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Compile Data Set for Download or QSAR

Found 359 hits Enz. Inhib. hit(s) with Target = 'Hepatic Lipase (HL)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151423
PNG
(US8987314, B234)
Show SMILES COCCS(=O)(=O)C(C(=O)NCc1cc(C)no1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1/C23H23N3O5S2/c1-15-12-18(31-26-15)14-24-22(27)21(33(28,29)11-10-30-2)23-25-19-9-8-17(13-20(19)32-23)16-6-4-3-5-7-16/h3-9,12-13,21H,10-11,14H2,1-2H3,(H,24,27)
KEGG

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n/an/a 0.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151465
PNG
(US8987314, B276)
Show SMILES CC(C)(C)OC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1/C29H31N3O7S3/c1-29(2,3)39-28(34)21-11-9-20(10-12-21)22-13-14-23-24(17-22)40-27(32-23)25(26(33)31-15-16-42(30,37)38)41(35,36)18-19-7-5-4-6-8-19/h4-14,17,25H,15-16,18H2,1-3H3,(H,31,33)(H2,30,37,38)
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n/an/a 0.800n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151397
PNG
(US8987314, B208)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cccc(Cl)c1
Show InChI InChI=1/C18H18ClN3O5S3/c1-29(24,25)16(17(23)21-7-8-30(20,26)27)18-22-14-6-5-12(10-15(14)28-18)11-3-2-4-13(19)9-11/h2-6,9-10,16H,7-8H2,1H3,(H,21,23)(H2,20,26,27)
KEGG

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n/an/a 0.800n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151421
PNG
(US8987314, B232)
Show SMILES COCCS(=O)(=O)C(C(=O)NCc1cc(no1)C(C)C)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1/C25H27N3O5S2/c1-16(2)21-14-19(33-28-21)15-26-24(29)23(35(30,31)12-11-32-3)25-27-20-10-9-18(13-22(20)34-25)17-7-5-4-6-8-17/h4-10,13-14,16,23H,11-12,15H2,1-3H3,(H,26,29)
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n/an/a 0.800n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151266
PNG
(US8987314, B62)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cccc(c1)N1CCCC1
Show InChI InChI=1/C22H26N4O5S3/c1-33(28,29)20(21(27)24-9-12-34(23,30)31)22-25-18-8-7-16(14-19(18)32-22)15-5-4-6-17(13-15)26-10-2-3-11-26/h4-8,13-14,20H,2-3,9-12H2,1H3,(H,24,27)(H2,23,30,31)
KEGG

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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151494
PNG
(US8987314, B305)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccccc1F
Show InChI InChI=1/C18H18FN3O5S3/c1-29(24,25)16(17(23)21-8-9-30(20,26)27)18-22-14-7-6-11(10-15(14)28-18)12-4-2-3-5-13(12)19/h2-7,10,16H,8-9H2,1H3,(H,21,23)(H2,20,26,27)
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151441
PNG
(US8987314, B252)
Show SMILES CC(C)c1cc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccccc2)S(C)(=O)=O)on1
Show InChI InChI=1/C23H23N3O4S2/c1-14(2)19-12-17(30-26-19)13-24-22(27)21(32(3,28)29)23-25-18-10-9-16(11-20(18)31-23)15-7-5-4-6-8-15/h4-12,14,21H,13H2,1-3H3,(H,24,27)
KEGG

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n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151496
PNG
(US8987314, B307)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccccc1F)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1/C20H19F4N3O5S3/c21-14-4-2-1-3-13(14)12-5-6-15-16(11-12)33-19(27-15)17(18(28)26-8-10-35(25,31)32)34(29,30)9-7-20(22,23)24/h1-6,11,17H,7-10H2,(H,26,28)(H2,25,31,32)
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n/an/a 1.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151268
PNG
(US8987314, B64)
Show SMILES COCCOC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C22H26N4O8S3/c1-33-10-11-34-22(28)25-16-6-3-14(4-7-16)15-5-8-17-18(13-15)35-21(26-17)19(36(2,29)30)20(27)24-9-12-37(23,31)32/h3-8,13,19H,9-12H2,1-2H3,(H,24,27)(H,25,28)(H2,23,31,32)
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n/an/a 1.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151399
PNG
(US8987314, B210)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cccc(Oc2ccccc2)c1
Show InChI InChI=1/C24H23N3O6S3/c1-35(29,30)22(23(28)26-12-13-36(25,31)32)24-27-20-11-10-17(15-21(20)34-24)16-6-5-9-19(14-16)33-18-7-3-2-4-8-18/h2-11,14-15,22H,12-13H2,1H3,(H,26,28)(H2,25,31,32)
KEGG

