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Found 356 hits Enz. Inhib. hit(s) with Target = 'Glycogen Synthase Kinase-3, beta'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM17149
PNG
(2-imino-thiazolidin-4-one analog, 11 | 4-(5-{[(5Z)...)
Show SMILES NS(=O)(=O)c1ccc(cc1C(F)(F)F)-c1ccc(\C=C2/SC(=N)NC2=O)o1
Show InChI InChI=1S/C15H10F3N3O4S2/c16-15(17,18)9-5-7(1-4-12(9)27(20,23)24)10-3-2-8(25-10)6-11-13(22)21-14(19)26-11/h1-6H,(H2,19,21,22)(H2,20,23,24)/b11-6-
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n/an/a 2n/an/an/an/a7.522



Vernalis (R&D) Ltd



Assay Description
In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...


Bioorg Med Chem Lett 17: 3880-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.110
BindingDB Entry DOI: 10.7270/Q28G8HZQ
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7262
PNG
(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
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n/an/a 4n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7425
PNG
((2 Z,3 E)-5,6-Dichloroindirubin-3 -acetoxime | 6,5...)
Show SMILES CC(=O)ON=C1C(Nc2ccccc12)=C1C(=O)Nc2cc(Cl)c(Cl)cc12
Show InChI InChI=1S/C18H11Cl2N3O3/c1-8(24)26-23-16-9-4-2-3-5-13(9)21-17(16)15-10-6-11(19)12(20)7-14(10)22-18(15)25/h2-7,21H,1H3,(H,22,25)
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n/an/a 4n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7424
PNG
((2 Z,3 E)-5,6-Dichloroindirubin-3 -oxime | 5,6-dic...)
Show SMILES Clc1cc2NC(=O)C(c2cc1Cl)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H9Cl2N3O2/c17-9-5-8-12(6-10(9)18)20-16(22)13(8)15-14(21-23)7-3-1-2-4-11(7)19-15/h1-6,13,19H,(H,20,22)
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n/an/a 4n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7401
PNG
((2 Z,3 E)-6-Bromoindirubin-3 -oxime | (3E)-6-bromo...)
Show SMILES Brc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,13,18H,(H,19,21)
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n/an/a 5n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7421
PNG
((2 Z,3 E)-6-Bromo-5-methylindirubin-3 -oxime | 6-b...)
Show SMILES Cc1cc2C(C(=O)Nc2cc1Br)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C17H12BrN3O2/c1-8-6-10-13(7-11(8)18)20-17(22)14(10)16-15(21-23)9-4-2-3-5-12(9)19-16/h2-7,14,19H,1H3,(H,20,22)
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n/an/a 6n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7428
PNG
((2 Z,3 E)-6-Bromo-5-nitroindirubin-3 -acetoxime | ...)
Show SMILES CC(=O)[O+]=Nc1c([nH]c2ccccc12)-[c-]1c2cc(c(Br)cc2[nH]c1=O)[N+]([O-])=O
Show InChI InChI=1S/C18H11BrN4O5/c1-8(24)28-22-16-9-4-2-3-5-12(9)20-17(16)15-10-6-14(23(26)27)11(19)7-13(10)21-18(15)25/h2-7,20H,1H3,(H,21,25)
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n/an/a 6n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7422
PNG
((2 Z,3 E)-6-Bromo-5-methylindirubin-3 -acetoxime |...)
Show SMILES CC(=O)ON=C1C(Nc2ccccc12)=C1C(=O)Nc2cc(Br)c(C)cc12
Show InChI InChI=1S/C19H14BrN3O3/c1-9-7-12-15(8-13(9)20)22-19(25)16(12)18-17(23-26-10(2)24)11-5-3-4-6-14(11)21-18/h3-8,21H,1-2H3,(H,22,25)
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n/an/a 7n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7427
PNG
((2 Z,3 E)-6-Bromo-5-nitroindirubin-3 -oxime | 6-Br...)
Show SMILES [O-][N+](=O)c1cc2[c-](-c3[nH]c4ccccc4c3N=[OH+])c(=O)[nH]c2cc1Br
Show InChI InChI=1S/C16H8BrN4O4/c17-9-6-11-8(5-12(9)21(24)25)13(16(22)19-11)15-14(20-23)7-3-1-2-4-10(7)18-15/h1-6,18H,(H,19,22)/q-1/p+1
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n/an/a 7n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7492
PNG
(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Show SMILES Ic1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10IN3O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)15-14(20-22)9-3-1-2-4-11(9)18-15/h1-7,13,18H,(H,19,21)
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n/an/a 9n/an/an/an/a7.530



