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Compile Data Set for Download or QSAR

Found 59 hits Enz. Inhib. hit(s) with Target = 'Growth hormone-releasing hormone receptor' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004993
PNG
(CHEMBL386366 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)CC(=O)CCc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C151H248N42O42S/c1-21-79(13)118(191-125(212)84(18)168-134(221)107(69-115(204)205)178-122(209)81(15)65-91(200)49-42-86-40-45-89(198)46-41-86)147(234)185-105(66-87-33-24-23-25-34-87)140(227)193-120(85(19)197)148(235)186-106(68-114(156)203)139(226)189-111(73-196)144(231)182-104(67-88-43-47-90(199)48-44-88)138(225)175-96(39-32-59-166-151(162)163)127(214)174-94(36-27-29-56-153)132(219)190-117(78(11)12)145(232)184-100(61-74(3)4)133(220)167-82(16)124(211)172-97(50-52-112(154)201)129(216)180-103(64-77(9)10)137(224)188-109(71-194)142(229)169-83(17)123(210)171-95(38-31-58-165-150(160)161)126(213)173-93(35-26-28-55-152)128(215)179-102(63-76(7)8)136(223)181-101(62-75(5)6)135(222)176-98(51-53-113(155)202)130(217)183-108(70-116(206)207)141(228)192-119(80(14)22-2)146(233)177-99(54-60-236-20)131(218)187-110(72-195)143(230)170-92(121(157)208)37-30-57-164-149(158)159/h23-25,33-34,40-41,43-48,74-85,92-111,117-120,194-199H,21-22,26-32,35-39,42,49-73,152-153H2,1-20H3,(H2,154,201)(H2,155,202)(H2,156,203)(H2,157,208)(H,167,220)(H,168,221)(H,169,229)(H,170,230)(H,171,210)(H,172,211)(H,173,213)(H,174,214)(H,175,225)(H,176,222)(H,177,233)(H,178,209)(H,179,215)(H,180,216)(H,181,223)(H,182,231)(H,183,217)(H,184,232)(H,185,234)(H,186,235)(H,187,218)(H,188,224)(H,189,226)(H,190,219)(H,191,212)(H,192,228)(H,193,227)(H,204,205)(H,206,207)(H4,158,159,164)(H4,160,161,165)(H4,162,163,166)/t79-,80-,81+,82-,83-,84-,85+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,117-,118-,119-,120-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.730n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004979
PNG
(CHEMBL440262 | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C149H245N43O43S/c1-20-77(13)116(190-121(209)81(17)167-131(219)104(66-113(203)204)177-120(208)79(15)166-122(210)88(152)62-84-39-43-86(197)44-40-84)144(232)184-102(63-83-32-23-22-24-33-83)137(225)192-118(82(18)196)145(233)185-103(65-111(155)201)136(224)188-108(71-195)141(229)181-101(64-85-41-45-87(198)46-42-85)135(223)173-92(37-30-55-163-148(158)159)125(213)172-90(35-26-28-53-151)130(218)189-115(76(11)12)142(230)183-97(58-72(3)4)123(211)165-68-112(202)169-93(47-49-109(153)199)127(215)179-100(61-75(9)10)134(222)187-106(69-193)139(227)168-80(16)119(207)170-91(36-29-54-162-147(156)157)124(212)171-89(34-25-27-52-150)126(214)178-99(60-74(7)8)133(221)180-98(59-73(5)6)132(220)174-94(48-50-110(154)200)128(216)182-105(67-114(205)206)138(226)191-117(78(14)21-2)143(231)175-95(51-57-236-19)129(217)186-107(70-194)140(228)176-96(146(234)235)38-31-56-164-149(160)161/h22-24,32-33,39-46,72-82,88-108,115-118,193-198H,20-21,25-31,34-38,47-71,150-152H2,1-19H3,(H2,153,199)(H2,154,200)(H2,155,201)(H,165,211)(H,166,210)(H,167,219)(H,168,227)(H,169,202)(H,170,207)(H,171,212)(H,172,213)(H,173,223)(H,174,220)(H,175,231)(H,176,228)(H,177,208)(H,178,214)(H,179,215)(H,180,221)(H,181,229)(H,182,216)(H,183,230)(H,184,232)(H,185,233)(H,186,217)(H,187,222)(H,188,224)(H,189,218)(H,190,209)(H,191,226)(H,192,225)(H,203,204)(H,205,206)(H,234,235)(H4,156,157,162)(H4,158,159,163)(H4,160,161,164)/t77-,78-,79-,80-,81-,82+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,115-,116-,117-,118-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.800n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004976
PNG
(CHEMBL385308 | GRF-analogues)
Show InChI InChI=1S/C157H253N49O41S/c1-21-81(12)122(203-129(223)86(17)181-140(234)114(69-121(218)219)191-128(222)85(16)180-139(233)111(182-88(19)210)66-92-70-170-75-177-92)151(245)200-110(63-89-33-25-24-26-34-89)147(241)206-125(87(18)209)153(247)202-116(74-208)149(243)201-115(73-207)148(242)196-109(65-91-42-46-95(212)47-43-91)144(238)188-99(38-31-56-174-156(166)167)132(226)187-100(39-32-57-175-157(168)169)136(230)204-124(83(14)23-3)152(246)199-104(59-77(4)5)130(224)176-72-119(215)183-101(48-50-117(159)213)134(228)193-106(61-79(8)9)142(236)195-108(64-90-40-44-94(211)45-41-90)138(232)179-84(15)127(221)185-98(37-30-55-173-155(164)165)131(225)186-97(35-27-28-53-158)133(227)192-105(60-78(6)7)141(235)194-107(62-80(10)11)143(237)197-112(67-93-71-171-76-178-93)145(239)189-102(49-51-120(216)217)137(231)205-123(82(13)22-2)150(244)190-103(52-58-248-20)135(229)198-113(68-118(160)214)146(240)184-96(126(161)220)36-29-54-172-154(162)163/h24-26,33-34,40-47,70-71,75-87,96-116,122-125,207-209,211-212H,21-23,27-32,35-39,48-69,72-74,158H2,1-20H3,(H2,159,213)(H2,160,214)(H2,161,220)(H,170,177)(H,171,178)(H,176,224)(H,179,232)(H,180,233)(H,181,234)(H,182,210)(H,183,215)(H,184,240)(H,185,221)(H,186,225)(H,187,226)(H,188,238)(H,189,239)(H,190,244)(H,191,222)(H,192,227)(H,193,228)(H,194,235)(H,195,236)(H,196,242)(H,197,237)(H,198,229)(H,199,246)(H,200,245)(H,201,243)(H,202,247)(H,203,223)(H,204,230)(H,205,231)(H,206,241)(H,216,217)(H,218,219)(H4,162,163,172)(H4,164,165,173)(H4,166,167,174)(H4,168,169,175)/t81-,82-,83-,84-,85-,86-,87+,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,122-,123-,124-,125-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.90n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004966
PNG
(CHEMBL428135 | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C149H246N44O42S/c1-20-77(13)116(191-122(211)81(17)168-132(221)104(66-113(204)205)178-121(210)79(15)167-123(212)88(152)62-84-39-43-86(198)44-40-84)145(234)185-102(63-83-32-23-22-24-33-83)138(227)193-118(82(18)197)146(235)186-103(65-111(155)202)137(226)189-108(71-196)142(231)182-101(64-85-41-45-87(199)46-42-85)136(225)175-93(38-31-56-165-149(161)162)126(215)174-91(35-26-28-53-151)131(220)190-115(76(11)12)143(232)184-97(58-72(3)4)124(213)166-68-112(203)170-94(47-49-109(153)200)128(217)180-100(61-75(9)10)135(224)188-106(69-194)140(229)169-80(16)120(209)172-92(37-30-55-164-148(159)160)125(214)173-90(34-25-27-52-150)127(216)179-99(60-74(7)8)134(223)181-98(59-73(5)6)133(222)176-95(48-50-110(154)201)129(218)183-105(67-114(206)207)139(228)192-117(78(14)21-2)144(233)177-96(51-57-236-19)130(219)187-107(70-195)141(230)171-89(119(156)208)36-29-54-163-147(157)158/h22-24,32-33,39-46,72-82,88-108,115-118,194-199H,20-21,25-31,34-38,47-71,150-152H2,1-19H3,(H2,153,200)(H2,154,201)(H2,155,202)(H2,156,208)(H,166,213)(H,167,212)(H,168,221)(H,169,229)(H,170,203)(H,171,230)(H,172,209)(H,173,214)(H,174,215)(H,175,225)(H,176,222)(H,177,233)(H,178,210)(H,179,216)(H,180,217)(H,181,223)(H,182,231)(H,183,218)(H,184,232)(H,185,234)(H,186,235)(H,187,219)(H,188,224)(H,189,226)(H,190,220)(H,191,211)(H,192,228)(H,193,227)(H,204,205)(H,206,207)(H4,157,158,163)(H4,159,160,164)(H4,161,162,165)/t77-,78-,79-,80-,81-,82+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,115-,116-,117-,118-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 5.60n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004973
PNG
(CHEMBL216479 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C155H257N45O43S/c1-20-82(13)122(198-128(219)86(17)174-138(229)109(71-119(212)213)185-127(218)85(16)173-137(228)105(68-89-43-47-91(205)48-44-89)177-117(210)42-26-23-29-56-156)151(242)192-107(67-88-35-24-22-25-36-88)144(235)200-124(87(18)204)152(243)193-108(70-116(161)209)143(234)196-113(76-203)148(239)189-106(69-90-45-49-92(206)50-46-90)142(233)182-97(41-34-61-171-155(167)168)131(222)181-95(38-28-31-58-158)136(227)197-121(81(11)12)149(240)191-101(63-77(3)4)129(220)172-73-118(211)176-98(51-53-114(159)207)133(224)187-104(66-80(9)10)141(232)195-111(74-201)146(237)175-84(15)126(217)179-96(40-33-60-170-154(165)166)130(221)180-94(37-27-30-57-157)132(223)186-103(65-79(7)8)140(231)188-102(64-78(5)6)139(230)183-99(52-54-115(160)208)134(225)190-110(72-120(214)215)145(236)199-123(83(14)21-2)150(241)184-100(55-62-244-19)135(226)194-112(75-202)147(238)178-93(125(162)216)39-32-59-169-153(163)164/h22,24-25,35-36,43-50,77-87,93-113,121-124,201-206H,20-21,23,26-34,37-42,51-76,156-158H2,1-19H3,(H2,159,207)(H2,160,208)(H2,161,209)(H2,162,216)(H,172,220)(H,173,228)(H,174,229)(H,175,237)(H,176,211)(H,177,210)(H,178,238)(H,179,217)(H,180,221)(H,181,222)(H,182,233)(H,183,230)(H,184,241)(H,185,218)(H,186,223)(H,187,224)(H,188,231)(H,189,239)(H,190,225)(H,191,240)(H,192,242)(H,193,243)(H,194,226)(H,195,232)(H,196,234)(H,197,227)(H,198,219)(H,199,236)(H,200,235)(H,212,213)(H,214,215)(H4,163,164,169)(H4,165,166,170)(H4,167,168,171)/t82-,83-,84-,85-,86-,87+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 6.60n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004970