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n/an/a 1.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151554
PNG
(US8987314, B365)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccccc1F)S(=O)(=O)Cc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1/C25H21F4N3O6S3/c26-19-4-2-1-3-18(19)16-7-10-20-21(13-16)39-24(32-20)22(23(33)31-11-12-41(30,36)37)40(34,35)14-15-5-8-17(9-6-15)38-25(27,28)29/h1-10,13,22H,11-12,14H2,(H,31,33)(H2,30,36,37)
KEGG

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n/an/a 2.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151292
PNG
(US8987314, B88)
Show SMILES COc1cc(ccn1)-c1ccc2sc(nc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C18H20N4O6S3/c1-28-15-10-12(5-6-20-15)11-3-4-14-13(9-11)22-18(29-14)16(30(2,24)25)17(23)21-7-8-31(19,26)27/h3-6,9-10,16H,7-8H2,1-2H3,(H,21,23)(H2,19,26,27)
KEGG

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n/an/a 2.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151432
PNG
(US8987314, B243)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1cccc(Cl)c1)S(=O)(=O)Cc1ccc(F)cc1
Show InChI InChI=1/C24H21ClFN3O5S3/c25-18-3-1-2-16(12-18)17-6-9-20-21(13-17)35-24(29-20)22(23(30)28-10-11-37(27,33)34)36(31,32)14-15-4-7-19(26)8-5-15/h1-9,12-13,22H,10-11,14H2,(H,28,30)(H2,27,33,34)
KEGG

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n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151267
PNG
(US8987314, B63)
Show SMILES COCc1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C20H23N3O6S3/c1-29-12-13-3-5-14(6-4-13)15-7-8-16-17(11-15)30-20(23-16)18(31(2,25)26)19(24)22-9-10-32(21,27)28/h3-8,11,18H,9-10,12H2,1-2H3,(H,22,24)(H2,21,27,28)
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n/an/a 2.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151473
PNG
(US8987314, B284)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1/C20H20F3N3O5S3/c21-20(22,23)8-10-33(28,29)17(18(27)25-9-11-34(24,30)31)19-26-15-7-6-14(12-16(15)32-19)13-4-2-1-3-5-13/h1-7,12,17H,8-11H2,(H,25,27)(H2,24,30,31)
KEGG

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US Patent
n/an/a 2.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151291
PNG
(US8987314, B87)
Show SMILES COc1ccc(cn1)-c1ccc2sc(nc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C18H20N4O6S3/c1-28-15-6-4-12(10-21-15)11-3-5-14-13(9-11)22-18(29-14)16(30(2,24)25)17(23)20-7-8-31(19,26)27/h3-6,9-10,16H,7-8H2,1-2H3,(H,20,23)(H2,19,26,27)
KEGG

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n/an/a 2.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151468
PNG
(US8987314, B279)
Show SMILES Cc1nnc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccc(cc2)C(=O)OC(C)(C)C)S(C)(=O)=O)s1
Show InChI InChI=1/C25H26N4O5S3/c1-14-28-29-20(35-14)13-26-22(30)21(37(5,32)33)23-27-18-11-10-17(12-19(18)36-23)15-6-8-16(9-7-15)24(31)34-25(2,3)4/h6-12,21H,13H2,1-5H3,(H,26,30)
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n/an/a 2.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151396
PNG
(US8987314, B207)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(Cl)cc1
Show InChI InChI=1/C18H18ClN3O5S3/c1-29(24,25)16(17(23)21-8-9-30(20,26)27)18-22-14-7-4-12(10-15(14)28-18)11-2-5-13(19)6-3-11/h2-7,10,16H,8-9H2,1H3,(H,21,23)(H2,20,26,27)
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n/an/a 2.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151409
PNG
(US8987314, B220)
Show SMILES CC(C)(C)OC(=O)n1ccc(c1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C21H26N4O7S3/c1-21(2,3)32-20(27)25-9-7-14(12-25)13-5-6-15-16(11-13)33-19(24-15)17(34(4,28)29)18(26)23-8-10-35(22,30)31/h5-7,9,11-12,17H,8,10H2,1-4H3,(H,23,26)(H2,22,30,31)
KEGG

