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Found 850 hits Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280795
PNG
((S)-3-(2-{4-amino-2-[6- fluoro-1-(2-fluorobenzyl)-...)
Show SMILES CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(F)ccc12)C(O)=O
Show InChI InChI=1S/C29H25F2N7O3S/c1-28(2,27(40)41)11-16-13-42-26(33-16)29(3)20-22(32)34-24(35-23(20)36-25(29)39)21-17-9-8-15(30)10-19(17)38(37-21)12-14-6-4-5-7-18(14)31/h4-10,13H,11-12H2,1-3H3,(H,40,41)(H3,32,34,35,36,39)/t29-/m0/s1
PDB

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0.0220n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280822
PNG
((S)-2-(3-(4-{4-amino-2- [1-(2-fluorobenzyl)-1H- py...)
Show SMILES CC(C)(NC(=O)CCc1ccc(cc1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)C(O)=O
Show InChI InChI=1S/C33H31FN8O4/c1-32(2,31(45)46)40-23(43)15-12-18-10-13-20(14-11-18)33(3)24-26(35)37-28(38-27(24)39-30(33)44)25-21-8-6-16-36-29(21)42(41-25)17-19-7-4-5-9-22(19)34/h4-11,13-14,16H,12,15,17H2,1-3H3,(H,40,43)(H,45,46)(H3,35,37,38,39,44)/t33-/m0/s1
PDB

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US Patent
0.0260n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280911
PNG
(3-(2-{4-amino-2- [6-chloro-1-(2- fluoro-3-methyl- ...)
Show SMILES Cc1cccc(Cn2nc(-c3nc4NC(=O)C(C)(c5nc(CC(C)(C)C(O)=O)co5)c4c(N)n3)c3ccc(Cl)cc23)c1F
Show InChI InChI=1S/C30H27ClFN7O4/c1-14-6-5-7-15(21(14)32)12-39-19-10-16(31)8-9-18(19)22(38-39)25-35-23(33)20-24(36-25)37-26(40)30(20,4)27-34-17(13-43-27)11-29(2,3)28(41)42/h5-10,13H,11-12H2,1-4H3,(H,41,42)(H3,33,35,36,37,40)
PDB

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0.0290n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280876
PNG
(3-(2-{4-amino- 2-[1-(cyclohexyl- methyl)-1H- pyraz...)
Show SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(CC2CCCCC2)c2ncccc12)C(O)=O
Show InChI InChI=1S/C28H32N8O4/c1-27(2,26(38)39)12-16-14-40-25(31-16)28(3)18-20(29)32-22(33-21(18)34-24(28)37)19-17-10-7-11-30-23(17)36(35-19)13-15-8-5-4-6-9-15/h7,10-11,14-15H,4-6,8-9,12-13H2,1-3H3,(H,38,39)(H3,29,32,33,34,37)
PDB

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US Patent
0.0310n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280904
PNG
(3-(2-{4-amino-2- [6-chloro-1-(2,3- difluorobenzyl)...)
Show SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2cccc(F)c2F)c2cc(Cl)ccc12)C(O)=O
Show InChI InChI=1S/C29H24ClF2N7O4/c1-28(2,27(41)42)10-15-12-43-26(34-15)29(3)19-22(33)35-24(36-23(19)37-25(29)40)21-16-8-7-14(30)9-18(16)39(38-21)11-13-5-4-6-17(31)20(13)32/h4-9,12H,10-11H2,1-3H3,(H,41,42)(H3,33,35,36,37,40)
PDB

