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Compile Data Set for Download or QSAR

Found 281 hits Enz. Inhib. hit(s) with Target = 'Growth arrest-specific protein 6' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308335
PNG
(US9649309, Compound UNC4242A)
Show SMILES Cc1ccc(Nc2ncc(c(N[C@H]3CC[C@H](O)CC3)n2)-c2ccc(CN3CCCC3)cn2)cc1
Show InChI InChI=1S/C27H34N6O/c1-19-4-7-22(8-5-19)31-27-29-17-24(26(32-27)30-21-9-11-23(34)12-10-21)25-13-6-20(16-28-25)18-33-14-2-3-15-33/h4-8,13,16-17,21,23,34H,2-3,9-12,14-15,18H2,1H3,(H2,29,30,31,32)/t21-,23-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308226
PNG
(US9649309, Compound UNC4103A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CNCC23CC4CC(CC(C4)C2)C3)cn1
Show InChI InChI=1S/C31H46N6O/c1-2-3-10-33-30-35-19-27(29(37-30)36-25-5-7-26(38)8-6-25)28-9-4-21(18-34-28)17-32-20-31-14-22-11-23(15-31)13-24(12-22)16-31/h4,9,18-19,22-26,32,38H,2-3,5-8,10-17,20H2,1H3,(H2,33,35,36,37)/t22?,23?,24?,25-,26-,31?
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308338
PNG
(US9649309, Compound UNC4247A)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cccc(F)c2)ncc1-c1ccc(CN2CCCC2)cn1
Show InChI InChI=1S/C26H31FN6O/c27-19-4-3-5-21(14-19)31-26-29-16-23(25(32-26)30-20-7-9-22(34)10-8-20)24-11-6-18(15-28-24)17-33-12-1-2-13-33/h3-6,11,14-16,20,22,34H,1-2,7-10,12-13,17H2,(H2,29,30,31,32)/t20-,22-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308334
PNG
(US9649309, Compound UNC4241A)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(F)cc2)ncc1-c1ccc(CN2CCCC2)cn1
Show InChI InChI=1S/C26H31FN6O/c27-19-4-6-21(7-5-19)31-26-29-16-23(25(32-26)30-20-8-10-22(34)11-9-20)24-12-3-18(15-28-24)17-33-13-1-2-14-33/h3-7,12,15-16,20,22,34H,1-2,8-11,13-14,17H2,(H2,29,30,31,32)/t20-,22-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308333
PNG
(US9649309, Compound UNC4240A)
Show SMILES COc1ccc(Nc2ncc(c(N[C@H]3CC[C@H](O)CC3)n2)-c2ccc(CN3CCCC3)cn2)cc1
Show InChI InChI=1S/C27H34N6O2/c1-35-23-11-7-21(8-12-23)31-27-29-17-24(26(32-27)30-20-5-9-22(34)10-6-20)25-13-4-19(16-28-25)18-33-14-2-3-15-33/h4,7-8,11-13,16-17,20,22,34H,2-3,5-6,9-10,14-15,18H2,1H3,(H2,29,30,31,32)/t20-,22-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308326
PNG
(US9649309, Compound UNC3223A)
Show SMILES O[C@H]1CCC(CC1)Nc1nc(Nc2cccc(c2)C#C)ncc1-c1ccccn1
Show InChI InChI=1S/C23H23N5O/c1-2-16-6-5-7-18(14-16)27-23-25-15-20(21-8-3-4-13-24-21)22(28-23)26-17-9-11-19(29)12-10-17/h1,3-8,13-15,17,19,29H,9-12H2,(H2,25,26,27,28)/t17?,19-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308337
PNG
(US9649309, Compound UNC4244A)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccccc2F)ncc1-c1ccc(CN2CCCC2)cn1
Show InChI InChI=1S/C26H31FN6O/c27-22-5-1-2-6-24(22)31-26-29-16-21(25(32-26)30-19-8-10-20(34)11-9-19)23-12-7-18(15-28-23)17-33-13-3-4-14-33/h1-2,5-7,12,15-16,19-20,34H,3-4,8-11,13-14,17H2,(H2,29,30,31,32)/t19-,20-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308339
PNG
