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Found 97 hits Enz. Inhib. hit(s) with Target = 'Histamine H2 receptor' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H2 receptor


(RAT)
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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17n/an/an/an/an/an/an/an/a



Boehringer Ingelheim Italia

Curated by PDSP Ki Database




Naunyn Schmiedebergs Arch Pharmacol 352: 276-82 (1995)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Pudue Pharma Discovery Research

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50094703
PNG
(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Show SMILES Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 295: 1156-64 (2000)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026279
PNG
(3-{2-[2-(2-tert-Butoxycarbonylamino-propionylamino...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C29H42N6O8/c1-15(2)11-21(26(40)33-20(24(30)38)13-23(36)37)35-27(41)22(12-17-14-31-19-10-8-7-9-18(17)19)34-25(39)16(3)32-28(42)43-29(4,5)6/h7-10,14-16,20-22,31H,11-13H2,1-6H3,(H2,30,38)(H,32,42)(H,33,40)(H,34,39)(H,35,41)(H,36,37)/t16-,20-,21-,22-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026288
PNG
(3-{2-[2-(2-tert-Butoxycarbonylamino-propionylamino...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C28H40N6O8S/c1-15(31-27(41)42-28(2,3)4)24(38)34-21(12-16-14-30-18-9-7-6-8-17(16)18)26(40)32-19(10-11-43-5)25(39)33-20(23(29)37)13-22(35)36/h6-9,14-15,19-21,30H,10-13H2,1-5H3,(H2,29,37)(H,31,41)(H,32,40)(H,33,39)(H,34,38)(H,35,36)/t15-,19-,20-,21-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026297
PNG
(4-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCC(O)=O)C(N)=O
Show InChI InChI=1S/C27H39N5O7/c1-15(2)12-20(24(36)30-19(23(28)35)10-11-22(33)34)31-25(37)21(32-26(38)39-27(3,4)5)13-16-14-29-18-9-7-6-8-17(16)18/h6-9,14-15,19-21,29H,10-13H2,1-5H3,(H2,28,35)(H,30,36)(H,31,37)(H,32,38)(H,33,34)/t19-,20-,21-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026298
PNG
(3-{2-[2-(2-tert-Butoxycarbonylamino-acetylamino)-3...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C27H38N6O8S/c1-27(2,3)41-26(40)30-14-21(34)31-20(11-15-13-29-17-8-6-5-7-16(15)17)25(39)32-18(9-10-42-4)24(38)33-19(23(28)37)12-22(35)36/h5-8,13,18-20,29H,9-12,14H2,1-4H3,(H2,28,37)(H,30,40)(H,31,34)(H,32,39)(H,33,38)(H,35,36)/t18-,19-,20-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026282
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C29H35N5O7/c1-29(2,3)41-28(40)34-23(14-18-16-31-20-12-8-7-11-19(18)20)27(39)33-22(13-17-9-5-4-6-10-17)26(38)32-21(25(30)37)15-24(35)36/h4-12,16,21-23,31H,13-15H2,1-3H3,(H2,30,37)(H,32,38)(H,33,39)(H,34,40)(H,35,36)/t21-,22-,23-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026283
PNG
(1-(2-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCCC[C@H]1C(O)=O
Show InChI InChI=1S/C32H45N5O9/c1-18(2)14-22(27(40)35-24(16-26(38)39)29(42)37-13-9-8-12-25(37)30(43)44)34-28(41)23(36-31(45)46-32(3,4)5)15-19-17-33-21-11-7-6-10-20(19)21/h6-7,10-11,17-18,22-25,33H,8-9,12-16H2,1-5H3,(H,34,41)(H,35,40)(H,36,45)(H,38,39)(H,43,44)/t22-,23-,24-,25-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026284
