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Compile Data Set for Download or QSAR

Found 255 hits Enz. Inhib. hit(s) with Target = 'Histone acetyltransferase KAT2A/KAT2B'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br
Show InChI InChI=1/C17H21BrN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3/t13-,14+/s2
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1.30n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to human partial length GCN5 expressed in bacterial expression system by BROMOscan method


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br
Show InChI InChI=1/C17H21BrN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3/t13-,14+/s2
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1.30n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to human partial length PCAF bromodomain expressed in mammalian expression system by BROMOscan method


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br
Show InChI InChI=1/C17H21BrN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3/t13-,14+/s2
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1.40n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to human partial length GCN5 expressed in bacterial expression system by BROMOscan method


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br
Show InChI InChI=1/C17H21BrN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3/t13-,14+/s2
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1.40n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to human partial length PCAF bromodomain expressed in mammalian expression system by BROMOscan method


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens (Human))
BDBM50443232
PNG
(CHEMBL3086883)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)cc1O
Show InChI InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)/b22-21+
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5.52E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS239 from recombinant human PCAF after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234932
PNG
(CHEMBL4103402 | US10239861, Example 20)
Show SMILES CC(C)C[C@H]1C[C@H](CN(C)C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C15H25ClN4O/c1-10(2)5-11-6-12(9-19(3)8-11)18-13-7-17-20(4)15(21)14(13)16/h7,10-12,18H,5-6,8-9H2,1-4H3/t11-,12+/s2
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n/an/a 12.7n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234932
PNG
(CHEMBL4103402 | US10239861, Example 20)
Show SMILES CC(C)C[C@H]1C[C@H](CN(C)C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C15H25ClN4O/c1-10(2)5-11-6-12(9-19(3)8-11)18-13-7-17-20(4)15(21)14(13)16/h7,10-12,18H,5-6,8-9H2,1-4H3/t11-,12+/s2
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM311486
PNG
(CHEM-US-00192 | US10155764, Example 65B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2cccnc12)[C@H](N(C)C)c1ccccc1
Show InChI InChI=1/C19H23N5O/c1-13(17(23(2)3)14-9-6-5-7-10-14)21-18-16-15(11-8-12-20-16)19(25)24(4)22-18/h5-13,17H,1-4H3,(H,21,22)/t13-,17+/s2
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n/an/a 19n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371542
PNG
(4-chloro-5-(((3R,5S)-1,5-dimethylpiperidin-3-yl)am...)
Show SMILES C[C@H]1C[C@H](CN(C)C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1S/C12H19ClN4O/c1-8-4-9(7-16(2)6-8)15-10-5-14-17(3)12(18)11(10)13/h5,8-9,15H,4,6-7H2,1-3H3/t8-,9+/m0/s1
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n/an/a 21.5n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371577
PNG
((S)-4-chloro-2-methyl-5-((1-methylazepan-3-yl)amin...)
Show SMILES CN1CCCC[C@@H](C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1S/C12H19ClN4O/c1-16-6-4-3-5-9(8-16)15-10-7-14-17(2)12(18)11(10)13/h7,9,15H,3-6,8H2,1-2H3/t9-/m0/s1
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n/an/a 32.9n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371546
PNG
(US10239861, Example 26)
Show SMILES C[C@@H]1CC[C@H](CN1C)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C12H19ClN4O/c1-8-4-5-9(7-16(8)2)15-10-6-14-17(3)12(18)11(10)13/h6,8-9,15H,4-5,7H2,1-3H3/t8-,9-/s2
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n/an/a 34.8n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371541
PNG
((racemic)-4-chloro-5-(((3RS,5SR)-1,5-dimethylpiper...)
Show SMILES CC1CC(CN(C)C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C12H19ClN4O/c1-8-4-9(7-16(2)6-8)15-10-5-14-17(3)12(18)11(10)13/h5,8-9,15H,4,6-7H2,1-3H3
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n/an/a 36.5n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br
Show InChI InChI=1/C17H21BrN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3/t13-,14+/s2
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n/an/a 40n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assay


