Found 990 hits Enz. Inhib. hit(s) with Target = 'Histamine H2 receptor' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM81543
(Alpha-Dimethylhistane-alpha | CAS_195960 | NSC_195...)Show InChI InChI=1/C7H13N3/c1-6(8-2)3-7-4-9-5-10-7/h4-6,8H,3H2,1-2H3,(H,9,10) | UniProtKB/SwissProt
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's Medical Centre
Curated by PDSP Ki Database
| |
Biochem Soc Trans 20: 122-5 (1992)
Article DOI: 10.1042/bst0200122
BindingDB Entry DOI: 10.7270/Q2RX99KH |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM81541
(CAS_195530 | NSC_195530 | S-Beta-Dimethylhistamine...)Show InChI InChI=1/C7H13N3/c1-5(6(2)8)7-3-9-4-10-7/h3-6H,8H2,1-2H3,(H,9,10) | UniProtKB/SwissProt
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's Medical Centre
Curated by PDSP Ki Database
| |
Biochem Soc Trans 20: 122-5 (1992)
Article DOI: 10.1042/bst0200122
BindingDB Entry DOI: 10.7270/Q2RX99KH |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50406642
(CHEMBL72193)Show SMILES Nc1ccc(cc1I)C(=O)NCCNC(NCCCOc1cccc(CN2CCCCC2)c1)=NC#N Show InChI InChI=1S/C26H34IN7O2/c27-23-17-21(8-9-24(23)29)25(35)30-11-12-32-26(33-19-28)31-10-5-15-36-22-7-4-6-20(16-22)18-34-13-2-1-3-14-34/h4,6-9,16-17H,1-3,5,10-15,18,29H2,(H,30,35)(H2,31,32,33) | UniProtKB/SwissProt
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| 0.708 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin
Curated by ChEMBL
| Assay Description
Inhibition of [125I]APT binding to histamine H2 receptor in guinea pig cerebral membranes. |
J Med Chem 35: 2231-8 (1992)
Article DOI: 10.1021/jm00090a013
BindingDB Entry DOI: 10.7270/Q23T9JFP |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM81542
(Beta-Methylhistamine | CAS_565544 | NSC_565544)Show InChI InChI=1/C6H11N3/c1-5(2-7)6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9) | UniProtKB/SwissProt
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| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's Medical Centre
Curated by PDSP Ki Database
| |
Biochem Soc Trans 20: 122-5 (1992)
Article DOI: 10.1042/bst0200122
BindingDB Entry DOI: 10.7270/Q2RX99KH |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22904
((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)Show InChI InChI=1/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/s2 | UniProtKB/SwissProt
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| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's Medical Centre
Curated by PDSP Ki Database
| |
Biochem Soc Trans 20: 122-5 (1992)
Article DOI: 10.1042/bst0200122
BindingDB Entry DOI: 10.7270/Q2RX99KH |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM50253754
(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)Show SMILES CNC(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C28H31ClN2O2/c1-30-26(32)28(23-8-4-2-5-9-23,24-10-6-3-7-11-24)18-21-31-19-16-27(33,17-20-31)22-12-14-25(29)15-13-22/h2-15,33H,16-21H2,1H3,(H,30,32) | Reactome pathway
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| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health
Curated by ChEMBL
| Assay Description
Displacement of [3H]tiotidine from human histamine H2 receptor |
J Med Chem 51: 6034-43 (2008)
Article DOI: 10.1021/jm800510m
BindingDB Entry DOI: 10.7270/Q2BV7GFM |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50406643
(CHEMBL73994)Show SMILES Ic1cccc(c1)C(=O)NCCNC(NCCCOc1cccc(CN2CCCCC2)c1)=NC#N Show InChI InChI=1S/C26H33IN6O2/c27-23-9-5-8-22(18-23)25(34)29-12-13-31-26(32-20-28)30-11-6-16-35-24-10-4-7-21(17-24)19-33-14-2-1-3-15-33/h4-5,7-10,17-18H,1-3,6,11-16,19H2,(H,29,34)(H2,30,31,32) | UniProtKB/SwissProt
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| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin
Curated by ChEMBL
| Assay Description
Inhibition of [125I]APT binding to H2 receptors in guinea pig cerebral membranes. |
J Med Chem 35: 2231-8 (1992)
Article DOI: 10.1021/jm00090a013
BindingDB Entry DOI: 10.7270/Q23T9JFP |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50404821
(CHEMBL306465)Show InChI InChI=1/C17H25N5O2S/c18-16-17(21-25(23)20-16)19-8-5-11-24-15-7-4-6-14(12-15)13-22-9-2-1-3-10-22/h4,6-7,12H,1-3,5,8-11,13H2,(H2,18,20)(H,19,21) | UniProtKB/SwissProt
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h... |
J Med Chem 25: 207-10 (1982)
Article DOI: 10.1021/jm00345a002
BindingDB Entry DOI: 10.7270/Q2HH6M8R |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM50315205
((R)-2-(6-fluoro-3-(1-(3-methoxypyrazin-2-yl)ethyl)...)Show SMILES COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(F)ccc12 Show InChI InChI=1/C20H24FN3O/c1-13(19-20(25-4)23-9-8-22-19)18-14(7-10-24(2)3)11-15-12-16(21)5-6-17(15)18/h5-6,8-9,12-13H,7,10-11H2,1-4H3/t13-/s2 | Reactome pathway
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| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc
Curated by ChEMBL
| Assay Description
Inhibition of H2 receptor |
Bioorg Med Chem Lett 20: 5874-8 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.117
BindingDB Entry DOI: 10.7270/Q26W9BDC |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50229612
(CHEMBL304608)Show SMILES Ic1cccc(c1)C(=O)NCC\N=C(\NCCCCOc1cccc(CN2CCCCC2)c1)NC#N Show InChI InChI=1S/C27H35IN6O2/c28-24-10-7-9-23(19-24)26(35)30-13-14-32-27(33-21-29)31-12-2-5-17-36-25-11-6-8-22(18-25)20-34-15-3-1-4-16-34/h6-11,18-19H,1-5,12-17,20H2,(H,30,35)(H2,31,32,33) | UniProtKB/SwissProt
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| 5.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin
Curated by ChEMBL
| Assay Description
Inhibition of [125I]APT binding to H2 receptors in guinea pig cerebral membranes. |
J Med Chem 35: 2231-8 (1992)
Article DOI: 10.1021/jm00090a013
BindingDB Entry DOI: 10.7270/Q23T9JFP |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50229613
(ICI-125211 | TIOTIDINE | Tiotidine)Show InChI InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18) | UniProtKB/SwissProt
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| 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin
Curated by ChEMBL
| Assay Description
Inhibition of [125I]APT binding to H2 receptors in guinea pig cerebral membranes. |
J Med Chem 35: 2231-8 (1992)
Article DOI: 10.1021/jm00090a013
BindingDB Entry DOI: 10.7270/Q23T9JFP |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM50445613
(ASENAPINE MALEATE | Asenapine maleate | CHEBI:7124...)Show SMILES CN1C[C@@H]2[C@@H](C1)c1cc(Cl)ccc1Oc1ccccc21 Show InChI InChI=1/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3/t14-,15-/s2 | Reactome pathway
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| 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description
Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024
BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM50445613
(ASENAPINE MALEATE | Asenapine maleate | CHEBI:7124...)Show SMILES CN1C[C@@H]2[C@@H](C1)c1cc(Cl)ccc1Oc1ccccc21 Show InChI InChI=1/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3/t14-,15-/s2 | Reactome pathway
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| 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description
Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024
BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50404822
(CHEMBL8982)Show InChI InChI=1/C12H19N5O2S2/c1-17(2)7-9-3-4-10(19-9)8-20-6-5-14-12-11(13)15-21(18)16-12/h3-4H,5-8H2,1-2H3,(H2,13,15)(H,14,16) | UniProtKB/SwissProt
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| 6.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h... |
J Med Chem 25: 207-10 (1982)
Article DOI: 10.1021/jm00345a002
BindingDB Entry DOI: 10.7270/Q2HH6M8R |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50404823
(CHEMBL63299)Show InChI InChI=1S/C12H19N5O3S2/c1-17(2)7-9-3-4-10(20-9)8-21-6-5-14-12-11(13)15-22(18,19)16-12/h3-4H,5-8H2,1-2H3,(H2,13,15)(H,14,16) | UniProtKB/SwissProt
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| 6.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h... |
J Med Chem 25: 207-10 (1982)
Article DOI: 10.1021/jm00345a002
BindingDB Entry DOI: 10.7270/Q2HH6M8R |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86740
(UR-AK24 | UR-AK57)Show InChI InChI=1/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23) | UniProtKB/SwissProt
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50406645
(AMINOPOTENTIDINE)Show SMILES Nc1ccc(cc1)C(=O)NCCNC(NCCCOc1cccc(CN2CCCCC2)c1)=NC#N Show InChI InChI=1S/C26H35N7O2/c27-20-32-26(31-14-13-29-25(34)22-8-10-23(28)11-9-22)30-12-5-17-35-24-7-4-6-21(18-24)19-33-15-2-1-3-16-33/h4,6-11,18H,1-3,5,12-17,19,28H2,(H,29,34)(H2,30,31,32) | UniProtKB/SwissProt
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| 9.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin
Curated by ChEMBL
| Assay Description
muscarinic acetylcholine receptor M3-antagonistic activity on the isolated guinea pig ileum determined by Schild plot. |
J Med Chem 35: 2231-8 (1992)
Article DOI: 10.1021/jm00090a013
BindingDB Entry DOI: 10.7270/Q23T9JFP |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50406644
(CHEMBL307952)Show SMILES Ic1cc(ccc1N=[N+]=[N-])C(=O)NCCNC(NCCCOc1cccc(CN2CCCCC2)c1)=NC#N Show InChI InChI=1S/C26H32IN9O2/c27-23-17-21(8-9-24(23)34-35-29)25(37)30-11-12-32-26(33-19-28)31-10-5-15-38-22-7-4-6-20(16-22)18-36-13-2-1-3-14-36/h4,6-9,16-17H,1-3,5,10-15,18H2,(H,30,37)(H2,31,32,33) | UniProtKB/SwissProt
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin
Curated by ChEMBL
| Assay Description
Inhibition of [125I]APT binding to histamine H2 receptor in guinea pig cerebral membranes. |
J Med Chem 35: 2231-8 (1992)
Article DOI: 10.1021/jm00090a013
