Found 978 hits Enz. Inhib. hit(s) with Target = 'Histamine H2 receptor' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM81543
 (Alpha-Dimethylhistane-alpha | CAS_195960 | NSC_195...)Show InChI InChI=1S/C7H13N3/c1-6(8-2)3-7-4-9-5-10-7/h4-6,8H,3H2,1-2H3,(H,9,10) | UniProtKB/SwissProt
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's Medical Centre
Curated by PDSP Ki Database
| |
Biochem Soc Trans 20: 122-5 (1992)
BindingDB Entry DOI: 10.7270/Q2RX99KH |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM81541
 (CAS_195530 | NSC_195530 | S-Beta-Dimethylhistamine...)Show InChI InChI=1S/C7H13N3/c1-5(6(2)8)7-3-9-4-10-7/h3-6H,8H2,1-2H3,(H,9,10) | UniProtKB/SwissProt
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's Medical Centre
Curated by PDSP Ki Database
| |
Biochem Soc Trans 20: 122-5 (1992)
BindingDB Entry DOI: 10.7270/Q2RX99KH |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM81542
 (Beta-Methylhistamine | CAS_565544 | NSC_565544)Show InChI InChI=1S/C6H11N3/c1-5(2-7)6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9) | UniProtKB/SwissProt
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| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's Medical Centre
Curated by PDSP Ki Database
| |
Biochem Soc Trans 20: 122-5 (1992)
BindingDB Entry DOI: 10.7270/Q2RX99KH |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22904
 ((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1 | UniProtKB/SwissProt
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| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's Medical Centre
Curated by PDSP Ki Database
| |
Biochem Soc Trans 20: 122-5 (1992)
BindingDB Entry DOI: 10.7270/Q2RX99KH |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50253754
 (4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)Show SMILES CNC(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C28H31ClN2O2/c1-30-26(32)28(23-8-4-2-5-9-23,24-10-6-3-7-11-24)18-21-31-19-16-27(33,17-20-31)22-12-14-25(29)15-13-22/h2-15,33H,16-21H2,1H3,(H,30,32) | Reactome pathway KEGG
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| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health
Curated by ChEMBL
| Assay Description Displacement of [3H]tiotidine from human histamine H2 receptor |
J Med Chem 51: 6034-43 (2008)
Article DOI: 10.1021/jm800510m BindingDB Entry DOI: 10.7270/Q2BV7GFM |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50404821
 (CHEMBL306465)Show InChI InChI=1S/C17H25N5O2S/c18-16-17(21-25(23)20-16)19-8-5-11-24-15-7-4-6-14(12-15)13-22-9-2-1-3-10-22/h4,6-7,12H,1-3,5,8-11,13H2,(H2,18,20)(H,19,21) | UniProtKB/SwissProt
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h... |
J Med Chem 25: 207-10 (1982)
Article DOI: 10.1021/jm00345a002 BindingDB Entry DOI: 10.7270/Q2HH6M8R |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50315205
 ((R)-2-(6-fluoro-3-(1-(3-methoxypyrazin-2-yl)ethyl)...)Show SMILES COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(F)ccc12 Show InChI InChI=1S/C20H24FN3O/c1-13(19-20(25-4)23-9-8-22-19)18-14(7-10-24(2)3)11-15-12-16(21)5-6-17(15)18/h5-6,8-9,12-13H,7,10-11H2,1-4H3/t13-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences
Curated by ChEMBL
| Assay Description Inhibition of H2 receptor |
Bioorg Med Chem Lett 20: 5874-8 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.117 BindingDB Entry DOI: 10.7270/Q26W9BDC |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50445613
 (ASENAPINE MALEATE | Asenapine maleate | CHEBI:7124...)Show SMILES CN1C[C@@H]2[C@@H](C1)c1cc(Cl)ccc1Oc1ccccc21 Show InChI InChI=1S/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3/t14-,15-/m0/s1 | Reactome pathway KEGG
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| 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024 BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50445613
 (ASENAPINE MALEATE | Asenapine maleate | CHEBI:7124...)Show SMILES CN1C[C@@H]2[C@@H](C1)c1cc(Cl)ccc1Oc1ccccc21 Show InChI InChI=1S/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3/t14-,15-/m0/s1 | Reactome pathway KEGG
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| 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024 BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50404822
 (CHEMBL8982)Show InChI InChI=1S/C12H19N5O2S2/c1-17(2)7-9-3-4-10(19-9)8-20-6-5-14-12-11(13)15-21(18)16-12/h3-4H,5-8H2,1-2H3,(H2,13,15)(H,14,16) | UniProtKB/SwissProt
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| 6.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h... |
J Med Chem 25: 207-10 (1982)
Article DOI: 10.1021/jm00345a002 BindingDB Entry DOI: 10.7270/Q2HH6M8R |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50404823
 (CHEMBL63299)Show InChI InChI=1S/C12H19N5O3S2/c1-17(2)7-9-3-4-10(20-9)8-21-6-5-14-12-11(13)15-22(18,19)16-12/h3-4H,5-8H2,1-2H3,(H2,13,15)(H,14,16) | UniProtKB/SwissProt
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| 6.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h... |
J Med Chem 25: 207-10 (1982)
Article DOI: 10.1021/jm00345a002 BindingDB Entry DOI: 10.7270/Q2HH6M8R |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86740