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371549
PNG
(US10239861, Example 29)
Show SMILES C[C@H]1CC[C@H](CN1C)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C12H19ClN4O/c1-8-4-5-9(7-16(8)2)15-10-6-14-17(3)12(18)11(10)13/h6,8-9,15H,4-5,7H2,1-3H3/t8-,9+/s2
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n/an/a 48.5n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234932
PNG
(CHEMBL4103402 | US10239861, Example 20)
Show SMILES CC(C)C[C@H]1C[C@H](CN(C)C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C15H25ClN4O/c1-10(2)5-11-6-12(9-19(3)8-11)18-13-7-17-20(4)15(21)14(13)16/h7,10-12,18H,5-6,8-9H2,1-4H3/t11-,12+/s2
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n/an/a 49.6n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371533
PNG
(4-bromo-2-methyl-5-((1-methylazepan-3-yl)amino)pyr...)
Show SMILES CN1CCCCC(C1)Nc1cnn(C)c(=O)c1Br
Show InChI InChI=1/C12H19BrN4O/c1-16-6-4-3-5-9(8-16)15-10-7-14-17(2)12(18)11(10)13/h7,9,15H,3-6,8H2,1-2H3
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n/an/a 51n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234945
PNG
(CHEMBL4061142 | US10239861, Example 59)
Show SMILES CN1CCC[C@@H](C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C11H17ClN4O/c1-15-5-3-4-8(7-15)14-9-6-13-16(2)11(17)10(9)12/h6,8,14H,3-5,7H2,1-2H3/t8-/s2
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n/an/a 51.2n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br
Show InChI InChI=1/C17H21BrN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3/t13-,14+/s2
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n/an/a 60n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of Halo-tagged histone H3.3 from NanoLuc-tagged full length human PCAF bromodomain expressed in HEK293 cells after 18 hrs by NanoBRET as...


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371545
PNG
(4-chloro-5-((1,6-dimethylpiperidin-3-yl)amino)-2-m...)
Show SMILES CC1CCC(CN1C)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C12H19ClN4O/c1-8-4-5-9(7-16(8)2)15-10-6-14-17(3)12(18)11(10)13/h6,8-9,15H,4-5,7H2,1-3H3
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n/an/a 60n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371521
PNG
(4-chloro-2-methyl-5-((1-methylazepan-3-yl)amino)py...)
Show SMILES CN1CCCCC(C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C12H19ClN4O/c1-16-6-4-3-5-9(8-16)15-10-7-14-17(2)12(18)11(10)13/h7,9,15H,3-6,8H2,1-2H3
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n/an/a 62n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br
Show InChI InChI=1/C17H21BrN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3/t13-,14+/s2
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n/an/a 63n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of Halo-tagged histone H3.3 from NanoLuc-tagged full length human PCAF bromodomain expressed in HEK293 cells after 18 hrs by NanoBRET as...


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234931
PNG
(CHEMBL4088595)
Show SMILES C[C@H](Nc1nn(C)c(=O)n(C)c1=O)[C@@H](N(C)C)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1/C22H27N5O4S/c1-15(23-20-21(28)26(4)22(29)27(5)24-20)19(25(2)3)16-11-13-18(14-12-16)32(30,31)17-9-7-6-8-10-17/h6-15,19H,1-5H3,(H,23,24)/t15-,19+/s2
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n/an/a 70n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234939
PNG
(CHEMBL4084253)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C17H21ClN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3/t13-,14+/s2
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n/an/a 79n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assay