(US9649309, Compound UNC4372A)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(cc2)[N+]#[C-])ncc1-c1ccc(CN2CCCC2)cn1
Show InChI InChI=1S/C27H31N7O/c1-28-20-5-7-22(8-6-20)32-27-30-17-24(26(33-27)31-21-9-11-23(35)12-10-21)25-13-4-19(16-29-25)18-34-14-2-3-15-34/h4-8,13,16-17,21,23,35H,2-3,9-12,14-15,18H2,(H2,30,31,32,33)/t21-,23-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308304
PNG
(US9649309, Compound UNC3203A)
Show SMILES O[C@H]1CCC(CC1)Nc1nc(Nc2ccc(cc2)C#C)ncc1-c1ccccn1
Show InChI InChI=1S/C23H23N5O/c1-2-16-6-8-18(9-7-16)27-23-25-15-20(21-5-3-4-14-24-21)22(28-23)26-17-10-12-19(29)13-11-17/h1,3-9,14-15,17,19,29H,10-13H2,(H2,25,26,27,28)/t17?,19-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308336
PNG
(US9649309, Compound UNC4243A)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(cc2)C(F)(F)F)ncc1-c1ccc(CN2CCCC2)cn1
Show InChI InChI=1S/C27H31F3N6O/c28-27(29,30)19-4-6-21(7-5-19)34-26-32-16-23(25(35-26)33-20-8-10-22(37)11-9-20)24-12-3-18(15-31-24)17-36-13-1-2-14-36/h3-7,12,15-16,20,22,37H,1-2,8-11,13-14,17H2,(H2,32,33,34,35)/t20-,22-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308354
PNG
(US9649309, Compound UNC4169A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CN2C3CCC2CCC3)cn1
Show InChI InChI=1S/C27H40N6O/c1-2-3-15-28-27-30-17-24(26(32-27)31-20-8-12-23(34)13-9-20)25-14-7-19(16-29-25)18-33-21-5-4-6-22(33)11-10-21/h7,14,16-17,20-23,34H,2-6,8-13,15,18H2,1H3,(H2,28,30,31,32)/t20-,21?,22?,23-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308340
PNG
(US9649309, Compound UNC4373A)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(Cl)cc2)ncc1-c1ccc(CN2CCCC2)cn1
Show InChI InChI=1S/C26H31ClN6O/c27-19-4-6-21(7-5-19)31-26-29-16-23(25(32-26)30-20-8-10-22(34)11-9-20)24-12-3-18(15-28-24)17-33-13-1-2-14-33/h3-7,12,15-16,20,22,34H,1-2,8-11,13-14,17H2,(H2,29,30,31,32)/t20-,22-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308341
PNG
(US9649309, Compound UNC4377A)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(Br)cc2)ncc1-c1ccc(CN2CCCC2)cn1
Show InChI InChI=1S/C26H31BrN6O/c27-19-4-6-21(7-5-19)31-26-29-16-23(25(32-26)30-20-8-10-22(34)11-9-20)24-12-3-18(15-28-24)17-33-13-1-2-14-33/h3-7,12,15-16,20,22,34H,1-2,8-11,13-14,17H2,(H2,29,30,31,32)/t20-,22-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.60n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308332
PNG
(US9649309, Compound UNC3208A)
Show SMILES O[C@H]1CCC(CC1)Nc1nc(Nc2ccncc2)ncc1-c1ccccn1
Show InChI InChI=1S/C20H22N6O/c27-16-6-4-14(5-7-16)24-19-17(18-3-1-2-10-22-18)13-23-20(26-19)25-15-8-11-21-12-9-15/h1-3,8-14,16,27H,4-7H2,(H2,21,23,24,25,26)/t14?,16-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308229
PNG
(US9649309, Compound UNC4162A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CN(CC)CC)cn1
Show InChI InChI=1S/C24H38N6O/c1-4-7-14-25-24-27-16-21(23(29-24)28-19-9-11-20(31)12-10-19)22-13-8-18(15-26-22)17-30(5-2)6-3/h8,13,15-16,19-20,31H,4-7,9-12,14,17H2,1-3H3,(H2,25,27,28,29)/t19-,20-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.20n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308351
