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Compile Data Set for Download or QSAR

Found 7 hits Enz. Inhib. hit(s) with Target = 'Heat shock protein beta-1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Heat shock protein beta-1


(Homo sapiens)
BDBM50263167
PNG
(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCCCC2)cc1-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C29H32N4O2/c1-20-5-12-25(32-29(35)24-13-14-30-27(17-24)33-15-3-2-4-16-33)18-26(20)22-8-10-23(11-9-22)28(34)31-19-21-6-7-21/h5,8-14,17-18,21H,2-4,6-7,15-16,19H2,1H3,(H,31,34)(H,32,35)
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n/an/a 6n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells


Citation and Details
More data for this
Ligand-Target Pair
Heat shock protein beta-1


(Homo sapiens)
BDBM50263168
PNG
(CHEMBL476351 | N-[4'-(Cyclopropylmethyl-carbamoyl)...)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C28H30N4O3/c1-19-2-9-24(31-28(34)23-10-11-29-26(16-23)32-12-14-35-15-13-32)17-25(19)21-5-7-22(8-6-21)27(33)30-18-20-3-4-20/h2,5-11,16-17,20H,3-4,12-15,18H2,1H3,(H,30,33)(H,31,34)
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n/an/a 27n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells


Citation and Details
More data for this
Ligand-Target Pair
Heat shock protein beta-1


(Homo sapiens)
BDBM50263093
PNG
(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Show SMILES Cc1ccc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)NC1CC1
Show InChI InChI=1S/C22H24N2O2/c1-14-2-5-18(22(26)24-19-10-11-19)12-20(14)16-6-8-17(9-7-16)21(25)23-13-15-3-4-15/h2,5-9,12,15,19H,3-4,10-11,13H2,1H3,(H,23,25)(H,24,26)
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n/an/a 53n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells


Citation and Details
More data for this
Ligand-Target Pair
Heat shock protein beta-1


(Homo sapiens)
BDBM13533
PNG
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
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n/an/a 58n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells


Citation and Details
More data for this
Ligand-Target Pair
Heat shock protein beta-1


(Homo sapiens)
BDBM50262865
PNG
(CHEMBL477583 | Furan-3-carboxylic acid [4'-(cyclop...)
Show SMILES Cc1ccc(NC(=O)c2ccoc2)cc1-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C23H22N2O3/c1-15-2-9-20(25-23(27)19-10-11-28-14-19)12-21(15)17-5-7-18(8-6-17)22(26)24-13-16-3-4-16/h2,5-12,14,16H,3-4,13H2,1H3,(H,24,26)(H,25,27)
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n/an/a 88n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells


Citation and Details
More data for this
Ligand-Target Pair
Heat shock protein beta-1


(Homo sapiens)
BDBM15458
PNG
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Show SMILES COc1nccc(n1)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN5O/c1-26-19-22-11-8-16(24-19)18-17(13-2-4-14(20)5-3-13)23-12-25(18)15-6-9-21-10-7-15/h2-5,8,11-12,15,21H,6-7,9-10H2,1H3
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n/an/a 160n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells


Citation and Details
More data for this
Ligand-Target Pair
Heat shock protein beta-1


(Homo sapiens)
BDBM50097558
PNG
(CHEMBL1935538 | NSC-751382)
Show SMILES CN(c1ccc(NC(=O)c2ccc3OCOc3c2)cc1OCc1cc(C)ccc1C)S(C)(=O)=O
Show InChI InChI=1S/C23H21N3O3/c1-3-29-18-11-9-17(10-12-18)19-13-14-24-21-20(19)22(27)26(23(28)25(21)2)15-16-7-5-4-6-8-16/h4-14H,3,15H2,1-2H3
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n/an/a 200n/an/an/an/an/an/a



Dipartimento di Farmacia, UniversitÓ degli Studi di Genova, Viale Benedetto XV n.3, 16132 Genova, Italy.

Curated by ChEMBL


Assay Description
Inhibition of HSP27 (unknown origin) by insulin aggregation assay


Citation and Details
More data for this
Ligand-Target Pair