BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 101 hits Enz. Inhib. hit(s) with Target = 'Glycogen synthase (GYS1)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433680
PNG
(CHEMBL2381133)
Show SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc(c2)C(=O)N(C)CCO)cc1
Show InChI InChI=1S/C24H23F2NO4/c1-27(10-11-28)24(29)18-5-3-4-16(12-18)15-31-19-8-6-17(7-9-19)20-13-21(25)22(26)14-23(20)30-2/h3-9,12-14,28H,10-11,15H2,1-2H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 4.10E+3n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433681
PNG
(CHEMBL2381159)
Show SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(C[C@@H](O)CO)c3=O)cc1
Show InChI InChI=1S/C24H22F2N2O5/c1-32-22-10-21(26)20(25)9-19(22)14-5-7-17(8-6-14)33-13-15-3-2-4-18-23(15)27-28(24(18)31)11-16(30)12-29/h2-10,16,27,29-30H,11-13H2,1H3/t16-/m1/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 270n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433682
PNG
(CHEMBL2381158)
Show SMILES Cc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(C[C@@H](O)CO)c3=O)cc1
Show InChI InChI=1S/C24H22F2N2O4/c1-14-9-21(25)22(26)10-20(14)15-5-7-18(8-6-15)32-13-16-3-2-4-19-23(16)27-28(24(19)31)11-17(30)12-29/h2-10,17,27,29-30H,11-13H2,1H3/t17-/m1/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 230n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433683
PNG
(CHEMBL2381157)
Show SMILES OC[C@H](O)Cn1[nH]c2c(COc3ccc(cc3)-c3cc(F)c(F)cc3Cl)cccc2c1=O
Show InChI InChI=1S/C23H19ClF2N2O4/c24-19-9-21(26)20(25)8-18(19)13-4-6-16(7-5-13)32-12-14-2-1-3-17-22(14)27-28(23(17)31)10-15(30)11-29/h1-9,15,27,29-30H,10-12H2/t15-/m1/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 260n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433684
PNG
(CHEMBL2381156)
Show SMILES OC[C@H](O)Cn1[nH]c2c(COc3ccc(cc3)-c3cc(F)c(F)cc3F)cccc2c1=O
Show InChI InChI=1S/C23H19F3N2O4/c24-19-9-21(26)20(25)8-18(19)13-4-6-16(7-5-13)32-12-14-2-1-3-17-22(14)27-28(23(17)31)10-15(30)11-29/h1-9,15,27,29-30H,10-12H2/t15-/m1/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 680n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433685
PNG
(CHEMBL2381155)
Show SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(C[C@H](O)CO)c3=O)cc1
Show InChI InChI=1S/C24H22F2N2O5/c1-32-22-10-21(26)20(25)9-19(22)14-5-7-17(8-6-14)33-13-15-3-2-4-18-23(15)27-28(24(18)31)11-16(30)12-29/h2-10,16,27,29-30H,11-13H2,1H3/t16-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 250n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433686
PNG
(CHEMBL2381154)
Show SMILES Cc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(C[C@H](O)CO)c3=O)cc1
Show InChI InChI=1S/C24H22F2N2O4/c1-14-9-21(25)22(26)10-20(14)15-5-7-18(8-6-15)32-13-16-3-2-4-19-23(16)27-28(24(19)31)11-17(30)12-29/h2-10,17,27,29-30H,11-13H2,1H3/t17-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 340n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433687
PNG
(CHEMBL2381153)
Show SMILES OC[C@@H](O)Cn1[nH]c2c(COc3ccc(cc3)-c3cc(F)c(F)cc3Cl)cccc2c1=O
Show InChI InChI=1S/C23H19ClF2N2O4/c24-19-9-21(26)20(25)8-18(19)13-4-6-16(7-5-13)32-12-14-2-1-3-17-22(14)27-28(23(17)31)10-15(30)11-29/h1-9,15,27,29-30H,10-12H2/t15-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 300n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433688
PNG
(CHEMBL2381152)