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0.0310n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280914
PNG
((S)-3-(2-{4-amino- 2-[6-chloro-1- (2,3,6-trifluoro...)
Show SMILES CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2c(F)ccc(F)c2F)c2cc(Cl)ccc12)C(O)=O
Show InChI InChI=1S/C29H23ClF3N7O3S/c1-28(2,27(42)43)9-13-11-44-26(35-13)29(3)19-22(34)36-24(37-23(19)38-25(29)41)21-14-5-4-12(30)8-18(14)40(39-21)10-15-16(31)6-7-17(32)20(15)33/h4-8,11H,9-10H2,1-3H3,(H,42,43)(H3,34,36,37,38,41)/t29-/m0/s1
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0.0310n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280821
PNG
((S)-(3-(4-{4-Amino-2-[1-(2-fluorobenzyl)-1H-pyrazo...)
Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1ccc(CCC(=O)NCC(O)=O)cc1
Show InChI InChI=1S/C31H27FN8O4/c1-31(19-11-8-17(9-12-19)10-13-22(41)35-15-23(42)43)24-26(33)36-28(37-27(24)38-30(31)44)25-20-6-4-14-34-29(20)40(39-25)16-18-5-2-3-7-21(18)32/h2-9,11-12,14H,10,13,15-16H2,1H3,(H,35,41)(H,42,43)(H3,33,36,37,38,44)/t31-/m0/s1
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0.0390n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280918
PNG
((S)-3-(2-{4-amino- 2-[6-fluoro-1-(3- fluorobenzyl)...)
Show SMILES CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2cccc(F)c2)c2cc(F)ccc12)C(O)=O
Show InChI InChI=1S/C29H25F2N7O3S/c1-28(2,27(40)41)11-17-13-42-26(33-17)29(3)20-22(32)34-24(35-23(20)36-25(29)39)21-18-8-7-16(31)10-19(18)38(37-21)12-14-5-4-6-15(30)9-14/h4-10,13H,11-12H2,1-3H3,(H,40,41)(H3,32,34,35,36,39)/t29-/m0/s1
PDB

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PC sid
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US Patent
0.0410n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280824
PNG
((5S,2S)-2-(3-(4-{4- amino-2-[1-(2- fluorobenzyl)-1...)
Show SMILES CC[C@H](NC(=O)CCc1ccc(cc1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)C(O)=O
Show InChI InChI=1S/C33H31FN8O4/c1-3-23(31(44)45)37-24(43)15-12-18-10-13-20(14-11-18)33(2)25-27(35)38-29(39-28(25)40-32(33)46)26-21-8-6-16-36-30(21)42(41-26)17-19-7-4-5-9-22(19)34/h4-11,13-14,16,23H,3,12,15,17H2,1-2H3,(H,37,43)(H,44,45)(H3,35,38,39,40,46)/t23-,33-/m0/s1
PDB

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US Patent
0.0420n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280823
PNG
((5S)-(3-(4-{4-amino-2-[1- (2-fluorobenzyl)-1H- pyr...)
Show SMILES C[C@H](NC(=O)CCc1ccc(cc1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)C(O)=O
Show InChI InChI=1S/C32H29FN8O4/c1-17(30(43)44)36-23(42)14-11-18-9-12-20(13-10-18)32(2)24-26(34)37-28(38-27(24)39-31(32)45)25-21-7-5-15-35-29(21)41(40-25)16-19-6-3-4-8-22(19)33/h3-10,12-13,15,17H,11,14,16H2,1-2H3,(H,36,42)(H,43,44)(H3,34,37,38,39,45)/t17-,32-/m0/s1
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0.0450n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280740
PNG
(3-(2-{4-Amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,...)
Show SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)C(O)=O
Show InChI InChI=1S/C28H25FN8O4/c1-27(2,26(39)40)11-15-13-41-25(32-15)28(3)18-20(30)33-22(34-21(18)35-24(28)38)19-16-8-6-10-31-23(16)37(36-19)12-14-7-4-5-9-17(14)29/h4-10,13H,11-12H2,1-3H3,(H,39,40)(H3,30,33,34,35,38)
PDB

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0.0470n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280973
PNG
(4-Amino-2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-5-m...)
Show SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ccccc12)c1nn[nH]n1
Show InChI InChI=1S/C29H26FN11O2/c1-28(2,25-36-39-40-37-25)12-16-14-43-27(32-16)29(3)20-22(31)33-24(34-23(20)35-26(29)42)21-17-9-5-7-11-19(17)41(38-21)13-15-8-4-6-10-18(15)30/h4-11,14H,12-13H2,1-3H3,(H,36,37,39,40)(H3,31,33,34,35,42)
PDB

