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Found 212 hits Enz. Inhib. hit(s) with Target = 'Heme Oxygenase 2 (HO-2)' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31673
PNG
(imidazole-dioxolane, 25)
Show SMILES Fc1ccc(OC[C@@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Show InChI InChI=1S/C22H22ClFN2O3/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)28-14-21(29-22)13-27-20-7-5-19(24)6-8-20/h1-8,11-12,16,21H,9-10,13-15H2/t21-,22-/m1/s1
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n/an/a 500n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50079986
PNG
(CHEMBL3415256)
Show SMILES Brc1cccc(OCCCCCn2cncn2)c1
Show InChI InChI=1S/C13H16BrN3O/c14-12-5-4-6-13(9-12)18-8-3-1-2-7-17-11-15-10-16-17/h4-6,9-11H,1-3,7-8H2
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n/an/a 800n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of HO2 in Sprague-Dawley rat brain microsomal fraction assessed as reduction in bilirubin formation incubated for 60 mins by double beam s...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50079993
PNG
(CHEMBL3415249)
Show SMILES C(CCn1ccnc1)CSc1nc2ccccc2s1
Show InChI InChI=1S/C14H15N3S2/c1-2-6-13-12(5-1)16-14(19-13)18-10-4-3-8-17-9-7-15-11-17/h1-2,5-7,9,11H,3-4,8,10H2
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n/an/a 800n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of HO2 in Sprague-Dawley rat brain microsomal fraction assessed as reduction in bilirubin formation incubated for 60 mins by double beam s...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50079989
PNG
(CHEMBL3415253)
Show SMILES Clc1ccc2sc(SCCCCCn3ccnc3)nc2c1
Show InChI InChI=1S/C15H16ClN3S2/c16-12-4-5-14-13(10-12)18-15(21-14)20-9-3-1-2-7-19-8-6-17-11-19/h4-6,8,10-11H,1-3,7,9H2
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n/an/a 900n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of HO2 in Sprague-Dawley rat brain microsomal fraction assessed as reduction in bilirubin formation incubated for 60 mins by double beam s...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50079990
PNG
(CHEMBL3415252)
Show SMILES Clc1ccc2sc(SCCCCn3ccnc3)nc2c1
Show InChI InChI=1S/C14H14ClN3S2/c15-11-3-4-13-12(9-11)17-14(20-13)19-8-2-1-6-18-7-5-16-10-18/h3-5,7,9-10H,1-2,6,8H2
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n/an/a 900n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of HO2 in Sprague-Dawley rat brain microsomal fraction assessed as reduction in bilirubin formation incubated for 60 mins by double beam s...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50079991
PNG
(CHEMBL3415251)
Show SMILES Clc1ccc2sc(SCCCn3ccnc3)nc2c1
Show InChI InChI=1S/C13H12ClN3S2/c14-10-2-3-12-11(8-10)16-13(19-12)18-7-1-5-17-6-4-15-9-17/h2-4,6,8-9H,1,5,7H2
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n/an/a 900n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of HO2 in Sprague-Dawley rat brain microsomal fraction assessed as reduction in bilirubin formation incubated for 60 mins by double beam s...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50079983
PNG
(CHEMBL3415244)
Show SMILES Ic1ccc(OCCCCCn2ccnc2)cc1