 (UR-AK24 | UR-AK57)Show InChI InChI=1S/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23) | UniProtKB/SwissProt
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22891
 (3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-y...)Show InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14) | UniProtKB/SwissProt
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0 BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86740
 (UR-AK24 | UR-AK57)Show InChI InChI=1S/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23) | UniProtKB/SwissProt
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86742
 (UR-AK64)Show InChI InChI=1S/C17H29N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h12-14H,1-11H2,(H,19,21)(H3,18,20,22,23) | UniProtKB/SwissProt
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(RAT) | BDBM7966
 (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | KEGG
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Italia
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 352: 276-82 (1995)
BindingDB Entry DOI: 10.7270/Q2Q52N48 |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM22568
 (1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-...)Show InChI InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18) | Reactome pathway KEGG
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Broad Institute of MIT and Harvard
Curated by ChEMBL
| Assay Description Displacement of [125I]Aminopotentidine from human recombinant histamine H2 receptor expressed in CHOK1 cells after 2 hrs |
Bioorg Med Chem Lett 23: 1834-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.025 BindingDB Entry DOI: 10.7270/Q2P55PWC |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86747
 (UR-AK67)Show InChI InChI=1S/C17H23N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,19,21)(H3,18,20,22,23) | UniProtKB/SwissProt
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86738
 (UR-AK46)Show InChI InChI=1S/C14H23N5O/c15-14(17-8-4-7-12-9-16-10-18-12)19-13(20)11-5-2-1-3-6-11/h9-11H,1-8H2,(H,16,18)(H3,15,17,19,20) | UniProtKB/SwissProt
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86743
 (UR-AK49)Show InChI InChI=1S/C16H27N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,18,20)(H3,17,19,21,22) | UniProtKB/SwissProt
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| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86742
 (UR-AK64)Show InChI InChI=1S/C17H29N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h12-14H,1-11H2,(H,19,21)(H3,18,20,22,23) | Reactome pathway KEGG
UniProtKB/SwissProt
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86744
 (UR-AK62)Show InChI InChI=1S/C15H25N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h10-12H,1-9H2,(H,17,19)(H3,16,18,20,21) | UniProtKB/SwissProt
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86740
 (UR-AK24 | UR-AK57)Show InChI InChI=1S/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23) | Reactome pathway KEGG
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86745
 (UR-AK51)Show InChI InChI=1S/C16H21N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-10H2,(H,18,20)(H3,17,19,21,22) | UniProtKB/SwissProt
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86736
 (UR-AK68)Show InChI InChI=1S/C16H21N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,18,20)(H3,17,19,21,22) | UniProtKB/SwissProt
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22568
 (1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-...)Show InChI InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18) | UniProtKB/SwissProt
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Evaluated in vitro for Histamine H2 receptor inhibition using the dimaprit stimulated chronotropic response of the guinea pig atrium |
J Med Chem 26: 140-4 (1983)
Article DOI: 10.1021/jm00356a005 BindingDB Entry DOI: 10.7270/Q2R212KZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22568
 (1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-...)Show InChI InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18) | UniProtKB/SwissProt
GoogleScholar AffyNet 
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0 BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86741
 (UR-AK59)Show InChI InChI=1S/C16H27N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h10-13H,2-9H2,1H3,(H,18,20)(H3,17,19,21,22) | UniProtKB/SwissProt
GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86738
 (UR-AK46)Show InChI InChI=1S/C14H23N5O/c15-14(17-8-4-7-12-9-16-10-18-12)19-13(20)11-5-2-1-3-6-11/h9-11H,1-8H2,(H,16,18)(H3,15,17,19,20) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86743
 (UR-AK49)Show InChI InChI=1S/C16H27N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,18,20)(H3,17,19,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86737
 (UR-AK22)Show InChI InChI=1S/C18H25N5O/c19-18(21-12-6-10-16-13-20-14-22-16)23-17(24)11-5-4-9-15-7-2-1-3-8-15/h1-3,7-8,13-14H,4-6,9-12H2,(H,20,22)(H3,19,21,23,24) | UniProtKB/SwissProt
GoogleScholar AffyNet 
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Similars
| Article PubMed
| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86744
