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Compile Data Set for Download or QSAR

Found 425 hits Enz. Inhib. hit(s) with Target = 'HTR4' AND taxid = 10141   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HTR4


(GUINEA PIG)
BDBM82505
PNG
(CAS_121881 | NSC_121881 | SB204070)
Show SMILES CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
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0.0100n/an/an/an/an/an/an/an/a



Roche Bioscience

Curated by PDSP Ki Database




FASEB J 10: 1398-407 (1996)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM85020
PNG
(5-Fluoro-2-methoxy-1H-indole-3-carboxylic acid [1-...)
Show InChI InChI=1S/C19H26FN3O5S/c1-27-18-17(15-11-14(20)3-4-16(15)22-18)19(24)28-12-13-5-8-23(9-6-13)10-7-21-29(2,25)26/h3-4,11,13,21-22H,5-10,12H2,1-2H3
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0.0300n/an/an/an/an/an/an/an/a



Roche Bioscience

Curated by PDSP Ki Database




FASEB J 10: 1398-407 (1996)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.0600n/an/an/an/an/an/an/an/a



Roche Bioscience

Curated by PDSP Ki Database




FASEB J 10: 1398-407 (1996)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM82505
PNG
(CAS_121881 | NSC_121881 | SB204070)
Show SMILES CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
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0.0700n/an/an/an/an/an/an/an/a



Janssen Research Foundation

Curated by PDSP Ki Database




J Neurochem 69: 1810-9 (1997)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM85027
PNG
(1-(7-Chloro-8-amino-1,4-benzodioxane-5-yl)-3-[1-[3...)
Show SMILES COc1ccc(CCCN2CCC(CCC(=O)c3cc(Cl)c(N)c4OCCOc34)CC2)cc1OC
Show InChI InChI=1S/C27H35ClN2O5/c1-32-23-8-6-19(16-24(23)33-2)4-3-11-30-12-9-18(10-13-30)5-7-22(31)20-17-21(28)25(29)27-26(20)34-14-15-35-27/h6,8,16-18H,3-5,7,9-15,29H2,1-2H3
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0.100n/an/an/an/an/an/an/an/a



Roche Bioscience

Curated by PDSP Ki Database




FASEB J 10: 1398-407 (1996)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.110n/an/an/an/an/an/an/an/a



FAES, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as radioligand


J Med Chem 42: 2870-80 (1999)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50181840
PNG
((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-Meth...)
Show SMILES O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H20N2O2/c20-17(14-10-18-15-5-2-1-4-13(14)15)21-11-12-7-9-19-8-3-6-16(12)19/h1-2,4-5,10,12,16,18H,3,6-9,11H2/t12-,16-/m0/s1
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0.183n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


J Med Chem 49: 1125-39 (2006)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50181844
PNG
((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amin...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12
Show InChI InChI=1S/C16H21ClN2O3/c1-21-15-8-13(18)12(17)7-11(15)16(20)22-9-10-4-6-19-5-2-3-14(10)19/h7-8,10,14H,2-6,9,18H2,1H3/t10-,14-/m0/s1
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0.183n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


J Med Chem 49: 1125-39 (2006)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM85020
PNG
(5-Fluoro-2-methoxy-1H-indole-3-carboxylic acid [1-...)
Show InChI InChI=1S/C19H26FN3O5S/c1-27-18-17(15-11-14(20)3-4-16(15)22-18)19(24)28-12-13-5-8-23(9-6-13)10-7-21-29(2,25)26/h3-4,11,13,21-22H,5-10,12H2,1-2H3
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0.190n/an/an/an/an/an/an/an/a



Janssen Research Foundation

Curated by PDSP Ki Database




J Neurochem 69: 1810-9 (1997)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50327858
PNG
((1-Butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-d...)
Show SMILES CCCCN1CCC(COC(=O)c2cc(I)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C19H27IN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
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0.200n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


J Med Chem 53: 7035-47 (2010)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50327865
PNG
((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(2-fluoroe...)
Show SMILES CCCCN1CCC(COC(=O)c2ccc(N)c(OCCF)c2)CC1
Show InChI InChI=1S/C19H29FN2O3/c1-2-3-9-22-10-6-15(7-11-22)14-25-19(23)16-4-5-17(21)18(13-16)24-12-8-20/h4-5,13,15H,2-3,6-12,14,21H2,1H3
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0.215n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


J Med Chem 53: 7035-47 (2010)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.25n/an/an/an/an/an/an/an/a



University of Alberta

Curated by PDSP Ki Database




Neuropharmacology 33: 275-317

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.25n/an/an/an/an/an/an/an/a



Glaxo Group Research Ltd.