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7263
PNG
(9-cyanopaullone | 9-oxo-8,18-diazatetracyclo[9.7.0...)
Show SMILES O=C1Cc2c([nH]c3ccc(cc23)C#N)-c2ccccc2N1
Show InChI InChI=1S/C17H11N3O/c18-9-10-5-6-15-12(7-10)13-8-16(21)19-14-4-2-1-3-11(14)17(13)20-15/h1-7,20H,8H2,(H,19,21)
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n/an/a 10n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7491
PNG
((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)
Show SMILES NC1=NC(=O)C(N1)=C1CCNC(=O)c2[nH]c(Br)cc12
Show InChI InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)
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n/an/a 10n/an/an/an/a7.530



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7410
PNG
((2 Z,3 E)-6-Iodoindirubin-3 -oxime | 3-[(2Z,3E)-3-...)
Show SMILES Ic1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10IN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,13,18H,(H,19,21)
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n/an/a 10n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7402
PNG
((2 Z,3 E)-6-Bromoindirubin-3 -acetoxime | 6-bromoi...)
Show SMILES CC(=O)ON=C1C(Nc2ccccc12)=C1C(=O)Nc2cc(Br)ccc12
Show InChI InChI=1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)
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n/an/a 10n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7411
PNG
((2 Z,3 E)-6-Iodoindirubin-3 -acetoxime | 6-iodoind...)
Show SMILES CC(=O)ON=C1C(Nc2ccccc12)=C1C(=O)Nc2cc(I)ccc12
Show InChI InChI=1S/C18H12IN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)
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n/an/a 13n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7264
PNG
(2,3-dimethoxy-9-nitropaullone | 4,5-dimethoxy-14-n...)
Show SMILES COc1cc2NC(=O)Cc3c([nH]c4ccc(cc34)[N+]([O-])=O)-c2cc1OC
Show InChI InChI=1S/C18H15N3O5/c1-25-15-6-12-14(8-16(15)26-2)19-17(22)7-11-10-5-9(21(23)24)3-4-13(10)20-18(11)12/h3-6,8,20H,7H2,1-2H3,(H,19,22)
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n/an/a 13n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM17150
PNG
(2-chloro-4-(5-{[(5Z)-2-imino-4-oxo-1,3-thiazolidin...)
Show SMILES NS(=O)(=O)c1ccc(cc1Cl)-c1ccc(\C=C2/SC(=N)NC2=O)o1
Show InChI InChI=1S/C14H10ClN3O4S2/c15-9-5-7(1-4-12(9)24(17,20)21)10-3-2-8(22-10)6-11-13(19)18-14(16)23-11/h1-6H,(H2,16,18,19)(H2,17,20,21)/b11-6-
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n/an/a 14n/an/an/an/a7.522



Vernalis (R&D) Ltd



Assay Description
In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...


Bioorg Med Chem Lett 17: 3880-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.110
BindingDB Entry DOI: 10.7270/Q28G8HZQ
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7408
PNG
((2 Z,3 E)-6-Chloroindirubin-3 -acetoxime | 6-chlor...)
Show SMILES CC(=O)ON=C1C(Nc2ccccc12)=C1C(=O)Nc2cc(Cl)ccc12
Show InChI InChI=1S/C18H12ClN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)
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n/an/a 17n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7322
PNG
(14-bromo-5-hydroxy-8,18-diazatetracyclo[9.7.0.0^{2...)
Show SMILES Oc1ccc2-c3[nH]c4ccc(Br)cc4c3CC(=O)Nc2c1
Show InChI InChI=1S/C16H11BrN2O2/c17-8-1-4-13-11(5-8)12-7-15(21)18-14-6-9(20)2-3-10(14)16(12)19-13/h1-6,19-20H,7H2,(H,18,21)
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n/an/a 18n/an/an/an/an/a30



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7497
PNG
(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4cccnc-34)c2c1
Show InChI InChI=1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
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n/an/a 18n/an/an/an/a7.530