PNG
(2-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C26H36N4O8/c1-14(2)10-18(22(33)29-20(24(35)36)12-21(31)32)28-23(34)19(30-25(37)38-26(3,4)5)11-15-13-27-17-9-7-6-8-16(15)17/h6-9,13-14,18-20,27H,10-12H2,1-5H3,(H,28,34)(H,29,33)(H,30,37)(H,31,32)(H,35,36)/t18-,19-,20-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026286
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C26H37N5O7/c1-5-6-10-18(23(35)30-19(22(27)34)13-21(32)33)29-24(36)20(31-25(37)38-26(2,3)4)12-15-14-28-17-11-8-7-9-16(15)17/h7-9,11,14,18-20,28H,5-6,10,12-13H2,1-4H3,(H2,27,34)(H,29,36)(H,30,35)(H,31,37)(H,32,33)/t18-,19-,20-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026299
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C25H35N5O7S/c1-25(2,3)37-24(36)30-19(11-14-13-27-16-8-6-5-7-15(14)16)23(35)28-17(9-10-38-4)22(34)29-18(21(26)33)12-20(31)32/h5-8,13,17-19,27H,9-12H2,1-4H3,(H2,26,33)(H,28,35)(H,29,34)(H,30,36)(H,31,32)/t17-,18-,19-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026291
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C26H37N5O7/c1-14(2)10-19(23(35)29-18(22(27)34)12-21(32)33)30-24(36)20(31-25(37)38-26(3,4)5)11-15-13-28-17-9-7-6-8-16(15)17/h6-9,13-14,18-20,28H,10-12H2,1-5H3,(H2,27,34)(H,29,35)(H,30,36)(H,31,37)(H,32,33)/t18-,19+,20+/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026295
PNG
(3-{2-[2-Benzyloxycarbonylamino-3-(1H-indol-3-yl)-p...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C29H35N5O7/c1-17(2)12-23(27(38)32-22(26(30)37)14-25(35)36)33-28(39)24(13-19-15-31-21-11-7-6-10-20(19)21)34-29(40)41-16-18-8-4-3-5-9-18/h3-11,15,17,22-24,31H,12-14,16H2,1-2H3,(H2,30,37)(H,32,38)(H,33,39)(H,34,40)(H,35,36)/t22-,23-,24-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50367238
PNG
(CHEMBL1790763)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C26H37N5O7/c1-6-14(2)21(24(36)29-18(22(27)34)12-20(32)33)31-23(35)19(30-25(37)38-26(3,4)5)11-15-13-28-17-10-8-7-9-16(15)17/h7-10,13-14,18-19,21,28H,6,11-12H2,1-5H3,(H2,27,34)(H,29,36)(H,30,37)(H,31,35)(H,32,33)/t14-,18-,19-,21-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026296
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)CC(NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C26H37N5O7/c1-14(2)10-19(23(35)29-18(22(27)34)12-21(32)33)30-24(36)20(31-25(37)38-26(3,4)5)11-15-13-28-17-9-7-6-8-16(15)17/h6-9,13-14,18-20,28H,10-12H2,1-5H3,(H2,27,34)(H,29,35)(H,30,36)(H,31,37)(H,32,33)/t18-,19?,20-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026292
PNG
(2-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O
Show InChI InChI=1S/C26H37N5O7/c1-14(2)10-18(22(33)30-20(24(35)36)12-21(27)32)29-23(34)19(31-25(37)38-26(3,4)5)11-15-13-28-17-9-7-6-8-16(15)17/h6-9,13-14,18-20,28H,10-12H2,1-5H3,(H2,27,32)(H,29,34)(H,30,33)(H,31,37)(H,35,36)/t18-,19-,20-/m0/s1
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n/an/a 7.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026280
PNG
(2-{2-[2-(2-tert-Butoxycarbonylamino-propionylamino...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O
