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Found 101 hits Enz. Inhib. hit(s) with Target = 'Glycogen synthase (GYS1)' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212154
PNG
(US9290487, compound of Ex. 1)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)cc3CCOc23)c1
Show InChI InChI=1S/C27H24FNO5/c28-21-14-19-10-12-33-25(19)23(15-21)18-6-8-22(9-7-18)34-16-17-3-1-4-20(13-17)26(30)29-11-2-5-24(29)27(31)32/h1,3-4,6-9,13-15,24H,2,5,10-12,16H2,(H,31,32)/t24-/m0/s1
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n/an/an/an/a 260n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212155
PNG
(US9290487, compound of Ex. 2)
Show SMILES CN(CC(O)=O)C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)cc3CCOc23)c1
Show InChI InChI=1S/C25H22FNO5/c1-27(14-23(28)29)25(30)19-4-2-3-16(11-19)15-32-21-7-5-17(6-8-21)22-13-20(26)12-18-9-10-31-24(18)22/h2-8,11-13H,9-10,14-15H2,1H3,(H,28,29)
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212156
PNG
(US9290487, compound of Ex. 3)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc(F)c3ccoc23)c1
Show InChI InChI=1S/C27H22FNO5/c28-23-11-10-21(25-22(23)12-14-33-25)18-6-8-20(9-7-18)34-16-17-3-1-4-19(15-17)26(30)29-13-2-5-24(29)27(31)32/h1,3-4,6-12,14-15,24H,2,5,13,16H2,(H,31,32)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212157
PNG
(US9290487, compound of Ex. 4)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3OCOc23)c1
Show InChI InChI=1S/C26H23NO6/c28-25(27-13-3-7-22(27)26(29)30)19-5-1-4-17(14-19)15-31-20-11-9-18(10-12-20)21-6-2-8-23-24(21)33-16-32-23/h1-2,4-6,8-12,14,22H,3,7,13,15-16H2,(H,29,30)/t22-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212158
PNG
(US9290487, compound of Ex. 5)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3CCOc23)c1
Show InChI InChI=1S/C27H25NO5/c29-26(28-14-3-8-24(28)27(30)31)21-6-1-4-18(16-21)17-33-22-11-9-19(10-12-22)23-7-2-5-20-13-15-32-25(20)23/h1-2,4-7,9-12,16,24H,3,8,13-15,17H2,(H,30,31)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212159
PNG
(US9290487, compound of Ex. 6)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc3occc3c2)c1
Show InChI InChI=1S/C27H23NO5/c29-26(28-13-2-5-24(28)27(30)31)22-4-1-3-18(15-22)17-33-23-9-6-19(7-10-23)20-8-11-25-21(16-20)12-14-32-25/h1,3-4,6-12,14-16,24H,2,5,13,17H2,(H,30,31)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212160
PNG
(US9290487, compound of Ex. 7)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3ccoc23)c1
Show InChI InChI=1S/C27H23NO5/c29-26(28-14-3-8-24(28)27(30)31)21-6-1-4-18(16-21)17-33-22-11-9-19(10-12-22)23-7-2-5-20-13-15-32-25(20)23/h1-2,4-7,9-13,15-16,24H,3,8,14,17H2,(H,30,31)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212161
PNG
(US9290487, compound of Ex. 8)
Show SMILES Cc1cc2cccc(-c3ccc(OCc4cccc(c4)C(=O)N4CCC[C@H]4C(O)=O)cc3)c2o1
Show InChI InChI=1S/C28H25NO5/c1-18-15-21-6-3-8-24(26(21)34-18)20-10-12-23(13-11-20)33-17-19-5-2-7-22(16-19)27(30)29-14-4-9-25(29)28(31)32/h2-3,5-8,10-13,15-16,25H,4,9,14,17H2,1H3,(H,31,32)/t25-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212162
PNG
(US9290487, compound of Ex. 9)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3C=CCOc23)c1