PNG
(CHEMBL438545 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C146H241N43O40S/c1-20-76(13)114(187-120(206)80(17)165-130(216)103(66-111(199)200)175-119(205)78(15)164-121(207)87(149)62-83-39-43-85(193)44-40-83)142(228)182-101(63-82-32-23-22-24-33-82)136(222)189-116(81(18)192)143(229)183-102(65-109(152)197)135(221)185-106(70-191)139(225)179-100(64-84-41-45-86(194)46-42-84)134(220)172-92(38-31-56-162-146(158)159)124(210)171-90(35-26-28-53-148)129(215)186-113(75(11)12)140(226)181-96(58-71(3)4)122(208)163-68-110(198)167-93(47-49-107(150)195)126(212)177-99(61-74(9)10)133(219)184-105(69-190)138(224)166-79(16)118(204)169-91(37-30-55-161-145(156)157)123(209)170-89(34-25-27-52-147)125(211)176-98(60-73(7)8)132(218)178-97(59-72(5)6)131(217)173-94(48-50-108(151)196)127(213)180-104(67-112(201)202)137(223)188-115(77(14)21-2)141(227)174-95(51-57-230-19)128(214)168-88(117(153)203)36-29-54-160-144(154)155/h22-24,32-33,39-46,71-81,87-106,113-116,190-194H,20-21,25-31,34-38,47-70,147-149H2,1-19H3,(H2,150,195)(H2,151,196)(H2,152,197)(H2,153,203)(H,163,208)(H,164,207)(H,165,216)(H,166,224)(H,167,198)(H,168,214)(H,169,204)(H,170,209)(H,171,210)(H,172,220)(H,173,217)(H,174,227)(H,175,205)(H,176,211)(H,177,212)(H,178,218)(H,179,225)(H,180,213)(H,181,226)(H,182,228)(H,183,229)(H,184,219)(H,185,221)(H,186,215)(H,187,206)(H,188,223)(H,189,222)(H,199,200)(H,201,202)(H4,154,155,160)(H4,156,157,161)(H4,158,159,162)/t76-,77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 7.20n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004969
PNG
(CHEMBL266658 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C144H237N43O41/c1-19-74(13)112(185-118(205)78(17)163-127(214)100(63-109(198)199)172-117(204)76(15)162-119(206)85(147)59-81-38-42-83(192)43-39-81)139(226)179-98(60-80-31-22-21-23-32-80)133(220)187-114(79(18)191)141(228)180-99(62-107(150)196)132(219)182-103(67-189)137(224)176-97(61-82-40-44-84(193)45-41-82)131(218)170-90(37-30-54-160-144(156)157)122(209)169-88(34-25-27-51-146)126(213)184-111(73(11)12)138(225)178-93(55-69(3)4)120(207)161-65-108(197)165-91(46-48-105(148)194)124(211)174-96(58-72(9)10)130(217)181-102(66-188)135(222)164-77(16)116(203)167-89(36-29-53-159-143(154)155)121(208)168-87(33-24-26-50-145)123(210)173-95(57-71(7)8)129(216)175-94(56-70(5)6)128(215)171-92(47-49-106(149)195)125(212)177-101(64-110(200)201)134(221)186-113(75(14)20-2)140(227)183-104(68-190)136(223)166-86(115(151)202)35-28-52-158-142(152)153/h21-23,31-32,38-45,69-79,85-104,111-114,188-193H,19-20,24-30,33-37,46-68,145-147H2,1-18H3,(H2,148,194)(H2,149,195)(H2,150,196)(H2,151,202)(H,161,207)(H,162,206)(H,163,214)(H,164,222)(H,165,197)(H,166,223)(H,167,203)(H,168,208)(H,169,209)(H,170,218)(H,171,215)(H,172,204)(H,173,210)(H,174,211)(H,175,216)(H,176,224)(H,177,212)(H,178,225)(H,179,226)(H,180,228)(H,181,217)(H,182,219)(H,183,227)(H,184,213)(H,185,205)(H,186,221)(H,187,220)(H,198,199)(H,200,201)(H4,152,153,158)(H4,154,155,159)(H4,156,157,160)/t74-,75-,76-,77-,78-,79+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,111-,112-,113-,114-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 9.5n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004989
PNG
(CHEMBL265167 | His-Ala-Asp-Ala-Ile-Phe-Thr-Ser-Ser...)
Show InChI InChI=1S/C155H251N49O40S/c1-20-80(12)120(201-127(220)85(17)180-138(231)112(68-119(215)216)189-126(219)83(15)178-128(221)94(157)65-90-69-169-74-176-90)149(242)198-109(62-87-32-24-23-25-33-87)145(238)204-123(86(18)207)151(244)200-114(73-206)147(240)199-113(72-205)146(239)194-108(64-89-41-45-93(209)46-42-89)142(235)186-98(37-30-55-173-154(165)166)131(224)185-99(38-31-56-174-155(167)168)135(228)202-122(82(14)22-3)150(243)197-103(58-76(4)5)129(222)175-71-117(212)181-100(47-49-115(158)210)133(226)191-105(60-78(8)9)140(233)193-107(63-88-39-43-92(208)44-40-88)137(230)179-84(16)125(218)183-97(36-29-54-172-153(163)164)130(223)184-96(34-26-27-52-156)132(225)190-104(59-77(6)7)139(232)192-106(61-79(10)11)141(234)195-110(66-91-70-170-75-177-91)143(236)187-101(48-50-118(213)214)136(229)203-121(81(13)21-2)148(241)188-102(51-57-245-19)134(227)196-111(67-116(159)211)144(237)182-95(124(160)217)35-28-53-171-152(161)162/h23-25,32-33,39-46,69-70,74-86,94-114,120-123,205-209H,20-22,26-31,34-38,47-68,71-73,156-157H2,1-19H3,(H2,158,210)(H2,159,211)(H2,160,217)(H,169,176)(H,170,177)(H,175,222)(H,178,221)(H,179,230)(H,180,231)(H,181,212)(H,182,237)(H,183,218)(H,184,223)(H,185,224)(H,186,235)(H,187,236)(H,188,241)(H,189,219)(H,190,225)(H,191,226)(H,192,232)(H,193,233)(H,194,239)(H,195,234)(H,196,227)(H,197,243)(H,198,242)(H,199,240)(H,200,244)(H,201,220)(H,202,228)(H,203,229)(H,204,238)(H,213,214)(H,215,216)(H4,161,162,171)(H4,163,164,172)(H4,165,166,173)(H4,167,168,174)/t80-,81-,82-,83-,84-,85-,86+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,120-,121-,122-,123-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 9.80n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004978
PNG
(CHEMBL262750 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C153H253N45O43S/c1-20-80(13)120(196-126(217)84(17)172-136(227)107(69-117(210)211)183-125(216)83(16)171-135(226)103(175-115(208)40-29-56-156)66-87-41-45-89(203)46-42-87)149(240)190-105(65-86-33-23-22-24-34-86)142(233)198-122(85(18)202)150(241)191-106(68-114(159)207)141(232)194-111(74-201)146(237)187-104(67-88-43-47-90(204)48-44-88)140(231)180-95(39-32-59-169-153(165)166)129(220)179-93(36-26-28-55-155)134(225)195-119(79(11)12)147(238)189-99(61-75(3)4)127(218)170-71-116(209)174-96(49-51-112(157)205)131(222)185-102(64-78(9)10)139(230)193-109(72-199)144(235)173-82(15)124(215)177-94(38-31-58-168-152(163)164)128(219)178-92(35-25-27-54-154)130(221)184-101(63-77(7)8)138(229)186-100(62-76(5)6)137(228)181-97(50-52-113(158)206)132(223)188-108(70-118(212)213)143(234)197-121(81(14)21-2)148(239)182-98(53-60-242-19)133(224)192-110(73-200)145(236)176-91(123(160)214)37-30-57-167-151(161)162/h22-24,33-34,41-48,75-85,91-111,119-122,199-204H,20-21,25-32,35-40,49-74,154-156H2,1-19H3,(H2,157,205)(H2,158,206)(H2,159,207)(H2,160,214)(H,170,218)(H,171,226)(H,172,227)(H,173,235)(H,174,209)(H,175,208)(H,176,236)(H,177,215)(H,178,219)(H,179,220)(H,180,231)(H,181,228)(H,182,239)(H,183,216)(H,184,221)(H,185,222)(H,186,229)(H,187,237)(H,188,223)(H,189,238)(H,190,240)(H,191,241)(H,192,224)(H,193,230)(H,194,232)(H,195,225)(H,196,217)(H,197,234)(H,198,233)(H,210,211)(H,212,213)(H4,161,162,167)(H4,163,164,168)(H4,165,166,169)/t80-,81-,82-,83-,84-,85+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,119-,120-,121-,122-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 13.7n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004992
PNG