Curated by PDSP Ki Database




Br J Pharmacol 109: 618-24 (1993)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.310n/an/an/an/an/an/an/an/a



CNRS UPR 9023

Curated by PDSP Ki Database




Eur J Pharmacol 298: 165-74 (1996)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.310n/an/an/an/an/an/an/an/a



Glaxo Group Research Ltd.

Curated by PDSP Ki Database




Br J Pharmacol 109: 618-24 (1993)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.310n/an/an/an/an/an/an/an/a



University of Alberta

Curated by PDSP Ki Database




Neuropharmacology 33: 275-317

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50327864
PNG
((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(fluoromet...)
Show SMILES CCCCN1CCC(COC(=O)c2ccc(N)c(OCF)c2)CC1
Show InChI InChI=1S/C18H27FN2O3/c1-2-3-8-21-9-6-14(7-10-21)12-23-18(22)15-4-5-16(20)17(11-15)24-13-19/h4-5,11,14H,2-3,6-10,12-13,20H2,1H3
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0.334n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


J Med Chem 53: 7035-47 (2010)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50327863
PNG
((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Show SMILES CCCCN1CCC(COC(=O)c2cc(F)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C19H27FN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
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0.334n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


J Med Chem 53: 7035-47 (2010)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50181845
PNG
((1S,7aS)-1-{[(4-amino-5-chloro-2-methoxybenzoyl)am...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12
Show InChI InChI=1S/C17H24ClN3O2/c1-21-6-3-4-15(21)11(5-7-21)10-20-17(22)12-8-13(18)14(19)9-16(12)23-2/h8-9,11,15H,3-7,10H2,1-2H3,(H2-,19,20,22)/p+1/t11-,15-,21+/m0/s1
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0.350n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


J Med Chem 49: 1125-39 (2006)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM85026
PNG
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)
Show SMILES CCCCN1CCC(CNC(=O)c2c3OCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26)
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0.390n/an/an/an/an/an/an/an/a



Roche Bioscience

Curated by PDSP Ki Database




FASEB J 10: 1398-407 (1996)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.390n/an/an/an/an/an/an/an/a



Janssen Research Foundation

Curated by PDSP Ki Database




J Neurochem 69: 1810-9 (1997)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50181837
PNG
((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Show SMILES Cn1nc(C(=O)OC[C@@H]2CCN3CCC[C@@H]23)c2ccccc12
Show InChI InChI=1S/C17H21N3O2/c1-19-15-6-3-2-5-13(15)16(18-19)17(21)22-11-12-8-10-20-9-4-7-14(12)20/h2-3,5-6,12,14H,4,7-11H2,1H3/t12-,14-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


J Med Chem 49: 1125-39 (2006)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50327859
PNG
((1-Butylpiperidin-4-yl)methyl 8-amino-7-cyano-2,3-...)
Show SMILES CCCCN1CCC(COC(=O)c2cc(C#N)c(N)c3OCCOc23)CC1
Show InChI InChI=1S/C20H27N3O4/c1-2-3-6-23-7-4-14(5-8-23)13-27-20(24)16-11-15(12-21)17(22)19-18(16)25-9-10-26-19/h11,14H,2-10,13,22H2,1H3
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0.450n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


J Med Chem 53: 7035-47 (2010)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50327860
PNG
((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Show SMILES CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3OCCOc23)CC1
Show InChI InChI=1S/C20H29ClN2O4/c1-3-4-7-23-8-5-14(6-9-23)13-27-20(24)15-12-16(21)17(22-2)19-18(15)25-10-11-26-19/h12,14,22H,3-11,13H2,1-2H3
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0.577n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