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n/an/a 2.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151469
PNG
(US8987314, B280)
Show SMILES CC(C)S(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2c(F)cc(cc2s1)-c1cccc(c1)C(=O)OC(C)(C)C
Show InChI InChI=1/C25H30FN3O7S3/c1-14(2)39(34,35)21(22(30)28-9-10-38(27,32)33)23-29-20-18(26)12-17(13-19(20)37-23)15-7-6-8-16(11-15)24(31)36-25(3,4)5/h6-8,11-14,21H,9-10H2,1-5H3,(H,28,30)(H2,27,32,33)
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n/an/a 2.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151402
PNG
(US8987314, B213)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cccc(OC(F)F)c1
Show InChI InChI=1/C19H19F2N3O6S3/c1-32(26,27)16(17(25)23-7-8-33(22,28)29)18-24-14-6-5-12(10-15(14)31-18)11-3-2-4-13(9-11)30-19(20)21/h2-6,9-10,16,19H,7-8H2,1H3,(H,23,25)(H2,22,28,29)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151462
PNG
(US8987314, B273)
Show SMILES Cc1cc2nc(sc2cc1-c1ccc(cc1)C(=O)OC(C)(C)C)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1/C30H33N3O7S3/c1-19-16-24-25(17-23(19)21-10-12-22(13-11-21)29(35)40-30(2,3)4)41-28(33-24)26(27(34)32-14-15-43(31,38)39)42(36,37)18-20-8-6-5-7-9-20/h5-13,16-17,26H,14-15,18H2,1-4H3,(H,32,34)(H2,31,38,39)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151422
PNG
(US8987314, B233)
Show SMILES Cc1cc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccccc2)S(C)(=O)=O)on1
Show InChI InChI=1/C21H19N3O4S2/c1-13-10-16(28-24-13)12-22-20(25)19(30(2,26)27)21-23-17-9-8-15(11-18(17)29-21)14-6-4-3-5-7-14/h3-11,19H,12H2,1-2H3,(H,22,25)
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n/an/a 3.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151404
PNG
(US8987314, B215)
Show SMILES COCc1cccc(c1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C20H23N3O6S3/c1-29-12-13-4-3-5-14(10-13)15-6-7-16-17(11-15)30-20(23-16)18(31(2,25)26)19(24)22-8-9-32(21,27)28/h3-7,10-11,18H,8-9,12H2,1-2H3,(H,22,24)(H2,21,27,28)
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n/an/a 3.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151406
PNG
(US8987314, B217)
Show SMILES CC(C)Oc1ccc(cc1Cl)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C21H24ClN3O6S3/c1-12(2)31-17-7-5-13(10-15(17)22)14-4-6-16-18(11-14)32-21(25-16)19(33(3,27)28)20(26)24-8-9-34(23,29)30/h4-7,10-12,19H,8-9H2,1-3H3,(H,24,26)(H2,23,29,30)
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n/an/a 3.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151463
PNG
(US8987314, B274)
Show SMILES Cc1cc2nc(sc2cc1-c1ccc(cc1)C(=O)OC(C)(C)C)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C24H29N3O7S3/c1-14-12-18-19(13-17(14)15-6-8-16(9-7-15)23(29)34-24(2,3)4)35-22(27-18)20(36(5,30)31)21(28)26-10-11-37(25,32)33/h6-9,12-13,20H,10-11H2,1-5H3,(H,26,28)(H2,25,32,33)
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n/an/a 5.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151407
PNG
(US8987314, B218)
Show SMILES COc1c(F)cc(cc1F)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C19H19F2N3O6S3/c1-30-16-12(20)7-11(8-13(16)21)10-3-4-14-15(9-10)31-19(24-14)17(32(2,26)27)18(25)23-5-6-33(22,28)29/h3-4,7-9,17H,5-6H2,1-2H3,(H,23,25)(H2,22,28,29)
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n/an/a 5.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151567
PNG
(US8987314, B378)
Show SMILES COCc1ccc(cc1)-c1ccc2sc(nc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C20H23N3O6S3/c1-29-12-13-3-5-14(6-4-13)15-7-8-17-16(11-15)23-20(30-17)18(31(2,25)26)19(24)22-9-10-32(21,27)28/h3-8,11,18H,9-10,12H2,1-2H3,(H,22,24)(H2,21,27,28)
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n/an/a 6.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151297
PNG
(US8987314, B93)