(CHEMBL427794 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C145H241N43O39S/c1-20-76(13)113(186-119(204)80(17)164-129(214)103(66-111(199)200)174-118(203)78(15)163-120(205)87(148)62-83-39-43-85(193)44-40-83)141(226)180-101(63-82-32-23-22-24-33-82)135(220)188-115(81(18)192)142(227)181-102(65-109(151)197)134(219)184-106(70-191)138(223)178-100(64-84-41-45-86(194)46-42-84)133(218)171-92(38-31-56-161-145(157)158)123(208)170-90(35-26-28-53-147)127(212)185-112(75(11)12)139(224)179-96(58-71(3)4)121(206)162-67-110(198)166-93(47-49-107(149)195)125(210)176-99(61-74(9)10)132(217)183-104(68-189)136(221)165-79(16)117(202)168-91(37-30-55-160-144(155)156)122(207)169-89(34-25-27-52-146)124(209)175-98(60-73(7)8)131(216)177-97(59-72(5)6)130(215)172-94(48-50-108(150)196)128(213)187-114(77(14)21-2)140(225)173-95(51-57-228-19)126(211)182-105(69-190)137(222)167-88(116(152)201)36-29-54-159-143(153)154/h22-24,32-33,39-46,71-81,87-106,112-115,189-194H,20-21,25-31,34-38,47-70,146-148H2,1-19H3,(H2,149,195)(H2,150,196)(H2,151,197)(H2,152,201)(H,162,206)(H,163,205)(H,164,214)(H,165,221)(H,166,198)(H,167,222)(H,168,202)(H,169,207)(H,170,208)(H,171,218)(H,172,215)(H,173,225)(H,174,203)(H,175,209)(H,176,210)(H,177,216)(H,178,223)(H,179,224)(H,180,226)(H,181,227)(H,182,211)(H,183,217)(H,184,219)(H,185,212)(H,186,204)(H,187,213)(H,188,220)(H,199,200)(H4,153,154,159)(H4,155,156,160)(H4,157,158,161)/t76-,77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,112-,113-,114-,115-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 16.9n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004974
PNG
(Ac-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C151H248N44O43S/c1-21-78(13)118(193-124(214)82(17)169-134(224)106(67-115(207)208)180-123(213)81(16)168-133(223)102(171-84(19)200)64-86-40-44-88(201)45-41-86)147(237)187-104(63-85-33-24-23-25-34-85)140(230)195-120(83(18)199)148(238)188-105(66-113(156)205)139(229)191-110(72-198)144(234)184-103(65-87-42-46-89(202)47-43-87)138(228)177-94(39-32-57-166-151(162)163)127(217)176-92(36-27-29-54-153)132(222)192-117(77(11)12)145(235)186-98(59-73(3)4)125(215)167-69-114(206)172-95(48-50-111(154)203)129(219)182-101(62-76(9)10)137(227)190-108(70-196)142(232)170-80(15)122(212)174-93(38-31-56-165-150(160)161)126(216)175-91(35-26-28-53-152)128(218)181-100(61-75(7)8)136(226)183-99(60-74(5)6)135(225)178-96(49-51-112(155)204)130(220)185-107(68-116(209)210)141(231)194-119(79(14)22-2)146(236)179-97(52-58-239-20)131(221)189-109(71-197)143(233)173-90(121(157)211)37-30-55-164-149(158)159/h23-25,33-34,40-47,73-83,90-110,117-120,196-199,201-202H,21-22,26-32,35-39,48-72,152-153H2,1-20H3,(H2,154,203)(H2,155,204)(H2,156,205)(H2,157,211)(H,167,215)(H,168,223)(H,169,224)(H,170,232)(H,171,200)(H,172,206)(H,173,233)(H,174,212)(H,175,216)(H,176,217)(H,177,228)(H,178,225)(H,179,236)(H,180,213)(H,181,218)(H,182,219)(H,183,226)(H,184,234)(H,185,220)(H,186,235)(H,187,237)(H,188,238)(H,189,221)(H,190,227)(H,191,229)(H,192,222)(H,193,214)(H,194,231)(H,195,230)(H,207,208)(H,209,210)(H4,158,159,164)(H4,160,161,165)(H4,162,163,166)/t78-,79-,80-,81-,82-,83+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,117-,118-,119-,120-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 17.6n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004985
PNG
(CHEMBL414943 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C143H234N40O41S/c1-20-74(13)112(181-118(201)78(17)159-128(211)100(63-109(194)195)168-117(200)76(15)158-119(202)85(146)59-81-37-41-83(188)42-38-81)140(223)175-98(60-80-31-23-22-24-32-80)134(217)183-114(79(18)187)141(224)176-99(62-107(149)192)133(216)179-104(68-186)137(220)172-97(61-82-39-43-84(189)44-40-82)132(215)165-89(36-30-53-156-143(153)154)122(205)164-87(34-26-28-51-145)127(210)180-111(73(11)12)138(221)174-93(55-69(3)4)120(203)157-65-108(193)161-90(45-47-105(147)190)124(207)170-96(58-72(9)10)131(214)178-103(67-185)136(219)160-77(16)116(199)162-88(35-29-52-155-142(151)152)121(204)163-86(33-25-27-50-144)123(206)169-95(57-71(7)8)130(213)171-94(56-70(5)6)129(212)166-91(46-48-106(148)191)125(208)173-101(64-110(196)197)135(218)182-113(75(14)21-2)139(222)167-92(49-54-225-19)126(209)177-102(66-184)115(150)198/h22-24,31-32,37-44,69-79,85-104,111-114,184-189H,20-21,25-30,33-36,45-68,144-146H2,1-19H3,(H2,147,190)(H2,148,191)(H2,149,192)(H2,150,198)(H,157,203)(H,158,202)(H,159,211)(H,160,219)(H,161,193)(H,162,199)(H,163,204)(H,164,205)(H,165,215)(H,166,212)(H,167,222)(H,168,200)(H,169,206)(H,170,207)(H,171,213)(H,172,220)(H,173,208)(H,174,221)(H,175,223)(H,176,224)(H,177,209)(H,178,214)(H,179,216)(H,180,210)(H,181,201)(H,182,218)(H,183,217)(H,194,195)(H,196,197)(H4,151,152,155)(H4,153,154,156)/t74-,75-,76-,77-,78-,79+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,111-,112-,113-,114-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 20.2n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004994
PNG
(CHEMBL437461 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C143H235N43O41S/c1-18-74(12)112(185-117(204)77(15)162-127(214)100(63-109(197)198)172-116(203)75(13)161-118(205)84(146)59-80-36-40-82(191)41-37-80)139(226)179-98(60-79-29-20-19-21-30-79)134(221)186-113(78(16)190)140(227)180-99(62-107(149)195)132(219)183-104(68-189)137(224)176-97(61-81-38-42-83(192)43-39-81)131(218)169-89(35-28-53-159-143(155)156)121(208)168-87(32-23-25-50-145)126(213)184-111(73(10)11)138(225)178-93(55-69(2)3)119(206)160-65-108(196)164-90(44-46-105(147)193)123(210)174-96(58-72(8)9)130(217)182-102(66-187)135(222)163-76(14)115(202)166-88(34-27-52-158-142(153)154)120(207)167-86(31-22-24-49-144)122(209)173-95(57-71(6)7)129(216)175-94(56-70(4)5)128(215)170-91(45-47-106(148)194)124(211)177-101(64-110(199)200)133(220)171-92(48-54-228-17)125(212)181-103(67-188)136(223)165-85(114(150)201)33-26-51-157-141(151)152/h19-21,29-30,36-43,69-78,84-104,111-113,187-192H,18,22-28,31-35,44-68,144-146H2,1-17H3,(H2,147,193)(H2,148,194)(H2,149,195)(H2,150,201)(H,160,206)(H,161,205)(H,162,214)(H,163,222)(H,164,196)(H,165,223)(H,166,202)(H,167,207)(H,168,208)(H,169,218)(H,170,215)(H,171,220)(H,172,203)(H,173,209)(H,174,210)(H,175,216)(H,176,224)(H,177,211)(H,178,225)(H,179,226)(H,180,227)(H,181,212)(H,182,217)(H,183,219)(H,184,213)(H,185,204)(H,186,221)(H,197,198)(H,199,200)(H4,151,152,157)(H4,153,154,158)(H4,155,156,159)/t74-,75-,76-,77-,78+,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,111-,112-,113-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 20.3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004968
PNG
(CHEMBL439108 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C157H261N45O43S/c1-20-84(13)124(200-130(221)88(17)176-140(231)111(73-121(214)215)187-129(220)87(16)175-139(230)107(70-91-45-49-93(207)50-46-91)179-119(212)44-28-23-22-24-31-58-158)153(244)194-109(69-90-37-26-25-27-38-90)146(237)202-126(89(18)206)154(245)195-110(72-118(163)211)145(236)198-115(78-205)150(241)191-108(71-92-47-51-94(208)52-48-92)144(235)184-99(43-36-63-173-157(169)170)133(224)183-97(40-30-33-60-160)138(229)199-123(83(11)12)151(242)193-103(65-79(3)4)131(222)174-75-120(213)178-100(53-55-116(161)209)135(226)189-106(68-82(9)10)143(234)197-113(76-203)148(239)177-86(15)128(219)181-98(42-35-62-172-156(167)168)132(223)182-96(39-29-32-59-159)134(225)188-105(67-81(7)8)142(233)190-104(66-80(5)6)141(232)185-101(54-56-117(162)210)136(227)192-112(74-122(216)217)147(238)201-125(85(14)21-2)152(243)186-102(57-64-246-19)137(228)196-114(77-204)149(240)180-95(127(164)218)41-34-61-171-155(165)166/h25-27,37-38,45-52,79-89,95-115,123-126,203-208H,20-24,28-36,39-44,53-78,158-160H2,1-19H3,(H2,161,209)(H2,162,210)(H2,163,211)(H2,164,218)(H,174,222)(H,175,230)(H,176,231)(H,177,239)(H,178,213)(H,179,212)(H,180,240)(H,181,219)(H,182,223)(H,183,224)(H,184,235)(H,185,232)(H,186,243)(H,187,220)(H,188,225)(H,189,226)(H,190,233)(H,191,241)(H,192,227)(H,193,242)(H,194,244)(H,195,245)(H,196,228)(H,197,234)(H,198,236)(H,199,229)(H,200,221)(H,201,238)(H,202,237)(H,214,215)(H,216,217)(H4,165,166,171)(H4,167,168,172)(H4,169,170,173)/t84-,85-,86-,87-,88-,89+,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,123-,124-,125-,126-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 21.6n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004972
PNG