Show InChI InChI=1S/C28H25NO5/c30-27(29-15-3-10-25(29)28(31)32)22-7-1-5-19(17-22)18-34-23-13-11-20(12-14-23)24-9-2-6-21-8-4-16-33-26(21)24/h1-2,4-9,11-14,17,25H,3,10,15-16,18H2,(H,31,32)/t25-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212163
PNG
(US9290487, compound of Ex. 10)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc(F)c3CCOc23)c1
Show InChI InChI=1S/C27H24FNO5/c28-23-11-10-21(25-22(23)12-14-33-25)18-6-8-20(9-7-18)34-16-17-3-1-4-19(15-17)26(30)29-13-2-5-24(29)27(31)32/h1,3-4,6-11,15,24H,2,5,12-14,16H2,(H,31,32)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212164
PNG
(US9290487, compound of Ex. 11)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)cc3C=CCOc23)c1
Show InChI InChI=1S/C28H24FNO5/c29-22-15-20-6-3-13-34-26(20)24(16-22)19-8-10-23(11-9-19)35-17-18-4-1-5-21(14-18)27(31)30-12-2-7-25(30)28(32)33/h1,3-6,8-11,14-16,25H,2,7,12-13,17H2,(H,32,33)/t25-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212165
PNG
(US9290487, compound of Ex. 12)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)cc3ccoc23)c1
Show InChI InChI=1S/C27H22FNO5/c28-21-14-19-10-12-33-25(19)23(15-21)18-6-8-22(9-7-18)34-16-17-3-1-4-20(13-17)26(30)29-11-2-5-24(29)27(31)32/h1,3-4,6-10,12-15,24H,2,5,11,16H2,(H,31,32)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212166
PNG
(US9290487, compound of Ex. 13)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc(F)c3OCOc23)c1
Show InChI InChI=1S/C26H22FNO6/c27-21-11-10-20(23-24(21)34-15-33-23)17-6-8-19(9-7-17)32-14-16-3-1-4-18(13-16)25(29)28-12-2-5-22(28)26(30)31/h1,3-4,6-11,13,22H,2,5,12,14-15H2,(H,30,31)/t22-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212167
PNG
(US9290487, compound of Ex. 14)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c3occc3c2)c1
Show InChI InChI=1S/C27H22FNO5/c28-23-15-21(14-19-10-12-33-25(19)23)18-6-8-22(9-7-18)34-16-17-3-1-4-20(13-17)26(30)29-11-2-5-24(29)27(31)32/h1,3-4,6-10,12-15,24H,2,5,11,16H2,(H,31,32)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212168
PNG
(US9290487, compound of Ex. 15)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3ccoc23)c1
Show InChI InChI=1S/C27H21F2NO5/c28-22-14-21(25-20(24(22)29)10-12-34-25)17-6-8-19(9-7-17)35-15-16-3-1-4-18(13-16)26(31)30-11-2-5-23(30)27(32)33/h1,3-4,6-10,12-14,23H,2,5,11,15H2,(H,32,33)/t23-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212169
PNG
(US9290487, compound of Ex. 16)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc3ccoc3c(F)c2F)c1
Show InChI InChI=1S/C27H21F2NO5/c28-23-21(14-18-10-12-34-25(18)24(23)29)17-6-8-20(9-7-17)35-15-16-3-1-4-19(13-16)26(31)30-11-2-5-22(30)27(32)33/h1,3-4,6-10,12-14,22H,2,5,11,15H2,(H,32,33)/t22-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212170
PNG
(US9290487, compound of Ex. 17)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c3occc3c2F)c1
Show InChI InChI=1S/C27H21F2NO5/c28-22-14-21(24(29)20-10-12-34-25(20)22)17-6-8-19(9-7-17)35-15-16-3-1-4-18(13-16)26(31)30-11-2-5-23(30)27(32)33/h1,3-4,6-10,12-14,23H,2,5,11,15H2,(H,32,33)/t23-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212171
PNG
(US9290487, compound of Ex. 18)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3C=CCOc23)c1
Show InChI InChI=1S/C28H23F2NO5/c29-23-15-22(26-21(25(23)30)6-3-13-35-26)18-8-10-20(11-9-18)36-16-17-4-1-5-19(14-17)27(32)31-12-2-7-24(31)28(33)34/h1,3-6,8-11,14-15,24H,2,7,12-13,16H2,(H,33,34)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212172
