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Found 108 hits Enz. Inhib. hit(s) with Target = 'Glycogen Synthase Kinase-3, beta' AND taxid = 9986   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6870
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f ...)
Show SMILES Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N
Show InChI InChI=1S/C14H14N6O3S2/c1-8-6-7-24-11(8)12(21)20-13(15)18-14(19-20)17-9-2-4-10(5-3-9)25(16,22)23/h2-7H,1H3,(H2,16,22,23)(H3,15,17,18,19)
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n/an/a 26n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6867
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Show SMILES Cc1ccc(F)c(C(=O)n2nc(Nc3ccc(cc3)S(N)(=O)=O)nc2N)c1F
Show InChI InChI=1S/C16H14F2N6O3S/c1-8-2-7-11(17)12(13(8)18)14(25)24-15(19)22-16(23-24)21-9-3-5-10(6-4-9)28(20,26)27/h2-7H,1H3,(H2,20,26,27)(H3,19,21,22,23)
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n/an/a 31n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6866
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
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n/an/a 41n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6878
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=S)Nc1c(F)cccc1F
Show InChI InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
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n/an/a 140n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6421
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-1,2,4-triazol-1-yl...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cncn3)c2)c1
Show InChI InChI=1S/C20H19ClN8/c21-16-3-1-4-17(8-16)27-20-12-23-11-19(28-20)15-7-18(10-22-9-15)25-5-2-6-29-14-24-13-26-29/h1,3-4,7-14,25H,2,5-6H2,(H,27,28)
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n/an/a 196n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6419
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3cccnc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-6-1-7-20(11-19)29-23-16-27-15-22(30-23)18-10-21(14-26-13-18)28-9-3-5-17-4-2-8-25-12-17/h1-2,4,6-8,10-16,28H,3,5,9H2,(H,29,30)
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n/an/a 318n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6416
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a 478n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6416
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a 478n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7868
PNG
(2-chloro-1-(3,4-dibromothiophen-2-yl)ethan-1-one |...)
Show SMILES ClCC(=O)c1scc(Br)c1Br
Show InChI InChI=1S/C6H3Br2ClOS/c7-3-2-11-6(5(3)8)4(10)1-9/h2H,1H2
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n/an/a 500n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7876
PNG
(2-bromo-1-(4-bromophenyl)ethan-1-one | Halomethyl ...)
Show SMILES BrCC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
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n/an/a 500n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6420
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1
Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)
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n/an/a 606n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7869
PNG
(2-chloro-1-(4,5-dibromothiophen-2-yl)ethan-1-one |...)
Show SMILES ClCC(=O)c1cc(Br)c(Br)s1
Show InChI InChI=1S/C6H3Br2ClOS/c7-3-1-5(4(10)2-9)11-6(3)8/h1H,2H2
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n/an/a 1.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7804
PNG
(1-benzyl-2,5-dihydro-1H-pyrrole-2,5-dione | Maleim...)
Show SMILES O=C1C=CC(=O)N1Cc1ccccc1
Show InChI InChI=1S/C11H9NO2/c13-10-6-7-11(14)12(10)8-9-4-2-1-3-5-9/h1-7H,8H2
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n/an/a 1.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7879
PNG
(2-bromo-1-(4-methoxyphenyl)ethan-1-one | CHEMBL103...)
Show SMILES COc1ccc(cc1)C(=O)CBr
Show InChI InChI=1S/C9H9BrO2/c1-12-8-4-2-7(3-5-8)9(11)6-10/h2-5H,6H2,1H3
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n/an/a 1.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7856
PNG
(2-chloro-1-(2,4,5-tribromothiophen-3-yl)ethan-1-on...)
Show SMILES ClCC(=O)c1c(Br)sc(Br)c1Br
Show InChI InChI=1S/C6H2Br3ClOS/c7-4-3(2(11)1-10)5(8)12-6(4)9/h1H2
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n/an/a 1.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7877
PNG
(2-bromo-1-(4-chlorophenyl)ethan-1-one | Halomethyl...)