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0.0480n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280913
PNG
(3-(2-{4-amino-2- [6-chloro-1-(2,3,6- trifluorobenz...)
Show SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2c(F)ccc(F)c2F)c2cc(Cl)ccc12)C(O)=O
Show InChI InChI=1S/C29H23ClF3N7O4/c1-28(2,27(42)43)9-13-11-44-26(35-13)29(3)19-22(34)36-24(37-23(19)38-25(29)41)21-14-5-4-12(30)8-18(14)40(39-21)10-15-16(31)6-7-17(32)20(15)33/h4-8,11H,9-10H2,1-3H3,(H,42,43)(H3,34,36,37,38,41)
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0.0490n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280945
PNG
(3-(2-{4-amino-2- [1-(3-fluoro- benzyl)-1H- indazol...)
Show SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2cccc(F)c2)c2ccccc12)C(O)=O
Show InChI InChI=1S/C29H26FN7O4/c1-28(2,27(39)40)12-17-14-41-26(32-17)29(3)20-22(31)33-24(34-23(20)35-25(29)38)21-18-9-4-5-10-19(18)37(36-21)13-15-7-6-8-16(30)11-15/h4-11,14H,12-13H2,1-3H3,(H,39,40)(H3,31,33,34,35,38)
PDB

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0.0500n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280924
PNG
(3-(2-{4-amino-2- [1-(2,3-difluoro- benzyl)-6-fluor...)
Show SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2cccc(F)c2F)c2cc(F)ccc12)C(O)=O
Show InChI InChI=1S/C29H24F3N7O4/c1-28(2,27(41)42)10-15-12-43-26(34-15)29(3)19-22(33)35-24(36-23(19)37-25(29)40)21-16-8-7-14(30)9-18(16)39(38-21)11-13-5-4-6-17(31)20(13)32/h4-9,12H,10-11H2,1-3H3,(H,41,42)(H3,33,35,36,37,40)
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0.0520n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280917
PNG
(4-(2-{4-amino-2- [6-fluoro-1-(2- fluorobenzyl)-1H-...)
Show SMILES CC(C)(CCc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(F)ccc12)C(O)=O
Show InChI InChI=1S/C30H27F2N7O4/c1-29(2,28(41)42)11-10-17-14-43-27(34-17)30(3)21-23(33)35-25(36-24(21)37-26(30)40)22-18-9-8-16(31)12-20(18)39(38-22)13-15-6-4-5-7-19(15)32/h4-9,12,14H,10-11,13H2,1-3H3,(H,41,42)(H3,33,35,36,37,40)
PDB

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0.0520n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280826
PNG
((S)—N-((2H-Tetrazol-5-yl)methyl)-3-(4-{4-amin...)
Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1ccc(CCC(=O)NCc2nn[nH]n2)cc1
Show InChI InChI=1S/C31H27FN12O2/c1-31(19-11-8-17(9-12-19)10-13-23(45)35-15-22-39-42-43-40-22)24-26(33)36-28(37-27(24)38-30(31)46)25-20-6-4-14-34-29(20)44(41-25)16-18-5-2-3-7-21(18)32/h2-9,11-12,14H,10,13,15-16H2,1H3,(H,35,45)(H,39,40,42,43)(H3,33,36,37,38,46)/t31-/m0/s1
PDB

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0.0560n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280846
PNG
(4-(2-{4-amino-2-[6- chloro-1-(2-fluorobenzyl)- 1H-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1nc(CCC(F)(F)C(O)=O)co1
Show InChI InChI=1S/C28H21ClF3N7O4/c1-27(25-34-15(12-43-25)8-9-28(31,32)26(41)42)19-21(33)35-23(36-22(19)37-24(27)40)20-16-7-6-14(29)10-18(16)39(38-20)11-13-4-2-3-5-17(13)30/h2-7,10,12H,8-9,11H2,1H3,(H,41,42)(H3,33,35,36,37,40)
PDB