Show InChI InChI=1S/C29H42N6O8/c1-15(2)11-20(25(38)35-22(27(40)41)13-23(30)36)34-26(39)21(12-17-14-31-19-10-8-7-9-18(17)19)33-24(37)16(3)32-28(42)43-29(4,5)6/h7-10,14-16,20-22,31H,11-13H2,1-6H3,(H2,30,36)(H,32,42)(H,33,37)(H,34,39)(H,35,38)(H,40,41)/t16-,20-,21-,22-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026290
PNG
(3-{2-[2-(2-tert-Butoxycarbonylamino-propionylamino...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C29H42N6O8/c1-6-7-11-20(26(40)34-21(24(30)38)14-23(36)37)33-27(41)22(13-17-15-31-19-12-9-8-10-18(17)19)35-25(39)16(2)32-28(42)43-29(3,4)5/h8-10,12,15-16,20-22,31H,6-7,11,13-14H2,1-5H3,(H2,30,38)(H,32,42)(H,33,41)(H,34,40)(H,35,39)(H,36,37)/t16-,20-,21-,22-/m0/s1
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n/an/a 7.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026281
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N(C)C
Show InChI InChI=1S/C28H41N5O7/c1-16(2)12-20(24(36)31-22(14-23(34)35)26(38)33(6)7)30-25(37)21(32-27(39)40-28(3,4)5)13-17-15-29-19-11-9-8-10-18(17)19/h8-11,15-16,20-22,29H,12-14H2,1-7H3,(H,30,37)(H,31,36)(H,32,39)(H,34,35)/t20-,21-,22-/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026293
PNG
(3-({1-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C25H33N5O7/c1-25(2,3)37-24(36)29-18(11-14-13-27-16-8-5-4-7-15(14)16)23(35)30-10-6-9-19(30)22(34)28-17(21(26)33)12-20(31)32/h4-5,7-8,13,17-19,27H,6,9-12H2,1-3H3,(H2,26,33)(H,28,34)(H,29,36)(H,31,32)/t17-,18-,19-/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026294
PNG
(CHEMBL329524 | [1-[1-(1-Carbamoyl-ethylcarbamoyl)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C25H37N5O5/c1-14(2)11-19(22(32)28-15(3)21(26)31)29-23(33)20(30-24(34)35-25(4,5)6)12-16-13-27-18-10-8-7-9-17(16)18/h7-10,13-15,19-20,27H,11-12H2,1-6H3,(H2,26,31)(H,28,32)(H,29,33)(H,30,34)/t15-,19-,20-/m0/s1
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n/an/a 1.50E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50144035
PNG
((S)-2-(4-Chloro-benzoylamino)-3-(1H-indol-3-yl)-pr...)
Show SMILES OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H15ClN2O3/c19-13-7-5-11(6-8-13)17(22)21-16(18(23)24)9-12-10-20-15-4-2-1-3-14(12)15/h1-8,10,16,20H,9H2,(H,21,22)(H,23,24)/t16-/m0/s1
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n/an/a 2.50E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026285
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C23H31N5O7/c1-12(20(32)27-16(19(24)31)10-18(29)30)26-21(33)17(28-22(34)35-23(2,3)4)9-13-11-25-15-8-6-5-7-14(13)15/h5-8,11-12,16-17,25H,9-10H2,1-4H3,(H2,24,31)(H,26,33)(H,27,32)(H,28,34)(H,29,30)/t12-,16-,17-/m0/s1
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n/an/a 4.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50026287
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C22H29N5O7/c1-22(2,3)34-21(33)27-16(8-12-10-24-14-7-5-4-6-13(12)14)20(32)25-11-17(28)26-15(19(23)31)9-18(29)30/h4-7,10,15-16,24H,8-9,11H2,1-3H3,(H2,23,31)(H,25,32)(H,26,28)(H,27,33)(H,29,30)/t15-,16-/m0/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50014888
PNG
(4-Benzoylamino-4-dipropylcarbamoyl-butyric acid | ...)