J Med Chem 53: 7035-47 (2010)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50181842
PNG
((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 5-Fluo...)
Show SMILES Fc1ccc2[nH]cc(C(=O)OC[C@@H]3CCN4CCC[C@@H]34)c2c1
Show InChI InChI=1S/C17H19FN2O2/c18-12-3-4-15-13(8-12)14(9-19-15)17(21)22-10-11-5-7-20-6-1-2-16(11)20/h3-4,8-9,11,16,19H,1-2,5-7,10H2/t11-,16-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


J Med Chem 49: 1125-39 (2006)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50327861
PNG
((1-Butylpiperidin-4-yl)methyl 4-Amino-3-methoxyben...)
Show SMILES CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1
Show InChI InChI=1S/C18H28N2O3/c1-3-4-9-20-10-7-14(8-11-20)13-23-18(21)15-5-6-16(19)17(12-15)22-2/h5-6,12,14H,3-4,7-11,13,19H2,1-2H3
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0.738n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


J Med Chem 53: 7035-47 (2010)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM82273
PNG
(CAS_167710-87-4 | RS 39604)
Show SMILES COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1
Show InChI InChI=1S/C26H36ClN3O6S/c1-34-20-12-19(13-21(14-20)35-2)17-36-26-16-24(28)23(27)15-22(26)25(31)5-4-18-6-9-30(10-7-18)11-8-29-37(3,32)33/h12-16,18,29H,4-11,17,28H2,1-3H3
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0.790n/an/an/an/an/an/an/an/a



Roche Bioscience

Curated by PDSP Ki Database




FASEB J 10: 1398-407 (1996)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM82273
PNG
(CAS_167710-87-4 | RS 39604)
Show SMILES COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1
Show InChI InChI=1S/C26H36ClN3O6S/c1-34-20-12-19(13-21(14-20)35-2)17-36-26-16-24(28)23(27)15-22(26)25(31)5-4-18-6-9-30(10-7-18)11-8-29-37(3,32)33/h12-16,18,29H,4-11,17,28H2,1-3H3
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0.790n/an/an/an/an/an/an/an/a



Syntex Discovery Research

Curated by PDSP Ki Database




Br J Pharmacol 115: 1087-95 (1995)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50442803
PNG
(CHEMBL2440453)
Show SMILES CC(O)CCN1CCC(CNC(=O)c2c3OCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C22H31N3O3/c1-16(26)7-11-24-12-8-17(9-13-24)15-23-21(27)20-18-5-2-3-6-19(18)25-10-4-14-28-22(20)25/h2-3,5-6,16-17,26H,4,7-15H2,1H3,(H,23,27)
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0.794n/an/an/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes


Bioorg Med Chem 21: 7134-45 (2013)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50181841
PNG
((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1H-ind...)
Show SMILES O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1[nH]nc2ccccc12
Show InChI InChI=1S/C16H19N3O2/c20-16(15-12-4-1-2-5-13(12)17-18-15)21-10-11-7-9-19-8-3-6-14(11)19/h1-2,4-5,11,14H,3,6-10H2,(H,17,18)/t11-,14-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


J Med Chem 49: 1125-39 (2006)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50327862
PNG
((1-Propylpiperidin-4-yl)methyl 4-Amino-3-methoxybe...)
Show SMILES CCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1
Show InChI InChI=1S/C17H26N2O3/c1-3-8-19-9-6-13(7-10-19)12-22-17(20)14-4-5-15(18)16(11-14)21-2/h4-5,11,13H,3,6-10,12,18H2,1-2H3
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0.901n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes


J Med Chem 53: 7035-47 (2010)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50079375
PNG
(CHEMBL3417008)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCC1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C21H31ClN2O3/c1-26-20-12-19(23)18(22)11-17(20)21(25)27-14-16-7-9-24(10-8-16)13-15-5-3-2-4-6-15/h11-12,15-16H,2-10,13-14,23H2,1H3
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0.950n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


J Med Chem 58: 3172-87 (2015)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50181839
PNG
(CHEMBL202434 | N-exo-((4S,7alphaS)-tetrahydro-1H-p...)
Show SMILES Clc1cc(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2nccn2c1
Show InChI InChI=1S/C16H19ClN4O/c17-12-8-13(15-18-4-7-21(15)10-12)16(22)19-9-11-3-6-20-5-1-2-14(11)20/h4,7-8,10-11,14H,1-3,5-6,9H2,(H,19,22)/t11-,14-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum