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7265
PNG
(4,5-dimethoxy-9-oxo-8,18-diazatetracyclo[9.7.0.0^{...)
Show SMILES COc1cc2NC(=O)Cc3c([nH]c4ccc(cc34)C#N)-c2cc1OC
Show InChI InChI=1S/C19H15N3O3/c1-24-16-6-13-15(8-17(16)25-2)21-18(23)7-12-11-5-10(9-20)3-4-14(11)22-19(12)13/h3-6,8,22H,7H2,1-2H3,(H,21,23)
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n/an/a 18n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7407
PNG
((2 Z,3 E)-6-Chloroindirubin-3 -oxime | 6-chloro-3-...)
Show SMILES Clc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10ClN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,13,18H,(H,19,21)
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n/an/a 20n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7330
PNG
(2-Methoxy-9-nitro-7,12-dihydro-indolo[3,2-d][1]ben...)
Show SMILES COc1ccc2NC(=O)Cc3c([nH]c4ccc(cc34)[N+]([O-])=O)-c2c1
Show InChI InChI=1S/C17H13N3O4/c1-24-10-3-5-15-13(7-10)17-12(8-16(21)18-15)11-6-9(20(22)23)2-4-14(11)19-17/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 22n/an/an/an/an/a30



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7393
PNG
(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Show SMILES O=Nc1c([nH]c2ccccc12)C1C(=O)Nc2ccccc12
Show InChI InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,13,17H,(H,18,20)
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n/an/a 22n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7266
PNG
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
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n/an/a 23n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7266
PNG
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
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n/an/a 23n/an/an/an/a7.530



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7267
PNG
(14-chloro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12...)
Show SMILES Clc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11ClN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
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n/an/a 24n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7420
PNG
((2 Z)-6-Bromo-5-methylindirubin | 6-bromo-5-methyl...)
Show SMILES Cc1cc2\C(C(=O)Nc2cc1Br)=C1\Nc2ccccc2C1=O
Show InChI InChI=1S/C17H11BrN2O2/c1-8-6-10-13(7-11(8)18)20-17(22)14(10)15-16(21)9-4-2-3-5-12(9)19-15/h2-7,19H,1H3,(H,20,22)/b15-14-
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n/an/a 25n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6870
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f ...)
Show SMILES Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N
Show InChI InChI=1S/C14H14N6O3S2/c1-8-6-7-24-11(8)12(21)20-13(15)18-14(19-20)17-9-2-4-10(5-3-9)25(16,22)23/h2-7H,1H3,(H2,16,22,23)(H3,15,17,18,19)
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n/an/a 26n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)


Article DOI: 10.1021/jm050267e
BindingDB Entry DOI: 10.7270/Q22F7KNX
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7403
PNG
((2 Z,3 E)-6-Bromoindirubin-3 -methoxime | 6-bromo-...)
Show SMILES CO\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2cc(Br)ccc12
Show InChI InChI=1S/C17H12BrN3O2/c1-23-21-15-11-4-2-3-5-12(11)19-16(15)14-10-7-6-9(18)8-13(10)20-17(14)22/h2-8,19H,1H3,(H,20,22)/b16-14-,21-15+
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n/an/a 30n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7335
PNG
(5-(4-aminobutoxy)-14-bromo-8,18-diazatetracyclo[9....)
Show SMILES NCCCCOc1ccc2-c3[nH]c4ccc(Br)cc4c3CC(=O)Nc2c1
Show InChI InChI=1S/C20H20BrN3O2/c21-12-3-6-17-15(9-12)16-11-19(25)23-18-10-13(26-8-2-1-7-22)4-5-14(18)20(16)24-17/h3-6,9-10,24H,1-2,7-8,11,22H2,(H,23,25)
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n/an/a 30n/an/an/an/an/a30