(CHEMBL427665 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C149H244N46O39S/c1-20-77(12)115(192-122(211)82(17)171-132(221)107(67-114(206)207)180-120(209)80(15)151)143(232)189-104(62-84-32-24-23-25-33-84)139(228)195-118(83(18)198)145(234)191-109(71-197)141(230)190-108(70-196)140(229)185-103(64-86-41-45-89(200)46-42-86)136(225)177-93(37-30-55-166-148(159)160)125(214)176-94(38-31-56-167-149(161)162)129(218)193-117(79(14)22-3)144(233)188-98(58-73(4)5)123(212)168-69-112(203)172-95(47-49-110(152)201)127(216)182-100(60-75(8)9)134(223)184-102(63-85-39-43-88(199)44-40-85)131(220)170-81(16)121(210)174-92(36-29-54-165-147(157)158)124(213)175-91(34-26-27-52-150)126(215)181-99(59-74(6)7)133(222)183-101(61-76(10)11)135(224)186-105(65-87-68-163-72-169-87)137(226)178-96(48-50-113(204)205)130(219)194-116(78(13)21-2)142(231)179-97(51-57-235-19)128(217)187-106(66-111(153)202)138(227)173-90(119(154)208)35-28-53-164-146(155)156/h23-25,32-33,39-46,68,72-83,90-109,115-118,196-200H,20-22,26-31,34-38,47-67,69-71,150-151H2,1-19H3,(H2,152,201)(H2,153,202)(H2,154,208)(H,163,169)(H,168,212)(H,170,220)(H,171,221)(H,172,203)(H,173,227)(H,174,210)(H,175,213)(H,176,214)(H,177,225)(H,178,226)(H,179,231)(H,180,209)(H,181,215)(H,182,216)(H,183,222)(H,184,223)(H,185,229)(H,186,224)(H,187,217)(H,188,233)(H,189,232)(H,190,230)(H,191,234)(H,192,211)(H,193,218)(H,194,219)(H,195,228)(H,204,205)(H,206,207)(H4,155,156,164)(H4,157,158,165)(H4,159,160,166)(H4,161,162,167)/t77-,78-,79-,80-,81-,82-,83+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,115-,116-,117-,118-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 44.2n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004980
PNG
(CHEMBL262536 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C144H238N42O40S/c1-20-75(13)112(184-118(203)79(17)162-127(212)101(64-109(196)197)171-117(202)77(15)161-119(204)86(147)60-82-39-43-84(191)44-40-82)140(225)178-99(61-81-32-23-22-24-33-81)133(218)186-114(80(18)190)141(226)179-100(63-107(149)194)132(217)182-105(69-189)137(222)175-98(62-83-41-45-85(192)46-42-83)131(216)169-91(38-31-54-159-144(155)156)122(207)168-89(35-26-28-51-146)126(211)183-111(74(11)12)138(223)177-94(56-70(3)4)120(205)160-66-108(195)164-92(47-48-106(148)193)124(209)173-97(59-73(9)10)130(215)181-103(67-187)135(220)163-78(16)116(201)166-90(37-30-53-158-143(153)154)121(206)167-88(34-25-27-50-145)123(208)172-95(57-71(5)6)128(213)174-96(58-72(7)8)129(214)176-102(65-110(198)199)134(219)185-113(76(14)21-2)139(224)170-93(49-55-227-19)125(210)180-104(68-188)136(221)165-87(115(150)200)36-29-52-157-142(151)152/h22-24,32-33,39-46,70-80,86-105,111-114,187-192H,20-21,25-31,34-38,47-69,145-147H2,1-19H3,(H2,148,193)(H2,149,194)(H2,150,200)(H,160,205)(H,161,204)(H,162,212)(H,163,220)(H,164,195)(H,165,221)(H,166,201)(H,167,206)(H,168,207)(H,169,216)(H,170,224)(H,171,202)(H,172,208)(H,173,209)(H,174,213)(H,175,222)(H,176,214)(H,177,223)(H,178,225)(H,179,226)(H,180,210)(H,181,215)(H,182,217)(H,183,211)(H,184,203)(H,185,219)(H,186,218)(H,196,197)(H,198,199)(H4,151,152,157)(H4,153,154,158)(H4,155,156,159)/t75-,76-,77-,78-,79-,80+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,111-,112-,113-,114-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 45.2n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004971
PNG
(CHEMBL412558 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C145H240N42O40S/c1-20-76(13)113(185-119(204)80(17)163-129(214)102(65-110(197)198)173-118(203)78(15)162-120(205)87(148)62-83-39-43-85(192)44-40-83)141(226)180-101(63-82-32-23-22-24-33-82)134(219)187-115(81(18)191)142(227)183-106(70-190)138(223)177-100(64-84-41-45-86(193)46-42-84)133(218)170-92(38-31-56-160-145(156)157)123(208)169-90(35-26-28-53-147)128(213)184-112(75(11)12)139(224)179-96(58-71(3)4)121(206)161-67-109(196)165-93(47-49-107(149)194)125(210)175-99(61-74(9)10)132(217)182-104(68-188)136(221)164-79(16)117(202)167-91(37-30-55-159-144(154)155)122(207)168-89(34-25-27-52-146)124(209)174-98(60-73(7)8)131(216)176-97(59-72(5)6)130(215)171-94(48-50-108(150)195)126(211)178-103(66-111(199)200)135(220)186-114(77(14)21-2)140(225)172-95(51-57-228-19)127(212)181-105(69-189)137(222)166-88(116(151)201)36-29-54-158-143(152)153/h22-24,32-33,39-46,71-81,87-106,112-115,188-193H,20-21,25-31,34-38,47-70,146-148H2,1-19H3,(H2,149,194)(H2,150,195)(H2,151,201)(H,161,206)(H,162,205)(H,163,214)(H,164,221)(H,165,196)(H,166,222)(H,167,202)(H,168,207)(H,169,208)(H,170,218)(H,171,215)(H,172,225)(H,173,203)(H,174,209)(H,175,210)(H,176,216)(H,177,223)(H,178,211)(H,179,224)(H,180,226)(H,181,212)(H,182,217)(H,183,227)(H,184,213)(H,185,204)(H,186,220)(H,187,219)(H,197,198)(H,199,200)(H4,152,153,158)(H4,154,155,159)(H4,156,157,160)/t76-,77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,112-,113-,114-,115-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 95n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004981
PNG
(CHEMBL264522 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C141H232N42O39/c1-19-73(13)110(181-116(200)77(17)160-125(209)99(63-107(193)194)169-115(199)75(15)159-117(201)84(144)59-80-38-42-82(187)43-39-80)137(221)176-97(60-79-31-22-21-23-32-79)131(215)183-112(78(18)186)138(222)177-98(62-105(147)191)130(214)179-102(67-185)134(218)173-96(61-81-40-44-83(188)45-41-81)129(213)167-89(37-30-54-157-141(153)154)120(204)166-87(34-25-27-51-143)124(208)180-109(72(11)12)135(219)175-92(55-68(3)4)118(202)158-65-106(192)162-90(46-48-103(145)189)122(206)171-95(58-71(9)10)128(212)178-101(66-184)133(217)161-76(16)114(198)164-88(36-29-53-156-140(151)152)119(203)165-86(33-24-26-50-142)121(205)170-94(57-70(7)8)127(211)172-93(56-69(5)6)126(210)168-91(47-49-104(146)190)123(207)174-100(64-108(195)196)132(216)182-111(74(14)20-2)136(220)163-85(113(148)197)35-28-52-155-139(149)150/h21-23,31-32,38-45,68-78,84-102,109-112,184-188H,19-20,24-30,33-37,46-67,142-144H2,1-18H3,(H2,145,189)(H2,146,190)(H2,147,191)(H2,148,197)(H,158,202)(H,159,201)(H,160,209)(H,161,217)(H,162,192)(H,163,220)(H,164,198)(H,165,203)(H,166,204)(H,167,213)(H,168,210)(H,169,199)(H,170,205)(H,171,206)(H,172,211)(H,173,218)(H,174,207)(H,175,219)(H,176,221)(H,177,222)(H,178,212)(H,179,214)(H,180,208)(H,181,200)(H,182,216)(H,183,215)(H,193,194)(H,195,196)(H4,149,150,155)(H4,151,152,156)(H4,153,154,157)/t73-,74-,75-,76-,77-,78+,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,109-,110-,111-,112-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 120n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004991
PNG
(CHEMBL411913 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)CC(=O)CCc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C143H234N40O39/c1-20-75(13)112(181-119(201)80(18)160-127(209)102(66-109(193)194)169-116(198)77(15)62-87(189)48-41-82-39-44-85(187)45-40-82)139(221)176-100(63-83-32-23-22-24-33-83)133(215)183-114(81(19)186)140(222)177-101(65-108(148)192)132(214)179-105(69-185)136(218)173-99(64-84-42-46-86(188)47-43-84)131(213)167-92(38-31-57-158-143(154)155)121(203)166-90(35-26-28-54-145)125(207)180-111(74(11)12)137(219)175-95(58-70(3)4)126(208)159-78(16)118(200)164-93(49-51-106(146)190)123(205)171-98(61-73(9)10)130(212)178-104(68-184)135(217)161-79(17)117(199)163-91(37-30-56-157-142(152)153)120(202)165-89(34-25-27-53-144)122(204)170-97(60-72(7)8)129(211)172-96(59-71(5)6)128(210)168-94(50-52-107(147)191)124(206)174-103(67-110(195)196)134(216)182-113(76(14)21-2)138(220)162-88(115(149)197)36-29-55-156-141(150)151/h22-24,32-33,39-40,42-47,70-81,88-105,111-114,184-188H,20-21,25-31,34-38,41,48-69,144-145H2,1-19H3,(H2,146,190)(H2,147,191)(H2,148,192)(H2,149,197)(H,159,208)(H,160,209)(H,161,217)(H,162,220)(H,163,199)(H,164,200)(H,165,202)(H,166,203)(H,167,213)(H,168,210)(H,169,198)(H,170,204)(H,171,205)(H,172,211)(H,173,218)(H,174,206)(H,175,219)(H,176,221)(H,177,222)(H,178,212)(H,179,214)(H,180,207)(H,181,201)(H,182,216)(H,183,215)(H,193,194)(H,195,196)(H4,150,151,156)(H4,152,153,157)(H4,154,155,158)/t75-,76-,77+,78-,79-,80-,81+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,111-,112-,113-,114-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 130n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004988
PNG
