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Compile Data Set for Download or QSAR

Found 10 hits Enz. Inhib. hit(s) with Target = 'Glycosylasparaginase (GA)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycosylasparaginase (GA)


(Homo sapiens (Human))
BDBM85476
PNG
(GlcNAc-Asn analogue, 12)
Show SMILES CC(=O)NC1C(O)C(O)C(CO)OC1NC(=O)CBr
Show InChI InChI=1S/C10H17BrN2O6/c1-4(15)12-7-9(18)8(17)5(3-14)19-10(7)13-6(16)2-11/h5,7-10,14,17-18H,2-3H2,1H3,(H,12,15)(H,13,16)
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PubMed
5.60E+5 -19.3n/an/an/an/an/a5.837



University of North Carolina



Assay Description
Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...


J Enzym Inhib 16: 269-74 (2001)

More data for this
Ligand-Target Pair
Glycosylasparaginase (GA)


(Homo sapiens (Human))
BDBM18125
PNG
((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Show SMILES N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
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PubMed
6.00E+5 -19.1n/an/an/an/an/a5.837



University of North Carolina



Assay Description
Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...


J Enzym Inhib 16: 269-74 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycosylasparaginase (GA)


(Homo sapiens (Human))
BDBM85475
PNG
(GlcNAc-Asn analogue, 11)
Show SMILES CC(=O)NC1C(O)C(O)C(CO)OC1NC(=O)CCl
Show InChI InChI=1S/C10H17ClN2O6/c1-4(15)12-7-9(18)8(17)5(3-14)19-10(7)13-6(16)2-11/h5,7-10,14,17-18H,2-3H2,1H3,(H,12,15)(H,13,16)
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PubMed
6.40E+5 -19.0n/an/an/an/an/a5.837



University of North Carolina



Assay Description
Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...


J Enzym Inhib 16: 269-74 (2001)

More data for this
Ligand-Target Pair
Glycosylasparaginase (GA)


(Homo sapiens (Human))
BDBM85472
PNG
(D,L-2-Methylsuccinic acid, 5)
Show SMILES CC(CC(O)=O)C(O)=O
Show InChI InChI=1S/C5H8O4/c1-3(5(8)9)2-4(6)7/h3H,2H2,1H3,(H,6,7)(H,8,9)
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PubMed
7.00E+5 -18.7n/an/an/an/an/a5.837



University of North Carolina



Assay Description
Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...


J Enzym Inhib 16: 269-74 (2001)

More data for this
Ligand-Target Pair
Glycosylasparaginase (GA)


(Homo sapiens (Human))
BDBM85474
PNG
(GlcNAc-Asn analogue, 10)
Show SMILES CC(=O)NC1C(O)C(O)C(CO)OC1NC(=O)CN
Show InChI InChI=1S/C10H19N3O6/c1-4(15)12-7-9(18)8(17)5(3-14)19-10(7)13-6(16)2-11/h5,7-10,14,17-18H,2-3,11H2,1H3,(H,12,15)(H,13,16)
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PubMed
7.50E+5 -18.6n/an/an/an/an/a5.837



University of North Carolina



Assay Description
Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...


J Enzym Inhib 16: 269-74 (2001)

More data for this
Ligand-Target Pair
Glycosylasparaginase (GA)


(Homo sapiens (Human))
BDBM85077
PNG
(3-Phosphono-D,L-2-aminopropionic acid, 7 | CAS_230...)
Show SMILES NC(CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C3H8NO5P/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)
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PubMed
9.00E+5 -18.1n/an/an/an/an/a5.837



University of North Carolina



Assay Description
Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...


J Enzym Inhib 16: 269-74 (2001)

More data for this
Ligand-Target Pair
Glycosylasparaginase (GA)


(Homo sapiens (Human))
BDBM85473
PNG
(L-Cysteic acid, 8 | L-cysteic acid)
Show SMILES NC(CS(O)(=O)=O)C(O)=O
Show InChI InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)
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PubMed
1.40E+6 -16.9n/an/an/an/an/a5.837



University of North Carolina



Assay Description
Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...


J Enzym Inhib 16: 269-74 (2001)

More data for this
Ligand-Target Pair
Glycosylasparaginase (GA)


(Homo sapiens (Human))
BDBM85471
PNG
(L-2-bromosuccinic acid, 4)
Show SMILES OC(=O)CC(Br)C(O)=O
Show InChI InChI=1S/C4H5BrO4/c5-2(4(8)9)1-3(6)7/h2H,1H2,(H,6,7)(H,8,9)
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PubMed
2.70E+6 -15.3n/an/an/an/an/a5.837



University of North Carolina



Assay Description
Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...


J Enzym Inhib 16: 269-74 (2001)

More data for this
Ligand-Target Pair
Glycosylasparaginase (GA)


(Homo sapiens (Human))
BDBM26121
PNG
(Substrate analogue, 11 | Succinate | Succinic acid...)
Show SMILES OC(=O)CCC(O)=O
Show InChI InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
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PubMed
5.00E+6 -13.7n/an/an/an/an/a5.837



University of North Carolina



Assay Description
Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...


J Enzym Inhib 16: 269-74 (2001)

More data for this
Ligand-Target Pair
Glycosylasparaginase (GA)


(Homo sapiens (Human))
BDBM85470
PNG
(L-2-Chlorosuccinic acid, 3)
Show SMILES OC(=O)CC(Cl)C(O)=O
Show InChI InChI=1S/C4H5ClO4/c5-2(4(8)9)1-3(6)7/h2H,1H2,(H,6,7)(H,8,9)
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PubMed
7.70E+6 -12.5n/an/an/an/an/a5.837



University of North Carolina



Assay Description
Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...


J Enzym Inhib 16: 269-74 (2001)

More data for this
Ligand-Target Pair