Show InChI InChI=1S/C14H17IN2O/c15-13-4-6-14(7-5-13)18-11-3-1-2-9-17-10-8-16-12-17/h4-8,10,12H,1-3,9,11H2
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n/an/a 900n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of HO2 in Sprague-Dawley rat brain microsomal fraction assessed as reduction in bilirubin formation incubated for 60 mins by double beam s...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50079985
PNG
(CHEMBL3415242)
Show SMILES Brc1cccc(OCCCCCn2ccnc2)c1
Show InChI InChI=1S/C14H17BrN2O/c15-13-5-4-6-14(11-13)18-10-3-1-2-8-17-9-7-16-12-17/h4-7,9,11-12H,1-3,8,10H2
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n/an/a 900n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of HO2 in Sprague-Dawley rat brain microsomal fraction assessed as reduction in bilirubin formation incubated for 60 mins by double beam s...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441453
PNG
(CHEMBL2436290)
Show SMILES [O-][N+](=O)c1cccc(Cn2c(CN3CCCC3)nc3ccccc23)c1
Show InChI InChI=1S/C19H20N4O2/c24-23(25)16-7-5-6-15(12-16)13-22-18-9-2-1-8-17(18)20-19(22)14-21-10-3-4-11-21/h1-2,5-9,12H,3-4,10-11,13-14H2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441452
PNG
(CHEMBL2436287)
Show SMILES Brc1cccc(Cn2c(CN3CCCC3)nc3ccccc23)c1
Show InChI InChI=1S/C19H20BrN3/c20-16-7-5-6-15(12-16)13-23-18-9-2-1-8-17(18)21-19(23)14-22-10-3-4-11-22/h1-2,5-9,12H,3-4,10-11,13-14H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31671
PNG
(imidazole-dioxolane, 23)
Show SMILES Clc1ccc(CC[C@@]2(Cn3ccnc3)OC[C@@H](COc3ccccc3)O2)cc1
Show InChI InChI=1S/C22H23ClN2O3/c23-19-8-6-18(7-9-19)10-11-22(16-25-13-12-24-17-25)27-15-21(28-22)14-26-20-4-2-1-3-5-20/h1-9,12-13,17,21H,10-11,14-16H2/t21-,22-/m1/s1
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n/an/a 1.60E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441432
PNG
(CHEMBL2436292)
Show SMILES Brc1ccccc1Cn1c(CN2CCCC2)nc2ccccc12
Show InChI InChI=1S/C19H20BrN3/c20-16-8-2-1-7-15(16)13-23-18-10-4-3-9-17(18)21-19(23)14-22-11-5-6-12-22/h1-4,7-10H,5-6,11-14H2
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n/an/a 1.60E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441451
PNG
(CHEMBL2436286)
Show SMILES Clc1cccc(Cn2c(CN3CCCC3)nc3ccccc23)c1
Show InChI InChI=1S/C19H20ClN3/c20-16-7-5-6-15(12-16)13-23-18-9-2-1-8-17(18)21-19(23)14-22-10-3-4-11-22/h1-2,5-9,12H,3-4,10-11,13-14H2
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n/an/a 1.65E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31677
PNG
(imidazole-dioxolane, 29)
Show SMILES Clc1ccc(CC[C@@]2(Cn3ccnc3)OC[C@@H](COc3ccc(cc3)C#N)O2)cc1
Show InChI InChI=1S/C23H22ClN3O3/c24-20-5-1-18(2-6-20)9-10-23(16-27-12-11-26-17-27)29-15-22(30-23)14-28-21-7-3-19(13-25)4-8-21/h1-8,11-12,17,22H,9-10,14-16H2/t22-,23-/m1/s1
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n/an/a 1.70E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50207205
PNG
(1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanone h...)
Show SMILES Ic1ccc(CCC(=O)Cn2ccnc2)cc1
Show InChI InChI=1S/C13H13IN2O/c14-12-4-1-11(2-5-12)3-6-13(17)9-16-8-7-15-10-16/h1-2,4-5,7-8,10H,3,6,9H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain microsome HO2