(CHEMBL269041 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C146H240N42O41S/c1-20-76(13)114(186-119(204)80(17)164-129(214)103(66-111(198)199)174-118(203)78(15)163-120(205)87(149)62-83-39-43-85(192)44-40-83)141(226)181-101(63-82-32-23-22-24-33-82)135(220)188-116(81(18)191)142(227)182-102(65-109(152)196)134(219)178-100(64-84-41-45-86(193)46-42-84)133(218)170-91(37-30-55-160-145(155)156)123(208)169-89(35-26-28-53-148)128(213)185-113(75(11)12)139(224)180-96(58-71(3)4)121(206)162-68-110(197)166-92(47-49-107(150)194)125(210)176-99(61-74(9)10)132(217)184-105(69-189)137(222)165-79(16)117(202)167-90(36-29-54-159-144(153)154)122(207)168-88(34-25-27-52-147)124(209)175-98(60-73(7)8)131(216)177-97(59-72(5)6)130(215)171-93(48-50-108(151)195)126(211)179-104(67-112(200)201)136(221)187-115(77(14)21-2)140(225)172-94(51-57-230-19)127(212)183-106(70-190)138(223)173-95(143(228)229)38-31-56-161-146(157)158/h22-24,32-33,39-46,71-81,87-106,113-116,189-193H,20-21,25-31,34-38,47-70,147-149H2,1-19H3,(H2,150,194)(H2,151,195)(H2,152,196)(H,162,206)(H,163,205)(H,164,214)(H,165,222)(H,166,197)(H,167,202)(H,168,207)(H,169,208)(H,170,218)(H,171,215)(H,172,225)(H,173,223)(H,174,203)(H,175,209)(H,176,210)(H,177,216)(H,178,219)(H,179,211)(H,180,224)(H,181,226)(H,182,227)(H,183,212)(H,184,217)(H,185,213)(H,186,204)(H,187,221)(H,188,220)(H,198,199)(H,200,201)(H,228,229)(H4,153,154,159)(H4,155,156,160)(H4,157,158,161)/t76-,77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 217n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004990
PNG
(CHEMBL428284 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C138H234N42O39S/c1-20-71(13)106(178-112(196)75(17)155-113(197)80(141)60-103(189)190)134(218)172-94(58-77-32-23-22-24-33-77)127(211)180-108(76(18)184)135(219)173-95(61-102(144)188)126(210)176-99(65-183)131(215)169-93(59-78-39-41-79(185)42-40-78)125(209)163-85(38-31-52-154-138(150)151)115(199)162-83(35-26-28-49-140)120(204)177-105(70(11)12)132(216)171-89(54-66(3)4)121(205)156-73(15)111(195)160-86(43-45-100(142)186)117(201)167-92(57-69(9)10)124(208)175-97(63-181)129(213)157-74(16)110(194)159-84(37-30-51-153-137(148)149)114(198)161-82(34-25-27-48-139)116(200)166-91(56-68(7)8)123(207)168-90(55-67(5)6)122(206)164-87(44-46-101(143)187)118(202)170-96(62-104(191)192)128(212)179-107(72(14)21-2)133(217)165-88(47-53-220-19)119(203)174-98(64-182)130(214)158-81(109(145)193)36-29-50-152-136(146)147/h22-24,32-33,39-42,66-76,80-99,105-108,181-185H,20-21,25-31,34-38,43-65,139-141H2,1-19H3,(H2,142,186)(H2,143,187)(H2,144,188)(H2,145,193)(H,155,197)(H,156,205)(H,157,213)(H,158,214)(H,159,194)(H,160,195)(H,161,198)(H,162,199)(H,163,209)(H,164,206)(H,165,217)(H,166,200)(H,167,201)(H,168,207)(H,169,215)(H,170,202)(H,171,216)(H,172,218)(H,173,219)(H,174,203)(H,175,208)(H,176,210)(H,177,204)(H,178,196)(H,179,212)(H,180,211)(H,189,190)(H,191,192)(H4,146,147,152)(H4,148,149,153)(H4,150,151,154)/t71-,72-,73-,74-,75-,76+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,105-,106-,107-,108-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 311n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004962
PNG
(CHEMBL439306 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C141H239N43O40S/c1-21-72(13)108(182-115(201)77(18)159-124(210)97(62-105(193)194)169-112(198)74(15)144)137(223)176-95(59-79-33-24-23-25-34-79)130(216)184-110(78(19)188)138(224)177-96(61-104(147)192)129(215)180-101(66-187)134(220)173-94(60-80-40-42-81(189)43-41-80)128(214)166-86(39-32-53-157-141(153)154)117(203)165-84(36-27-29-50-143)122(208)181-107(71(11)12)135(221)175-90(55-67(3)4)123(209)158-75(16)114(200)163-87(44-46-102(145)190)119(205)171-93(58-70(9)10)127(213)179-99(64-185)132(218)160-76(17)113(199)162-85(38-31-52-156-140(151)152)116(202)164-83(35-26-28-49-142)118(204)170-92(57-69(7)8)126(212)172-91(56-68(5)6)125(211)167-88(45-47-103(146)191)120(206)174-98(63-106(195)196)131(217)183-109(73(14)22-2)136(222)168-89(48-54-225-20)121(207)178-100(65-186)133(219)161-82(111(148)197)37-30-51-155-139(149)150/h23-25,33-34,40-43,67-78,82-101,107-110,185-189H,21-22,26-32,35-39,44-66,142-144H2,1-20H3,(H2,145,190)(H2,146,191)(H2,147,192)(H2,148,197)(H,158,209)(H,159,210)(H,160,218)(H,161,219)(H,162,199)(H,163,200)(H,164,202)(H,165,203)(H,166,214)(H,167,211)(H,168,222)(H,169,198)(H,170,204)(H,171,205)(H,172,212)(H,173,220)(H,174,206)(H,175,221)(H,176,223)(H,177,224)(H,178,207)(H,179,213)(H,180,215)(H,181,208)(H,182,201)(H,183,217)(H,184,216)(H,193,194)(H,195,196)(H4,149,150,155)(H4,151,152,156)(H4,153,154,157)/t72-,73-,74-,75-,76-,77-,78+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,107-,108-,109-,110-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 377n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004984
PNG
(CHEMBL415373 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C143H234N42O41S/c1-20-73(13)111(183-117(203)77(17)161-126(212)99(62-108(196)197)170-116(202)75(15)160-118(204)84(145)58-80-36-40-82(190)41-37-80)139(225)177-97(59-79-30-23-22-24-31-79)132(218)185-113(78(18)189)140(226)178-98(61-106(148)194)131(217)181-103(67-188)136(222)174-96(60-81-38-42-83(191)43-39-81)130(216)167-88(35-29-52-158-143(154)155)125(211)182-110(72(11)12)137(223)176-92(54-68(3)4)119(205)159-64-107(195)163-89(44-46-104(146)192)122(208)172-95(57-71(9)10)129(215)180-101(65-186)134(220)162-76(16)115(201)165-87(34-28-51-157-142(152)153)120(206)166-86(32-25-26-49-144)121(207)171-94(56-70(7)8)128(214)173-93(55-69(5)6)127(213)168-90(45-47-105(147)193)123(209)175-100(63-109(198)199)133(219)184-112(74(14)21-2)138(224)169-91(48-53-227-19)124(210)179-102(66-187)135(221)164-85(114(149)200)33-27-50-156-141(150)151/h22-24,30-31,36-43,68-78,84-103,110-113,186-191H,20-21,25-29,32-35,44-67,144-145H2,1-19H3,(H2,146,192)(H2,147,193)(H2,148,194)(H2,149,200)(H,159,205)(H,160,204)(H,161,212)(H,162,220)(H,163,195)(H,164,221)(H,165,201)(H,166,206)(H,167,216)(H,168,213)(H,169,224)(H,170,202)(H,171,207)(H,172,208)(H,173,214)(H,174,222)(H,175,209)(H,176,223)(H,177,225)(H,178,226)(H,179,210)(H,180,215)(H,181,217)(H,182,211)(H,183,203)(H,184,219)(H,185,218)(H,196,197)(H,198,199)(H4,150,151,156)(H4,152,153,157)(H4,154,155,158)/t73-,74-,75-,76-,77-,78+,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,110-,111-,112-,113-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 836n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004996
PNG
(CHEMBL411047 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C144H238N42O40S/c1-20-75(13)112(184-118(203)79(17)162-127(212)101(64-109(196)197)172-117(202)77(15)161-119(204)86(147)60-82-39-43-84(191)44-40-82)140(225)178-99(61-81-32-23-22-24-33-81)133(218)186-114(80(18)190)141(226)179-100(63-107(149)194)132(217)182-105(69-189)137(222)175-98(62-83-41-45-85(192)46-42-83)131(216)169-91(38-31-54-159-144(155)156)122(207)168-89(35-26-28-51-146)126(211)183-111(74(11)12)138(223)177-94(56-70(3)4)120(205)160-66-108(195)164-95(57-71(5)6)128(213)181-103(67-187)135(220)163-78(16)116(201)166-90(37-30-53-158-143(153)154)121(206)167-88(34-25-27-50-145)123(208)173-97(59-73(9)10)130(215)174-96(58-72(7)8)129(214)170-92(47-48-106(148)193)124(209)176-102(65-110(198)199)134(219)185-113(76(14)21-2)139(224)171-93(49-55-227-19)125(210)180-104(68-188)136(221)165-87(115(150)200)36-29-52-157-142(151)152/h22-24,32-33,39-46,70-80,86-105,111-114,187-192H,20-21,25-31,34-38,47-69,145-147H2,1-19H3,(H2,148,193)(H2,149,194)(H2,150,200)(H,160,205)(H,161,204)(H,162,212)(H,163,220)(H,164,195)(H,165,221)(H,166,201)(H,167,206)(H,168,207)(H,169,216)(H,170,214)(H,171,224)(H,172,202)(H,173,208)(H,174,215)(H,175,222)(H,176,209)(H,177,223)(H,178,225)(H,179,226)(H,180,210)(H,181,213)(H,182,217)(H,183,211)(H,184,203)(H,185,219)(H,186,218)(H,196,197)(H,198,199)(H4,151,152,157)(H4,153,154,158)(H4,155,156,159)/t75-,76-,77-,78-,79-,80+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,111-,112-,113-,114-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-GRF in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004987
PNG