Show SMILES OC[C@@H](O)Cn1[nH]c2c(COc3ccc(cc3)-c3cc(F)c(F)cc3F)cccc2c1=O
Show InChI InChI=1S/C23H19F3N2O4/c24-19-9-21(26)20(25)8-18(19)13-4-6-16(7-5-13)32-12-14-2-1-3-17-22(14)27-28(23(17)31)10-15(30)11-29/h1-9,15,27,29-30H,10-12H2/t15-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 580n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433689
PNG
(CHEMBL2381151)
Show SMILES OCCn1[nH]c2c(COc3ccc(cc3)-c3cc(F)c(F)cc3F)cccc2c1=O
Show InChI InChI=1S/C22H17F3N2O3/c23-18-11-20(25)19(24)10-17(18)13-4-6-15(7-5-13)30-12-14-2-1-3-16-21(14)26-27(8-9-28)22(16)29/h1-7,10-11,26,28H,8-9,12H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 770n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433690
PNG
(CHEMBL2381150)
Show SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(CC(O)=O)c3=O)cc1
Show InChI InChI=1S/C23H18F2N2O5/c1-31-20-10-19(25)18(24)9-17(20)13-5-7-15(8-6-13)32-12-14-3-2-4-16-22(14)26-27(23(16)30)11-21(28)29/h2-10,26H,11-12H2,1H3,(H,28,29)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 200n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433691
PNG
(CHEMBL2381149)
Show SMILES Cc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(CC(O)=O)c3=O)cc1
Show InChI InChI=1S/C23H18F2N2O4/c1-13-9-19(24)20(25)10-18(13)14-5-7-16(8-6-14)31-12-15-3-2-4-17-22(15)26-27(23(17)30)11-21(28)29/h2-10,26H,11-12H2,1H3,(H,28,29)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 420n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433692
PNG
(CHEMBL2381148)
Show SMILES OC(=O)Cn1[nH]c2c(COc3ccc(cc3)-c3cc(F)c(F)cc3F)cccc2c1=O
Show InChI InChI=1S/C22H15F3N2O4/c23-17-9-19(25)18(24)8-16(17)12-4-6-14(7-5-12)31-11-13-2-1-3-15-21(13)26-27(22(15)30)10-20(28)29/h1-9,26H,10-11H2,(H,28,29)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.20E+3n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433693
PNG
(CHEMBL2381147)
Show SMILES Cc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(-c2ccc(F)cc2)c3=O)cc1
Show InChI InChI=1S/C27H19F3N2O2/c1-16-13-24(29)25(30)14-23(16)17-5-11-21(12-6-17)34-15-18-3-2-4-22-26(18)31-32(27(22)33)20-9-7-19(28)8-10-20/h2-14,31H,15H2,1H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.47E+3n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433694
PNG
(CHEMBL2381146)
Show SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(-c2ccc(F)cc2)c3=O)cc1
Show InChI InChI=1S/C27H19F3N2O3/c1-34-25-14-24(30)23(29)13-22(25)16-5-11-20(12-6-16)35-15-17-3-2-4-21-26(17)31-32(27(21)33)19-9-7-18(28)8-10-19/h2-14,31H,15H2,1H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.37E+3n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433695
PNG
(CHEMBL2381145)
Show SMILES Fc1cc(Cl)c(cc1F)-c1ccc(OCc2cccc3c2[nH]n(-c2cccnc2)c3=O)cc1
Show InChI InChI=1S/C25H16ClF2N3O2/c26-21-12-23(28)22(27)11-20(21)15-6-8-18(9-7-15)33-14-16-3-1-5-19-24(16)30-31(25(19)32)17-4-2-10-29-13-17/h1-13,30H,14H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.86E+3n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433696
PNG
(CHEMBL2381144)
Show SMILES Fc1cc(F)c(cc1F)-c1ccc(OCc2cccc3c2[nH]n(-c2cccnc2)c3=O)cc1
Show InChI InChI=1S/C25H16F3N3O2/c26-21-12-23(28)22(27)11-20(21)15-6-8-18(9-7-15)33-14-16-3-1-5-19-24(16)30-31(25(19)32)17-4-2-10-29-13-17/h1-13,30H,14H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 4.01E+3n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433697
PNG