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7268
PNG
(14-(trifluoromethyl)-8,18-diazatetracyclo[9.7.0.0^...)
Show SMILES FC(F)(F)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C17H11F3N2O/c18-17(19,20)9-5-6-14-11(7-9)12-8-15(23)21-13-4-2-1-3-10(13)16(12)22-14/h1-7,22H,8H2,(H,21,23)
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n/an/a 30n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7423
PNG
((2 Z)-5,6-Dichloroindirubin | 5,6-dichloro-3-[(2Z)...)
Show SMILES Clc1cc2NC(=O)\C(=C3/Nc4ccccc4C3=O)c2cc1Cl
Show InChI InChI=1S/C16H8Cl2N2O2/c17-9-5-8-12(6-10(9)18)20-16(22)13(8)14-15(21)7-3-1-2-4-11(7)19-14/h1-6,19H,(H,20,22)/b14-13-
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n/an/a 30n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6867
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Show SMILES Cc1ccc(F)c(C(=O)n2nc(Nc3ccc(cc3)S(N)(=O)=O)nc2N)c1F
Show InChI InChI=1S/C16H14F2N6O3S/c1-8-2-7-11(17)12(13(8)18)14(25)24-15(19)22-16(23-24)21-9-3-5-10(6-4-9)28(20,26)27/h2-7H,1H3,(H2,20,26,27)(H3,19,21,22,23)
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n/an/a 31n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)


Article DOI: 10.1021/jm050267e
BindingDB Entry DOI: 10.7270/Q22F7KNX
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7269
PNG
(3-(6-oxo-9-trifluoromethyl-5,6,7,12-tetrahydro-ind...)
Show SMILES FC(F)(F)c1ccc2[nH]c-3c(CC(=O)Nc4ccc(CCC#N)cc-34)c2c1
Show InChI InChI=1S/C20H14F3N3O/c21-20(22,23)12-4-6-16-13(9-12)14-10-18(27)25-17-5-3-11(2-1-7-24)8-15(17)19(14)26-16/h3-6,8-9,26H,1-2,10H2,(H,25,27)
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n/an/a 33n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7340
PNG
(13-nitro-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6}...)
Show SMILES [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccsc-34)c2c1
Show InChI InChI=1S/C14H9N3O3S/c18-12-6-9-8-5-7(17(19)20)1-2-10(8)16-13(9)14-11(15-12)3-4-21-14/h1-5,16H,6H2,(H,15,18)
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n/an/a 35n/an/an/an/an/a30



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6866
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
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n/an/a 41n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)


Article DOI: 10.1021/jm050267e
BindingDB Entry DOI: 10.7270/Q22F7KNX
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7400
PNG
(6-bromo-3-[(2Z)-3-oxo-2,3-dihydro-1H-indol-2-ylide...)
Show SMILES Brc1ccc2\C(C(=O)Nc2c1)=C1\Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9BrN2O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)14-15(20)10-3-1-2-4-11(10)18-14/h1-7,18H,(H,19,21)/b14-13-
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n/an/a 45n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7409
PNG
((2 Z)-6-Iodoindirubin | 6-iodo-3-[(2Z)-3-oxo-2,3-d...)
Show SMILES Ic1ccc2\C(C(=O)Nc2c1)=C1\Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9IN2O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)14-15(20)10-3-1-2-4-11(10)18-14/h1-7,18H,(H,19,21)/b14-13-
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n/an/a 55n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7413
PNG
((2 Z,3 E)-6-Vinylindirubin-3 -oxime | 6-ethenyl-3-...)
Show SMILES C=Cc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C18H13N3O2/c1-2-10-7-8-11-14(9-10)20-18(22)15(11)17-16(21-23)12-5-3-4-6-13(12)19-17/h2-9,15,19H,1H2,(H,20,22)
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n/an/a 60n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7414
PNG
((2 Z,3 E)-6-Vinylindirubin-3 -acetoxime | 6-vinyli...)
Show SMILES CC(=O)ON=C1C(Nc2ccccc12)=C1C(=O)Nc2cc(C=C)ccc12
Show InChI InChI=1S/C20H15N3O3/c1-3-12-8-9-13-16(10-12)22-20(25)17(13)19-18(23-26-11(2)24)14-6-4-5-7-15(14)21-19/h3-10,21H,1H2,2H3,(H,22,25)
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n/an/a 65n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7329
PNG
(3-Methoxy-9-nitro-7,12-dihydro-indolo[3,2-d][1]ben...)
Show SMILES COc1ccc2-c3[nH]c4ccc(cc4c3CC(=O)Nc2c1)[N+]([O-])=O
Show InChI InChI=1S/C17H13N3O4/c1-24-10-3-4-11-15(7-10)18-16(21)8-13-12-6-9(20(22)23)2-5-14(12)19-17(11)13/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 70n/an/an/an/an/a30



