4-Nitro-pyridine-2-carbonyl)-amino]-phenoxy...)
Show SMILES OC(=O)c1ccc(Oc2ccccc2NC(=O)c2cc(ccn2)[N+]([O-])=O)cc1C(O)=O
Show InChI InChI=1S/C20H13N3O8/c24-18(16-9-11(23(29)30)7-8-21-16)22-15-3-1-2-4-17(15)31-12-5-6-13(19(25)26)14(10-12)20(27)28/h1-10H,(H,22,24)(H,25,26)(H,27,28)
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n/an/a 3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HLGP(human liver glycogen phosphorylase)


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27743
PNG
((2S,3R)-3-(tert-butoxy)-2-{[2-({[4-(cyclopropylmet...)
Show SMILES C[C@@H](OC(C)(C)C)[C@H](NC(=O)c1ccc(F)cc1NC(=O)Nc1c(C)cc(CC2CC2)cc1C)C(O)=O
Show InChI InChI=1S/C28H36FN3O5/c1-15-11-19(13-18-7-8-18)12-16(2)23(15)32-27(36)30-22-14-20(29)9-10-21(22)25(33)31-24(26(34)35)17(3)37-28(4,5)6/h9-12,14,17-18,24H,7-8,13H2,1-6H3,(H,31,33)(H,34,35)(H2,30,32,36)/t17-,24+/m1/s1
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n/an/a 4n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27745
PNG
((2S,3R)-3-(tert-butoxy)-2-[(2-{[(2,6-dimethyl-4-pr...)
Show SMILES CCCc1cc(C)c(NC(=O)Nc2cc(ccc2C(=O)N[C@@H]([C@@H](C)OC(C)(C)C)C(O)=O)-c2ccc(OC)cc2)c(C)c1
Show InChI InChI=1S/C34H43N3O6/c1-9-10-23-17-20(2)29(21(3)18-23)37-33(41)35-28-19-25(24-11-14-26(42-8)15-12-24)13-16-27(28)31(38)36-30(32(39)40)22(4)43-34(5,6)7/h11-19,22,30H,9-10H2,1-8H3,(H,36,38)(H,39,40)(H2,35,37,41)/t22-,30+/m1/s1
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n/an/a 4n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50135557
PNG
(4-{3-[(4-Ethyl-pyridine-2-carbonyl)-amino]-naphtha...)
Show SMILES CCc1ccnc(c1)C(=O)Nc1cc2ccccc2cc1Oc1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C26H20N2O6/c1-2-15-9-10-27-22(11-15)24(29)28-21-12-16-5-3-4-6-17(16)13-23(21)34-18-7-8-19(25(30)31)20(14-18)26(32)33/h3-14H,2H2,1H3,(H,28,29)(H,30,31)(H,32,33)
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HLGP(human liver glycogen phosphorylase)


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50133438
PNG
(4-(2-Chloro-phenyl)-1-(3,4-dimethoxy-benzyl)-6-met...)
Show SMILES COc1ccc(CN2C(C)=C(C(C(C(O)=O)=C2C(O)=O)c2ccccc2Cl)C(=O)OC(C)C)cc1OC
Show InChI InChI=1S/C27H28ClNO8/c1-14(2)37-27(34)21-15(3)29(13-16-10-11-19(35-4)20(12-16)36-5)24(26(32)33)23(25(30)31)22(21)17-8-6-7-9-18(17)28/h6-12,14,22H,13H2,1-5H3,(H,30,31)(H,32,33)
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)


Bioorg Med Chem Lett 13: 3405-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27746
PNG
((2S,3R)-3-(tert-butoxy)-2-[(2-{[(2,6-dimethyl-4-pr...)
Show SMILES CCCc1cc(C)c(NC(=O)Nc2cc(ccc2C(=O)N[C@@H]([C@@H](C)OC(C)(C)C)C(O)=O)-c2cccc(F)c2)c(C)c1
Show InChI InChI=1S/C33H40FN3O5/c1-8-10-22-15-19(2)28(20(3)16-22)37-32(41)35-27-18-24(23-11-9-12-25(34)17-23)13-14-26(27)30(38)36-29(31(39)40)21(4)42-33(5,6)7/h9,11-18,21,29H,8,10H2,1-7H3,(H,36,38)(H,39,40)(H2,35,37,41)/t21-,29+/m1/s1
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n/an/a 4n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50133442
PNG
(4-(2-Chloro-phenyl)-6-methyl-1-(3-nitro-benzyl)-1,...)
Show SMILES CC(C)OC(=O)C1=C(C)N(Cc2cccc(c2)[N+]([O-])=O)C(C(O)=O)=C(C1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H23ClN2O8/c1-13(2)36-25(33)19-14(3)27(12-15-7-6-8-16(11-15)28(34)35)22(24(31)32)21(23(29)30)20(19)17-9-4-5-10-18(17)26/h4-11,13,20H,12H2,1-3H3,(H,29,30)(H,31,32)
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n/an/a 5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)