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234943
PNG
(CHEMBL4099456 | US10239861, Example 3)
Show SMILES CN1CCCC(C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C11H17ClN4O/c1-15-5-3-4-8(7-15)14-9-6-13-16(2)11(17)10(9)12/h6,8,14H,3-5,7H2,1-2H3
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n/an/a 85n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371527
PNG
((R)-5-((1-benzylpiperidin-3-yl)amino)-4-chloro-2-m...)
Show SMILES Cn1ncc(N[C@@H]2CCCN(Cc3ccccc3)C2)c(Cl)c1=O
Show InChI InChI=1S/C17H21ClN4O/c1-21-17(23)16(18)15(10-19-21)20-14-8-5-9-22(12-14)11-13-6-3-2-4-7-13/h2-4,6-7,10,14,20H,5,8-9,11-12H2,1H3/t14-/m1/s1
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n/an/a 85.6n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371564
PNG
(4-chloro-5-[[1-[[3-(difluoromethoxy)phenyl]methyl]...)
Show SMILES Cn1ncc(NC2CCCN(Cc3cccc(OC(F)F)c3)C2)c(Cl)c1=O
Show InChI InChI=1/C18H21ClF2N4O2/c1-24-17(26)16(19)15(9-22-24)23-13-5-3-7-25(11-13)10-12-4-2-6-14(8-12)27-18(20)21/h2,4,6,8-9,13,18,23H,3,5,7,10-11H2,1H3
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n/an/a 94.9n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371559
PNG
((R)-4-chloro-2-methyl-5-((2,3,4,5-tetrahydro-1H-be...)
Show SMILES Cn1ncc(Cl)c(N[C@@H]2Cc3ccccc3CNC2=O)c1=O
Show InChI InChI=1/C15H15ClN4O2/c1-20-15(22)13(11(16)8-18-20)19-12-6-9-4-2-3-5-10(9)7-17-14(12)21/h2-5,8,12,19H,6-7H2,1H3,(H,17,21)/t12-/s2
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n/an/a 102n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371576
PNG
(4-chloro-5-[[1-[(4-fluorophenyl)methyl]-3-piperidy...)
Show SMILES Cn1ncc(NC2CCCN(Cc3ccc(F)cc3)C2)c(Cl)c1=O
Show InChI InChI=1/C17H20ClFN4O/c1-22-17(24)16(18)15(9-20-22)21-14-3-2-8-23(11-14)10-12-4-6-13(19)7-5-12/h4-7,9,14,21H,2-3,8,10-11H2,1H3
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n/an/a 139n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371547
PNG
(US10239861, Example 27)
Show SMILES C[C@@H]1CC[C@@H](CN1C)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C12H19ClN4O/c1-8-4-5-9(7-16(8)2)15-10-6-14-17(3)12(18)11(10)13/h6,8-9,15H,4-5,7H2,1-3H3/t8-,9+/s2
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n/an/a 144n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371552
PNG
(4-chloro-5-((1-isopropylpiperidin-3-yl)amino)-2-me...)
Show SMILES CC(C)N1CCCC(C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C13H21ClN4O/c1-9(2)18-6-4-5-10(8-18)16-11-7-15-17(3)13(19)12(11)14/h7,9-10,16H,4-6,8H2,1-3H3
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n/an/a 147n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371560
PNG
(4-chloro-2-methyl-5-((1-methylazocan-3-yl)amino)py...)
Show SMILES CN1CCCCCC(C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C13H21ClN4O/c1-17-7-5-3-4-6-10(9-17)16-11-8-15-18(2)13(19)12(11)14/h8,10,16H,3-7,9H2,1-2H3
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n/an/a 155n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371554
PNG
(US10239861, Example 34 | racemic-5-((1-benzylpiper...)
Show SMILES Cn1ncc(NC2CCCN(Cc3ccccc3)C2)c(Cl)c1=O
Show InChI InChI=1/C17H21ClN4O/c1-21-17(23)16(18)15(10-19-21)20-14-8-5-9-22(12-14)11-13-6-3-2-4-7-13/h2-4,6-7,10,14,20H,5,8-9,11-12H2,1H3
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n/an/a 155n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371521
PNG
(4-chloro-2-methyl-5-((1-methylazepan-3-yl)amino)py...)
Show SMILES CN1CCCCC(C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C12H19ClN4O/c1-16-6-4-3-5-9(8-16)15-10-7-14-17(2)12(18)11(10)13/h7,9,15H,3-6,8H2,1-2H3
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n/an/a 165n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371544
PNG
(4-chloro-2-methyl-5-((1-methyl-5-phenylpiperidin-3...)
Show SMILES CN1CC(CC(C1)c1ccccc1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C17H21ClN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3
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n/an/a 167n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371578
PNG
((R)-4-chloro-2-methyl-5-((1-methylazepan-3-yl)amin...)