PNG
(US9649309, Compound UNC4167A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CN2C3CCC2CC3)cn1
Show InChI InChI=1S/C26H38N6O/c1-2-3-14-27-26-29-16-23(25(31-26)30-19-5-11-22(33)12-6-19)24-13-4-18(15-28-24)17-32-20-7-8-21(32)10-9-20/h4,13,15-16,19-22,33H,2-3,5-12,14,17H2,1H3,(H2,27,29,30,31)/t19-,20?,21?,22-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.40n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308203
PNG
(US9649309, Compound UNC2915A)
Show SMILES CCCCNc1ncc(c(NC2CC[C@H](O)CC2)n1)-c1ccc(cn1)C(=O)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C27H41N7O2/c1-4-5-14-28-27-30-18-23(25(32-27)31-20-7-9-22(35)10-8-20)24-11-6-19(17-29-24)26(36)34(3)21-12-15-33(2)16-13-21/h6,11,17-18,20-22,35H,4-5,7-10,12-16H2,1-3H3,(H2,28,30,31,32)/t20?,22-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.5n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308318
PNG
(US9649309, Compound UNC3667A)
Show SMILES CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(cn1)C1(CCCC1)N1CCOCC1
Show InChI InChI=1S/C28H42N6O2/c1-2-3-14-29-27-31-20-24(26(33-27)32-22-7-9-23(35)10-8-22)25-11-6-21(19-30-25)28(12-4-5-13-28)34-15-17-36-18-16-34/h6,11,19-20,22-23,35H,2-5,7-10,12-18H2,1H3,(H2,29,31,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.40n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308228
PNG
(US9649309, Compound UNC4161A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CNCC(C)(C)C)cn1
Show InChI InChI=1S/C25H40N6O/c1-5-6-13-27-24-29-16-21(23(31-24)30-19-8-10-20(32)11-9-19)22-12-7-18(15-28-22)14-26-17-25(2,3)4/h7,12,15-16,19-20,26,32H,5-6,8-11,13-14,17H2,1-4H3,(H2,27,29,30,31)/t19-,20-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308319
PNG
(US9649309, Compound UNC3669A)
Show SMILES CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(cn1)C1(CCC1)N1CCN(C)CC1
Show InChI InChI=1S/C28H43N7O/c1-3-4-14-29-27-31-20-24(26(33-27)32-22-7-9-23(36)10-8-22)25-11-6-21(19-30-25)28(12-5-13-28)35-17-15-34(2)16-18-35/h6,11,19-20,22-23,36H,3-5,7-10,12-18H2,1-2H3,(H2,29,31,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308231
PNG
(US9649309, Compound UNC4165A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CNC2CC3CCC(C2)N3C)cn1
Show InChI InChI=1S/C28H43N7O/c1-3-4-13-29-28-32-18-25(27(34-28)33-20-6-10-24(36)11-7-20)26-12-5-19(17-31-26)16-30-21-14-22-8-9-23(15-21)35(22)2/h5,12,17-18,20-24,30,36H,3-4,6-11,13-16H2,1-2H3,(H2,29,32,33,34)/t20-,21?,22?,23?,24-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308366
PNG
(US9649309, Compound UNC4340A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(C=C2CCN(CC2)C(C)C)cn1
Show InChI InChI=1S/C28H42N6O/c1-4-5-14-29-28-31-19-25(27(33-28)32-23-7-9-24(35)10-8-23)26-11-6-22(18-30-26)17-21-12-15-34(16-13-21)20(2)3/h6,11,17-20,23-24,35H,4-5,7-10,12-16H2,1-3H3,(H2,29,31,32,33)/t23-,24-
PDB