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0.0570n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280940
PNG
((2E)-3-(4-{4- amino-2-[6- chloro-1-(2- fluorobenzy...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1ccc(\C=C\C(O)=O)cc1
Show InChI InChI=1S/C30H22ClFN6O3/c1-30(18-9-6-16(7-10-18)8-13-23(39)40)24-26(33)34-28(35-27(24)36-29(30)41)25-20-12-11-19(31)14-22(20)38(37-25)15-17-4-2-3-5-21(17)32/h2-14H,15H2,1H3,(H,39,40)(H3,33,34,35,36,41)/b13-8+
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0.0570n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280862
PNG
(3-(2-{4-amino-2-[6- chloro-1-(2-fluorobenzyl)- 1H-...)
Show SMILES CC(C)(Cc1coc(n1)C1(C2CC2)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)C(O)=O
Show InChI InChI=1S/C31H27ClFN7O4/c1-30(2,29(42)43)12-18-14-44-28(35-18)31(16-7-8-16)22-24(34)36-26(37-25(22)38-27(31)41)23-19-10-9-17(32)11-21(19)40(39-23)13-15-5-3-4-6-20(15)33/h3-6,9-11,14,16H,7-8,12-13H2,1-2H3,(H,42,43)(H3,34,36,37,38,41)
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0.0580n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280825
PNG
((5S)-(3-(4-{4-amino-2-[1- (2-fluorobenzyl)-1H- pyr...)
Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1ccc(CCC(=O)N[C@H](CO)C(O)=O)cc1
Show InChI InChI=1S/C32H29FN8O5/c1-32(19-11-8-17(9-12-19)10-13-23(43)36-22(16-42)30(44)45)24-26(34)37-28(38-27(24)39-31(32)46)25-20-6-4-14-35-29(20)41(40-25)15-18-5-2-3-7-21(18)33/h2-9,11-12,14,22,42H,10,13,15-16H2,1H3,(H,36,43)(H,44,45)(H3,34,37,38,39,46)/t22-,32+/m1/s1
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0.0580n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280985
PNG
((4-{4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-inda...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C29H22ClFN6O4/c1-29(16-6-9-18(10-7-16)41-14-22(38)39)23-25(32)33-27(34-26(23)35-28(29)40)24-19-11-8-17(30)12-21(19)37(36-24)13-15-4-2-3-5-20(15)31/h2-12H,13-14H2,1H3,(H,38,39)(H3,32,33,34,35,40)
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0.0580n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280817
PNG
((S)-3-(2-{4-amino-2-[6- chloro-1-(2- fluorobenzyl)...)
Show SMILES CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)C(O)=O
Show InChI InChI=1S/C29H25ClFN7O3S/c1-28(2,27(40)41)11-16-13-42-26(33-16)29(3)20-22(32)34-24(35-23(20)36-25(29)39)21-17-9-8-15(30)10-19(17)38(37-21)12-14-6-4-5-7-18(14)31/h4-10,13H,11-12H2,1-3H3,(H,40,41)(H3,32,34,35,36,39)/t29-/m0/s1
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0.0600n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280884
PNG
((S)-3-(4-{4-amino- 2-[6-chloro-1- (cyclopentylmeth...)
Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(CC2CCCC2)c2cc(Cl)ccc12)c1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C29H29ClN6O3/c1-29(18-9-6-16(7-10-18)8-13-22(37)38)23-25(31)32-27(33-26(23)34-28(29)39)24-20-12-11-19(30)14-21(20)36(35-24)15-17-4-2-3-5-17/h6-7,9-12,14,17H,2-5,8,13,15H2,1H3,(H,37,38)(H3,31,32,33,34,39)/t29-/m0/s1
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0.0620n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280870
PNG