Show SMILES CN1CCCC[C@H](C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1S/C12H19ClN4O/c1-16-6-4-3-5-9(8-16)15-10-7-14-17(2)12(18)11(10)13/h7,9,15H,3-6,8H2,1-2H3/t9-/m1/s1
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n/an/a 169n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371548
PNG
(US10239861, Example 28)
Show SMILES C[C@H]1CC[C@@H](CN1C)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C12H19ClN4O/c1-8-4-5-9(7-16(8)2)15-10-6-14-17(3)12(18)11(10)13/h6,8-9,15H,4-5,7H2,1-3H3/t8-,9-/s2
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n/an/a 175n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371569
PNG
(4-chloro-5-[[1-(1H-imidazol-4-ylmethyl)-3-piperidy...)
Show SMILES Cn1ncc(NC2CCCN(Cc3c[nH]cn3)C2)c(Cl)c1=O
Show InChI InChI=1/C14H19ClN6O/c1-20-14(22)13(15)12(6-18-20)19-10-3-2-4-21(7-10)8-11-5-16-9-17-11/h5-6,9-10,19H,2-4,7-8H2,1H3,(H,16,17)
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n/an/a 178n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371524
PNG
((racemic)-4-chloro-2-methyl-5-((1-methylazepan-4-y...)
Show SMILES CN1CCCC(CC1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C12H19ClN4O/c1-16-6-3-4-9(5-7-16)15-10-8-14-17(2)12(18)11(10)13/h8-9,15H,3-7H2,1-2H3
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n/an/a 187n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371561
PNG
(Racemic-4-chloro-2-methyl-5-[[1-(3-phenylpropyl)-3...)
Show SMILES Cn1ncc(NC2CCCN(CCCc3ccccc3)C2)c(Cl)c1=O
Show InChI InChI=1/C19H25ClN4O/c1-23-19(25)18(20)17(13-21-23)22-16-10-6-12-24(14-16)11-5-9-15-7-3-2-4-8-15/h2-4,7-8,13,16,22H,5-6,9-12,14H2,1H3
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n/an/a 232n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234944
PNG
(CHEMBL4072538 | US10239861, Example 60)
Show SMILES CN1CCC[C@H](C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C11H17ClN4O/c1-15-5-3-4-8(7-15)14-9-6-13-16(2)11(17)10(9)12/h6,8,14H,3-5,7H2,1-2H3/t8-/s2
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n/an/a 235n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371566
PNG
(4-chloro-5-((1-(3,5-dichlorobenzyl)piperidin-3-yl)...)
Show SMILES Cn1ncc(NC2CCCN(Cc3cc(Cl)cc(Cl)c3)C2)c(Cl)c1=O
Show InChI InChI=1/C17H19Cl3N4O/c1-23-17(25)16(20)15(8-21-23)22-14-3-2-4-24(10-14)9-11-5-12(18)7-13(19)6-11/h5-8,14,22H,2-4,9-10H2,1H3
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n/an/a 278n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens (Human))
BDBM50151650
PNG
(CHEMBL3775229)
Show SMILES CNC(=O)C(C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(NC(=O)CNC(=O)CNC(=O)NC(CCCCNC(=O)CSCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n1cnc2c(N)ncnc12)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(O)=O)C(C)O)C(C)O)C(C)O
Show InChI InChI=1/C116H205N42O45P3S/c1-56(2)46-72(102(181)145-66(27-20-39-132-112(122)123)94(173)141-59(6)93(172)155-84(62(9)161)106(185)149-71(32-34-78(120)164)99(178)144-65(25-15-18-37-118)101(180)156-85(63(10)162)107(186)148-67(28-21-40-133-113(124)125)95(174)140-58(5)92(171)128-13)150-103(182)74(50-159)152-105(184)83(61(8)160)154-81(167)49-135-80(166)48-136-115(191)153-69(96(175)142-60(7)109(188)157-44-23-30-75(157)104(183)147-68(29-22-41-134-114(126)127)98(177)143-64(24-14-17-36-117)97(176)146-70(31-33-77(119)163)100(179)151-73(111(189)190)47-57(3)4)26-16-19-38-129-82(168)52-207-45-43-130-79(165)35-42-131-108(187)89(170)116(11,12)53-200-206(197,198)203-205(195,196)199-51-76-88(202-204(192,193)194)87(169)110(201-76)158-55-139-86-90(121)137-54-138-91(86)158/h54-76,83-85,87-89,110,159-162,169-170H,14-53,117-118H2,1-13H3,(H2,119,163)(H2,120,164)(H,128,171)(H,129,168)(H,130,165)(H,131,187)(H,135,166)(H,140,174)(H,141,173)(H,142,175)(H,143,177)(H,144,178)(H,145,181)(H,146,176)(H,147,183)(H,148,186)(H,149,185)(H,150,182)(H,151,179)(H,152,184)(H,154,167)(H,155,172)(H,156,180)(H,189,190)(H,195,196)(H,197,198)(H2,121,137,138)(H4,122,123,132)(H4,124,125,133)(H4,126,127,134)(H2,136,153,191)(H2,192,193,194)
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n/an/a 300n/an/an/an/an/an/a