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UniChem
US Patent
n/an/a 8.5n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308230
PNG
(US9649309, Compound UNC4163A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CNC2CC3CCC(C2)N3C)cn1
Show InChI InChI=1S/C28H43N7O/c1-3-4-13-29-28-32-18-25(27(34-28)33-20-6-10-24(36)11-7-20)26-12-5-19(17-31-26)16-30-21-14-22-8-9-23(15-21)35(22)2/h5,12,17-18,20-24,30,36H,3-4,6-11,13-16H2,1-2H3,(H2,29,32,33,34)/t20-,21?,22?,23?,24-
PDB

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UniChem
US Patent
n/an/a 8.70n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308350
PNG
(US9649309, Compound UNC4166A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CNC23CC4CC(CC(C4)C2)C3)cn1
Show InChI InChI=1S/C30H44N6O/c1-2-3-10-31-29-33-19-26(28(36-29)35-24-5-7-25(37)8-6-24)27-9-4-20(17-32-27)18-34-30-14-21-11-22(15-30)13-23(12-21)16-30/h4,9,17,19,21-25,34,37H,2-3,5-8,10-16,18H2,1H3,(H2,31,33,35,36)/t21?,22?,23?,24-,25-,30?
PDB

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UniChem
US Patent
n/an/a 9.40n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308349
PNG
(US9649309, Compound UNC4160A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CNC(C)(C)C)cn1
Show InChI InChI=1S/C24H38N6O/c1-5-6-13-25-23-27-16-20(22(30-23)29-18-8-10-19(31)11-9-18)21-12-7-17(14-26-21)15-28-24(2,3)4/h7,12,14,16,18-19,28,31H,5-6,8-11,13,15H2,1-4H3,(H2,25,27,29,30)/t18-,19-
PDB

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UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308189
PNG
(US9649309, Compound UNC2547A)
Show SMILES CCCCNc1ncc(c(NC2CC[C@H](O)CC2)n1)-c1ccc(CNCC2CC2)cn1
Show InChI InChI=1S/C24H36N6O/c1-2-3-12-26-24-28-16-21(23(30-24)29-19-7-9-20(31)10-8-19)22-11-6-18(15-27-22)14-25-13-17-4-5-17/h6,11,15-17,19-20,25,31H,2-5,7-10,12-14H2,1H3,(H2,26,28,29,30)/t19?,20-
PDB

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US Patent
n/an/a 11n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308317
PNG
(US9649309, Compound UNC3666A)
Show SMILES CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(cn1)C1(CCC1)N1CCOCC1
Show InChI InChI=1S/C27H40N6O2/c1-2-3-13-28-26-30-19-23(25(32-26)31-21-6-8-22(34)9-7-21)24-10-5-20(18-29-24)27(11-4-12-27)33-14-16-35-17-15-33/h5,10,18-19,21-22,34H,2-4,6-9,11-17H2,1H3,(H2,28,30,31,32)
PDB

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UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308227
PNG
(US9649309, Compound UNC4104A)
Show SMILES CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(CN2CC[C@H](C2)N(C)C)cn1
Show InChI InChI=1S/C26H41N7O/c1-4-5-13-27-26-29-16-23(25(31-26)30-20-7-9-22(34)10-8-20)24-11-6-19(15-28-24)17-33-14-12-21(18-33)32(2)3/h6,11,15-16,20-22,34H,4-5,7-10,12-14,17-18H2,1-3H3,(H2,27,29,30,31)/t20?,21-,22?/m1/s1
PDB

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UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308352
PNG
(US9649309, Compound UNC4168A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CNC2C(C)(C)C2(C)C)cn1
Show InChI InChI=1S/C27H42N6O/c1-6-7-14-28-25-31-17-21(23(33-25)32-19-9-11-20(34)12-10-19)22-13-8-18(15-29-22)16-30-24-26(2,3)27(24,4)5/h8,13,15,17,19-20,24,30,34H,6-7,9-12,14,16H2,1-5H3,(H2,28,31,32,33)/t19-,20-
PDB