BindingDB Entry DOI: 10.7270/Q23T9JFP |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86740
(UR-AK24 | UR-AK57)Show InChI InChI=1/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23) | UniProtKB/SwissProt
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22891
(3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-y...)Show InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14) | UniProtKB/SwissProt
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86742
(UR-AK64)Show InChI InChI=1S/C17H29N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h12-14H,1-11H2,(H,19,21)(H3,18,20,22,23) | UniProtKB/SwissProt
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(RAT) | BDBM7966
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | KEGG
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Italia
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 352: 276-82 (1995)
Article DOI: 10.1007/bf00168557
BindingDB Entry DOI: 10.7270/Q2Q52N48 |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM22568
(1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-...)Show InChI InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18) | Reactome pathway
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Broad Institute of MIT and Harvard
Curated by ChEMBL
| Assay Description
Displacement of [125I]Aminopotentidine from human recombinant histamine H2 receptor expressed in CHOK1 cells after 2 hrs |
Bioorg Med Chem Lett 23: 1834-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.025
BindingDB Entry DOI: 10.7270/Q2P55PWC |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86747
(UR-AK67)Show InChI InChI=1S/C17H23N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,19,21)(H3,18,20,22,23) | UniProtKB/SwissProt
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86738
(UR-AK46)Show InChI InChI=1S/C14H23N5O/c15-14(17-8-4-7-12-9-16-10-18-12)19-13(20)11-5-2-1-3-6-11/h9-11H,1-8H2,(H,16,18)(H3,15,17,19,20) | UniProtKB/SwissProt
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86743
(UR-AK49)Show InChI InChI=1S/C16H27N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,18,20)(H3,17,19,21,22) | UniProtKB/SwissProt
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| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86744
(UR-AK62)Show InChI InChI=1S/C15H25N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h10-12H,1-9H2,(H,17,19)(H3,16,18,20,21) | UniProtKB/SwissProt
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86745
(UR-AK51)Show InChI InChI=1S/C16H21N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-10H2,(H,18,20)(H3,17,19,21,22) | UniProtKB/SwissProt
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM86742
(UR-AK64)Show InChI InChI=1S/C17H29N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h12-14H,1-11H2,(H,19,21)(H3,18,20,22,23) | Reactome pathway
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM86740
(UR-AK24 | UR-AK57)Show InChI InChI=1/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23) | Reactome pathway
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86736
(UR-AK68)Show InChI InChI=1/C16H21N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,18,20)(H3,17,19,21,22) | UniProtKB/SwissProt
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22568
(1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-...)Show InChI InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18) | UniProtKB/SwissProt
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Evaluated in vitro for Histamine H2 receptor inhibition using the dimaprit stimulated chronotropic response of the guinea pig atrium |
J Med Chem 26: 140-4 (1983)
Article DOI: 10.1021/jm00356a005
BindingDB Entry DOI: 10.7270/Q2R212KZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22568
(1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-...)Show InChI InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18) | UniProtKB/SwissProt
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| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86741
(UR-AK59)Show InChI InChI=1/C16H27N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h10-13H,2-9H2,1H3,(H,18,20)(H3,17,19,21,22) | UniProtKB/SwissProt
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| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM86738
(UR-AK46)Show InChI InChI=1S/C14H23N5O/c15-14(17-8-4-7-12-9-16-10-18-12)19-13(20)11-5-2-1-3-6-11/h9-11H,1-8H2,(H,16,18)(H3,15,17,19,20) | Reactome pathway
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| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM86743
(UR-AK49)Show InChI InChI=1S/C16H27N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,18,20)(H3,17,19,21,22) | Reactome pathway
KEGG
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| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM50103506