(CHEMBL405515 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C144H237N43O41S/c1-18-74(11)112(185-118(205)78(15)163-128(215)101(64-110(198)199)173-117(204)76(13)162-119(206)85(147)60-81-37-41-83(192)42-38-81)140(227)180-99(61-80-30-21-20-22-31-80)134(221)187-114(79(16)191)141(228)181-100(63-108(150)196)133(220)184-105(69-190)138(225)178-98(62-82-39-43-84(193)44-40-82)132(219)170-90(36-29-54-160-144(156)157)122(209)169-87(32-23-25-50-145)123(210)174-94(56-70(3)4)120(207)161-66-109(197)165-91(45-47-106(148)194)125(212)176-97(59-73(9)10)131(218)183-103(67-188)136(223)164-77(14)116(203)167-89(35-28-53-159-143(154)155)121(208)168-88(33-24-26-51-146)124(211)175-96(58-72(7)8)130(217)177-95(57-71(5)6)129(216)171-92(46-48-107(149)195)126(213)179-102(65-111(200)201)135(222)186-113(75(12)19-2)139(226)172-93(49-55-229-17)127(214)182-104(68-189)137(224)166-86(115(151)202)34-27-52-158-142(152)153/h20-22,30-31,37-44,70-79,85-105,112-114,188-193H,18-19,23-29,32-36,45-69,145-147H2,1-17H3,(H2,148,194)(H2,149,195)(H2,150,196)(H2,151,202)(H,161,207)(H,162,206)(H,163,215)(H,164,223)(H,165,197)(H,166,224)(H,167,203)(H,168,208)(H,169,209)(H,170,219)(H,171,216)(H,172,226)(H,173,204)(H,174,210)(H,175,211)(H,176,212)(H,177,217)(H,178,225)(H,179,213)(H,180,227)(H,181,228)(H,182,214)(H,183,218)(H,184,220)(H,185,205)(H,186,222)(H,187,221)(H,198,199)(H,200,201)(H4,152,153,158)(H4,154,155,159)(H4,156,157,160)/t74-,75-,76-,77-,78-,79+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,112-,113-,114-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004986
PNG
(CHEMBL438936 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C120H193N33O34S/c1-17-62(11)94(151-99(168)65(14)134-106(175)84(53-91(162)163)141-98(167)64(13)133-100(169)72(122)49-68-31-35-70(157)36-32-68)117(186)146-82(50-67-26-20-19-21-27-67)111(180)153-96(66(15)156)118(187)147-83(52-89(124)160)110(179)149-87(57-155)114(183)143-81(51-69-33-37-71(158)38-34-69)109(178)138-75(30-25-44-131-120(128)129)102(171)137-74(28-22-23-42-121)105(174)150-93(61(9)10)115(184)145-78(46-58(3)4)101(170)132-55-90(161)135-79(47-59(5)6)107(176)142-80(48-60(7)8)108(177)139-76(39-40-88(123)159)103(172)144-85(54-92(164)165)112(181)152-95(63(12)18-2)116(185)140-77(41-45-188-16)104(173)148-86(56-154)113(182)136-73(97(125)166)29-24-43-130-119(126)127/h19-21,26-27,31-38,58-66,72-87,93-96,154-158H,17-18,22-25,28-30,39-57,121-122H2,1-16H3,(H2,123,159)(H2,124,160)(H2,125,166)(H,132,170)(H,133,169)(H,134,175)(H,135,161)(H,136,182)(H,137,171)(H,138,178)(H,139,177)(H,140,185)(H,141,167)(H,142,176)(H,143,183)(H,144,172)(H,145,184)(H,146,186)(H,147,187)(H,148,173)(H,149,179)(H,150,174)(H,151,168)(H,152,181)(H,153,180)(H,162,163)(H,164,165)(H4,126,127,130)(H4,128,129,131)/t62-,63-,64-,65-,66+,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,93-,94-,95-,96-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-GRF in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004983
PNG
(CHEMBL439298 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)CCCCCCCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C143H236N40O38S/c1-18-77(11)113(181-119(200)81(15)162-128(209)103(68-110(193)194)170-118(199)80(14)161-120(201)89(146)64-84-44-48-86(187)49-45-84)139(220)176-101(65-83-35-24-23-25-36-83)133(214)183-115(82(16)186)140(221)177-102(67-108(148)191)132(213)179-106(72-185)136(217)173-100(66-85-46-50-87(188)51-47-85)131(212)167-94(42-34-59-158-143(154)155)123(204)166-92(39-29-31-56-145)127(208)180-112(76(9)10)137(218)175-97(61-73(3)4)121(202)159-70-88(189)37-26-21-20-22-27-43-109(192)160-79(13)117(198)164-93(41-33-58-157-142(152)153)122(203)165-91(38-28-30-55-144)124(205)171-99(63-75(7)8)130(211)172-98(62-74(5)6)129(210)168-95(52-53-107(147)190)125(206)174-104(69-111(195)196)134(215)182-114(78(12)19-2)138(219)169-96(54-60-222-17)126(207)178-105(71-184)135(216)163-90(116(149)197)40-32-57-156-141(150)151/h23-25,35-36,44-51,73-82,89-106,112-115,184-188H,18-22,26-34,37-43,52-72,144-146H2,1-17H3,(H2,147,190)(H2,148,191)(H2,149,197)(H,159,202)(H,160,192)(H,161,201)(H,162,209)(H,163,216)(H,164,198)(H,165,203)(H,166,204)(H,167,212)(H,168,210)(H,169,219)(H,170,199)(H,171,205)(H,172,211)(H,173,217)(H,174,206)(H,175,218)(H,176,220)(H,177,221)(H,178,207)(H,179,213)(H,180,208)(H,181,200)(H,182,215)(H,183,214)(H,193,194)(H,195,196)(H4,150,151,156)(H4,152,153,157)(H4,154,155,158)/t77-,78-,79-,80-,81-,82+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,112-,113-,114-,115-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004977
PNG
(CHEMBL415372 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)CCCCCCCCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C143H233N37O40S/c1-19-77(13)115(178-120(199)80(16)158-128(207)101(66-112(193)194)166-119(198)79(15)157-121(200)87(145)62-83-41-45-85(185)46-42-83)140(219)172-99(63-82-34-26-25-27-35-82)134(213)180-117(81(17)184)141(220)173-100(65-109(148)190)133(212)176-105(71-183)137(216)169-98(64-84-43-47-86(186)48-44-84)132(211)163-90(38-33-56-155-143(152)153)123(202)162-89(36-30-31-54-144)127(206)177-114(76(11)12)138(217)171-94(58-72(3)4)122(201)156-68-111(192)159-91(49-51-107(146)188)124(203)167-97(61-75(9)10)131(210)174-103(69-181)106(187)39-28-23-21-22-24-29-40-110(191)160-95(59-73(5)6)129(208)168-96(60-74(7)8)130(209)164-92(50-52-108(147)189)125(204)170-102(67-113(195)196)135(214)179-116(78(14)20-2)139(218)165-93(53-57-221-18)126(205)175-104(70-182)136(215)161-88(118(149)197)37-32-55-154-142(150)151/h25-27,34-35,41-48,72-81,87-105,114-117,181-186H,19-24,28-33,36-40,49-71,144-145H2,1-18H3,(H2,146,188)(H2,147,189)(H2,148,190)(H2,149,197)(H,156,201)(H,157,200)(H,158,207)(H,159,192)(H,160,191)(H,161,215)(H,162,202)(H,163,211)(H,164,209)(H,165,218)(H,166,198)(H,167,203)(H,168,208)(H,169,216)(H,170,204)(H,171,217)(H,172,219)(H,173,220)(H,174,210)(H,175,205)(H,176,212)(H,177,206)(H,178,199)(H,179,214)(H,180,213)(H,193,194)(H,195,196)(H4,150,151,154)(H4,152,153,155)/t77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,114-,115-,116-,117-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004995
PNG
(CHEMBL439459 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C138H226N42O40S/c1-16-70(9)107(178-113(198)74(13)157-122(207)96(61-105(191)192)167-112(197)72(11)156-114(199)81(141)57-77-35-39-79(185)40-36-77)134(219)173-94(58-76-28-19-18-20-29-76)128(213)180-109(75(14)184)135(220)174-95(60-103(144)189)127(212)177-100(66-183)132(217)171-93(59-78-37-41-80(186)42-38-78)126(211)164-86(34-27-52-154-138(150)151)117(202)162-83(30-21-23-48-139)115(200)155-63-104(190)159-87(43-45-101(142)187)119(204)169-92(56-69(7)8)125(210)176-98(64-181)130(215)158-73(12)111(196)161-85(33-26-51-153-137(148)149)116(201)163-84(31-22-24-49-140)118(203)168-91(55-68(5)6)124(209)170-90(54-67(3)4)123(208)165-88(44-46-102(143)188)120(205)172-97(62-106(193)194)129(214)179-108(71(10)17-2)133(218)166-89(47-53-221-15)121(206)175-99(65-182)131(216)160-82(110(145)195)32-25-50-152-136(146)147/h18-20,28-29,35-42,67-75,81-100,107-109,181-186H,16-17,21-27,30-34,43-66,139-141H2,1-15H3,(H2,142,187)(H2,143,188)(H2,144,189)(H2,145,195)(H,155,200)(H,156,199)(H,157,207)(H,158,215)(H,159,190)(H,160,216)(H,161,196)(H,162,202)(H,163,201)(H,164,211)(H,165,208)(H,166,218)(H,167,197)(H,168,203)(H,169,204)(H,170,209)(H,171,217)(H,172,205)(H,173,219)(H,174,220)(H,175,206)(H,176,210)(H,177,212)(H,178,198)(H,179,214)(H,180,213)(H,191,192)(H,193,194)(H4,146,147,152)(H4,148,149,153)(H4,150,151,154)/t70-,71-,72-,73-,74-,75+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,107-,108-,109-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-GRF in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004963
PNG