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UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308186
PNG
(US9649309, Compound UNC2550A)
Show SMILES CCCCNc1ncc(c(NC2CC[C@H](O)CC2)n1)-c1ccc(CNC2CCC2)cn1
Show InChI InChI=1S/C24H36N6O/c1-2-3-13-25-24-28-16-21(23(30-24)29-19-8-10-20(31)11-9-19)22-12-7-17(15-27-22)14-26-18-5-4-6-18/h7,12,15-16,18-20,26,31H,2-6,8-11,13-14H2,1H3,(H2,25,28,29,30)/t19?,20-
PDB

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UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308362
PNG
(US9649309, Compound UNC4336A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(C=C2CCNCC2)cn1
Show InChI InChI=1S/C25H36N6O/c1-2-3-12-27-25-29-17-22(24(31-25)30-20-5-7-21(32)8-6-20)23-9-4-19(16-28-23)15-18-10-13-26-14-11-18/h4,9,15-17,20-21,26,32H,2-3,5-8,10-14H2,1H3,(H2,27,29,30,31)/t20-,21-
PDB

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US Patent
n/an/a 13n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308305
PNG
(US9649309, Compound UNC4223A)
Show SMILES CCCCNc1ncc(-c2ncc(CN3CCCC3)s2)c(NC2CC[C@H](O)CC2)n1
Show InChI InChI=1S/C22H34N6OS/c1-2-3-10-23-22-25-14-19(20(27-22)26-16-6-8-17(29)9-7-16)21-24-13-18(30-21)15-28-11-4-5-12-28/h13-14,16-17,29H,2-12,15H2,1H3,(H2,23,25,26,27)/t16?,17-
PDB

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UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308331
PNG
(US9649309, Compound UNC3209A)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cccnc2)ncc1-c1ccccn1
Show InChI InChI=1S/C20H22N6O/c27-16-8-6-14(7-9-16)24-19-17(18-5-1-2-11-22-18)13-23-20(26-19)25-15-4-3-10-21-12-15/h1-5,10-14,16,27H,6-9H2,(H2,23,24,25,26)/t14-,16-
PDB

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UniChem
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n/an/a 14n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308188
PNG
(US9649309, Compound UNC2489A)
Show SMILES CCCCNc1ncc(c(NC2CC[C@H](O)CC2)n1)-c1ccc(CNC2CCCC2)cn1
Show InChI InChI=1S/C25H38N6O/c1-2-3-14-26-25-29-17-22(24(31-25)30-20-9-11-21(32)12-10-20)23-13-8-18(16-28-23)15-27-19-6-4-5-7-19/h8,13,16-17,19-21,27,32H,2-7,9-12,14-15H2,1H3,(H2,26,29,30,31)/t20?,21-
PDB

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US Patent
n/an/a 16n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308359
PNG
(US9649309, Compound UNC4222A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1cc(Cl)c(CN2CCCC2)cn1
Show InChI InChI=1S/C24H35ClN6O/c1-2-3-10-26-24-28-15-20(23(30-24)29-18-6-8-19(32)9-7-18)22-13-21(25)17(14-27-22)16-31-11-4-5-12-31/h13-15,18-19,32H,2-12,16H2,1H3,(H2,26,28,29,30)/t18-,19-
PDB

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n/an/a 16n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308191
PNG
(US9649309, Compound UNC2549A)
Show SMILES CCCCNc1ncc(c(NC2CC[C@H](O)CC2)n1)-c1ccc(CNCC)cn1
Show InChI InChI=1S/C22H34N6O/c1-3-5-12-24-22-26-15-19(20-11-6-16(14-25-20)13-23-4-2)21(28-22)27-17-7-9-18(29)10-8-17/h6,11,14-15,17-18,23,29H,3-5,7-10,12-13H2,1-2H3,(H2,24,26,27,28)/t17?,18-
PDB