(4-(2-{4-amino-2- [1-(2-fluorobenzyl)- 1H-pyrazolo[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1nc(co1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C30H21FN8O4/c1-30(29-34-20(14-43-29)15-8-10-16(11-9-15)27(40)41)21-23(32)35-25(36-24(21)37-28(30)42)22-18-6-4-12-33-26(18)39(38-22)13-17-5-2-3-7-19(17)31/h2-12,14H,13H2,1H3,(H,40,41)(H3,32,35,36,37,42)
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0.0620n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280968
PNG
(5-[4-(2H-tetrazol- 5-yl)pyridin-2- yl]-4-amino-2- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1cc(ccn1)-c1nn[nH]n1
Show InChI InChI=1S/C27H19ClFN11O/c1-27(19-10-13(8-9-31-19)23-35-38-39-36-23)20-22(30)32-25(33-24(20)34-26(27)41)21-16-7-6-15(28)11-18(16)40(37-21)12-14-4-2-3-5-17(14)29/h2-11H,12H2,1H3,(H,35,36,38,39)(H3,30,32,33,34,41)
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0.0620n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280813
PNG
((S)-3-(2-{4-amino-2-[1- (2-fluorobenzyl)-1H- pyraz...)
Show SMILES CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)C(O)=O
Show InChI InChI=1S/C28H25FN8O3S/c1-27(2,26(39)40)11-15-13-41-25(32-15)28(3)18-20(30)33-22(34-21(18)35-24(28)38)19-16-8-6-10-31-23(16)37(36-19)12-14-7-4-5-9-17(14)29/h4-10,13H,11-12H2,1-3H3,(H,39,40)(H3,30,33,34,35,38)/t28-/m0/s1
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0.0630n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280969
PNG
(5-{4-[(2H-tetrazol- 5-yl)methyl] phenyl}-4-amino- ...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1ccc(Cc2nn[nH]n2)cc1
Show InChI InChI=1S/C29H22ClFN10O/c1-29(17-8-6-15(7-9-17)12-22-36-39-40-37-22)23-25(32)33-27(34-26(23)35-28(29)42)24-19-11-10-18(30)13-21(19)41(38-24)14-16-4-2-3-5-20(16)31/h2-11,13H,12,14H2,1H3,(H,36,37,39,40)(H3,32,33,34,35,42)
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0.0630n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280760
PNG
((S)-3-(4-{4-amino-2-[1-(2- fluorobenzyl)-1H- pyraz...)
Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C29H24FN7O3/c1-29(18-11-8-16(9-12-18)10-13-21(38)39)22-24(31)33-26(34-25(22)35-28(29)40)23-19-6-4-14-32-27(19)37(36-23)15-17-5-2-3-7-20(17)30/h2-9,11-12,14H,10,13,15H2,1H3,(H,38,39)(H3,31,33,34,35,40)/t29-/m0/s1
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0.0640n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280830
PNG
((S)-4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-inda...)
Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1ccc(CCc2nn[nH]n2)cc1
Show InChI InChI=1S/C30H24ClFN10O/c1-30(18-9-6-16(7-10-18)8-13-23-37-40-41-38-23)24-26(33)34-28(35-27(24)36-29(30)43)25-20-12-11-19(31)14-22(20)42(39-25)15-17-4-2-3-5-21(17)32/h2-7,9-12,14H,8,13,15H2,1H3,(H,37,38,40,41)(H3,33,34,35,36,43)/t30-/m0/s1
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0.0660n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280794
PNG
(3-(3-{4-amino-2-[6-fluoro-1- (2-fluorobenzyl)-1H-i...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(F)ccc12)c1cccc(CCC(O)=O)c1
Show InChI InChI=1S/C30H24F2N6O3/c1-30(18-7-4-5-16(13-18)9-12-23(39)40)24-26(33)34-28(35-27(24)36-29(30)41)25-20-11-10-19(31)14-22(20)38(37-25)15-17-6-2-3-8-21(17)32/h2-8,10-11,13-14H,9,12,15H2,1H3,(H,39,40)(H3,33,34,35,36,41)
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0.0660n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280946