Show SMILES Clc1ccc(cc1)C(=O)CBr
Show InChI InChI=1S/C8H6BrClO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
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n/an/a 1.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7859
PNG
(2-chloro-1-[4-(2-chloroacetyl)thiophen-2-yl]ethan-...)
Show SMILES ClCC(=O)c1csc(c1)C(=O)CCl
Show InChI InChI=1S/C8H6Cl2O2S/c9-2-6(11)5-1-8(13-4-5)7(12)3-10/h1,4H,2-3H2
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n/an/a 1.50E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7792
PNG
(4-(4-Methoxylphenyl)-2-methyl-1,2,4-thiadiazolidin...)
Show SMILES COc1ccc(cc1)-n1c(=O)sn(C)c1=O
Show InChI InChI=1S/C10H10N2O3S/c1-11-9(13)12(10(14)16-11)7-3-5-8(15-2)6-4-7/h3-6H,1-2H3
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n/an/a 2.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7784
PNG
(2-methyl-4-phenyl-1,2,4-thiadiazolidine-3,5-dione ...)
Show SMILES Cn1sc(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C9H8N2O2S/c1-10-8(12)11(9(13)14-10)7-5-3-2-4-6-7/h2-6H,1H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7881
PNG
(2-bromo-1-(4-nitrophenyl)ethan-1-one | Halomethyl ...)
Show SMILES BrCC(=O)c1ccc(cc1)N(=O)=O
Show InChI InChI=1S/C8H6BrNO3/c9-5-8(11)6-1-3-7(4-2-6)10(12)13/h1-4H,5H2
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n/an/a 2.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7852
PNG
(Thiadiazolidinone (TDZD) deriv. 59 | ethyl 2-(2-me...)
Show SMILES CCOC(=O)Cn1c(=O)sn(C)c1=O
Show InChI InChI=1S/C7H10N2O4S/c1-3-13-5(10)4-9-6(11)8(2)14-7(9)12/h3-4H2,1-2H3
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Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7781
PNG
(4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione ...)
Show SMILES Cn1sc(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7857
PNG
(1-(2-bromo-4,5-dichlorothiophen-3-yl)-2-chloroetha...)
Show SMILES ClCC(=O)c1c(Cl)c(Cl)sc1Br
Show InChI InChI=1S/C6H2BrCl3OS/c7-5-3(2(11)1-8)4(9)6(10)12-5/h1H2
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7807
PNG
(1-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-2,5-dione...)
Show SMILES O=C1C=CC(=O)N1CCc1ccccc1
Show InChI InChI=1S/C12H11NO2/c14-11-6-7-12(15)13(11)9-8-10-4-2-1-3-5-10/h1-7H,8-9H2
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Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7853
PNG
(2-chloro-1-(4,5-dichlorothiophen-2-yl)ethan-1-one ...)
Show SMILES ClCC(=O)c1cc(Cl)c(Cl)s1
Show InChI InChI=1S/C6H3Cl3OS/c7-2-4(10)5-1-3(8)6(9)11-5/h1H,2H2
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n/an/a 2.50E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7880
PNG
(2-bromo-1-(4-phenylphenyl)ethan-1-one | CHEMBL4130...)
Show SMILES BrCC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C14H11BrO/c15-10-14(16)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9H,10H2
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n/an/a 2.50E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7878
PNG
(2-bromo-1-(4-methylphenyl)ethan-1-one | Halomethyl...)
Show SMILES Cc1ccc(cc1)C(=O)CBr
Show InChI InChI=1S/C9H9BrO/c1-7-2-4-8(5-3-7)9(11)6-10/h2-5H,6H2,1H3
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n/an/a 2.50E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7874
PNG
(2-chloro-1-(4-chlorophenyl)ethan-1-one | Halomethy...)
Show SMILES ClCC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C8H6Cl2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
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n/an/a 2.50E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7806
PNG
(1-[(4-methoxyphenyl)methyl]-2,5-dihydro-1H-pyrrole...)