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n/an/a 18n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308193
PNG
(US9649309, Compound UNC2571A)
Show SMILES CCCCNc1ncc(c(NC2CC[C@H](O)CC2)n1)-c1ccc(CNCc2ccncc2)cn1
Show InChI InChI=1S/C26H35N7O/c1-2-3-12-29-26-31-18-23(25(33-26)32-21-5-7-22(34)8-6-21)24-9-4-20(17-30-24)16-28-15-19-10-13-27-14-11-19/h4,9-11,13-14,17-18,21-22,28,34H,2-3,5-8,12,15-16H2,1H3,(H2,29,31,32,33)/t21?,22-
PDB

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US Patent
n/an/a 18n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308185
PNG
(US9649309, Compound UNC2490A)
Show SMILES CCCCNc1ncc(c(NC2CC[C@H](O)CC2)n1)-c1ccc(CN2CCCC2)cn1
Show InChI InChI=1S/C24H36N6O/c1-2-3-12-25-24-27-16-21(23(29-24)28-19-7-9-20(31)10-8-19)22-11-6-18(15-26-22)17-30-13-4-5-14-30/h6,11,15-16,19-20,31H,2-5,7-10,12-14,17H2,1H3,(H2,25,27,28,29)/t19?,20-
PDB

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UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308348
PNG
(US9649309, Compound UNC4113A)
Show SMILES CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(CN2CCN[C@H](C)C2)cn1
Show InChI InChI=1S/C25H39N7O/c1-3-4-11-27-25-29-15-22(24(31-25)30-20-6-8-21(33)9-7-20)23-10-5-19(14-28-23)17-32-13-12-26-18(2)16-32/h5,10,14-15,18,20-21,26,33H,3-4,6-9,11-13,16-17H2,1-2H3,(H2,27,29,30,31)/t18-,20?,21?/m1/s1
PDB

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n/an/a 18n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308315
PNG
(US9649309, Compound UNC3664A)
Show SMILES CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(cn1)C1(CC1)N1CCOCC1
Show InChI InChI=1S/C26H38N6O2/c1-2-3-12-27-25-29-18-22(24(31-25)30-20-5-7-21(33)8-6-20)23-9-4-19(17-28-23)26(10-11-26)32-13-15-34-16-14-32/h4,9,17-18,20-21,33H,2-3,5-8,10-16H2,1H3,(H2,27,29,30,31)
PDB

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UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308347
PNG
(US9649309, Compound UNC4112A)
Show SMILES CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(CN2C[C@@H]3C[C@H]2CN3)cn1
Show InChI InChI=1S/C25H37N7O/c1-2-3-10-26-25-29-14-22(24(31-25)30-18-5-7-21(33)8-6-18)23-9-4-17(12-28-23)15-32-16-19-11-20(32)13-27-19/h4,9,12,14,18-21,27,33H,2-3,5-8,10-11,13,15-16H2,1H3,(H2,26,29,30,31)/t18?,19-,20-,21?/m0/s1
PDB

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n/an/a 19n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308345
PNG
(US9649309, Compound UNC4110A)
Show SMILES CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(CN2CCNCC2(C)C)cn1
Show InChI InChI=1S/C26H41N7O/c1-4-5-12-28-25-30-16-22(24(32-25)31-20-7-9-21(34)10-8-20)23-11-6-19(15-29-23)17-33-14-13-27-18-26(33,2)3/h6,11,15-16,20-21,27,34H,4-5,7-10,12-14,17-18H2,1-3H3,(H2,28,30,31,32)
PDB

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US Patent
n/an/a 19n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308192
PNG
(US9649309, Compound UNC2546A)
Show SMILES CCCCNc1ncc(c(NC2CC[C@H](O)CC2)n1)-c1ccc(CNCCO)cn1
Show InChI InChI=1S/C22H34N6O2/c1-2-3-10-24-22-26-15-19(20-9-4-16(14-25-20)13-23-11-12-29)21(28-22)27-17-5-7-18(30)8-6-17/h4,9,14-15,17-18,23,29-30H,2-3,5-8,10-13H2,1H3,(H2,24,26,27,28)/t17?,18-
PDB