(CHEMBL2381143)
Show SMILES COCCn1[nH]c2c(COc3ccc(cc3)-c3cc(F)c(F)cc3OC)cccc2c1=O
Show InChI InChI=1S/C24H22F2N2O4/c1-30-11-10-28-24(29)18-5-3-4-16(23(18)27-28)14-32-17-8-6-15(7-9-17)19-12-20(25)21(26)13-22(19)31-2/h3-9,12-13,27H,10-11,14H2,1-2H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 370n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433698
PNG
(CHEMBL2381142)
Show SMILES COCCn1[nH]c2c(COc3ccc(cc3)-c3cc(F)c(F)cc3F)cccc2c1=O
Show InChI InChI=1S/C23H19F3N2O3/c1-30-10-9-28-23(29)17-4-2-3-15(22(17)27-28)13-31-16-7-5-14(6-8-16)18-11-20(25)21(26)12-19(18)24/h2-8,11-12,27H,9-10,13H2,1H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 790n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433699
PNG
(CHEMBL2381141)
Show SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(C)c3=O)cc1
Show InChI InChI=1S/C22H18F2N2O3/c1-26-22(27)16-5-3-4-14(21(16)25-26)12-29-15-8-6-13(7-9-15)17-10-18(23)19(24)11-20(17)28-2/h3-11,25H,12H2,1-2H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 320n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433700
PNG
(CHEMBL2381140)
Show SMILES Cc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(C)c3=O)cc1
Show InChI InChI=1S/C22H18F2N2O2/c1-13-10-19(23)20(24)11-18(13)14-6-8-16(9-7-14)28-12-15-4-3-5-17-21(15)25-26(2)22(17)27/h3-11,25H,12H2,1-2H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 240n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433701
PNG
(CHEMBL2381139)
Show SMILES Cn1[nH]c2c(COc3ccc(cc3)-c3cc(F)c(F)cc3F)cccc2c1=O
Show InChI InChI=1S/C21H15F3N2O2/c1-26-21(27)15-4-2-3-13(20(15)25-26)11-28-14-7-5-12(6-8-14)16-9-18(23)19(24)10-17(16)22/h2-10,25H,11H2,1H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.78E+3n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433702
PNG
(CHEMBL2381138)
Show SMILES Fc1cc(F)c(cc1F)-c1ccc(OCc2cccc3c2[nH]oc3=O)cc1
Show InChI InChI=1S/C20H12F3NO3/c21-16-9-18(23)17(22)8-15(16)11-4-6-13(7-5-11)26-10-12-2-1-3-14-19(12)24-27-20(14)25/h1-9,24H,10H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/an/an/a 1.00E+3n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433703
PNG
(CHEMBL2381137)
Show SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc(c2)C(=O)N(C)CC(O)O)cc1
Show InChI InChI=1S/C24H23F2NO5/c1-27(13-23(28)29)24(30)17-5-3-4-15(10-17)14-32-18-8-6-16(7-9-18)19-11-20(25)21(26)12-22(19)31-2/h3-12,23,28-29H,13-14H2,1-2H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.03E+4n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433704
PNG
(CHEMBL2381136)
Show SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc(c2)C(=O)N(C)CC(O)=O)cc1
Show InChI InChI=1S/C24H21F2NO5/c1-27(13-23(28)29)24(30)17-5-3-4-15(10-17)14-32-18-8-6-16(7-9-18)19-11-20(25)21(26)12-22(19)31-2/h3-12H,13-14H2,1-2H3,(H,28,29)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 100n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433705
PNG
(CHEMBL2381134)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1ccc(COc2ccc(cc2)-c2ccccc2)o1
Show InChI InChI=1S/C23H21NO5/c25-22(24-14-4-7-20(24)23(26)27)21-13-12-19(29-21)15-28-18-10-8-17(9-11-18)16-5-2-1-3-6-16/h1-3,5-6,8-13,20H,4,7,14-15H2,(H,26,27)/t20-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/an/an/a 1.51E+4n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433706
PNG
(CHEMBL2381135 | US9290487, compound of Ex. 37)
