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Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Helicase IV' AND taxid = 83333   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Helicase IV


(Escherichia coli (strain K12))
BDBM50177710
PNG
((3-acetylamino-5-oxo-5,11-dihydro-10-thia-dibenzo[...)
Show SMILES CC(=O)Nc1ccc2CSc3ccc(CC(O)=O)cc3C(=O)c2c1
Show InChI InChI=1S/C18H15NO4S/c1-10(20)19-13-4-3-12-9-24-16-5-2-11(7-17(21)22)6-15(16)18(23)14(12)8-13/h2-6,8H,7,9H2,1H3,(H,19,20)(H,21,22)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity of Helicase4 from Escherichia coli in presence of ATP (5x Km(ATP)) and dT25 (5x KDNA)


Citation and Details
More data for this
Ligand-Target Pair
Helicase IV


(Escherichia coli (strain K12))
BDBM50177713
PNG
(2-(5-oxo-5,11-dihydro-10-thia-dibenzo[a,d]cyclohep...)
Show SMILES CC(C(O)=O)c1ccc2SCc3ccccc3C(=O)c2c1
Show InChI InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-14(8-11)16(18)13-5-3-2-4-12(13)9-21-15/h2-8,10H,9H2,1H3,(H,19,20)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity of Helicase4 from Escherichia coli in presence of ATP (5x Km(ATP)) and dT25 (5x KDNA)


Citation and Details
More data for this
Ligand-Target Pair
Helicase IV


(Escherichia coli (strain K12))
BDBM50177711
PNG
((5-oxo-5,11-dihydro-10-thia-dibenzo[a,d]cyclohepte...)
Show SMILES OC(=O)Cc1ccc2SCc3ccccc3C(=O)c2c1
Show InChI InChI=1S/C16H12O3S/c17-15(18)8-10-5-6-14-13(7-10)16(19)12-4-2-1-3-11(12)9-20-14/h1-7H,8-9H2,(H,17,18)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity of Helicase4 from Escherichia coli in presence of ATP (5x Km(ATP)) and dT25 (5x KDNA)


Citation and Details
More data for this
Ligand-Target Pair
Helicase IV


(Escherichia coli (strain K12))
BDBM50177711
PNG
((5-oxo-5,11-dihydro-10-thia-dibenzo[a,d]cyclohepte...)
Show SMILES OC(=O)Cc1ccc2SCc3ccccc3C(=O)c2c1
Show InChI InChI=1S/C16H12O3S/c17-15(18)8-10-5-6-14-13(7-10)16(19)12-4-2-1-3-11(12)9-20-14/h1-7H,8-9H2,(H,17,18)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 5.50E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity of Tyr473Ala mutated Helicase4 in presence of ATP (5x Km(ATP)) and dT25 (5x KDNA)


Citation and Details
More data for this
Ligand-Target Pair
Helicase IV


(Escherichia coli (strain K12))
BDBM50177712
PNG
((2-methyl-5-oxo-5,11-dihydro-10-thia-dibenzo[a,d]c...)
Show SMILES Cc1ccc2c(CSc3ccc(CC(O)=O)cc3C2=O)c1
Show InChI InChI=1S/C17H14O3S/c1-10-2-4-13-12(6-10)9-21-15-5-3-11(8-16(18)19)7-14(15)17(13)20/h2-7H,8-9H2,1H3,(H,18,19)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity of Helicase4 from Escherichia coli in presence of ATP (5x Km(ATP)) and dT25 (5x KDNA)


Citation and Details
More data for this
Ligand-Target Pair