Bioorg Med Chem Lett 13: 3405-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50194411
PNG
((S)-2,3-dichloro-N-(1-(dimethylamino)-1-oxo-3-phen...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1
Show InChI InChI=1S/C18H17Cl2N3O2S/c1-23(2)18(25)12(8-10-6-4-3-5-7-10)22-17(24)11-9-13-15(21-11)14(19)16(20)26-13/h3-7,9,12,21H,8H2,1-2H3,(H,22,24)/t12-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant human liver GPa by multienzyme coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50256329
PNG
(1-(3-(3-mesitylureido)-2-naphthamido)cyclooctaneca...)
Show SMILES Cc1cc(C)c(NC(=O)Nc2cc3ccccc3cc2C(=O)NC2(CCCCCCC2)C(O)=O)c(C)c1
Show InChI InChI=1S/C30H35N3O4/c1-19-15-20(2)26(21(3)16-19)32-29(37)31-25-18-23-12-8-7-11-22(23)17-24(25)27(34)33-30(28(35)36)13-9-5-4-6-10-14-30/h7-8,11-12,15-18H,4-6,9-10,13-14H2,1-3H3,(H,33,34)(H,35,36)(H2,31,32,37)
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n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucose


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50255975
PNG
((S)-2-cyclohexyl-2-(3-(3-(2,6-dichloro-4-(trifluor...)
Show SMILES OC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(Cl)cc(OC(F)(F)F)cc1Cl)C1CCCCC1
Show InChI InChI=1S/C27H24Cl2F3N3O5/c28-19-12-17(40-27(30,31)32)13-20(29)23(19)35-26(39)33-21-11-16-9-5-4-8-15(16)10-18(21)24(36)34-22(25(37)38)14-6-2-1-3-7-14/h4-5,8-14,22H,1-3,6-7H2,(H,34,36)(H,37,38)(H2,33,35,39)/t22-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucose


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50255977
PNG
((S)-2-cyclohexyl-2-(3-(3-mesitylureido)-2-naphtham...)
Show SMILES Cc1cc(C)c(NC(=O)Nc2cc3ccccc3cc2C(=O)N[C@@H](C2CCCCC2)C(O)=O)c(C)c1
Show InChI InChI=1S/C29H33N3O4/c1-17-13-18(2)25(19(3)14-17)32-29(36)30-24-16-22-12-8-7-11-21(22)15-23(24)27(33)31-26(28(34)35)20-9-5-4-6-10-20/h7-8,11-16,20,26H,4-6,9-10H2,1-3H3,(H,31,33)(H,34,35)(H2,30,32,36)/t26-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucose


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM39807
PNG
(CP-526,423)
Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)NCCOCCOCCNC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C25H27ClN4O4/c1-16-2-4-20-17(12-16)14-22(29-20)24(31)27-6-8-33-10-11-34-9-7-28-25(32)23-15-18-13-19(26)3-5-21(18)30-23/h2-5,12-15,29-30H,6-11H2,1H3,(H,27,31)(H,28,32)
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n/an/a 6n/an/an/an/a7.222



Pfizer Inc



Assay Description
Human liver glycogen phsphorylase (HLGP) activity was measured in the direction of glycogen synthesis by the release of phosphate from glucose-1-phos...