(RANITIDINE | Ranitidine | Tritec | Zantac)Show InChI InChI=1S/C13H22N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3/b13-9+ | UniProtKB/SwissProt
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| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin
Curated by ChEMBL
| Assay Description
Inhibition of [125I]APT binding to histamine H2 receptor in guinea pig cerebral membranes. |
J Med Chem 35: 2231-8 (1992)
Article DOI: 10.1021/jm00090a013
BindingDB Entry DOI: 10.7270/Q23T9JFP |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86737
(UR-AK22)Show InChI InChI=1S/C18H25N5O/c19-18(21-12-6-10-16-13-20-14-22-16)23-17(24)11-5-4-9-15-7-2-1-3-8-15/h1-3,7-8,13-14H,4-6,9-12H2,(H,20,22)(H3,19,21,23,24) | UniProtKB/SwissProt
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| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM86744
(UR-AK62)Show InChI InChI=1S/C15H25N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h10-12H,1-9H2,(H,17,19)(H3,16,18,20,21) | Reactome pathway
KEGG
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| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22884
(2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H...)Show InChI InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18) | UniProtKB/SwissProt
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| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM86747
(UR-AK67)Show InChI InChI=1S/C17H23N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,19,21)(H3,18,20,22,23) | Reactome pathway
KEGG
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| 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM86740
(UR-AK24 | UR-AK57)Show InChI InChI=1/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23) | Reactome pathway
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| 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM50403559
(Brumetadina | CIMETIDINE)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | Reactome pathway
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| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description
Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024
BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM50403559
(Brumetadina | CIMETIDINE)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | Reactome pathway
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| 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description
Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024
BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM86737
(UR-AK22)Show InChI InChI=1S/C18H25N5O/c19-18(21-12-6-10-16-13-20-14-22-16)23-17(24)11-5-4-9-15-7-2-1-3-8-15/h1-3,7-8,13-14H,4-6,9-12H2,(H,20,22)(H3,19,21,23,24) | Reactome pathway
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| 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM86736
(UR-AK68)Show InChI InChI=1/C16H21N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,18,20)(H3,17,19,21,22) | Reactome pathway
KEGG
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| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86735
(UR-AK26)Show InChI InChI=1S/C15H19N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h1-3,5-6,10-11H,4,7-9H2,(H,17,19)(H3,16,18,20,21) | UniProtKB/SwissProt
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| 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM50445616
(CHEMBL3104091)Show InChI InChI=1S/C20H20N2/c1-21-12-11-19-17(13-21)16-7-4-6-15-10-9-14-5-2-3-8-18(14)22(19)20(15)16/h2-8H,9-13H2,1H3 | Reactome pathway
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| 81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description
Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024
BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM50445616
(CHEMBL3104091)Show InChI InChI=1S/C20H20N2/c1-21-12-11-19-17(13-21)16-7-4-6-15-10-9-14-5-2-3-8-18(14)22(19)20(15)16/h2-8H,9-13H2,1H3 | Reactome pathway
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UniChem
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PubMed
| 81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Missouri
Curated by ChEMBL
| Assay Description
Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin) |
Bioorg Med Chem Lett 24: 576-9 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.024
BindingDB Entry DOI: 10.7270/Q2MS3V7R |
More data for this
Ligand-Target Pair | |
Histamine H2 Receptor
(Homo sapiens (Human)) | BDBM86741
(UR-AK59)Show InChI InChI=1/C16H27N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h10-13H,2-9H2,1H3,(H,18,20)(H3,17,19,21,22) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 99 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 1262-8 (2006)
Article DOI: 10.1124/jpet.106.102897
BindingDB Entry DOI: 10.7270/Q2X63KHZ |
More data for this
Ligand-Target Pair | |
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