(CHEMBL428464 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C137H222N38O40S/c1-20-70(13)107(173-113(193)74(17)152-121(201)95(59-104(186)187)161-111(191)72(15)151-114(194)81(139)55-77-34-38-79(180)39-35-77)134(214)167-93(56-76-29-23-22-24-30-76)127(207)175-109(75(18)179)135(215)168-94(58-102(142)184)126(206)171-99(64-178)131(211)164-92(57-78-36-40-80(181)41-37-78)125(205)157-84(33-28-49-149-137(146)147)116(196)156-83(31-25-26-47-138)120(200)172-106(69(11)12)132(212)166-88(51-65(3)4)115(195)150-61-103(185)154-85(42-44-100(140)182)117(197)162-91(54-68(9)10)124(204)170-97(62-176)129(209)153-73(16)112(192)160-89(52-66(5)6)123(203)163-90(53-67(7)8)122(202)158-86(43-45-101(141)183)118(198)165-96(60-105(188)189)128(208)174-108(71(14)21-2)133(213)159-87(46-50-216-19)119(199)169-98(63-177)130(210)155-82(110(143)190)32-27-48-148-136(144)145/h22-24,29-30,34-41,65-75,81-99,106-109,176-181H,20-21,25-28,31-33,42-64,138-139H2,1-19H3,(H2,140,182)(H2,141,183)(H2,142,184)(H2,143,190)(H,150,195)(H,151,194)(H,152,201)(H,153,209)(H,154,185)(H,155,210)(H,156,196)(H,157,205)(H,158,202)(H,159,213)(H,160,192)(H,161,191)(H,162,197)(H,163,203)(H,164,211)(H,165,198)(H,166,212)(H,167,214)(H,168,215)(H,169,199)(H,170,204)(H,171,206)(H,172,200)(H,173,193)(H,174,208)(H,175,207)(H,186,187)(H,188,189)(H4,144,145,148)(H4,146,147,149)/t70-,71-,72-,73-,74-,75+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,106-,107-,108-,109-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004964
PNG
(CHEMBL412221 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C147H243N43O41S/c1-20-76(13)114(188-120(207)80(17)165-129(216)103(66-111(200)201)175-119(206)78(15)164-121(208)87(150)62-83-39-43-85(195)44-40-83)143(230)182-101(63-82-32-23-22-24-33-82)136(223)190-116(81(18)194)144(231)183-102(65-110(153)199)135(222)186-107(70-193)140(227)179-100(64-84-41-45-86(196)46-42-84)134(221)171-92(38-31-56-163-147(159)160)123(210)170-90(35-26-28-53-149)128(215)187-113(75(11)12)141(228)181-99(61-74(9)10)131(218)173-93(47-49-108(151)197)125(212)177-98(60-73(7)8)133(220)185-105(68-191)138(225)166-79(16)118(205)168-91(37-30-55-162-146(157)158)122(209)169-89(34-25-27-52-148)124(211)176-97(59-72(5)6)132(219)178-96(58-71(3)4)130(217)172-94(48-50-109(152)198)126(213)180-104(67-112(202)203)137(224)189-115(77(14)21-2)142(229)174-95(51-57-232-19)127(214)184-106(69-192)139(226)167-88(117(154)204)36-29-54-161-145(155)156/h22-24,32-33,39-46,71-81,87-107,113-116,191-196H,20-21,25-31,34-38,47-70,148-150H2,1-19H3,(H2,151,197)(H2,152,198)(H2,153,199)(H2,154,204)(H,164,208)(H,165,216)(H,166,225)(H,167,226)(H,168,205)(H,169,209)(H,170,210)(H,171,221)(H,172,217)(H,173,218)(H,174,229)(H,175,206)(H,176,211)(H,177,212)(H,178,219)(H,179,227)(H,180,213)(H,181,228)(H,182,230)(H,183,231)(H,184,214)(H,185,220)(H,186,222)(H,187,215)(H,188,207)(H,189,224)(H,190,223)(H,200,201)(H,202,203)(H4,155,156,161)(H4,157,158,162)(H4,159,160,163)/t76-,77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,113-,114-,115-,116-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

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PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004982
PNG
(CHEMBL386367 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C136H223N41O39S/c1-16-69(9)105(175-111(194)73(13)154-120(203)95(61-103(187)188)164-110(193)71(11)153-112(195)80(139)57-76-35-39-78(182)40-36-76)132(215)170-93(58-75-28-19-18-20-29-75)126(209)177-107(74(14)181)133(216)171-94(60-102(142)186)125(208)174-99(65-180)130(213)168-92(59-77-37-41-79(183)42-38-77)124(207)160-85(34-27-52-152-136(148)149)115(198)158-82(30-21-23-48-137)113(196)161-86(43-45-100(140)184)117(200)166-91(56-68(7)8)123(206)173-97(63-178)128(211)155-72(12)109(192)157-84(33-26-51-151-135(146)147)114(197)159-83(31-22-24-49-138)116(199)165-90(55-67(5)6)122(205)167-89(54-66(3)4)121(204)162-87(44-46-101(141)185)118(201)169-96(62-104(189)190)127(210)176-106(70(10)17-2)131(214)163-88(47-53-217-15)119(202)172-98(64-179)129(212)156-81(108(143)191)32-25-50-150-134(144)145/h18-20,28-29,35-42,66-74,80-99,105-107,178-183H,16-17,21-27,30-34,43-65,137-139H2,1-15H3,(H2,140,184)(H2,141,185)(H2,142,186)(H2,143,191)(H,153,195)(H,154,203)(H,155,211)(H,156,212)(H,157,192)(H,158,198)(H,159,197)(H,160,207)(H,161,196)(H,162,204)(H,163,214)(H,164,193)(H,165,199)(H,166,200)(H,167,205)(H,168,213)(H,169,201)(H,170,215)(H,171,216)(H,172,202)(H,173,206)(H,174,208)(H,175,194)(H,176,210)(H,177,209)(H,187,188)(H,189,190)(H4,144,145,150)(H4,146,147,151)(H4,148,149,152)/t69-,70-,71-,72-,73-,74+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,105-,106-,107-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-GRF in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004965
PNG
(CHEMBL269263 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C134H217N37O39S/c1-19-69(13)105(169-110(188)72(16)149-118(196)93(58-102(182)183)156-109(187)71(15)148-111(189)79(136)54-75-33-37-77(176)38-34-75)131(209)163-91(55-74-28-22-21-23-29-74)124(202)171-107(73(17)175)132(210)164-92(57-100(139)180)123(201)167-97(63-174)128(206)160-90(56-76-35-39-78(177)40-36-76)122(200)153-82(32-27-48-146-134(143)144)113(191)152-81(30-24-25-46-135)117(195)168-104(68(11)12)129(207)162-86(50-64(3)4)112(190)147-60-101(181)150-83(41-43-98(137)178)114(192)157-89(53-67(9)10)121(199)166-96(62-173)127(205)159-88(52-66(7)8)120(198)158-87(51-65(5)6)119(197)154-84(42-44-99(138)179)115(193)161-94(59-103(184)185)125(203)170-106(70(14)20-2)130(208)155-85(45-49-211-18)116(194)165-95(61-172)126(204)151-80(108(140)186)31-26-47-145-133(141)142/h21-23,28-29,33-40,64-73,79-97,104-107,172-177H,19-20,24-27,30-32,41-63,135-136H2,1-18H3,(H2,137,178)(H2,138,179)(H2,139,180)(H2,140,186)(H,147,190)(H,148,189)(H,149,196)(H,150,181)(H,151,204)(H,152,191)(H,153,200)(H,154,197)(H,155,208)(H,156,187)(H,157,192)(H,158,198)(H,159,205)(H,160,206)(H,161,193)(H,162,207)(H,163,209)(H,164,210)(H,165,194)(H,166,199)(H,167,201)(H,168,195)(H,169,188)(H,170,203)(H,171,202)(H,182,183)(H,184,185)(H4,141,142,145)(H4,143,144,146)/t69-,70-,71-,72-,73+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,104-,105-,106-,107-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/a 1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-GRF in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004967
PNG
(CHEMBL437818 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)CCCCCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C145H239N41O40S/c1-16-77(9)115(184-121(205)81(13)163-129(213)103(69-113(198)199)173-120(204)79(11)162-122(206)88(148)65-84-43-47-86(191)48-44-84)141(225)179-101(66-83-34-23-22-24-35-83)135(219)186-117(82(14)190)142(226)180-102(68-111(151)196)134(218)183-107(73-189)139(223)177-100(67-85-45-49-87(192)50-46-85)133(217)170-93(40-33-60-161-145(157)158)123(207)166-89(36-27-29-56-146)108(193)41-25-20-18-19-21-26-42-112(197)165-94(51-53-109(149)194)126(210)175-99(64-76(7)8)132(216)182-105(71-187)137(221)164-80(12)119(203)168-92(39-32-59-160-144(155)156)124(208)169-91(37-28-30-57-147)125(209)174-98(63-75(5)6)131(215)176-97(62-74(3)4)130(214)171-95(52-54-110(150)195)127(211)178-104(70-114(200)201)136(220)185-116(78(10)17-2)140(224)172-96(55-61-227-15)128(212)181-106(72-188)138(222)167-90(118(152)202)38-31-58-159-143(153)154/h22-24,34-35,43-50,74-82,88-107,115-117,187-192H,16-21,25-33,36-42,51-73,146-148H2,1-15H3,(H2,149,194)(H2,150,195)(H2,151,196)(H2,152,202)(H,162,206)(H,163,213)(H,164,221)(H,165,197)(H,166,207)(H,167,222)(H,168,203)(H,169,208)(H,170,217)(H,171,214)(H,172,224)(H,173,204)(H,174,209)(H,175,210)(H,176,215)(H,177,223)(H,178,211)(H,179,225)(H,180,226)(H,181,212)(H,182,216)(H,183,218)(H,184,205)(H,185,220)(H,186,219)(H,198,199)(H,200,201)(H4,153,154,159)(H4,155,156,160)(H4,157,158,161)/t77-,78-,79-,80-,81-,82+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,115-,116-,117-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004975
PNG
(CHEMBL428163 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C143H234N42O41S/c1-20-73(13)111(183-117(203)77(17)161-126(212)99(62-108(196)197)170-116(202)75(15)160-118(204)84(145)58-80-36-40-82(190)41-37-80)139(225)177-97(59-79-30-23-22-24-31-79)132(218)185-113(78(18)189)140(226)178-98(61-106(148)194)131(217)181-103(67-188)136(222)174-96(60-81-38-42-83(191)43-39-81)130(216)167-88(35-29-52-158-143(154)155)120(206)166-86(32-25-26-49-144)125(211)182-110(72(11)12)137(223)176-92(54-68(3)4)119(205)159-64-107(195)163-89(44-46-104(146)192)122(208)172-95(57-71(9)10)129(215)180-101(65-186)134(220)162-76(16)115(201)165-87(34-28-51-157-142(152)153)121(207)171-94(56-70(7)8)128(214)173-93(55-69(5)6)127(213)168-90(45-47-105(147)193)123(209)175-100(63-109(198)199)133(219)184-112(74(14)21-2)138(224)169-91(48-53-227-19)124(210)179-102(66-187)135(221)164-85(114(149)200)33-27-50-156-141(150)151/h22-24,30-31,36-43,68-78,84-103,110-113,186-191H,20-21,25-29,32-35,44-67,144-145H2,1-19H3,(H2,146,192)(H2,147,193)(H2,148,194)(H2,149,200)(H,159,205)(H,160,204)(H,161,212)(H,162,220)(H,163,195)(H,164,221)(H,165,201)(H,166,206)(H,167,216)(H,168,213)(H,169,224)(H,170,202)(H,171,207)(H,172,208)(H,173,214)(H,174,222)(H,175,209)(H,176,223)(H,177,225)(H,178,226)(H,179,210)(H,180,215)(H,181,217)(H,182,211)(H,183,203)(H,184,219)(H,185,218)(H,196,197)(H,198,199)(H4,150,151,156)(H4,152,153,157)(H4,154,155,158)/t73-,74-,75-,76-,77-,78+,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,110-,111-,112-,113-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)