PNG
(US9290487, compound of Ex. 19)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3CCOc23)c1
Show InChI InChI=1S/C27H23F2NO5/c28-22-14-21(25-20(24(22)29)10-12-34-25)17-6-8-19(9-7-17)35-15-16-3-1-4-18(13-16)26(31)30-11-2-5-23(30)27(32)33/h1,3-4,6-9,13-14,23H,2,5,10-12,15H2,(H,32,33)/t23-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212173
PNG
(US9290487, compound of Ex. 20)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2c(F)cc(F)c3ccoc23)c1
Show InChI InChI=1S/C27H21F2NO5/c28-21-14-22(29)24(25-20(21)10-12-34-25)17-6-8-19(9-7-17)35-15-16-3-1-4-18(13-16)26(31)30-11-2-5-23(30)27(32)33/h1,3-4,6-10,12-14,23H,2,5,11,15H2,(H,32,33)/t23-/m0/s1
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n/an/an/an/a 64n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212175
PNG
(US9290487, compound of Ex. 22)
Show SMILES CC1(C)Cc2cc(F)cc(c2O1)-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H28FNO5/c1-29(2)16-21-14-22(30)15-24(26(21)36-29)19-8-10-23(11-9-19)35-17-18-5-3-6-20(13-18)27(32)31-12-4-7-25(31)28(33)34/h3,5-6,8-11,13-15,25H,4,7,12,16-17H2,1-2H3,(H,33,34)/t25-/m0/s1
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n/an/an/an/a 180n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212176
PNG
(US9290487, compound of Ex. 23)
Show SMILES Cc1cc2c(F)c(F)cc(-c3ccc(OCc4cccc(c4)C(=O)N4CCC[C@H]4C(O)=O)cc3)c2o1
Show InChI InChI=1S/C28H23F2NO5/c1-16-12-22-25(30)23(29)14-21(26(22)36-16)18-7-9-20(10-8-18)35-15-17-4-2-5-19(13-17)27(32)31-11-3-6-24(31)28(33)34/h2,4-5,7-10,12-14,24H,3,6,11,15H2,1H3,(H,33,34)/t24-/m0/s1
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n/an/an/an/a 110n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212177
PNG
(US9290487, compound of Ex. 24)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3CCCc23)c1
Show InChI InChI=1S/C28H27NO4/c30-27(29-16-4-11-26(29)28(31)32)22-8-1-5-19(17-22)18-33-23-14-12-21(13-15-23)25-10-3-7-20-6-2-9-24(20)25/h1,3,5,7-8,10,12-15,17,26H,2,4,6,9,11,16,18H2,(H,31,32)/t26-/m0/s1
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n/an/an/an/a 670n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212178
PNG
(US9290487, compound of Ex. 25)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc(F)c3occc23)c1
Show InChI InChI=1S/C27H22FNO5/c28-23-11-10-21(22-12-14-33-25(22)23)18-6-8-20(9-7-18)34-16-17-3-1-4-19(15-17)26(30)29-13-2-5-24(29)27(31)32/h1,3-4,6-12,14-15,24H,2,5,13,16H2,(H,31,32)/t24-/m0/s1
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n/an/an/an/a 400n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212179
PNG
(US9290487, compound of Ex. 26)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3[nH]ccc23)c1
Show InChI InChI=1S/C27H24N2O4/c30-26(29-15-3-8-25(29)27(31)32)20-5-1-4-18(16-20)17-33-21-11-9-19(10-12-21)22-6-2-7-24-23(22)13-14-28-24/h1-2,4-7,9-14,16,25,28H,3,8,15,17H2,(H,31,32)/t25-/m0/s1
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n/an/an/an/a 160n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212180
PNG
(US9290487, compound of Ex. 27)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc(F)c3OCC=Cc23)c1
Show InChI InChI=1S/C28H24FNO5/c29-24-13-12-22(23-6-3-15-34-26(23)24)19-8-10-21(11-9-19)35-17-18-4-1-5-20(16-18)27(31)30-14-2-7-25(30)28(32)33/h1,3-6,8-13,16,25H,2,7,14-15,17H2,(H,32,33)/t25-/m0/s1