J Med Chem 49: 1125-39 (2006)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM84951
PNG
(CAS_133075 | NSC_133075 | RS 67506)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(C)(=O)=O)CC1
Show InChI InChI=1S/C18H28ClN3O4S/c1-26-18-12-16(20)15(19)11-14(18)17(23)4-3-13-5-8-22(9-6-13)10-7-21-27(2,24)25/h11-13,21H,3-10,20H2,1-2H3
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1.58n/an/an/an/an/an/an/an/a



Syntex Discovery Research

Curated by PDSP Ki Database




Br J Pharmacol 115: 1387-92 (1995)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM85026
PNG
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)
Show SMILES CCCCN1CCC(CNC(=O)c2c3OCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26)
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1.60n/an/an/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes


Bioorg Med Chem 21: 7134-45 (2013)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50293279
PNG
(1-Methyl-5-[(1-propylpiperidin-4-yl)methyloxy]-pyr...)
Show SMILES CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1
Show InChI InChI=1S/C19H25N3OS/c1-3-8-21-10-6-15(7-11-21)12-23-18-16-5-4-9-22(16)17-14(2)13-24-19(17)20-18/h4-5,9,13,15H,3,6-8,10-12H2,1-2H3
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1.74n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membrane


Bioorg Med Chem 17: 2607-22 (2009)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM84950
PNG
(CAS_183782 | NSC_183782 | RS 67333)
Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1
Show InChI InChI=1S/C19H29ClN2O2/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2/h12-14H,3-11,21H2,1-2H3
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1.99n/an/an/an/an/an/an/an/a



Syntex Discovery Research

Curated by PDSP Ki Database




Br J Pharmacol 115: 1387-92 (1995)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM85028
PNG
(1-[4-Amino-5-chloro-2-(3,5-dimethoxybenzyloxy)phen...)
Show SMILES COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCCCN2CCCCC2)cc(OC)c1
Show InChI InChI=1S/C25H33ClN2O4/c1-30-19-12-18(13-20(14-19)31-2)17-32-25-16-23(27)22(26)15-21(25)24(29)8-4-7-11-28-9-5-3-6-10-28/h12-16H,3-11,17,27H2,1-2H3
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1.99n/an/an/an/an/an/an/an/a



Roche Bioscience

Curated by PDSP Ki Database




FASEB J 10: 1398-407 (1996)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50399614
PNG
(CHEMBL2181170)
Show SMILES CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1
Show InChI InChI=1S/C21H24FN3O/c1-2-11-25-12-8-15(9-13-25)14-26-21-17-6-4-10-23-19(17)16-5-3-7-18(22)20(16)24-21/h3-7,10,15H,2,8-9,11-14H2,1H3
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2.20n/an/an/an/an/an/an/an/a



Universit£ de Caen Basse-Normandie

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


J Med Chem 55: 9693-707 (2012)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50399614
PNG
(CHEMBL2181170)
Show SMILES CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1
Show InChI InChI=1S/C21H24FN3O/c1-2-11-25-12-8-15(9-13-25)14-26-21-17-6-4-10-23-19(17)16-5-3-7-18(22)20(16)24-21/h3-7,10,15H,2,8-9,11-14H2,1H3
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2.20n/an/an/an/an/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


Bioorg Med Chem 21: 7529-38 (2013)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50079377
PNG
(CHEMBL3417007)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C21H32ClN3O2/c1-27-20-12-19(23)18(22)11-17(20)21(26)24-13-15-7-9-25(10-8-15)14-16-5-3-2-4-6-16/h11-12,15-16H,2-10,13-14,23H2,1H3,(H,24,26)
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2.30n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


J Med Chem 58: 3172-87 (2015)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50079367
PNG
(CHEMBL3416998)
Show SMILES Cl.COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCNCC2)CC1
Show InChI InChI=1S/C21H32ClN3O2/c1-27-21-13-19(23)18(22)12-17(21)20(26)3-2-15-6-10-25(11-7-15)14-16-4-8-24-9-5-16/h12-13,15-16,24H,2-11,14,23H2,1H3
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2.5n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