Show SMILES CCCN(CCC)C(=O)C(CCC(O)=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
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n/an/a 2.50E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro


J Med Chem 28: 273-8 (1985)

More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287239
PNG
(CHEMBL30656 | N-{[2-(2-Guanidino-thiazol-4-ylmethy...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(C)c2)C1=O)c1cccc(OCC(=O)NCC(=O)NCCSCc2csc(N=C(N)N)n2)c1
Show InChI InChI=1S/C35H38N10O5S2/c1-21-7-5-9-23(15-21)40-34(49)43-31-32(48)45(2)27-12-4-3-11-26(27)30(42-31)22-8-6-10-25(16-22)50-18-29(47)39-17-28(46)38-13-14-51-19-24-20-52-35(41-24)44-33(36)37/h3-12,15-16,20,31H,13-14,17-19H2,1-2H3,(H,38,46)(H,39,47)(H2,40,43,49)(H4,36,37,41,44)
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n/an/an/a 1.00E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287242
PNG
(3-(2-{3-[1-Methyl-2-oxo-3-(3-m-tolyl-ureido)-2,3-d...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(C)c2)C1=O)c1cccc(OCC(=O)NCCC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C44H51N7O6/c1-31-12-8-15-34(26-31)47-44(55)49-42-43(54)50(2)38-19-5-4-18-37(38)41(48-42)33-14-10-17-36(28-33)57-30-40(53)46-22-20-39(52)45-21-11-25-56-35-16-9-13-32(27-35)29-51-23-6-3-7-24-51/h4-5,8-10,12-19,26-28,42H,3,6-7,11,20-25,29-30H2,1-2H3,(H,45,52)(H,46,53)(H2,47,49,55)
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n/an/an/a 501n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287258
PNG
(3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-b...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(c2)C(=O)NCCCOc2cccc(CN3CCCCC3)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C39H42N6O4/c1-44-34-20-7-6-19-33(34)35(29-14-4-2-5-15-29)42-36(38(44)47)43-39(48)41-31-17-11-16-30(26-31)37(46)40-21-12-24-49-32-18-10-13-28(25-32)27-45-22-8-3-9-23-45/h2,4-7,10-11,13-20,25-26,36H,3,8-9,12,21-24,27H2,1H3,(H,40,46)(H2,41,43,48)/t36-/m0/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287236
PNG
(CHEMBL286907 | N-[2-(2-Guanidino-thiazol-4-ylmethy...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1
Show InChI InChI=1S/C36H40N10O4S2/c1-23-9-7-12-25(19-23)41-35(50)44-32-33(49)46(28-14-6-5-13-27(28)31(43-32)24-10-3-2-4-11-24)20-30(48)39-16-8-15-29(47)40-17-18-51-21-26-22-52-36(42-26)45-34(37)38/h2-7,9-14,19,22,32H,8,15-18,20-21H2,1H3,(H,39,48)(H,40,47)(H2,41,44,50)(H4,37,38,42,45)
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n/an/an/a 3.16E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287248
PNG
(CHEMBL30430 | N-[2-(2-Guanidino-thiazol-4-ylmethyl...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C32H33N9O3S2/c1-41-25-13-6-5-12-24(25)27(21-9-3-2-4-10-21)38-28(29(41)43)39-31(44)36-22-11-7-8-20(16-22)17-26(42)35-14-15-45-18-23-19-46-32(37-23)40-30(33)34/h2-13,16,19,28H,14-15,17-18H2,1H3,(H,35,42)(H2,36,39,44)(H4,33,34,37,40)/t28-/m0/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287257
PNG
(2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C40H44N6O4/c1-45-35-20-7-6-19-34(35)37(31-15-4-2-5-16-31)43-38(39(45)48)44-40(49)42-32-17-10-13-29(25-32)27-36(47)41-21-12-24-50-33-18-11-14-30(26-33)28-46-22-8-3-9-23-46/h2,4-7,10-11,13-20,25-26,38H,3,8-9,12,21-24,27-28H2,1H3,(H,41,47)(H2,42,44,49)/t38-/m0/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50403559
PNG
(Brumetadina | CIMETIDINE)
Show SMILES CNC(NCCSCc1[nH]cnc1C)=NC#N
Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
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n/an/an/a 251n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287247
PNG
(2-{3-[1-Methyl-2-oxo-3-(3-m-tolyl-ureido)-2,3-dihy...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(C)c2)C1=O)c1cccc(OCC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C41H46N6O5/c1-29-12-8-15-32(24-29)43-41(50)45-39-40(49)46(2)36-19-5-4-18-35(36)38(44-39)31-14-10-17-34(26-31)52-28-37(48)42-20-11-23-51-33-16-9-13-30(25-33)27-47-21-6-3-7-22-47/h4-5,8-10,12-19,24-26,39H,3,6-7,11,20-23,27-28H2,1-2H3,(H,42,48)(H2,43,45,50)
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n/an/an/a 5.01E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287232
PNG
(CHEMBL31726 | N-[2-(2-Guanidino-thiazol-4-ylmethyl...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(C)c2)C1=O)c1cccc(OCC(=O)NCCCC(=O)NCCSCc2csc(N=C(N)N)n2)c1
Show InChI InChI=1S/C37H42N10O5S2/c1-23-8-5-10-25(18-23)42-36(51)45-33-34(50)47(2)29-13-4-3-12-28(29)32(44-33)24-9-6-11-27(19-24)52-20-31(49)40-15-7-14-30(48)41-16-17-53-21-26-22-54-37(43-26)46-35(38)39/h3-6,8-13,18-19,22,33H,7,14-17,20-21H2,1-2H3,(H,40,49)(H,41,48)(H2,42,45,51)(H4,38,39,43,46)
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n/an/an/a 631n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287240
PNG
(6-(2-{3-[1-Methyl-2-oxo-3-(3-m-tolyl-ureido)-2,3-d...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(C)c2)C1=O)c1cccc(OCC(=O)NCCCCCC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C47H57N7O6/c1-34-15-11-18-37(29-34)50-47(58)52-45-46(57)53(2)41-22-7-6-21-40(41)44(51-45)36-17-13-20-39(31-36)60-33-43(56)49-24-8-3-5-23-42(55)48-25-14-28-59-38-19-12-16-35(30-38)32-54-26-9-4-10-27-54/h6-7,11-13,15-22,29-31,45H,3-5,8-10,14,23-28,32-33H2,1-2H3,(H,48,55)(H,49,56)(H2,50,52,58)
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n/an/an/a 631n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287252
PNG
(3-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihy...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1
Show InChI InChI=1S/C43H49N7O5/c1-31-13-10-17-34(27-31)46-43(54)48-41-42(53)50(37-20-7-6-19-36(37)40(47-41)33-15-4-2-5-16-33)30-39(52)45-23-21-38(51)44-22-12-26-55-35-18-11-14-32(28-35)29-49-24-8-3-9-25-49/h2,4-7,10-11,13-20,27-28,41H,3,8-9,12,21-26,29-30H2,1H3,(H,44,51)(H,45,52)(H2,46,48,54)
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n/an/an/a 794n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287255
PNG
(CHEMBL30821 | N-[2-(2-Guanidino-thiazol-4-ylmethyl...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C35H38N10O4S2/c1-45-27-13-6-5-12-26(27)30(23-9-3-2-4-10-23)42-31(32(45)48)43-34(49)40-24-11-7-8-22(18-24)19-29(47)38-15-14-28(46)39-16-17-50-20-25-21-51-35(41-25)44-33(36)37/h2-13,18,21,31H,14-17,19-20H2,1H3,(H,38,47)(H,39,46)(H2,40,43,49)(H4,36,37,41,44)/t31-/m0/s1
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n/an/an/a 398n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287256
PNG
(6-(2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydr...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C46H55N7O5/c1-52-40-23-9-8-22-39(40)43(36-18-5-2-6-19-36)50-44(45(52)56)51-46(57)49-37-20-13-16-34(30-37)32-42(55)48-25-10-3-7-24-41(54)47-26-15-29-58-38-21-14-17-35(31-38)33-53-27-11-4-12-28-53/h2,5-6,8-9,13-14,16-23,30-31,44H,3-4,7,10-12,15,24-29,32-33H2,1H3,(H,47,54)(H,48,55)(H2,49,51,57)/t44-/m0/s1