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n/an/an/an/a 210n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212181
PNG
(US9290487, compound of Ex. 28)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3ccsc23)c1
Show InChI InChI=1S/C27H23NO4S/c29-26(28-14-3-8-24(28)27(30)31)21-6-1-4-18(16-21)17-32-22-11-9-19(10-12-22)23-7-2-5-20-13-15-33-25(20)23/h1-2,4-7,9-13,15-16,24H,3,8,14,17H2,(H,30,31)/t24-/m0/s1
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n/an/an/an/a 890n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212182
PNG
(US9290487, compound of Ex. 29)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc(F)c3[nH]ccc23)c1
Show InChI InChI=1S/C27H23FN2O4/c28-23-11-10-21(22-12-13-29-25(22)23)18-6-8-20(9-7-18)34-16-17-3-1-4-19(15-17)26(31)30-14-2-5-24(30)27(32)33/h1,3-4,6-13,15,24,29H,2,5,14,16H2,(H,32,33)/t24-/m0/s1
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n/an/an/an/a 230n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212183
PNG
(US9290487, compound of Ex. 30)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3occc23)c1
Show InChI InChI=1S/C27H21F2NO5/c28-22-14-21(20-10-12-34-25(20)24(22)29)17-6-8-19(9-7-17)35-15-16-3-1-4-18(13-16)26(31)30-11-2-5-23(30)27(32)33/h1,3-4,6-10,12-14,23H,2,5,11,15H2,(H,32,33)/t23-/m0/s1
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n/an/an/an/a 140n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212184
PNG
(US9290487, compound of Ex. 31)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3OCC=Cc23)c1
Show InChI InChI=1S/C28H23F2NO5/c29-23-15-22(21-6-3-13-35-26(21)25(23)30)18-8-10-20(11-9-18)36-16-17-4-1-5-19(14-17)27(32)31-12-2-7-24(31)28(33)34/h1,3-6,8-11,14-15,24H,2,7,12-13,16H2,(H,33,34)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212185
PNG
(US9290487, compound of Ex. 32)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cccc3NC(=O)COc23)c1
Show InChI InChI=1S/C27H24N2O6/c30-24-16-35-25-21(6-2-7-22(25)28-24)18-9-11-20(12-10-18)34-15-17-4-1-5-19(14-17)26(31)29-13-3-8-23(29)27(32)33/h1-2,4-7,9-12,14,23H,3,8,13,15-16H2,(H,28,30)(H,32,33)/t23-/m0/s1
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n/an/an/an/a 750n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212186
PNG
(US9290487, compound of Ex. 33)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3[nH]ccc23)c1
Show InChI InChI=1S/C27H22F2N2O4/c28-22-14-21(20-10-11-30-25(20)24(22)29)17-6-8-19(9-7-17)35-15-16-3-1-4-18(13-16)26(32)31-12-2-5-23(31)27(33)34/h1,3-4,6-11,13-14,23,30H,2,5,12,15H2,(H,33,34)/t23-/m0/s1
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n/an/an/an/a 34n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212187
PNG
(US9290487, compound of Ex. 34)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)cc2OCC#C)c1
Show InChI InChI=1S/C28H23F2NO5/c1-2-13-35-26-16-24(30)23(29)15-22(26)19-8-10-21(11-9-19)36-17-18-5-3-6-20(14-18)27(32)31-12-4-7-25(31)28(33)34/h1,3,5-6,8-11,14-16,25H,4,7,12-13,17H2,(H,33,34)/t25-/m0/s1
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n/an/an/an/a 17n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212188
PNG
(US9290487, compound of Ex. 35)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)cc2OCC#N)c1