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50207198
PNG
(1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hy...)
Show SMILES OC(CCc1ccc(I)cc1)Cn1ccnc1
Show InChI InChI=1S/C13H15IN2O/c14-12-4-1-11(2-5-12)3-6-13(17)9-16-8-7-15-10-16/h1-2,4-5,7-8,10,13,17H,3,6,9H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain microsome HO2


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441429
PNG
(CHEMBL2436293)
Show SMILES Cc1ccccc1Cn1c(CN2CCCC2)nc2ccccc12
Show InChI InChI=1S/C20H23N3/c1-16-8-2-3-9-17(16)14-23-19-11-5-4-10-18(19)21-20(23)15-22-12-6-7-13-22/h2-5,8-11H,6-7,12-15H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50438658
PNG
(CHEMBL1188560)
Show SMILES OC(CCc1ccc(I)cc1)Cn1ccnc1
Show InChI InChI=1S/C13H15IN2O/c14-12-4-1-11(2-5-12)3-6-13(17)9-16-8-7-15-10-16/h1-2,4-5,7-8,10,13,17H,3,6,9H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50207206
PNG
(4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanone...)
Show SMILES Fc1ccc(CCC(=O)Cn2ccnc2)cc1
Show InChI InChI=1S/C13H13FN2O/c14-12-4-1-11(2-5-12)3-6-13(17)9-16-8-7-15-10-16/h1-2,4-5,7-8,10H,3,6,9H2
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n/an/a 1.90E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain microsome HO2


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441426
PNG
(CHEMBL2436275)
Show SMILES Fc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1
Show InChI InChI=1S/C19H20FN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441450
PNG
(CHEMBL2436266)
Show SMILES Clc1cc(Cl)cc(Cn2c(CN3CCCC3)nc3ccccc23)c1
Show InChI InChI=1S/C19H19Cl2N3/c20-15-9-14(10-16(21)11-15)12-24-18-6-2-1-5-17(18)22-19(24)13-23-7-3-4-8-23/h1-2,5-6,9-11H,3-4,7-8,12-13H2
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n/an/a 2.10E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50271549
PNG
(1-(4-(3-bromophenoxy)butyl)-1H-imidazole | CHEMBL4...)
Show SMILES Brc1cccc(OCCCCn2ccnc2)c1
Show InChI InChI=1S/C13H15BrN2O/c14-12-4-3-5-13(10-12)17-9-2-1-7-16-8-6-15-11-16/h3-6,8,10-11H,1-2,7,9H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31658
PNG
(imidazole-dioxolane, 10)
Show SMILES Clc1ccc(CC[C@@]2(Cn3ccnc3)OC[C@@H](CSc3ccc(Br)cc3)O2)cc1
Show InChI InChI=1S/C22H22BrClN2O2S/c23-18-3-7-21(8-4-18)29-14-20-13-27-22(28-20,15-26-12-11-25-16-26)10-9-17-1-5-19(24)6-2-17/h1-8,11-12,16,20H,9-10,13-15H2/t20-,22+/m0/s1
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n/an/a 2.40E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31659
PNG
(imidazole-dioxolane, 11)
Show SMILES COc1ccc(SC[C@@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Show InChI InChI=1S/C23H25ClN2O3S/c1-27-20-6-8-22(9-7-20)30-15-21-14-28-23(29-21,16-26-13-12-25-17-26)11-10-18-2-4-19(24)5-3-18/h2-9,12-13,17,21H,10-11,14-16H2,1H3/t21-,23+/m0/s1
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n/an/a 2.50E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50207201
PNG
(4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol h...)
Show SMILES OC(CCc1ccc(Br)cc1)Cn1ccnc1
Show InChI InChI=1S/C13H15BrN2O/c14-12-4-1-11(2-5-12)3-6-13(17)9-16-8-7-15-10-16/h1-2,4-5,7-8,10,13,17H,3,6,9H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain microsome HO2