Chem Biol 7: 677-82 (2000)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50256669
PNG
((2S,3R)-2-(3-(3-mesitylureido)-2-naphthamido)-3-(1...)
Show SMILES C[C@@H](OC1(C)CCCC1)[C@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)C(O)=O
Show InChI InChI=1S/C31H37N3O5/c1-18-14-19(2)26(20(3)15-18)34-30(38)32-25-17-23-11-7-6-10-22(23)16-24(25)28(35)33-27(29(36)37)21(4)39-31(5)12-8-9-13-31/h6-7,10-11,14-17,21,27H,8-9,12-13H2,1-5H3,(H,33,35)(H,36,37)(H2,32,34,38)/t21-,27+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assay


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50149207
PNG
(2N-(2-{2-[2-(5-chloro-1H-2-indolylcarboxamido)etho...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)NCCOCCOCCNC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C24H24Cl2N4O4/c25-17-1-3-19-15(11-17)13-21(29-19)23(31)27-5-7-33-9-10-34-8-6-28-24(32)22-14-16-12-18(26)2-4-20(16)30-22/h1-4,11-14,29-30H,5-10H2,(H,27,31)(H,28,32)
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n/an/a 6n/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase a (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27744
PNG
((2S,3R)-3-(tert-butoxy)-2-{[4-(3,4-difluorophenyl)...)
Show SMILES CCCc1cc(C)c(NC(=O)Nc2cc(ccc2C(=O)N[C@@H]([C@@H](C)OC(C)(C)C)C(O)=O)-c2ccc(F)c(F)c2)c(C)c1
Show InChI InChI=1S/C33H39F2N3O5/c1-8-9-21-14-18(2)28(19(3)15-21)38-32(42)36-27-17-23(22-11-13-25(34)26(35)16-22)10-12-24(27)30(39)37-29(31(40)41)20(4)43-33(5,6)7/h10-17,20,29H,8-9H2,1-7H3,(H,37,39)(H,40,41)(H2,36,38,42)/t20-,29+/m1/s1
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n/an/a 7n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24385
PNG
(2,3-dichloro-N-[1-(2-hydroxyethyl)-2-oxo-1,2,3,4-t...)
Show SMILES OCCN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1
Show InChI InChI=1S/C18H15Cl2N3O3S/c19-14-15-13(27-16(14)20)8-10(21-15)17(25)22-11-7-9-3-1-2-4-12(9)23(5-6-24)18(11)26/h1-4,8,11,21,24H,5-7H2,(H,22,25)
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n/an/a 7n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27726
PNG
((2S,3R)-3-(tert-butoxy)-2-[(3-{[(2,4,6-trimethylph...)
Show SMILES C[C@@H](OC(C)(C)C)[C@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)C(O)=O
Show InChI InChI=1S/C29H35N3O5/c1-16-12-17(2)24(18(3)13-16)32-28(36)30-23-15-21-11-9-8-10-20(21)14-22(23)26(33)31-25(27(34)35)19(4)37-29(5,6)7/h8-15,19,25H,1-7H3,(H,31,33)(H,34,35)(H2,30,32,36)/t19-,25+/m1/s1
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n/an/a 7n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27734
PNG
((2S,3R)-3-(tert-butoxy)-2-{[4-(4-fluorophenyl)-2-{...)
Show SMILES C[C@@H](OC(C)(C)C)[C@H](NC(=O)c1ccc(cc1NC(=O)Nc1c(C)cc(C)cc1C)-c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C31H36FN3O5/c1-17-14-18(2)26(19(3)15-17)35-30(39)33-25-16-22(21-8-11-23(32)12-9-21)10-13-24(25)28(36)34-27(29(37)38)20(4)40-31(5,6)7/h8-16,20,27H,1-7H3,(H,34,36)(H,37,38)(H2,33,35,39)/t20-,27+/m1/s1
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n/an/a 7n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27726
PNG
((2S,3R)-3-(tert-butoxy)-2-[(3-{[(2,4,6-trimethylph...)
Show SMILES C[C@@H](OC(C)(C)C)[C@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)C(O)=O
Show InChI InChI=1S/C29H35N3O5/c1-16-12-17(2)24(18(3)13-16)32-28(36)30-23-15-21-11-9-8-10-20(21)14-22(23)26(33)31-25(27(34)35)19(4)37-29(5,6)7/h8-15,19,25H,1-7H3,(H,31,33)(H,34,35)(H2,30,32,36)/t19-,25+/m1/s1
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n/an/a 7n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50133443
PNG
(4-(2-Chloro-phenyl)-1-ethyl-5-isobutylcarbamoyl-6-...)
Show SMILES CCN1C(C)=C(C(C(C(O)=O)=C1C(O)=O)c1ccccc1Cl)C(=O)NCC(C)C
Show InChI InChI=1S/C21H25ClN2O5/c1-5-24-12(4)15(19(25)23-10-11(2)3)16(13-8-6-7-9-14(13)22)17(20(26)27)18(24)21(28)29/h6-9,11,16H,5,10H2,1-4H3,(H,23,25)(H,26,27)(H,28,29)
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n/an/a 7.88n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)