Show SMILES COc1ccc(CN2C(=O)C=CC2=O)cc1
Show InChI InChI=1S/C12H11NO3/c1-16-10-4-2-9(3-5-10)8-13-11(14)6-7-12(13)15/h2-7H,8H2,1H3
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n/an/a 2.50E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7805
PNG
(Maleimide-Related Compound 4 | N-(Ethoxycarbonylme...)
Show SMILES CCOC(=O)CN1C(=O)C=CC1=O
Show InChI InChI=1S/C8H9NO4/c1-2-13-8(12)5-9-6(10)3-4-7(9)11/h3-4H,2,5H2,1H3
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n/an/a 3.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7785
PNG
(4-(4-Bromophenyl)-2-methyl-1,2,4-thiadiazolidine-3...)
Show SMILES Cn1sc(=O)n(-c2ccc(Br)cc2)c1=O
Show InChI InChI=1S/C9H7BrN2O2S/c1-11-8(13)12(9(14)15-11)7-4-2-6(10)3-5-7/h2-5H,1H3
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n/an/a 3.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7854
PNG
(1-(4-bromothiophen-2-yl)-2-chloroethan-1-one | Chl...)
Show SMILES ClCC(=O)c1cc(Br)cs1
Show InChI InChI=1S/C6H4BrClOS/c7-4-1-6(10-3-4)5(9)2-8/h1,3H,2H2
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n/an/a 3.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7808
PNG
(1-[2-(4-methoxyphenyl)ethyl]-2,5-dihydro-1H-pyrrol...)
Show SMILES COc1ccc(CCN2C(=O)C=CC2=O)cc1
Show InChI InChI=1S/C13H13NO3/c1-17-11-4-2-10(3-5-11)8-9-14-12(15)6-7-13(14)16/h2-7H,8-9H2,1H3
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n/an/a 3.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7809
PNG
(1-(3-phenylpropyl)-2,5-dihydro-1H-pyrrole-2,5-dion...)
Show SMILES O=C1C=CC(=O)N1CCCc1ccccc1
Show InChI InChI=1S/C13H13NO2/c15-12-8-9-13(16)14(12)10-4-7-11-5-2-1-3-6-11/h1-3,5-6,8-9H,4,7,10H2
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n/an/a 3.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7810
PNG
(1-(5-phenylpentyl)-2,5-dihydro-1H-pyrrole-2,5-dion...)
Show SMILES O=C1C=CC(=O)N1CCCCCc1ccccc1
Show InChI InChI=1S/C15H17NO2/c17-14-10-11-15(18)16(14)12-6-2-5-9-13-7-3-1-4-8-13/h1,3-4,7-8,10-11H,2,5-6,9,12H2
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7793
PNG
(2-methyl-4-(1-naphthyl)-1,2,4-thiadiazolidine-3,5-...)
Show SMILES Cn1sc(=O)n(-c2cccc3ccccc23)c1=O
Show InChI InChI=1S/C13H10N2O2S/c1-14-12(16)15(13(17)18-14)11-8-4-6-9-5-2-3-7-10(9)11/h2-8H,1H3
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n/an/a 3.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7789
PNG
(4-(4-Fluorophenyl)-2-methyl-1,2,4-thiadiazolidine-...)
Show SMILES Cn1sc(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C9H7FN2O2S/c1-11-8(13)12(9(14)15-11)7-4-2-6(10)3-5-7/h2-5H,1H3
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n/an/a 4.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7788
PNG
(4-(4-Chlorophenyl)-2-methyl-1,2,4-thiadiazolidine-...)
Show SMILES Cn1sc(=O)n(-c2ccc(Cl)cc2)c1=O
Show InChI InChI=1S/C9H7ClN2O2S/c1-11-8(13)12(9(14)15-11)7-4-2-6(10)3-5-7/h2-5H,1H3
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n/an/a 4.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7786
PNG
(4-(3-Bromophenyl)-2-methyl-1,2,4-thiadiazolidine-3...)