Show InChI InChI=1S/C27H22F2N2O5/c28-22-14-21(25(15-23(22)29)35-12-10-30)18-6-8-20(9-7-18)36-16-17-3-1-4-19(13-17)26(32)31-11-2-5-24(31)27(33)34/h1,3-4,6-9,13-15,24H,2,5,11-12,16H2,(H,33,34)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212189
PNG
(US9290487, compound of Ex. 36)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)cc2OCC=C)c1
Show InChI InChI=1S/C28H25F2NO5/c1-2-13-35-26-16-24(30)23(29)15-22(26)19-8-10-21(11-9-19)36-17-18-5-3-6-20(14-18)27(32)31-12-4-7-25(31)28(33)34/h2-3,5-6,8-11,14-16,25H,1,4,7,12-13,17H2,(H,33,34)/t25-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM50433706
PNG
(CHEMBL2381135 | US9290487, compound of Ex. 37)
Show SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C26H23F2NO5/c1-33-24-14-22(28)21(27)13-20(24)17-7-9-19(10-8-17)34-15-16-4-2-5-18(12-16)25(30)29-11-3-6-23(29)26(31)32/h2,4-5,7-10,12-14,23H,3,6,11,15H2,1H3,(H,31,32)/t23-/m0/s1
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n/an/an/an/a 10n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212190
PNG
(US9290487, compound of Ex. 38)
Show SMILES CSc1cc(F)c(F)cc1-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C26H23F2NO4S/c1-34-24-14-22(28)21(27)13-20(24)17-7-9-19(10-8-17)33-15-16-4-2-5-18(12-16)25(30)29-11-3-6-23(29)26(31)32/h2,4-5,7-10,12-14,23H,3,6,11,15H2,1H3,(H,31,32)/t23-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212191
PNG
(US9290487, compound of Ex. 39)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3ccsc23)c1
Show InChI InChI=1S/C27H21F2NO4S/c28-22-14-21(25-20(24(22)29)10-12-35-25)17-6-8-19(9-7-17)34-15-16-3-1-4-18(13-16)26(31)30-11-2-5-23(30)27(32)33/h1,3-4,6-10,12-14,23H,2,5,11,15H2,(H,32,33)/t23-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212192
PNG
(US9290487, compound of Ex. 40)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)cc2S)c1
Show InChI InChI=1S/C25H21F2NO4S/c26-20-12-19(23(33)13-21(20)27)16-6-8-18(9-7-16)32-14-15-3-1-4-17(11-15)24(29)28-10-2-5-22(28)25(30)31/h1,3-4,6-9,11-13,22,33H,2,5,10,14H2,(H,30,31)/t22-/m0/s1
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n/an/an/an/a 110n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212193
PNG
(US9290487, compound of Ex. 41)
Show SMILES Cc1cc2c(cc(F)c(F)c2[nH]1)-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C28H24F2N2O4/c1-16-12-22-21(14-23(29)25(30)26(22)31-16)18-7-9-20(10-8-18)36-15-17-4-2-5-19(13-17)27(33)32-11-3-6-24(32)28(34)35/h2,4-5,7-10,12-14,24,31H,3,6,11,15H2,1H3,(H,34,35)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212194
PNG
(US9290487, compound of Ex. 42)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c(NCC#N)c2)c1
Show InChI InChI=1S/C27H23F2N3O4/c28-22-14-20(15-23(25(22)29)31-11-10-30)18-6-8-21(9-7-18)36-16-17-3-1-4-19(13-17)26(33)32-12-2-5-24(32)27(34)35/h1,3-4,6-9,13-15,24,31H,2,5,11-12,16H2,(H,34,35)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212195
PNG
(US9290487, compound of Ex. 43)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)cc2C=O)c1
Show InChI InChI=1S/C26H21F2NO5/c27-22-12-19(14-30)21(13-23(22)28)17-6-8-20(9-7-17)34-15-16-3-1-4-18(11-16)25(31)29-10-2-5-24(29)26(32)33/h1,3-4,6-9,11-14,24H,2,5,10,15H2,(H,32,33)/t24-/m0/s1
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n/an/an/an/a 70n/an/an/an/a



AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212196