Bioorg Med Chem Lett 13: 3405-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50133431
PNG
(1-(3-Chloro-benzyl)-4-(2-chloro-phenyl)-6-methyl-1...)
Show SMILES CC(C)OC(=O)C1=C(C)N(Cc2cccc(Cl)c2)C(C(O)=O)=C(C1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H23Cl2NO6/c1-13(2)34-25(33)19-14(3)28(12-15-7-6-8-16(26)11-15)22(24(31)32)21(23(29)30)20(19)17-9-4-5-10-18(17)27/h4-11,13,20H,12H2,1-3H3,(H,29,30)(H,31,32)
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n/an/a 8n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)


Bioorg Med Chem Lett 13: 3405-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27731
PNG
((2S,3R)-3-(tert-butoxy)-2-{[4-(3-methoxyphenyl)-2-...)
Show SMILES COc1cccc(c1)-c1ccc(C(=O)N[C@@H]([C@@H](C)OC(C)(C)C)C(O)=O)c(NC(=O)Nc2c(C)cc(C)cc2C)c1
Show InChI InChI=1S/C32H39N3O6/c1-18-14-19(2)27(20(3)15-18)35-31(39)33-26-17-23(22-10-9-11-24(16-22)40-8)12-13-25(26)29(36)34-28(30(37)38)21(4)41-32(5,6)7/h9-17,21,28H,1-8H3,(H,34,36)(H,37,38)(H2,33,35,39)/t21-,28+/m1/s1
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n/an/a 8n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50256573
PNG
((S)-2-(3-(3-mesitylureido)-2-naphthamido)-5-methyl...)
Show SMILES CC(C)CC[C@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)C(O)=O
Show InChI InChI=1S/C28H33N3O4/c1-16(2)10-11-23(27(33)34)29-26(32)22-14-20-8-6-7-9-21(20)15-24(22)30-28(35)31-25-18(4)12-17(3)13-19(25)5/h6-9,12-16,23H,10-11H2,1-5H3,(H,29,32)(H,33,34)(H2,30,31,35)/t23-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assay


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50194415
PNG
(2,3-dichloro-N-((1R,2R)-1-hydroxy-2,3-dihydro-1H-i...)
Show SMILES O[C@H]1[C@@H](Cc2ccccc12)NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1
Show InChI InChI=1S/C16H12Cl2N2O2S/c17-12-13-11(23-15(12)18)6-10(19-13)16(22)20-9-5-7-3-1-2-4-8(7)14(9)21/h1-4,6,9,14,19,21H,5H2,(H,20,22)/t9-,14-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant human liver GPa by multienzyme coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50133444
PNG
(4-(2-Chloro-phenyl)-1-ethyl-5-isopropylcarbamoyl-6...)
Show SMILES CCN1C(C)=C(C(C(C(O)=O)=C1C(O)=O)c1ccccc1Cl)C(=O)NC(C)C
Show InChI InChI=1S/C20H23ClN2O5/c1-5-23-11(4)14(18(24)22-10(2)3)15(12-8-6-7-9-13(12)21)16(19(25)26)17(23)20(27)28/h6-10,15H,5H2,1-4H3,(H,22,24)(H,25,26)(H,27,28)
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n/an/a 9.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)


Bioorg Med Chem Lett 13: 3405-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27729
PNG
((2S,3R)-3-(tert-butoxy)-2-[(4-phenyl-2-{[(2,4,6-tr...)
Show SMILES C[C@@H](OC(C)(C)C)[C@H](NC(=O)c1ccc(cc1NC(=O)Nc1c(C)cc(C)cc1C)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C31H37N3O5/c1-18-15-19(2)26(20(3)16-18)34-30(38)32-25-17-23(22-11-9-8-10-12-22)13-14-24(25)28(35)33-27(29(36)37)21(4)39-31(5,6)7/h8-17,21,27H,1-7H3,(H,33,35)(H,36,37)(H2,32,34,38)/t21-,27+/m1/s1
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n/an/a 10n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50135550
PNG
(4-{2-[(4-Chloro-pyridine-2-carbonyl)-amino]-3-fluo...)
Show SMILES OC(=O)c1ccc(Oc2cccc(F)c2NC(=O)c2cc(Cl)ccn2)cc1C(O)=O
Show InChI InChI=1S/C20H12ClFN2O6/c21-10-6-7-23-15(8-10)18(25)24-17-14(22)2-1-3-16(17)30-11-4-5-12(19(26)27)13(9-11)20(28)29/h1-9H,(H,24,25)(H,26,27)(H,28,29)
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n/an/a 10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HLGP(human liver glycogen phosphorylase)