J Med Chem 58: 3172-87 (2015)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50399621
PNG
(CHEMBL2181166)
Show SMILES Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc21
Show InChI InChI=1S/C27H27FIN3O/c28-24-7-1-5-22-25-23(6-2-14-30-25)27(31-26(22)24)33-18-20-12-16-32(17-13-20)15-3-4-19-8-10-21(29)11-9-19/h1-2,5-11,14,20H,3-4,12-13,15-18H2
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2.5n/an/an/an/an/an/an/an/a



Universit£ de Caen Basse-Normandie

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


J Med Chem 55: 9693-707 (2012)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50056401
PNG
(2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]be...)
Show SMILES CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3
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2.51n/an/an/an/an/an/an/an/a



Roche Bioscience

Curated by PDSP Ki Database




FASEB J 10: 1398-407 (1996)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50122716
PNG
(5-(Piperidin-4-ylmethoxy)-9-propyl-1,2,3,4-tetrahy...)
Show SMILES CCCN1CCC(COc2nc3ccccc3c3NCCCc23)CC1
Show InChI InChI=1S/C21H29N3O/c1-2-12-24-13-9-16(10-14-24)15-25-21-18-7-5-11-22-20(18)17-6-3-4-8-19(17)23-21/h3-4,6,8,16,22H,2,5,7,9-15H2,1H3
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2.90n/an/an/an/an/an/an/an/a



Université de Caen

Curated by ChEMBL


Assay Description
Ability to displace [3H]GR-113808 from 5-hydroxytryptamine 4 receptor


J Med Chem 46: 138-47 (2002)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50079365
PNG
(CHEMBL3416996)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCC2)CC1
Show InChI InChI=1S/C21H31ClN2O2/c1-26-21-13-19(23)18(22)12-17(21)20(25)7-6-15-8-10-24(11-9-15)14-16-4-2-3-5-16/h12-13,15-16H,2-11,14,23H2,1H3
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3n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


J Med Chem 58: 3172-87 (2015)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50079366
PNG
(CHEMBL3416997)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCCC2)CC1
Show InChI InChI=1S/C23H35ClN2O2/c1-28-23-15-21(25)20(24)14-19(23)22(27)9-8-17-10-12-26(13-11-17)16-18-6-4-2-3-5-7-18/h14-15,17-18H,2-13,16,25H2,1H3
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3.90n/an/an/an/an/an/an/an/a



CERMN

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay


J Med Chem 58: 3172-87 (2015)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50056415
PNG
(2-piperidinopropyl 4-amino-5-chloro-2-methoxybenzo...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCCN1CCCCC1
Show InChI InChI=1S/C16H23ClN2O3/c1-21-15-11-14(18)13(17)10-12(15)16(20)22-9-5-8-19-6-3-2-4-7-19/h10-11H,2-9,18H2,1H3
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3.98n/an/an/an/an/an/an/an/a



Roche Bioscience

Curated by PDSP Ki Database




FASEB J 10: 1398-407 (1996)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50443687
PNG
(CHEMBL3093187)
Show SMILES Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc21
Show InChI InChI=1S/C22H23F4N3O/c23-18-6-1-4-16-19-17(5-2-10-27-19)21(28-20(16)18)30-14-15-7-12-29(13-8-15)11-3-9-22(24,25)26/h1-2,4-6,10,15H,3,7-9,11-14H2
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4.20n/an/an/an/an/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


Bioorg Med Chem 21: 7529-38 (2013)

More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50399622
PNG
(CHEMBL2181168)
Show SMILES CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1
Show InChI InChI=1S/C21H24IN3O/c1-2-11-25-12-8-15(9-13-25)14-26-21-17-6-4-10-23-19(17)16-5-3-7-18(22)20(16)24-21/h3-7,10,15H,2,8-9,11-14H2,1H3
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4.60n/an/an/an/an/an/an/an/a



Universit£ de Caen Basse-Normandie

Curated by ChEMBL


Assay Description
Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes


J Med Chem 55: 9693-707 (2012)

More data for this
Ligand-Target Pair
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