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n/an/an/a 631n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287241
PNG
(CHEMBL285746 | N-[2-(2-Guanidino-thiazol-4-ylmethy...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1
Show InChI InChI=1S/C32H33N9O3S2/c1-20-8-7-11-22(16-20)36-31(44)39-28-29(43)41(25-13-6-5-12-24(25)27(38-28)21-9-3-2-4-10-21)17-26(42)35-14-15-45-18-23-19-46-32(37-23)40-30(33)34/h2-13,16,19,28H,14-15,17-18H2,1H3,(H,35,42)(H2,36,39,44)(H4,33,34,37,40)
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n/an/an/a>1.00E+4n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287254
PNG
(CHEMBL281082 | N-{[2-(2-Guanidino-thiazol-4-ylmeth...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1
Show InChI InChI=1S/C34H36N10O4S2/c1-21-8-7-11-23(16-21)39-33(48)42-30-31(47)44(26-13-6-5-12-25(26)29(41-30)22-9-3-2-4-10-22)18-28(46)38-17-27(45)37-14-15-49-19-24-20-50-34(40-24)43-32(35)36/h2-13,16,20,30H,14-15,17-19H2,1H3,(H,37,45)(H,38,46)(H2,39,42,48)(H4,35,36,40,43)
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n/an/an/a 3.98E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287251
PNG
(CHEMBL262125 | N-[2-(2-Guanidino-thiazol-4-ylmethy...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C36H40N10O4S2/c1-46-28-14-6-5-13-27(28)31(24-10-3-2-4-11-24)43-32(33(46)49)44-35(50)41-25-12-7-9-23(19-25)20-30(48)39-16-8-15-29(47)40-17-18-51-21-26-22-52-36(42-26)45-34(37)38/h2-7,9-14,19,22,32H,8,15-18,20-21H2,1H3,(H,39,48)(H,40,47)(H2,41,44,50)(H4,37,38,42,45)/t32-/m0/s1
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n/an/an/a 501n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287253
PNG
(6-(2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydr...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C38H44N10O4S2/c1-48-30-16-8-7-15-29(30)33(26-12-4-2-5-13-26)45-34(35(48)51)46-37(52)43-27-14-10-11-25(21-27)22-32(50)41-18-9-3-6-17-31(49)42-19-20-53-23-28-24-54-38(44-28)47-36(39)40/h2,4-5,7-8,10-16,21,24,34H,3,6,9,17-20,22-23H2,1H3,(H,41,50)(H,42,49)(H2,43,46,52)(H4,39,40,44,47)/t34-/m0/s1
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n/an/an/a 1.00E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287237
PNG
(CHEMBL29888 | N-[2-(2-Guanidino-thiazol-4-ylmethyl...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(C)c2)C1=O)c1cccc(OCC(=O)NCCSCc2csc(N=C(N)N)n2)c1
Show InChI InChI=1S/C33H35N9O4S2/c1-20-7-5-9-22(15-20)37-32(45)40-29-30(44)42(2)26-12-4-3-11-25(26)28(39-29)21-8-6-10-24(16-21)46-17-27(43)36-13-14-47-18-23-19-48-33(38-23)41-31(34)35/h3-12,15-16,19,29H,13-14,17-18H2,1-2H3,(H,36,43)(H2,37,40,45)(H4,34,35,38,41)
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n/an/an/a 5.01E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287238
PNG
(6-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihy...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1
Show InChI InChI=1S/C46H55N7O5/c1-34-16-13-20-37(30-34)49-46(57)51-44-45(56)53(40-23-9-8-22-39(40)43(50-44)36-18-5-2-6-19-36)33-42(55)48-25-10-3-7-24-41(54)47-26-15-29-58-38-21-14-17-35(31-38)32-52-27-11-4-12-28-52/h2,5-6,8-9,13-14,16-23,30-31,44H,3-4,7,10-12,15,24-29,32-33H2,1H3,(H,47,54)(H,48,55)(H2,49,51,57)
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n/an/an/a 398n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287249
PNG
(2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro...)