More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403628
PNG
(L-692585)
Show SMILES C[C@@H](O)CNC(C)(C)CC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C1=O
Show InChI InChI=1S/C32H37N7O3/c1-21(40)19-33-32(2,3)18-29(41)34-27-17-16-24-8-4-7-11-28(24)39(31(27)42)20-22-12-14-23(15-13-22)25-9-5-6-10-26(25)30-35-37-38-36-30/h4-15,21,27,33,40H,16-20H2,1-3H3,(H,34,41)(H,35,36,37,38)/t21-,27-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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Purchase

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UniChem

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Article
n/an/an/an/a 3n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403629
PNG
(CHEMBL553478)
Show SMILES CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(C[C@@H](CC(O)=O)c3ccccc23)CC1
Show InChI InChI=1S/C30H39N3O4/c1-29(2,31)28(37)32-25(14-8-11-21-9-4-3-5-10-21)27(36)33-17-15-30(16-18-33)20-22(19-26(34)35)23-12-6-7-13-24(23)30/h3-7,9-10,12-13,22,25H,8,11,14-20,31H2,1-2H3,(H,32,37)(H,34,35)/t22-,25-/m1/s1
Reactome pathway
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UniChem

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Article
n/an/an/an/a 1.90n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403630
PNG
(CHEMBL558802 | L-162752)
Show SMILES CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C28H34N4O2/c1-27(2,29)26(34)31-24(17-20-18-30-23-10-6-4-8-21(20)23)25(33)32-15-13-28(14-16-32)12-11-19-7-3-5-9-22(19)28/h3-10,18,24,30H,11-17,29H2,1-2H3,(H,31,34)/t24-/m1/s1
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n/an/an/an/a 14n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403631
PNG
(CHEMBL557206)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C27H35N3O3/c1-26(2,28)25(32)29-23(19-33-18-20-8-4-3-5-9-20)24(31)30-16-14-27(15-17-30)13-12-21-10-6-7-11-22(21)27/h3-11,23H,12-19,28H2,1-2H3,(H,29,32)/t23-/m1/s1
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n/an/an/an/a 17n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403632
PNG
(CHEMBL558422)
Show SMILES CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(C[C@@H](CC(O)=O)c3ccccc23)CC1
Show InChI InChI=1S/C30H36N4O4/c1-29(2,31)28(38)33-25(15-20-18-32-24-10-6-4-8-22(20)24)27(37)34-13-11-30(12-14-34)17-19(16-26(35)36)21-7-3-5-9-23(21)30/h3-10,18-19,25,32H,11-17,31H2,1-2H3,(H,33,38)(H,35,36)/t19-,25-/m1/s1
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n/an/an/an/a 5.80n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403633
PNG
(CHEMBL554852)
Show SMILES CCOC(=O)C[C@H]1CC2(CCN(CC2)C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c2ccccc12
Show InChI InChI=1S/C32H40N4O4/c1-4-40-28(37)18-21-19-32(25-11-7-5-9-23(21)25)13-15-36(16-14-32)29(38)27(35-30(39)31(2,3)33)17-22-20-34-26-12-8-6-10-24(22)26/h5-12,20-21,27,34H,4,13-19,33H2,1-3H3,(H,35,39)/t21-,27+/m0/s1
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n/an/an/an/a 28n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403634
PNG
(CHEMBL552657)
Show SMILES CCOC(=O)C[C@@H]1CC2(CCN(CC2)C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c2ccccc12
Show InChI InChI=1S/C32H40N4O4/c1-4-40-28(37)18-21-19-32(25-11-7-5-9-23(21)25)13-15-36(16-14-32)29(38)27(35-30(39)31(2,3)33)17-22-20-34-26-12-8-6-10-24(22)26/h5-12,20-21,27,34H,4,13-19,33H2,1-3H3,(H,35,39)/t21-,27-/m1/s1
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n/an/an/an/a 7n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403635
PNG
(CHEMBL553507)
Show SMILES CCOC(=O)[C@H]1CC2(CCN(CC2)C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c2ccccc12
Show InChI InChI=1S/C31H38N4O4/c1-4-39-28(37)23-18-31(24-11-7-5-10-22(23)24)13-15-35(16-14-31)27(36)26(34-29(38)30(2,3)32)17-20-19-33-25-12-8-6-9-21(20)25/h5-12,19,23,26,33H,4,13-18,32H2,1-3H3,(H,34,38)/t23-,26+/m0/s1
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n/an/an/an/a 6n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403636
PNG
(CHEMBL545003)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(C[C@H](C(O)=O)c3ccccc23)CC1
Show InChI InChI=1S/C28H35N3O5/c1-27(2,29)26(35)30-23(18-36-17-19-8-4-3-5-9-19)24(32)31-14-12-28(13-15-31)16-21(25(33)34)20-10-6-7-11-22(20)28/h3-11,21,23H,12-18,29H2,1-2H3,(H,30,35)(H,33,34)/t21-,23+/m0/s1
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n/an/an/an/a 4.40n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50049481
PNG
((R)-N-(1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)meth...)
Show SMILES CC(C)(N)CC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C1=O
Show InChI InChI=1S/C29H31N7O2/c1-29(2,30)17-26(37)31-24-16-15-21-7-3-6-10-25(21)36(28(24)38)18-19-11-13-20(14-12-19)22-8-4-5-9-23(22)27-32-34-35-33-27/h3-14,24H,15-18,30H2,1-2H3,(H,31,37)(H,32,33,34,35)/t24-/m1/s1
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n/an/an/an/a 60n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403637
PNG
(CHEMBL555821)
Show SMILES CCOC(=O)[C@@H]1CC2(CCN(CC2)C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c2ccccc12
Show InChI InChI=1S/C31H38N4O4/c1-4-39-28(37)23-18-31(24-11-7-5-10-22(23)24)13-15-35(16-14-31)27(36)26(34-29(38)30(2,3)32)17-20-19-33-25-12-8-6-9-21(20)25/h5-12,19,23,26,33H,4,13-18,32H2,1-3H3,(H,34,38)/t23-,26-/m1/s1
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n/an/an/an/a 8.30n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403627
PNG
(CHEMBL545465)
Show SMILES CCOC(=O)[C@H]1CC2(CCN(CC2)C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)c2ccccc12
Show InChI InChI=1S/C31H41N3O4/c1-4-38-28(36)24-21-31(25-15-9-8-14-23(24)25)17-19-34(20-18-31)27(35)26(33-29(37)30(2,3)32)16-10-13-22-11-6-5-7-12-22/h5-9,11-12,14-15,24,26H,4,10,13,16-21,32H2,1-3H3,(H,33,37)/t24-,26+/m0/s1
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n/an/an/an/a 1n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403626
PNG
(CHEMBL544536)
Show SMILES CCOC(=O)[C@H]1CC2(CCN(CC2)C(=O)[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)c2ccccc12
Show InChI InChI=1S/C30H39N3O5/c1-4-38-27(35)23-18-30(24-13-9-8-12-22(23)24)14-16-33(17-15-30)26(34)25(32-28(36)29(2,3)31)20-37-19-21-10-6-5-7-11-21/h5-13,23,25H,4,14-20,31H2,1-3H3,(H,32,36)/t23-,25+/m0/s1
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n/an/an/an/a 2.90n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403625
PNG
(CHEMBL545002)
Show SMILES CCOC(=O)C[C@@H]1CC2(CCN(CC2)C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)c2ccccc12
Show InChI InChI=1S/C32H43N3O4/c1-4-39-28(36)21-24-22-32(26-15-9-8-14-25(24)26)17-19-35(20-18-32)29(37)27(34-30(38)31(2,3)33)16-10-13-23-11-6-5-7-12-23/h5-9,11-12,14-15,24,27H,4,10,13,16-22,33H2,1-3H3,(H,34,38)/t24-,27-/m1/s1
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n/an/an/an/a 0.800n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50403624
PNG
(CHEMBL542653)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CN(c3ccccc23)S(C)(=O)=O)CC1
Show InChI InChI=1S/C27H36N4O5S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27/h4-12,22H,13-19,28H2,1-3H3,(H,29,33)/t22-/m1/s1
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n/an/an/an/a 1.5n/an/an/an/a


TBA

Assay Description
Ability to release growth hormone in a rat pituitary cell assay


Citation and Details
More data for this
Ligand-Target Pair
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