Show SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C26H23F2NO5/c1-33-24-14-22(28)21(27)13-20(24)17-7-9-19(10-8-17)34-15-16-4-2-5-18(12-16)25(30)29-11-3-6-23(29)26(31)32/h2,4-5,7-10,12-14,23H,3,6,11,15H2,1H3,(H,31,32)/t23-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/an/an/a 140n/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometry


Bioorg Med Chem Lett 23: 2936-40 (2013)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212154
PNG
(US9290487, compound of Ex. 1)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)cc3CCOc23)c1
Show InChI InChI=1/C27H24FNO5/c28-21-14-19-10-12-33-25(19)23(15-21)18-6-8-22(9-7-18)34-16-17-3-1-4-20(13-17)26(30)29-11-2-5-24(29)27(31)32/h1,3-4,6-9,13-15,24H,2,5,10-12,16H2,(H,31,32)/t24-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 260n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212155
PNG
(US9290487, compound of Ex. 2)
Show SMILES CN(CC(O)=O)C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)cc3CCOc23)c1
Show InChI InChI=1S/C25H22FNO5/c1-27(14-23(28)29)25(30)19-4-2-3-16(11-19)15-32-21-7-5-17(6-8-21)22-13-20(26)12-18-9-10-31-24(18)22/h2-8,11-13H,9-10,14-15H2,1H3,(H,28,29)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 590n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212156
PNG
(US9290487, compound of Ex. 3)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc(F)c3ccoc23)c1
Show InChI InChI=1/C27H22FNO5/c28-23-11-10-21(25-22(23)12-14-33-25)18-6-8-20(9-7-18)34-16-17-3-1-4-19(15-17)26(30)29-13-2-5-24(29)27(31)32/h1,3-4,6-12,14-15,24H,2,5,13,16H2,(H,31,32)/t24-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 110n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212157
PNG
(US9290487, compound of Ex. 4)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3OCOc23)c1
Show InChI InChI=1/C26H23NO6/c28-25(27-13-3-7-22(27)26(29)30)19-5-1-4-17(14-19)15-31-20-11-9-18(10-12-20)21-6-2-8-23-24(21)33-16-32-23/h1-2,4-6,8-12,14,22H,3,7,13,15-16H2,(H,29,30)/t22-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 250n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212158
PNG
(US9290487, compound of Ex. 5)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3CCOc23)c1
Show InChI InChI=1/C27H25NO5/c29-26(28-14-3-8-24(28)27(30)31)21-6-1-4-18(16-21)17-33-22-11-9-19(10-12-22)23-7-2-5-20-13-15-32-25(20)23/h1-2,4-7,9-12,16,24H,3,8,13-15,17H2,(H,30,31)/t24-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 500n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212159
PNG
(US9290487, compound of Ex. 6)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc3occc3c2)c1
Show InChI InChI=1/C27H23NO5/c29-26(28-13-2-5-24(28)27(30)31)22-4-1-3-18(15-22)17-33-23-9-6-19(7-10-23)20-8-11-25-21(16-20)12-14-32-25/h1,3-4,6-12,14-16,24H,2,5,13,17H2,(H,30,31)/t24-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 330n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212160
PNG
(US9290487, compound of Ex. 7)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3ccoc23)c1
Show InChI InChI=1/C27H23NO5/c29-26(28-14-3-8-24(28)27(30)31)21-6-1-4-18(16-21)17-33-22-11-9-19(10-12-22)23-7-2-5-20-13-15-32-25(20)23/h1-2,4-7,9-13,15-16,24H,3,8,14,17H2,(H,30,31)/t24-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 260n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212161
PNG
(US9290487, compound of Ex. 8)