Show SMILES Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1
Show InChI InChI=1S/C40H44N6O4/c1-29-13-10-17-32(25-29)42-40(49)44-38-39(48)46(35-20-7-6-19-34(35)37(43-38)31-15-4-2-5-16-31)28-36(47)41-21-12-24-50-33-18-11-14-30(26-33)27-45-22-8-3-9-23-45/h2,4-7,10-11,13-20,25-26,38H,3,8-9,12,21-24,27-28H2,1H3,(H,41,47)(H2,42,44,49)
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n/an/an/a>1.00E+4n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287243
PNG
(2-{3-[1-Methyl-2-oxo-3-(3-m-tolyl-ureido)-2,3-dihy...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(C)c2)C1=O)c1cccc(OCC(=O)NCC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C43H49N7O6/c1-30-12-8-15-33(24-30)46-43(54)48-41-42(53)49(2)37-19-5-4-18-36(37)40(47-41)32-14-10-17-35(26-32)56-29-39(52)45-27-38(51)44-20-11-23-55-34-16-9-13-31(25-34)28-50-21-6-3-7-22-50/h4-5,8-10,12-19,24-26,41H,3,6-7,11,20-23,27-29H2,1-2H3,(H,44,51)(H,45,52)(H2,46,48,54)
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n/an/an/a 501n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287234
PNG
(3-(2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydr...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C43H49N7O5/c1-49-37-20-7-6-19-36(37)40(33-15-4-2-5-16-33)47-41(42(49)53)48-43(54)46-34-17-10-13-31(27-34)29-39(52)45-23-21-38(51)44-22-12-26-55-35-18-11-14-32(28-35)30-50-24-8-3-9-25-50/h2,4-7,10-11,13-20,27-28,41H,3,8-9,12,21-26,29-30H2,1H3,(H,44,51)(H,45,52)(H2,46,48,54)/t41-/m0/s1
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n/an/an/a 251n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287245
PNG
(CHEMBL285586 | N-[2-(2-Guanidino-thiazol-4-ylmethy...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(C)c2)C1=O)c1cccc(OCC(=O)NCCC(=O)NCCSCc2csc(N=C(N)N)n2)c1
Show InChI InChI=1S/C36H40N10O5S2/c1-22-7-5-9-24(17-22)41-35(50)44-32-33(49)46(2)28-12-4-3-11-27(28)31(43-32)23-8-6-10-26(18-23)51-19-30(48)39-14-13-29(47)40-15-16-52-20-25-21-53-36(42-25)45-34(37)38/h3-12,17-18,21,32H,13-16,19-20H2,1-2H3,(H,39,48)(H,40,47)(H2,41,44,50)(H4,37,38,42,45)
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n/an/an/a 794n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(RAT)
BDBM50287235
PNG
(4-(2-{3-[1-Methyl-2-oxo-3-(3-m-tolyl-ureido)-2,3-d...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(C)c2)C1=O)c1cccc(OCC(=O)NCCCC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C45H53N7O6/c1-32-13-8-16-35(27-32)48-45(56)50-43-44(55)51(2)39-20-5-4-19-38(39)42(49-43)34-15-10-18-37(29-34)58-31-41(54)47-22-11-21-40(53)46-23-12-26-57-36-17-9-14-33(28-36)30-52-24-6-3-7-25-52/h4-5,8-10,13-20,27-29,43H,3,6-7,11-12,21-26,30-31H2,1-2H3,(H,46,53)(H,47,54)(H2,48,50,56)
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n/an/an/a 316n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats


Citation and Details
More data for this
Ligand-Target Pair
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