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50135560
PNG
(4-{3-[(4-Methyl-pyridine-2-carbonyl)-amino]-naphth...)
Show SMILES Cc1ccnc(c1)C(=O)Nc1cc2ccccc2cc1Oc1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C25H18N2O6/c1-14-8-9-26-21(10-14)23(28)27-20-11-15-4-2-3-5-16(15)12-22(20)33-17-6-7-18(24(29)30)19(13-17)25(31)32/h2-13H,1H3,(H,27,28)(H,29,30)(H,31,32)
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n/an/a 10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HLGP(human liver glycogen phosphorylase)


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM27742
PNG
((2S,3R)-3-(tert-butoxy)-2-[(2-{[(2,6-dimethyl-4-pr...)
Show SMILES CCCc1cc(C)c(NC(=O)Nc2cc(F)ccc2C(=O)N[C@@H]([C@@H](C)OC(C)(C)C)C(O)=O)c(C)c1
Show InChI InChI=1S/C27H36FN3O5/c1-8-9-18-12-15(2)22(16(3)13-18)31-26(35)29-21-14-19(28)10-11-20(21)24(32)30-23(25(33)34)17(4)36-27(5,6)7/h10-14,17,23H,8-9H2,1-7H3,(H,30,32)(H,33,34)(H2,29,31,35)/t17-,23+/m1/s1
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n/an/a 10n/an/an/an/a7.625



GSK



Assay Description
An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50256169
PNG
((S)-2-cyclohexyl-2-(3-(3-mesitylureido)-2-naphtham...)
Show SMILES Cc1cc(C)c(NC(=O)Nc2cc3ccccc3cc2C(=O)N[C@@](C)(C2CCCCC2)C(O)=O)c(C)c1
Show InChI InChI=1S/C30H35N3O4/c1-18-14-19(2)26(20(3)15-18)32-29(37)31-25-17-22-11-9-8-10-21(22)16-24(25)27(34)33-30(4,28(35)36)23-12-6-5-7-13-23/h8-11,14-17,23H,5-7,12-13H2,1-4H3,(H,33,34)(H,35,36)(H2,31,32,37)/t30-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucose


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50133429
PNG
(5-Benzylcarbamoyl-4-(2-chloro-phenyl)-1-ethyl-6-me...)
Show SMILES CCN1C(C)=C(C(C(C(O)=O)=C1C(O)=O)c1ccccc1Cl)C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H23ClN2O5/c1-3-27-14(2)18(22(28)26-13-15-9-5-4-6-10-15)19(16-11-7-8-12-17(16)25)20(23(29)30)21(27)24(31)32/h4-12,19H,3,13H2,1-2H3,(H,26,28)(H,29,30)(H,31,32)
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n/an/a 10.9n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)


Bioorg Med Chem Lett 13: 3405-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50135561
PNG
(4-{3-Fluoro-2-[(4-methoxy-pyridine-2-carbonyl)-ami...)
Show SMILES COc1ccnc(c1)C(=O)Nc1c(F)cccc1Oc1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C21H15FN2O7/c1-30-11-7-8-23-16(10-11)19(25)24-18-15(22)3-2-4-17(18)31-12-5-6-13(20(26)27)14(9-12)21(28)29/h2-10H,1H3,(H,24,25)(H,26,27)(H,28,29)
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n/an/a 11n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HLGP(human liver glycogen phosphorylase)


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM50133430
PNG
(1-Benzyl-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-...)
Show SMILES CC(C)OC(=O)C1=C(C)N(Cc2ccccc2)C(C(O)=O)=C(C1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H24ClNO6/c1-14(2)33-25(32)19-15(3)27(13-16-9-5-4-6-10-16)22(24(30)31)21(23(28)29)20(19)17-11-7-8-12-18(17)26/h4-12,14,20H,13H2,1-3H3,(H,28,29)(H,30,31)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)


Bioorg Med Chem Lett 13: 3405-8 (2003)

More data for this
Ligand-Target Pair
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