Show SMILES Cn1sc(=O)n(-c2cccc(Br)c2)c1=O
Show InChI InChI=1S/C9H7BrN2O2S/c1-11-8(13)12(9(14)15-11)7-4-2-3-6(10)5-7/h2-5H,1H3
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n/an/a 4.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM6417
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H20ClN5O/c20-15-4-3-5-16(9-15)24-19-13-22-12-18(25-19)14-8-17(11-21-10-14)23-6-1-2-7-26/h3-5,8-13,23,26H,1-2,6-7H2,(H,24,25)
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n/an/a 4.02E+3n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


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Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7803
PNG
(1-methyl-2,5-dihydro-1H-pyrrole-2,5-dione | Maleim...)
Show SMILES CN1C(=O)C=CC1=O
Show InChI InChI=1S/C5H5NO2/c1-6-4(7)2-3-5(6)8/h2-3H,1H3
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n/an/a 5.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7791
PNG
(2-methyl-4-(4-methylphenyl)-1,2,4-thiadiazolidine-...)
Show SMILES Cc1ccc(cc1)-n1c(=O)sn(C)c1=O
Show InChI InChI=1S/C10H10N2O2S/c1-7-3-5-8(6-4-7)12-9(13)11(2)15-10(12)14/h3-6H,1-2H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7875
PNG
(2-bromo-1-phenylethan-1-one | CHEMBL102953 | Halom...)
Show SMILES BrCC(=O)c1ccccc1
Show InChI InChI=1S/C8H7BrO/c9-6-8(10)7-4-2-1-3-5-7/h1-5H,6H2
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7861
PNG
(2-chloro-1-[4-(2-chloroacetyl)-5-methylthiophen-2-...)
Show SMILES Cc1sc(cc1C(=O)CCl)C(=O)CCl
Show InChI InChI=1S/C9H8Cl2O2S/c1-5-6(7(12)3-10)2-9(14-5)8(13)4-11/h2H,3-4H2,1H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7865
PNG
(2-chloro-1-[4-(2-chloroacetyl)-3-methylthiophen-2-...)
Show SMILES Cc1c(csc1C(=O)CCl)C(=O)CCl
Show InChI InChI=1S/C9H8Cl2O2S/c1-5-6(7(12)2-10)4-14-9(5)8(13)3-11/h4H,2-3H2,1H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7870
PNG
(2-chloro-1-(2,5-dichlorothiophen-3-yl)ethan-1-one ...)
Show SMILES ClCC(=O)c1cc(Cl)sc1Cl
Show InChI InChI=1S/C6H3Cl3OS/c7-2-4(10)3-1-5(8)11-6(3)9/h1H,2H2
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7774
PNG
(4-Ethyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione |...)
Show SMILES CCn1c(=O)sn(C)c1=O
Show InChI InChI=1S/C5H8N2O2S/c1-3-7-4(8)6(2)10-5(7)9/h3H2,1-2H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7802
PNG
(2,5-dihydro-1H-pyrrole-2,5-dione | Maleimide-Relat...)
Show SMILES O=C1NC(=O)C=C1
Show InChI InChI=1S/C4H3NO2/c6-3-1-2-4(7)5-3/h1-2H,(H,5,6,7)
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n/an/a 6.00E+3n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7797
PNG
(4-Benzyl-2-ethyl-5-oxo-1,2,4-thiadiazolidine-3-thi...)
Show SMILES CCn1sc(=O)n(Cc2ccccc2)c1=S
Show InChI InChI=1S/C11H12N2OS2/c1-2-13-10(15)12(11(14)16-13)8-9-6-4-3-5-7-9/h3-7H,2,8H2,1H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Citation and Details
More data for this
Ligand-Target Pair
Glycogen Synthase Kinase-3, beta


(Oryctolagus cuniculus (rabbit))
BDBM7851
PNG
(2-Ethyl-4-phenyl-1,2,4-thiadiazolidine-3,5-dione |...)
Show SMILES CCn1sc(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C10H10N2O2S/c1-2-11-9(13)12(10(14)15-11)8-6-4-3-5-7-8/h3-7H,2H2,1H3
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Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


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Ligand-Target Pair
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