PNG
((S)-3-(2-{4-amino- 5-methyl-6- oxo-2-[1-(2,3,6- tr...)
Show SMILES CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2c(F)ccc(F)c2F)c2ccccc12)C(O)=O
Show InChI InChI=1S/C29H24F3N7O3S/c1-28(2,27(41)42)10-13-12-43-26(34-13)29(3)19-22(33)35-24(36-23(19)37-25(29)40)21-14-6-4-5-7-18(14)39(38-21)11-15-16(30)8-9-17(31)20(15)32/h4-9,12H,10-11H2,1-3H3,(H,41,42)(H3,33,35,36,37,40)/t29-/m0/s1
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0.0670n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280939
PNG
((2E)-3-(4-{4- amino-2-[1-(2- fluorobenzyl)-1H- pyr...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1ccc(\C=C\C(O)=O)cc1
Show InChI InChI=1S/C29H22FN7O3/c1-29(18-11-8-16(9-12-18)10-13-21(38)39)22-24(31)33-26(34-25(22)35-28(29)40)23-19-6-4-14-32-27(19)37(36-23)15-17-5-2-3-7-20(17)30/h2-14H,15H2,1H3,(H,38,39)(H3,31,33,34,35,40)/b13-10+
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0.0670n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280742
PNG
(3-(2-{4-amino- 2-[6-chloro-1- (2-fluorobenzyl)- 1H...)
Show SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)C(O)=O
Show InChI InChI=1S/C29H25ClFN7O4/c1-28(2,27(40)41)11-16-13-42-26(33-16)29(3)20-22(32)34-24(35-23(20)36-25(29)39)21-17-9-8-15(30)10-19(17)38(37-21)12-14-6-4-5-7-18(14)31/h4-10,13H,11-12H2,1-3H3,(H,40,41)(H3,32,34,35,36,39)
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0.0670n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280964
PNG
(4-amino-2-[6- chloro-1-(2- fluorobenzyl)-1H- indaz...)
Show SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1nn[nH]n1
Show InChI InChI=1S/C29H25ClFN11O2/c1-28(2,25-37-40-41-38-25)11-16-13-44-27(33-16)29(3)20-22(32)34-24(35-23(20)36-26(29)43)21-17-9-8-15(30)10-19(17)42(39-21)12-14-6-4-5-7-18(14)31/h4-10,13H,11-12H2,1-3H3,(H,37,38,40,41)(H3,32,34,35,36,43)
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0.0680n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280974
PNG
(4-Amino-2-[6-fluoro-1-(2-fluorobenzyl)-1H-indazol-...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(F)ccc12)c1cccc(c1)-c1nn[nH]n1
Show InChI InChI=1S/C28H20F2N10O/c1-28(16-7-4-6-14(11-16)24-35-38-39-36-24)21-23(31)32-26(33-25(21)34-27(28)41)22-18-10-9-17(29)12-20(18)40(37-22)13-15-5-2-3-8-19(15)30/h2-12H,13H2,1H3,(H,35,36,38,39)(H3,31,32,33,34,41)
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0.0680n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280891
PNG
(4-(2-{4-amino-2- [6-chloro-1-(2- fluorobenzyl)-1H-...)
Show SMILES CC(C)(CCc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)C(O)=O
Show InChI InChI=1S/C30H27ClFN7O4/c1-29(2,28(41)42)11-10-17-14-43-27(34-17)30(3)21-23(33)35-25(36-24(21)37-26(30)40)22-18-9-8-16(31)12-20(18)39(38-22)13-15-6-4-5-7-19(15)32/h4-9,12,14H,10-11,13H2,1-3H3,(H,41,42)(H3,33,35,36,37,40)
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0.0700n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280923
PNG
((S)-3-(2-{4-amino- 2-[1-(2,3- difluorobenzyl)-6- f...)
Show SMILES CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2cccc(F)c2F)c2cc(F)ccc12)C(O)=O
