BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 13 hits Enz. Inhib. hit(s) with Target = 'Golgi alpha-mannosidase II' AND taxid = 7227   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84869
PNG
(Swainsonine derivative, 4)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C[C@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12
Show InChI InChI=1S/C20H29NO4/c1-20(2,3)13-6-4-12(5-7-13)16(23)10-14-8-9-15(22)18-19(25)17(24)11-21(14)18/h4-7,14-15,17-19,22,24-25H,8-11H2,1-3H3/t14-,15-,17-,18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
2.70 -48.9 29n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Citation and Details
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84868
PNG
(Swainsonine derivative, 3)
Show SMILES Cc1ccc(cc1)C(=O)C[C@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12
Show InChI InChI=1S/C17H23NO4/c1-10-2-4-11(5-3-10)14(20)8-12-6-7-13(19)16-17(22)15(21)9-18(12)16/h2-5,12-13,15-17,19,21-22H,6-9H2,1H3/t12-,13-,15-,16?,17-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
2.70 -48.9 29n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Citation and Details
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84867
PNG
(Swainsonine derivative, 2)
Show SMILES O[C@@H]1CN2C([C@@H]1O)[C@H](O)CC[C@@H]2CC(=O)c1ccccc1
Show InChI InChI=1S/C16H21NO4/c18-12-7-6-11(17-9-14(20)16(21)15(12)17)8-13(19)10-4-2-1-3-5-10/h1-5,11-12,14-16,18,20-21H,6-9H2/t11-,12-,14-,15?,16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
2.80 -48.8 30n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Citation and Details
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM50168995
PNG
((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O
Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PDB
Article
PubMed
3 -48.6 37n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM50078117
PNG
((1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTAN...)
Show SMILES CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3S/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
Article
PubMed
36n/an/an/an/an/an/an/an/a



University of Toronto



Assay Description
The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM50088625
PNG
((1R,2R,3R,4S,5R)-4-Amino-5-methoxy-cyclopentane-1,...)
Show SMILES CO[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
AffyNet 
MMDB
PDB
Article
PubMed
76n/an/an/an/an/an/an/an/a



University of Toronto



Assay Description
The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84614
PNG
(Mannostatin B, 2)
Show SMILES CS(=O)[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4S/c1-12(11)6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+,12?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
150n/an/an/an/an/an/an/an/a



University of Toronto



Assay Description
The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...


Citation and Details
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84615
PNG
(Mannostatin analogue, 4a)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2/t1-,2-,3-,4+,5-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
MMDB
PDB
Article
PubMed
300n/an/an/an/an/an/an/an/a



University of Toronto



Assay Description
The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM50088627
PNG
((1S,2S,3R,4R)-4-Amino-cyclopentane-1,2,3-triol | (...)
Show SMILES N[C@@H]1C[C@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO3/c6-2-1-3(7)5(9)4(2)8/h2-5,7-9H,1,6H2/t2-,3+,4-,5+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
MMDB
PDB
Article
PubMed
2.65E+5n/an/an/an/an/an/an/an/a



University of Toronto



Assay Description
The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84871
PNG
(Swainsonine derivative, 6)
Show SMILES CC(C)(C)c1ccc(CC[C@H]2CC[C@@H](O)C3[C@H](O)[C@H](O)CN23)cc1
Show InChI InChI=1S/C20H31NO3/c1-20(2,3)14-7-4-13(5-8-14)6-9-15-10-11-16(22)18-19(24)17(23)12-21(15)18/h4-5,7-8,15-19,22-24H,6,9-12H2,1-3H3/t15-,16+,17+,18?,19+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 44n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Citation and Details
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84870
PNG
(Swainsonine derivative, 5)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C[C@@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12
Show InChI InChI=1S/C20H29NO4/c1-20(2,3)13-6-4-12(5-7-13)16(23)10-14-8-9-15(22)18-19(25)17(24)11-21(14)18/h4-7,14-15,17-19,22,24-25H,8-11H2,1-3H3/t14-,15+,17+,18?,19+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 250n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Citation and Details
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84872
PNG
(Swainsonine derivative, 7)
Show SMILES CC(C)(C)c1ccc(CC[C@@H]2CC[C@@H](O)C3[C@H](O)[C@H](O)CN23)cc1
Show InChI InChI=1S/C20H31NO3/c1-20(2,3)14-7-4-13(5-8-14)6-9-15-10-11-16(22)18-19(24)17(23)12-21(15)18/h4-5,7-8,15-19,22-24H,6,9-12H2,1-3H3/t15-,16-,17-,18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 250n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Citation and Details
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84468
PNG
(Mannostatin analogue, 4b | Meso-aminocyclopentitet...)
Show SMILES N[C@@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2/t1-,2+,3-,4+,5-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
MMDB
PDB
Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



University of Toronto



Assay Description
The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)