Show SMILES Cc1cc2cccc(-c3ccc(OCc4cccc(c4)C(=O)N4CCC[C@H]4C(O)=O)cc3)c2o1
Show InChI InChI=1/C28H25NO5/c1-18-15-21-6-3-8-24(26(21)34-18)20-10-12-23(13-11-20)33-17-19-5-2-7-22(16-19)27(30)29-14-4-9-25(29)28(31)32/h2-3,5-8,10-13,15-16,25H,4,9,14,17H2,1H3,(H,31,32)/t25-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 820n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212162
PNG
(US9290487, compound of Ex. 9)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3C=CCOc23)c1
Show InChI InChI=1/C28H25NO5/c30-27(29-15-3-10-25(29)28(31)32)22-7-1-5-19(17-22)18-34-23-13-11-20(12-14-23)24-9-2-6-21-8-4-16-33-26(21)24/h1-2,4-9,11-14,17,25H,3,10,15-16,18H2,(H,31,32)/t25-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 320n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212163
PNG
(US9290487, compound of Ex. 10)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc(F)c3CCOc23)c1
Show InChI InChI=1/C27H24FNO5/c28-23-11-10-21(25-22(23)12-14-33-25)18-6-8-20(9-7-18)34-16-17-3-1-4-19(15-17)26(30)29-13-2-5-24(29)27(31)32/h1,3-4,6-11,15,24H,2,5,12-14,16H2,(H,31,32)/t24-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 350n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212164
PNG
(US9290487, compound of Ex. 11)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)cc3C=CCOc23)c1
Show InChI InChI=1/C28H24FNO5/c29-22-15-20-6-3-13-34-26(20)24(16-22)19-8-10-23(11-9-19)35-17-18-4-1-5-21(14-18)27(31)30-12-2-7-25(30)28(32)33/h1,3-6,8-11,14-16,25H,2,7,12-13,17H2,(H,32,33)/t25-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 780n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212165
PNG
(US9290487, compound of Ex. 12)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)cc3ccoc23)c1
Show InChI InChI=1/C27H22FNO5/c28-21-14-19-10-12-33-25(19)23(15-21)18-6-8-22(9-7-18)34-16-17-3-1-4-20(13-17)26(30)29-11-2-5-24(29)27(31)32/h1,3-4,6-10,12-15,24H,2,5,11,16H2,(H,31,32)/t24-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 350n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212166
PNG
(US9290487, compound of Ex. 13)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc(F)c3OCOc23)c1
Show InChI InChI=1/C26H22FNO6/c27-21-11-10-20(23-24(21)34-15-33-23)17-6-8-19(9-7-17)32-14-16-3-1-4-18(13-16)25(29)28-12-2-5-22(28)26(30)31/h1,3-4,6-11,13,22H,2,5,12,14-15H2,(H,30,31)/t22-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 270n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212167
PNG
(US9290487, compound of Ex. 14)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c3occc3c2)c1
Show InChI InChI=1/C27H22FNO5/c28-23-15-21(14-19-10-12-33-25(19)23)18-6-8-22(9-7-18)34-16-17-3-1-4-20(13-17)26(30)29-11-2-5-24(29)27(31)32/h1,3-4,6-10,12-15,24H,2,5,11,16H2,(H,31,32)/t24-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 70n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212168
PNG
(US9290487, compound of Ex. 15)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3ccoc23)c1
Show InChI InChI=1/C27H21F2NO5/c28-22-14-21(25-20(24(22)29)10-12-34-25)17-6-8-19(9-7-17)35-15-16-3-1-4-18(13-16)26(31)30-11-2-5-23(30)27(32)33/h1,3-4,6-10,12-14,23H,2,5,11,15H2,(H,32,33)/t23-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 22n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212169
PNG
(US9290487, compound of Ex. 16)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc3ccoc3c(F)c2F)c1