Show SMILES COCCNC(=O)c1ccc(cc1)-c1ccc2sc(nc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C22H26N4O7S3/c1-33-11-9-24-20(27)15-5-3-14(4-6-15)16-7-8-18-17(13-16)26-22(34-18)19(35(2,29)30)21(28)25-10-12-36(23,31)32/h3-8,13,19H,9-12H2,1-2H3,(H,24,27)(H,25,28)(H2,23,31,32)
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n/an/a 7.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151428
PNG
(US8987314, B239)
Show SMILES COCc1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1/C22H24F3N3O6S3/c1-34-13-14-2-4-15(5-3-14)16-6-7-17-18(12-16)35-21(28-17)19(20(29)27-9-11-37(26,32)33)36(30,31)10-8-22(23,24)25/h2-7,12,19H,8-11,13H2,1H3,(H,27,29)(H2,26,32,33)
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n/an/a 7.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151412
PNG
(US8987314, B223)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(cc1)-c1nnc(N)s1
Show InChI InChI=1/C20H20N6O5S4/c1-34(28,29)16(17(27)23-8-9-35(22,30)31)19-24-14-7-6-13(10-15(14)32-19)11-2-4-12(5-3-11)18-25-26-20(21)33-18/h2-7,10,16H,8-9H2,1H3,(H2,21,26)(H,23,27)(H2,22,30,31)
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n/an/a 7.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151442
PNG
(US8987314, B253)
Show SMILES Cc1nnc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccc(F)cc2)S(=O)(=O)Cc2ccccc2)o1
Show InChI InChI=1/C26H21FN4O4S2/c1-16-30-31-23(35-16)14-28-25(32)24(37(33,34)15-17-5-3-2-4-6-17)26-29-21-12-9-19(13-22(21)36-26)18-7-10-20(27)11-8-18/h2-13,24H,14-15H2,1H3,(H,28,32)
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n/an/a 9.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151349
PNG
(US8987314, B147)
Show SMILES COc1cc(ccn1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C18H20N4O6S3/c1-28-15-10-12(5-6-20-15)11-3-4-13-14(9-11)29-18(22-13)16(30(2,24)25)17(23)21-7-8-31(19,26)27/h3-6,9-10,16H,7-8H2,1-2H3,(H,21,23)(H2,19,26,27)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151331
PNG
(US8987314, B129)
Show SMILES Cc1cc2nc(sc2cc1-c1ccc(F)nc1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C18H19FN4O5S3/c1-10-7-13-14(8-12(10)11-3-4-15(19)22-9-11)29-18(23-13)16(30(2,25)26)17(24)21-5-6-31(20,27)28/h3-4,7-9,16H,5-6H2,1-2H3,(H,21,24)(H2,20,27,28)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151358
PNG
(US8987314, B156)
Show SMILES CC(C)(C)OC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C23H27N3O7S3/c1-23(2,3)33-22(28)15-7-5-14(6-8-15)16-9-10-17-18(13-16)34-21(26-17)19(35(4,29)30)20(27)25-11-12-36(24,31)32/h5-10,13,19H,11-12H2,1-4H3,(H,25,27)(H2,24,31,32)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151380
PNG
(US8987314, B185)
Show SMILES COc1cccc(n1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C18H20N4O6S3/c1-28-15-5-3-4-12(21-15)11-6-7-13-14(10-11)29-18(22-13)16(30(2,24)25)17(23)20-8-9-31(19,26)27/h3-7,10,16H,8-9H2,1-2H3,(H,20,23)(H2,19,26,27)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151413
PNG
(US8987314, B224)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(cc1)-c1ncco1
Show InChI InChI=1/C21H20N4O6S3/c1-33(27,28)18(19(26)23-9-11-34(22,29)30)21-25-16-7-6-15(12-17(16)32-21)13-2-4-14(5-3-13)20-24-8-10-31-20/h2-8,10,12,18H,9,11H2,1H3,(H,23,26)(H2,22,29,30)
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n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151240
PNG
(US8987314, B36)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(F)cc1
Show InChI InChI=1/C18H18FN3O5S3/c1-29(24,25)16(17(23)21-8-9-30(20,26)27)18-22-14-7-4-12(10-15(14)28-18)11-2-5-13(19)6-3-11/h2-7,10,16H,8-9H2,1H3,(H,21,23)(H2,20,26,27)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151241
PNG
(US8987314, B37)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cccc(F)c1
Show InChI InChI=1/C18H18FN3O5S3/c1-29(24,25)16(17(23)21-7-8-30(20,26)27)18-22-14-6-5-12(10-15(14)28-18)11-3-2-4-13(19)9-11/h2-6,9-10,16H,7-8H2,1H3,(H,21,23)(H2,20,26,27)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151242