Show InChI InChI=1S/C29H24F3N7O3S/c1-28(2,27(41)42)10-15-12-43-26(34-15)29(3)19-22(33)35-24(36-23(19)37-25(29)40)21-16-8-7-14(30)9-18(16)39(38-21)11-13-5-4-6-17(31)20(13)32/h4-9,12H,10-11H2,1-3H3,(H,41,42)(H3,33,35,36,37,40)/t29-/m0/s1
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0.0700n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280934
PNG
(3-(2-{4-amino-2- [6-fluoro-1-(2- fluoro-3-methyl- ...)
Show SMILES Cc1cccc(Cn2nc(-c3nc4NC(=O)C(C)(c5nc(CC(C)(C)C(O)=O)co5)c4c(N)n3)c3ccc(F)cc23)c1F
Show InChI InChI=1S/C30H27F2N7O4/c1-14-6-5-7-15(21(14)32)12-39-19-10-16(31)8-9-18(19)22(38-39)25-35-23(33)20-24(36-25)37-26(40)30(20,4)27-34-17(13-43-27)11-29(2,3)28(41)42/h5-10,13H,11-12H2,1-4H3,(H,41,42)(H3,33,35,36,37,40)
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0.0720n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280980
PNG
(6-{4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-indaz...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1cccc(n1)C(O)=O
Show InChI InChI=1S/C27H19ClFN7O3/c1-27(19-8-4-7-17(31-19)25(37)38)20-22(30)32-24(33-23(20)34-26(27)39)21-15-10-9-14(28)11-18(15)36(35-21)12-13-5-2-3-6-16(13)29/h2-11H,12H2,1H3,(H,37,38)(H3,30,32,33,34,39)
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0.0730n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280981
PNG
((S)-4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-inda...)
Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1ccc(CCc2noc(=O)[nH]2)cc1
Show InChI InChI=1S/C31H24ClFN8O3/c1-31(18-9-6-16(7-10-18)8-13-23-35-30(43)44-40-23)24-26(34)36-28(37-27(24)38-29(31)42)25-20-12-11-19(32)14-22(20)41(39-25)15-17-4-2-3-5-21(17)33/h2-7,9-12,14H,8,13,15H2,1H3,(H,35,40,43)(H3,34,36,37,38,42)/t31-/m0/s1
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0.0740n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280986
PNG
(3-[1-{4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-in...)
Show SMILES CC1(N2CCC(CCC(O)=O)C2)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12
Show InChI InChI=1S/C28H27ClFN7O3/c1-28(36-11-10-15(13-36)6-9-21(38)39)22-24(31)32-26(33-25(22)34-27(28)40)23-18-8-7-17(29)12-20(18)37(35-23)14-16-4-2-3-5-19(16)30/h2-5,7-8,12,15H,6,9-11,13-14H2,1H3,(H,38,39)(H3,31,32,33,34,40)
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0.0740n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280851
PNG
(3-{2-[4-amino-2-{6- chloro-1-[4- methylcyclohexylm...)
Show SMILES CC1CCC(Cn2nc(-c3nc4NC(=O)C(C)(c5nc(CC(C)(C)C(O)=O)co5)c4c(N)n3)c3ccc(Cl)cc23)CC1
Show InChI InChI=1S/C30H34ClN7O4/c1-15-5-7-16(8-6-15)13-38-20-11-17(31)9-10-19(20)22(37-38)25-34-23(32)21-24(35-25)36-26(39)30(21,4)27-33-18(14-42-27)12-29(2,3)28(40)41/h9-11,14-16H,5-8,12-13H2,1-4H3,(H,40,41)(H3,32,34,35,36,39)
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0.0740n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280871
PNG
(4-(2-{4-amino-2- [1-(2-fluorobenzyl)- 1H-pyrazolo[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1nc(cs1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C30H21FN8O3S/c1-30(29-34-20(14-43-29)15-8-10-16(11-9-15)27(40)41)21-23(32)35-25(36-24(21)37-28(30)42)22-18-6-4-12-33-26(18)39(38-22)13-17-5-2-3-7-19(17)31/h2-12,14H,13H2,1H3,(H,40,41)(H3,32,35,36,37,42)
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0.0750n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280796