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7270
PNG
(2,3-dimethoxy-9-trifluoromethylpaullone | 4,5-dime...)
Show SMILES COc1cc2NC(=O)Cc3c([nH]c4ccc(cc34)C(F)(F)F)-c2cc1OC
Show InChI InChI=1S/C19H15F3N2O3/c1-26-15-6-12-14(8-16(15)27-2)23-17(25)7-11-10-5-9(19(20,21)22)3-4-13(10)24-18(11)12/h3-6,8,24H,7H2,1-2H3,(H,23,25)
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n/an/a 75n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7271
PNG
(9-bromo-12-methyloxycarbonylmethylpaullone | CHEMB...)
Show SMILES COC(=O)Cn1c-2c(CC(=O)Nc3ccccc-23)c2cc(Br)ccc12
Show InChI InChI=1S/C19H15BrN2O3/c1-25-18(24)10-22-16-7-6-11(20)8-13(16)14-9-17(23)21-15-5-3-2-4-12(15)19(14)22/h2-8H,9-10H2,1H3,(H,21,23)
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n/an/a 75n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7272
PNG
(14-fluoro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12...)
Show SMILES Fc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11FN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
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n/an/a 80n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM17144
PNG
(2-imino-thiazolidin-4-one analog, 6 | 4-(5-{[(5Z)-...)
Show SMILES CNS(=O)(=O)c1ccc(cc1)-c1ccc(\C=C2/SC(=N)NC2=O)o1
Show InChI InChI=1S/C15H13N3O4S2/c1-17-24(20,21)11-5-2-9(3-6-11)12-7-4-10(22-12)8-13-14(19)18-15(16)23-13/h2-8,17H,1H3,(H2,16,18,19)/b13-8-
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n/an/a 80n/an/an/an/a7.522



Vernalis (R&D) Ltd



Assay Description
In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...


Bioorg Med Chem Lett 17: 3880-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.110
BindingDB Entry DOI: 10.7270/Q28G8HZQ
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7325
PNG
(2-(2-oxopropyl)-9-(trifluoromethyl)-7,12-dihydroin...)
Show SMILES CC(=O)Cc1ccc2NC(=O)Cc3c([nH]c4ccc(cc34)C(F)(F)F)-c2c1
Show InChI InChI=1S/C20H15F3N2O2/c1-10(26)6-11-2-4-17-15(7-11)19-14(9-18(27)24-17)13-8-12(20(21,22)23)3-5-16(13)25-19/h2-5,7-8,25H,6,9H2,1H3,(H,24,27)
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n/an/a 90n/an/an/an/an/a30



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7417
PNG
((2 Z,3 E)-6-Fluoroindirubin-3 -acetoxime | 6-fluor...)
Show SMILES CC(=O)ON=C1C(Nc2ccccc12)=C1C(=O)Nc2cc(F)ccc12
Show InChI InChI=1S/C18H12FN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)
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n/an/a 90n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Rattus norvegicus (rat))
BDBM7273
PNG
(14-bromo-4,5-dimethoxy-8,18-diazatetracyclo[9.7.0....)
Show SMILES COc1cc2NC(=O)Cc3c([nH]c4ccc(Br)cc34)-c2cc1OC
Show InChI InChI=1S/C18H15BrN2O3/c1-23-15-6-12-14(8-16(15)24-2)20-17(22)7-11-10-5-9(19)3-4-13(10)21-18(11)12/h3-6,8,21H,7H2,1-2H3,(H,20,22)
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n/an/a 100n/an/an/an/an/a30



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Porcine)
BDBM7426
PNG
((2 Z)-6-Bromo-5-nitroindirubin | 6-Bromo-5-nitroin...)
Show SMILES [O-]c1c([nH]c2ccccc12)[C+]1C(=O)Nc2cc(Br)c(cc12)[N+]([O-])=O
Show InChI InChI=1S/C16H8BrN3O4/c17-9-6-11-8(5-12(9)20(23)24)13(16(22)19-11)14-15(21)7-3-1-2-4-10(7)18-14/h1-6,18H,(H-,19,21,22)
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n/an/a 100n/an/an/an/an/a30



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
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