PNG
(US8987314, B38)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc2OCOc2c1
Show InChI InChI=1/C19H19N3O7S3/c1-31(24,25)17(18(23)21-6-7-32(20,26)27)19-22-13-4-2-12(9-16(13)30-19)11-3-5-14-15(8-11)29-10-28-14/h2-5,8-9,17H,6-7,10H2,1H3,(H,21,23)(H2,20,26,27)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151243
PNG
(US8987314, B39)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1/C19H18F3N3O6S3/c1-33(27,28)16(17(26)24-8-9-34(23,29)30)18-25-14-7-4-12(10-15(14)32-18)11-2-5-13(6-3-11)31-19(20,21)22/h2-7,10,16H,8-9H2,1H3,(H,24,26)(H2,23,29,30)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151246
PNG
(US8987314, B42)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1/C24H30N4O7S3/c1-37(30,31)22(23(29)26-8-15-38(25,32)33)24-27-20-7-4-18(16-21(20)36-24)17-2-5-19(6-3-17)35-14-11-28-9-12-34-13-10-28/h2-7,16,22H,8-15H2,1H3,(H,26,29)(H2,25,32,33)
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n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151247
PNG
(US8987314, B43)
Show SMILES CC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C25H30N4O6S3/c1-16-9-12-29(13-10-16)25(31)18-5-3-17(4-6-18)19-7-8-20-21(15-19)36-24(28-20)22(37(2,32)33)23(30)27-11-14-38(26,34)35/h3-8,15-16,22H,9-14H2,1-2H3,(H,27,30)(H2,26,34,35)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151255
PNG
(US8987314, B51)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cccc(c1)[N+]#[C-]
Show InChI InChI=1/C19H18N4O5S3/c1-21-14-5-3-4-12(10-14)13-6-7-15-16(11-13)29-19(23-15)17(30(2,25)26)18(24)22-8-9-31(20,27)28/h3-7,10-11,17H,8-9H2,2H3,(H,22,24)(H2,20,27,28)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151272
PNG
(US8987314, B68)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1/C22H23N5O5S3/c1-34(29,30)20(21(28)24-9-10-35(23,31)32)22-26-18-8-7-16(11-19(18)33-22)17-12-25-27(14-17)13-15-5-3-2-4-6-15/h2-8,11-12,14,20H,9-10,13H2,1H3,(H,24,28)(H2,23,31,32)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151274
PNG
(US8987314, B70)
Show SMILES COCCS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(NC(=O)OC(C)(C)C)cc1
Show InChI InChI=1/C25H32N4O8S3/c1-25(2,3)37-24(31)28-18-8-5-16(6-9-18)17-7-10-19-20(15-17)38-23(29-19)21(39(32,33)14-12-36-4)22(30)27-11-13-40(26,34)35/h5-10,15,21H,11-14H2,1-4H3,(H,27,30)(H,28,31)(H2,26,34,35)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151275
PNG
(US8987314, B71)
Show SMILES COCCS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(NC(=O)OC)cc1
Show InChI InChI=1/C22H26N4O8S3/c1-33-10-12-36(29,30)19(20(27)24-9-11-37(23,31)32)21-26-17-8-5-15(13-18(17)35-21)14-3-6-16(7-4-14)25-22(28)34-2/h3-8,13,19H,9-12H2,1-2H3,(H,24,27)(H,25,28)(H2,23,31,32)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151278
PNG
(US8987314, B74)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cnn(c1)-c1ccc(F)cc1
Show InChI InChI=1/C21H20FN5O5S3/c1-34(29,30)19(20(28)24-8-9-35(23,31)32)21-26-17-7-2-13(10-18(17)33-21)14-11-25-27(12-14)16-5-3-15(22)4-6-16/h2-7,10-12,19H,8-9H2,1H3,(H,24,28)(H2,23,31,32)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151283
PNG
(US8987314, B79)
Show SMILES COc1cccc(c1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C19H21N3O6S3/c1-28-14-5-3-4-12(10-14)13-6-7-15-16(11-13)29-19(22-15)17(30(2,24)25)18(23)21-8-9-31(20,26)27/h3-7,10-11,17H,8-9H2,1-2H3,(H,21,23)(H2,20,26,27)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151284
PNG
(US8987314, B80)
Show SMILES Cc1nnc(CNC(=O)C(c2nc3cc(C)c(cc3s2)-c2ccc(F)nc2)S(C)(=O)=O)o1
Show InChI InChI=1/C20H18FN5O4S2/c1-10-6-14-15(7-13(10)12-4-5-16(21)22-8-12)31-20(24-14)18(32(3,28)29)19(27)23-9-17-26-25-11(2)30-17/h4-8,18H,9H2,1-3H3,(H,23,27)
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n/an/a<10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
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