Show InChI InChI=1/C27H21F2NO5/c28-23-21(14-18-10-12-34-25(18)24(23)29)17-6-8-20(9-7-17)35-15-16-3-1-4-19(13-16)26(31)30-11-2-5-22(30)27(32)33/h1,3-4,6-10,12-14,22H,2,5,11,15H2,(H,32,33)/t22-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 35n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212170
PNG
(US9290487, compound of Ex. 17)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c3occc3c2F)c1
Show InChI InChI=1/C27H21F2NO5/c28-22-14-21(24(29)20-10-12-34-25(20)22)17-6-8-19(9-7-17)35-15-16-3-1-4-18(13-16)26(31)30-11-2-5-23(30)27(32)33/h1,3-4,6-10,12-14,23H,2,5,11,15H2,(H,32,33)/t23-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 270n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212171
PNG
(US9290487, compound of Ex. 18)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3C=CCOc23)c1
Show InChI InChI=1/C28H23F2NO5/c29-23-15-22(26-21(25(23)30)6-3-13-35-26)18-8-10-20(11-9-18)36-16-17-4-1-5-19(14-17)27(32)31-12-2-7-24(31)28(33)34/h1,3-6,8-11,14-15,24H,2,7,12-13,16H2,(H,33,34)/t24-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 100n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212172
PNG
(US9290487, compound of Ex. 19)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3CCOc23)c1
Show InChI InChI=1/C27H23F2NO5/c28-22-14-21(25-20(24(22)29)10-12-34-25)17-6-8-19(9-7-17)35-15-16-3-1-4-18(13-16)26(31)30-11-2-5-23(30)27(32)33/h1,3-4,6-9,13-14,23H,2,5,10-12,15H2,(H,32,33)/t23-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 31n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212173
PNG
(US9290487, compound of Ex. 20)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2c(F)cc(F)c3ccoc23)c1
Show InChI InChI=1/C27H21F2NO5/c28-21-14-22(29)24(25-20(21)10-12-34-25)17-6-8-19(9-7-17)35-15-16-3-1-4-18(13-16)26(31)30-11-2-5-23(30)27(32)33/h1,3-4,6-10,12-14,23H,2,5,11,15H2,(H,32,33)/t23-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 64n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212174
PNG
(US9290487, compound of Ex. 21)
Show SMILES Cc1coc2c(cc(F)c(F)c12)-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1/C28H23F2NO5/c1-16-14-36-26-21(13-22(29)25(30)24(16)26)18-7-9-20(10-8-18)35-15-17-4-2-5-19(12-17)27(32)31-11-3-6-23(31)28(33)34/h2,4-5,7-10,12-14,23H,3,6,11,15H2,1H3,(H,33,34)/t23-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 54n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212175
PNG
(US9290487, compound of Ex. 22)
Show SMILES CC1(C)Cc2cc(F)cc(c2O1)-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1/C29H28FNO5/c1-29(2)16-21-14-22(30)15-24(26(21)36-29)19-8-10-23(11-9-19)35-17-18-5-3-6-20(13-18)27(32)31-12-4-7-25(31)28(33)34/h3,5-6,8-11,13-15,25H,4,7,12,16-17H2,1-2H3,(H,33,34)/t25-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 180n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212176
PNG
(US9290487, compound of Ex. 23)
Show SMILES Cc1cc2c(F)c(F)cc(-c3ccc(OCc4cccc(c4)C(=O)N4CCC[C@H]4C(O)=O)cc3)c2o1
Show InChI InChI=1/C28H23F2NO5/c1-16-12-22-25(30)23(29)14-21(26(22)36-16)18-7-9-20(10-8-18)35-15-17-4-2-5-19(13-17)27(32)31-11-3-6-24(31)28(33)34/h2,4-5,7-10,12-14,24H,3,6,11,15H2,1H3,(H,33,34)/t24-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 110n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 101 total )  |  Next  |  Last  >>
Jump to: