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Found 5 hits Enz. Inhib. hit(s) with Target = 'HIV-2 Reverse Transcriptase' AND taxid = 11709   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM33045
PNG
(2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophe...)
Show SMILES NC(=O)c1c(N)sc2CCCCCc12
Show InChI InChI=1S/C10H14N2OS/c11-9(13)8-6-4-2-1-3-5-7(6)14-10(8)12/h1-5,12H2,(H2,11,13)
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UniChem

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Article
PubMed
n/an/a 2.50E+3n/an/an/an/a8.020



National Cancer Institute



Assay Description
RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...


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More data for this
Ligand-Target Pair
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM33963
PNG
(vinylogous urea, NSC727448)
Show SMILES Cc1sc(NC(=O)c2ccco2)c(C(N)=O)c1C
Show InChI InChI=1S/C12H12N2O3S/c1-6-7(2)18-12(9(6)10(13)15)14-11(16)8-4-3-5-17-8/h3-5H,1-2H3,(H2,13,15)(H,14,16)
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Article
PubMed
n/an/a 5.00E+3n/an/an/an/a8.020



National Cancer Institute



Assay Description
RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...


Citation and Details
More data for this
Ligand-Target Pair
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM2339
PNG
(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Show SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C13H13ClN2O4S/c1-2-20-13(17)11-4-3-7-16(11)21(18,19)12-8-9(14)5-6-10(12)15/h3-8H,2,15H2,1H3
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UniChem

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Article
PubMed
n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


Citation and Details
More data for this
Ligand-Target Pair
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM2338
PNG
(Methyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1H-pyr...)
Show SMILES COC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C12H11ClN2O4S/c1-19-12(16)10-3-2-6-15(10)20(17,18)11-7-8(13)4-5-9(11)14/h2-7H,14H2,1H3
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UniChem

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Article
PubMed
n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


Citation and Details
More data for this
Ligand-Target Pair
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM1434
PNG
(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Show InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
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Article
PubMed
n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


Citation and Details
More data for this
Ligand-Target Pair