University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human FLAG-tagged PCAF expressed in baculovirus expression system using histone substrate incubated for 10 mins...


J Med Chem 59: 1249-70 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01502
BindingDB Entry DOI: 10.7270/Q2DV1MRN
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234926
PNG
(CHEMBL4101945)
Show SMILES CN1CCc2c(C1)cccc2Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1S/C15H17ClN4O/c1-19-7-6-11-10(9-19)4-3-5-12(11)18-13-8-17-20(2)15(21)14(13)16/h3-5,8,18H,6-7,9H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assay


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371563
PNG
(4-chloro-5-[[1-[(4-dimethylaminophenyl)methyl]-3-p...)
Show SMILES CN(C)c1ccc(CN2CCCC(C2)Nc2cnn(C)c(=O)c2Cl)cc1
Show InChI InChI=1/C19H26ClN5O/c1-23(2)16-8-6-14(7-9-16)12-25-10-4-5-15(13-25)22-17-11-21-24(3)19(26)18(17)20/h6-9,11,15,22H,4-5,10,12-13H2,1-3H3
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n/an/a 310n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371537
PNG
((E)-2-(but-2-en-1-yl)-4-chloro-5-((1-methylazepan-...)
Show SMILES C\C=C\CN1NC=C(NC2CCCCN(C)C2)C(Cl)=C1
Show InChI InChI=1/C15H25ClN4/c1-3-4-9-20-12-14(16)15(10-17-20)18-13-7-5-6-8-19(2)11-13/h3-4,10,12-13,17-18H,5-9,11H2,1-2H3/b4-3+
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n/an/a 312n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371550
PNG
(4-chloro-5-((1-(2-methoxyethyl)piperidin-3-yl)amin...)
Show SMILES COCCN1CCCC(C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1/C13H21ClN4O2/c1-17-13(19)12(14)11(8-15-17)16-10-4-3-5-18(9-10)6-7-20-2/h8,10,16H,3-7,9H2,1-2H3
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n/an/a 315n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234926
PNG
(CHEMBL4101945)
Show SMILES CN1CCc2c(C1)cccc2Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1S/C15H17ClN4O/c1-19-7-6-11-10(9-19)4-3-5-12(11)18-13-8-17-20(2)15(21)14(13)16/h3-5,8,18H,6-7,9H2,1-2H3
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n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assay


J Med Chem 60: 695-709 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01566
BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A


(Homo sapiens (Human))
BDBM50028142
PNG
(CHEMBL2177300)
Show SMILES C[C@H]1C[C@@H](Nc2ccc(Cl)cc2)c2cc(ccc2N1C(C)=O)-c1ccc(cc1)C(O)=O
Show InChI InChI=1/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/s2
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of human GCN5 by BROMOscan assay


J Med Chem 57: 8111-31 (2014)


Article DOI: 10.1021/jm5010539
BindingDB Entry DOI: 10.7270/Q23R0VGR
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371528
PNG
((S)-5-((1-benzylpiperidin-3-yl)amino)-4-chloro-2-m...)
Show SMILES Cn1ncc(N[C@H]2CCCN(Cc3ccccc3)C2)c(Cl)c1=O
Show InChI InChI=1S/C17H21ClN4O/c1-21-17(23)16(18)15(10-19-21)20-14-8-5-9-22(12-14)11-13-6-3-2-4-7-13/h2-4,6-7,10,14,20H,5,8-9,11-12H2,1H3/t14-/m0/s1
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n/an/a 349n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371571
PNG
(4-chloro-2-methyl-5-[[1-[(1-methylpyrazol-4-yl)met...)
Show SMILES Cn1cc(CN2CCCC(C2)Nc2cnn(C)c(=O)c2Cl)cn1
Show InChI InChI=1/C15H21ClN6O/c1-20-8-11(6-17-20)9-22-5-3-4-12(10-22)19-13-7-18-21(2)15(23)14(13)16/h6-8,12,19H,3-5,9-10H2,1-2H3
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n/an/a 371n/an/an/an/an/an/a



GENETECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10239861 (2019)

More data for this
Ligand-Target Pair
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