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n/an/a 20n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308364
PNG
(US9649309, Compound UNC4338A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(C=C2CCN(C)CC2)cn1
Show InChI InChI=1S/C26H38N6O/c1-3-4-13-27-26-29-18-23(25(31-26)30-21-6-8-22(33)9-7-21)24-10-5-20(17-28-24)16-19-11-14-32(2)15-12-19/h5,10,16-18,21-22,33H,3-4,6-9,11-15H2,1-2H3,(H2,27,29,30,31)/t21-,22-
PDB

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PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308346
PNG
(US9649309, Compound UNC4111A)
Show SMILES CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(CN2CCNC[C@@H]2C)cn1
Show InChI InChI=1S/C25H39N7O/c1-3-4-11-27-25-29-16-22(24(31-25)30-20-6-8-21(33)9-7-20)23-10-5-19(15-28-23)17-32-13-12-26-14-18(32)2/h5,10,15-16,18,20-21,26,33H,3-4,6-9,11-14,17H2,1-2H3,(H2,27,29,30,31)/t18-,20?,21?/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308190
PNG
(US9649309, Compound UNC2488A)
Show SMILES CCCCNc1ncc(c(NC2CC[C@H](O)CC2)n1)-c1ccc(CN(C)C)cn1
Show InChI InChI=1S/C22H34N6O/c1-4-5-12-23-22-25-14-19(20-11-6-16(13-24-20)15-28(2)3)21(27-22)26-17-7-9-18(29)10-8-17/h6,11,13-14,17-18,29H,4-5,7-10,12,15H2,1-3H3,(H2,23,25,26,27)/t17?,18-
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308365
PNG
(US9649309, Compound UNC4339A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CC2CCN(CC2)C(C)C)cn1
Show InChI InChI=1S/C28H44N6O/c1-4-5-14-29-28-31-19-25(27(33-28)32-23-7-9-24(35)10-8-23)26-11-6-22(18-30-26)17-21-12-15-34(16-13-21)20(2)3/h6,11,18-21,23-24,35H,4-5,7-10,12-17H2,1-3H3,(H2,29,31,32,33)/t23-,24-
PDB

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PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308343
PNG
(US9649309, Compound UNC4106A)
Show SMILES CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(CN2CCN[C@@H](C)C2)cn1
Show InChI InChI=1S/C25H39N7O/c1-3-4-11-27-25-29-15-22(24(31-25)30-20-6-8-21(33)9-7-20)23-10-5-19(14-28-23)17-32-13-12-26-18(2)16-32/h5,10,14-15,18,20-21,26,33H,3-4,6-9,11-13,16-17H2,1-2H3,(H2,27,29,30,31)/t18-,20?,21?/m0/s1
PDB

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PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308275
PNG
(US9649309, Compound UNC3118A)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccnc(N)n1
Show InChI InChI=1S/C18H27N7O/c1-2-3-9-21-18-22-11-14(15-8-10-20-17(19)24-15)16(25-18)23-12-4-6-13(26)7-5-12/h8,10-13,26H,2-7,9H2,1H3,(H2,19,20,24)(H2,21,22,23,25)/t12-,13-
PDB

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PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
Growth arrest-specific protein 6


(Homo sapiens (Human))
BDBM308198
PNG
(US9649309, Compound UNC2251B)
Show SMILES CCCCNc1ncc(c(NC2CC[C@H](O)CC2)n1)-c1ccc(CN2CCN(C)CC2)cn1
Show InChI InChI=1S/C25H39N7O/c1-3-4-11-26-25-28-17-22(24(30-25)29-20-6-8-21(33)9-7-20)23-10-5-19(16-27-23)18-32-14-12-31(2)13-15-32/h5,10,16-17,20-21,33H,3-4,6-9,11-15,18H2,1-2H3,(H2,26,28,29,30)/t20?,21-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...


US Patent US9649309 (2017)

More data for this
Ligand-Target Pair
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