PNG
((S)-3-(4-{4-amino-2-[6- chloro-1-(2,6- difluoroben...)
Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2c(F)cccc2F)c2cc(Cl)ccc12)c1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C30H23ClF2N6O3/c1-30(16-8-5-15(6-9-16)7-12-23(40)41)24-26(34)35-28(36-27(24)37-29(30)42)25-18-11-10-17(31)13-22(18)39(38-25)14-19-20(32)3-2-4-21(19)33/h2-6,8-11,13H,7,12,14H2,1H3,(H,40,41)(H3,34,35,36,37,42)/t30-/m0/s1
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0.0750n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280965
PNG
((S)-4-amino-2- [1-(2-fluoro- benzyl)-1H- pyrazolo[...)
Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1ccc(CCc2nn[nH]n2)cc1
Show InChI InChI=1S/C29H24FN11O/c1-29(18-11-8-16(9-12-18)10-13-21-36-39-40-37-21)22-24(31)33-26(34-25(22)35-28(29)42)23-19-6-4-14-32-27(19)41(38-23)15-17-5-2-3-7-20(17)30/h2-9,11-12,14H,10,13,15H2,1H3,(H,36,37,39,40)(H3,31,33,34,35,42)/t29-/m0/s1
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0.0750n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280907
PNG
((S)-3-(2-{4-amino- 2-[6-chloro-1-(2,6- difluoroben...)
Show SMILES CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2c(F)cccc2F)c2cc(Cl)ccc12)C(O)=O
Show InChI InChI=1S/C29H24ClF2N7O3S/c1-28(2,27(41)42)10-14-12-43-26(34-14)29(3)20-22(33)35-24(36-23(20)37-25(29)40)21-15-8-7-13(30)9-19(15)39(38-21)11-16-17(31)5-4-6-18(16)32/h4-9,12H,10-11H2,1-3H3,(H,41,42)(H3,33,35,36,37,40)/t29-/m0/s1
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0.0760n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280844
PNG
(3-{2-[4-amino-5-methyl- 2-{1-[4- methylcyclohexylm...)
Show SMILES CC1CCC(Cn2nc(-c3nc4NC(=O)C(C)(c5nc(CC(C)(C)C(O)=O)co5)c4c(N)n3)c3cccnc23)CC1
Show InChI InChI=1S/C29H34N8O4/c1-15-7-9-16(10-8-15)13-37-24-18(6-5-11-31-24)20(36-37)23-33-21(30)19-22(34-23)35-25(38)29(19,4)26-32-17(14-41-26)12-28(2,3)27(39)40/h5-6,11,14-16H,7-10,12-13H2,1-4H3,(H,39,40)(H3,30,33,34,35,38)
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0.0770n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280761
PNG
(3-(3-{4-amino-2-[1-(2- fluorobenzyl)-1H- pyrazolo[...)
Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1cccc(CCC(O)=O)c1
Show InChI InChI=1S/C29H24FN7O3/c1-29(18-8-4-6-16(14-18)11-12-21(38)39)22-24(31)33-26(34-25(22)35-28(29)40)23-19-9-5-13-32-27(19)37(36-23)15-17-7-2-3-10-20(17)30/h2-10,13-14H,11-12,15H2,1H3,(H,38,39)(H3,31,33,34,35,40)
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0.0780n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM280950
PNG
(3-(2-{4-amino-2- [1-(cyclohexyl- methyl)-1H- indaz...)
Show SMILES CC(C)(Cc1coc(n1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(CC2CCCCC2)c2ccccc12)C(O)=O
Show InChI InChI=1S/C29H33N7O4/c1-28(2,27(38)39)13-17-15-40-26(31-17)29(3)20-22(30)32-24(33-23(20)34-25(29)37)21-18-11-7-8-12-19(18)36(35-21)14-16-9-5-4-6-10-16/h7-8,11-12,15-16H,4-6,9-10,13-14H2,1-3H3,(H,38,39)(H3,30,32,33,34,37)
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0.0790n/an/an/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...


US Patent US10030027 (2018)

More data for this
Ligand-Target Pair
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