 (UR-AK62)Show InChI InChI=1S/C15H25N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h10-12H,1-9H2,(H,17,19)(H3,16,18,20,21) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22884
 (2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H...)Show InChI InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18) | UniProtKB/SwissProt
GoogleScholar AffyNet 
| PC cid PC sid UniChem
Patents
| Article PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0 BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86740
 (UR-AK24 | UR-AK57)Show InChI InChI=1S/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86747
 (UR-AK67)Show InChI InChI=1S/C17H23N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,19,21)(H3,18,20,22,23) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50403559
 (Brumetadina | CIMETIDINE)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024 BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50403559
 (Brumetadina | CIMETIDINE)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024 BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86737
 (UR-AK22)Show InChI InChI=1S/C18H25N5O/c19-18(21-12-6-10-16-13-20-14-22-16)23-17(24)11-5-4-9-15-7-2-1-3-8-15/h1-3,7-8,13-14H,4-6,9-12H2,(H,20,22)(H3,19,21,23,24) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86736
 (UR-AK68)Show InChI InChI=1S/C16H21N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,18,20)(H3,17,19,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86735
 (UR-AK26)Show InChI InChI=1S/C15H19N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h1-3,5-6,10-11H,4,7-9H2,(H,17,19)(H3,16,18,20,21) | UniProtKB/SwissProt
GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50445616
 (CHEMBL3104091)Show InChI InChI=1S/C20H20N2/c1-21-12-11-19-17(13-21)16-7-4-6-15-10-9-14-5-2-3-8-18(14)22(19)20(15)16/h2-8H,9-13H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024 BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50445616
 (CHEMBL3104091)Show InChI InChI=1S/C20H20N2/c1-21-12-11-19-17(13-21)16-7-4-6-15-10-9-14-5-2-3-8-18(14)22(19)20(15)16/h2-8H,9-13H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024 BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86741
 (UR-AK59)Show InChI InChI=1S/C16H27N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h10-13H,2-9H2,1H3,(H,18,20)(H3,17,19,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 99 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM7966
 (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | UniProtKB/SwissProt
GoogleScholar AffyNet 
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CHEMBL DrugBank MMDB PC cid PC sid UniChem
Patents
Similars
| PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's Medical Centre
Curated by PDSP Ki Database
| |
Biochem Soc Trans 20: 122-5 (1992)
BindingDB Entry DOI: 10.7270/Q2RX99KH |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86745
 (UR-AK51)Show InChI InChI=1S/C16H21N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-10H2,(H,18,20)(H3,17,19,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50403559
 (Brumetadina | CIMETIDINE)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena
Curated by ChEMBL
| Assay Description Binding affinity to human histamine H2 receptor by radioligand displacement assay |
Eur J Med Chem 63: 85-94 (2013)
Article DOI: 10.1016/j.ejmech.2013.01.044 BindingDB Entry DOI: 10.7270/Q2JH3NKC |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM86735
 (UR-AK26)Show InChI InChI=1S/C15H19N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h1-3,5-6,10-11H,4,7-9H2,(H,17,19)(H3,16,18,20,21) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars
| Article PubMed
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50400902
 (1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)Show InChI InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity to human histamine H2 receptor |
J Med Chem 54: 3206-21 (2011)
Article DOI: 10.1021/jm101459g BindingDB Entry DOI: 10.7270/Q2W37XFC |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50404962
 (CHEMBL33850)Show SMILES CNC([CH-][N+]([O-])=O)=[NH+]c1cccc(c1)-c1csc(N=C(N)N)n1 Show InChI InChI=1S/C13H14N7O2S/c1-16-11(6-20(21)22)17-9-4-2-3-8(5-9)10-7-23-13(18-10)19-12(14)15/h2-7H,1H3,(H,16,17)(H4,14,15,18,19)/q-1/p+1 | UniProtKB/SwissProt
GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Evaluated in vitro for Histamine H2 receptor inhibition using the dimaprit stimulated chronotropic response of the guinea pig atrium |
J Med Chem 26: 140-4 (1983)
Article DOI: 10.1021/jm00356a005 BindingDB Entry DOI: 10.7270/Q2R212KZ |
More data for this Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (human)) | BDBM50119736
 (4-Bromo-N-{(S)-1-[3-(4-cyclopropanecarbonyl-phenox...)Show SMILES Brc1ccc(cc1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C23H27BrN2O4S/c24-19-6-10-22(11-7-19)31(28,29)25-20-12-14-26(16-20)13-1-15-30-21-8-4-18(5-9-21)23(27)17-2-3-17/h4-11,17,20,25H,1-3,12-16H2/t20-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to the human Histamine H2 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
Article DOI: 10.1016/s0960-894x(02)00685-6 BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this Ligand-Target Pair | |