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441425
PNG
(CHEMBL2436276)
Show SMILES Brc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1
Show InChI InChI=1S/C19H20BrN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441449
PNG
(CHEMBL2436268)
Show SMILES C(Cn1c(CN2CCCC2)nc2ccccc12)c1ccccc1
Show InChI InChI=1S/C20H23N3/c1-2-8-17(9-3-1)12-15-23-19-11-5-4-10-18(19)21-20(23)16-22-13-6-7-14-22/h1-5,8-11H,6-7,12-16H2
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n/an/a 2.70E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441448
PNG
(CHEMBL2436267)
Show SMILES C(N1CCCC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C19H21N3/c1-2-8-16(9-3-1)14-22-18-11-5-4-10-17(18)20-19(22)15-21-12-6-7-13-21/h1-5,8-11H,6-7,12-15H2
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n/an/a 3.10E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31687
PNG
(imidazole-dioxolane, 37)
Show SMILES COC[C@@H]1CO[C@@](CCc2ccc(Cl)cc2)(Cn2ccnc2)O1
Show InChI InChI=1S/C17H21ClN2O3/c1-21-10-16-11-22-17(23-16,12-20-9-8-19-13-20)7-6-14-2-4-15(18)5-3-14/h2-5,8-9,13,16H,6-7,10-12H2,1H3/t16-,17-/m1/s1
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n/an/a 3.30E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM85747
PNG
(CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 ...)
Show SMILES Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1
Show InChI InChI=1S/C19H20ClN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2
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n/an/a 3.40E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441447
PNG
(CHEMBL2436295)
Show SMILES [O-][N+](=O)c1ccccc1Cn1c(CN2CCCC2)nc2ccccc12
Show InChI InChI=1S/C19H20N4O2/c24-23(25)17-9-3-1-7-15(17)13-22-18-10-4-2-8-16(18)20-19(22)14-21-11-5-6-12-21/h1-4,7-10H,5-6,11-14H2
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n/an/a 3.50E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441428
PNG
(CHEMBL2436298)
Show SMILES Clc1ccc(Cl)c(Cn2c(CN3CCCC3)nc3ccccc23)c1
Show InChI InChI=1S/C19H19Cl2N3/c20-15-7-8-16(21)14(11-15)12-24-18-6-2-1-5-17(18)22-19(24)13-23-9-3-4-10-23/h1-2,5-8,11H,3-4,9-10,12-13H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50183074
PNG
(4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol ...)
Show SMILES OC(CCc1ccc(Cl)cc1)Cn1ccnc1
Show InChI InChI=1S/C13H15ClN2O/c14-12-4-1-11(2-5-12)3-6-13(17)9-16-8-7-15-10-16/h1-2,4-5,7-8,10,13,17H,3,6,9H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain microsome HO2


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441446
PNG
(CHEMBL2436294)
Show SMILES N#Cc1ccccc1Cn1c(CN2CCCC2)nc2ccccc12
Show InChI InChI=1S/C20H20N4/c21-13-16-7-1-2-8-17(16)14-24-19-10-4-3-9-18(19)22-20(24)15-23-11-5-6-12-23/h1-4,7-10H,5-6,11-12,14-15H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441445
PNG
(CHEMBL2436270)
Show SMILES C(N1CCCC1)c1nc2ccccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H25N3/c1-3-11-20(12-4-1)25(21-13-5-2-6-14-21)28-23-16-8-7-15-22(23)26-24(28)19-27-17-9-10-18-27/h1-8,11-16,25H,9-10,17-19H2
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n/an/a 4.10E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31682
PNG
(imidazole-dioxolane, 32)
Show SMILES FC[C@@H]1CO[C@@](CCc2ccc(Cl)cc2)(Cn2ccnc2)O1
Show InChI InChI=1S/C16H18ClFN2O2/c17-14-3-1-13(2-4-14)5-6-16(11-20-8-7-19-12-20)21-10-15(9-18)22-16/h1-4,7-8,12,15H,5-6,9-11H2/t15-,16-/m1/s1
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n/an/a 4.40E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441444
PNG
(CHEMBL2436291)
Show SMILES Clc1ccccc1Cn1c(CN2CCCC2)nc2ccccc12
Show InChI InChI=1S/C19H20ClN3/c20-16-8-2-1-7-15(16)13-23-18-10-4-3-9-17(18)21-19(23)14-22-11-5-6-12-22/h1-4,7-10H,5-6,11-14H2
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n/an/a 4.80E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441443
PNG
(CHEMBL2436288)
Show SMILES Cc1cccc(Cn2c(CN3CCCC3)nc3ccccc23)c1
Show InChI InChI=1S/C20H23N3/c1-16-7-6-8-17(13-16)14-23-19-10-3-2-9-18(19)21-20(23)15-22-11-4-5-12-22/h2-3,6-10,13H,4-5,11-12,14-15H2,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441423
PNG
(CHEMBL2436278)
Show SMILES Cc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1
Show InChI InChI=1S/C20H23N3/c1-16-8-10-17(11-9-16)14-23-19-7-3-2-6-18(19)21-20(23)15-22-12-4-5-13-22/h2-3,6-11H,4-5,12-15H2,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441442
PNG
(CHEMBL2436271)
Show SMILES C(N1CCCC1)c1nc2ccccc2n1Cc1ccc2ccccc2c1
Show InChI InChI=1S/C23H23N3/c1-2-8-20-15-18(11-12-19(20)7-1)16-26-22-10-4-3-9-21(22)24-23(26)17-25-13-5-6-14-25/h1-4,7-12,15H,5-6,13-14,16-17H2
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n/an/a 5.00E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31769
PNG
(Terconazole | cid_5404)
Show SMILES CC(C)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3cncn3)(O2)c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N5O3/c1-19(2)31-9-11-32(12-10-31)21-4-6-22(7-5-21)34-14-23-15-35-26(36-23,16-33-18-29-17-30-33)24-8-3-20(27)13-25(24)28/h3-8,13,17-19,23H,9-12,14-16H2,1-2H3/t23-,26-/m1/s1
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n/an/a 5.00E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31653
PNG
(CHEMBL421109 | imidazole-dioxolane, 5)
Show SMILES Nc1ccc(SC[C@@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Show InChI InChI=1S/C22H24ClN3O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15,24H2/t20-,22+/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against heme oxygenase 2 from rat brain