PNG
(US9290487, compound of Ex. 44)
Show SMILES COC(=O)c1cc(F)c(F)cc1-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C27H23F2NO6/c1-35-27(34)21-14-23(29)22(28)13-20(21)17-7-9-19(10-8-17)36-15-16-4-2-5-18(12-16)25(31)30-11-3-6-24(30)26(32)33/h2,4-5,7-10,12-14,24H,3,6,11,15H2,1H3,(H,32,33)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212197
PNG
(US9290487, compound of Ex. 45)
Show SMILES COCc1coc2c(cc(F)c(F)c12)-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H25F2NO6/c1-36-15-20-16-38-27-22(13-23(30)26(31)25(20)27)18-7-9-21(10-8-18)37-14-17-4-2-5-19(12-17)28(33)32-11-3-6-24(32)29(34)35/h2,4-5,7-10,12-13,16,24H,3,6,11,14-15H2,1H3,(H,34,35)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212198
PNG
(US9290487, compound of Ex. 46)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c3c(CC#N)coc23)c1
Show InChI InChI=1S/C29H22F2N2O5/c30-23-14-22(27-25(26(23)31)20(10-11-32)16-38-27)18-6-8-21(9-7-18)37-15-17-3-1-4-19(13-17)28(34)33-12-2-5-24(33)29(35)36/h1,3-4,6-9,13-14,16,24H,2,5,10,12,15H2,(H,35,36)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212199
PNG
(US9290487, compound of Ex. 47)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c(OCC#C)c2)c1
Show InChI InChI=1S/C28H23F2NO5/c1-2-13-35-25-16-21(15-23(29)26(25)30)19-8-10-22(11-9-19)36-17-18-5-3-6-20(14-18)27(32)31-12-4-7-24(31)28(33)34/h1,3,5-6,8-11,14-16,24H,4,7,12-13,17H2,(H,33,34)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212200
PNG
(US9290487, compound of Ex. 48)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c(F)c(OCC#N)c2)c1
Show InChI InChI=1S/C27H22F2N2O5/c28-22-14-20(15-24(25(22)29)35-12-10-30)18-6-8-21(9-7-18)36-16-17-3-1-4-19(13-17)26(32)31-11-2-5-23(31)27(33)34/h1,3-4,6-9,13-15,23H,2,5,11-12,16H2,(H,33,34)/t23-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212201
PNG
(US9290487, compound of Ex. 49)
Show SMILES CC(=O)COc1cc(cc(F)c1F)-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C28H25F2NO6/c1-17(32)15-37-25-14-21(13-23(29)26(25)30)19-7-9-22(10-8-19)36-16-18-4-2-5-20(12-18)27(33)31-11-3-6-24(31)28(34)35/h2,4-5,7-10,12-14,24H,3,6,11,15-16H2,1H3,(H,34,35)/t24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212202
PNG
(US9290487, compound of Ex. 50)
Show SMILES CC(O)COc1cc(cc(F)c1F)-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C28H27F2NO6/c1-17(32)15-37-25-14-21(13-23(29)26(25)30)19-7-9-22(10-8-19)36-16-18-4-2-5-20(12-18)27(33)31-11-3-6-24(31)28(34)35/h2,4-5,7-10,12-14,17,24,32H,3,6,11,15-16H2,1H3,(H,34,35)/t17?,24-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
Glycogen synthase (GYS1)


(Homo sapiens (Human))
BDBM212203
PNG
(US9290487, compound of Ex. 51)
Show SMILES CC(=O)CSc1cc(F)c(F)cc1-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C28H25F2NO5S/c1-17(32)16-37-26-14-24(30)23(29)13-22(26)19-7-9-21(10-8-19)36-15-18-4-2-5-20(12-18)27(33)31-11-3-6-25(31)28(34)35/h2,4-5,7-10,12-14,25H,3,6,11,15-16H2,1H3,(H,34,35)/t25-/m0/s1
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AJINOMOTO CO., INC.

US Patent


Assay Description
To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...


US Patent US9290487 (2016)


BindingDB Entry DOI: 10.7270/Q22R3QGX
More data for this
Ligand-Target Pair
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