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31661
PNG
(imidazole-dioxolane, 13)
Show SMILES Fc1ccc(SC[C@@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Show InChI InChI=1S/C22H22ClFN2O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15H2/t20-,22+/m0/s1
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n/an/a 5.00E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441441
PNG
(CHEMBL2436272)
Show SMILES C(C1CCCCC1)n1c(CN2CCCC2)nc2ccccc12
Show InChI InChI=1S/C19H27N3/c1-2-8-16(9-3-1)14-22-18-11-5-4-10-17(18)20-19(22)15-21-12-6-7-13-21/h4-5,10-11,16H,1-3,6-9,12-15H2
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n/an/a 6.00E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31655
PNG
(CHEMBL179494 | imidazole-dioxolane, 7)
Show SMILES Nc1cccc(SC[C@@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)c1
Show InChI InChI=1S/C22H24ClN3O2S/c23-18-6-4-17(5-7-18)8-9-22(15-26-11-10-25-16-26)27-13-20(28-22)14-29-21-3-1-2-19(24)12-21/h1-7,10-12,16,20H,8-9,13-15,24H2/t20-,22+/m0/s1
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n/an/a 6.00E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441431
PNG
(CHEMBL2436297)
Show SMILES Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C19H19Cl2N3/c20-15-8-7-14(16(21)11-15)12-24-18-6-2-1-5-17(18)22-19(24)13-23-9-3-4-10-23/h1-2,5-8,11H,3-4,9-10,12-13H2
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PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31657
PNG
(imidazole-dioxolane, 9)
Show SMILES Oc1ccc(SC[C@@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Show InChI InChI=1S/C22H23ClN2O3S/c23-18-3-1-17(2-4-18)9-10-22(15-25-12-11-24-16-25)27-13-20(28-22)14-29-21-7-5-19(26)6-8-21/h1-8,11-12,16,20,26H,9-10,13-15H2/t20-,22+/m0/s1
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PubMed
n/an/a 7.00E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31768
PNG
(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
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PubMed
n/an/a 7.00E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM31669
PNG
(imidazole-dioxolane, 21)
Show SMILES Oc1ccc(OC[C@@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Show InChI InChI=1S/C22H23ClN2O4/c23-18-3-1-17(2-4-18)9-10-22(15-25-12-11-24-16-25)28-14-21(29-22)13-27-20-7-5-19(26)6-8-20/h1-8,11-12,16,21,26H,9-10,13-15H2/t21-,22-/m1/s1
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PubMed
n/an/a 7.10E+3n/an/an/an/a7.437



Queen's University



Assay Description
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...


Citation and Details
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50441424
PNG
(CHEMBL2436277)
Show SMILES Ic1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1
Show InChI InChI=1S/C19H20IN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2
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Article
PubMed
n/an/a 7.60E+3n/an/an/an/an/an/a



Queen's University

Curated by ChEMBL


Assay Description
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...


Citation and Details
More data for this
Ligand-Target Pair
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