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Found 117 hits Enz. Inhib. hit(s) with Target = 'Histone acetyltransferase PCAF' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50443232
PNG
(CHEMBL3086883)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)cc1O
Show InChI InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)
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5.52E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS239 from recombinant human PCAF after 1 hr by fluorescence anisotropy assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346554
PNG
(CHEMBL106011)
Show SMILES Fc1ccc(cc1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C12H7FN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H
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n/an/a 720n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346563
PNG
(CHEMBL1795605)
Show SMILES [O-][N+](=O)c1cnc2sn(-c3ccc(Br)cc3)c(=O)c2c1
Show InChI InChI=1S/C12H6BrN3O3S/c13-7-1-3-8(4-2-7)15-12(17)10-5-9(16(18)19)6-14-11(10)20-15/h1-6H
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n/an/a 860n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247911
PNG
(2-(4-Pyridyl)-isothiazol-3(2H)-one | CHEMBL499919)
Show SMILES O=c1ccsn1-c1ccncc1
Show InChI InChI=1S/C8H6N2OS/c11-8-3-6-12-10(8)7-1-4-9-5-2-7/h1-6H
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n/an/a 1.50E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant HAT PCAF expressed in Escherichia coli by filter assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50398244
PNG
(CHEMBL609728)
Show SMILES Cc1ccc(NCCCN)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C10H15N3O2/c1-8-3-4-9(12-6-2-5-11)10(7-8)13(14)15/h3-4,7,12H,2,5-6,11H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of biotinylated Tat-KAc50 peptide binding to PCAF


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346554
PNG
(CHEMBL106011)
Show SMILES Fc1ccc(cc1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C12H7FN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H
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n/an/a 1.64E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50445037
PNG
(CHEMBL3098704)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](COP(O)(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCn1cc(CSCCNC(=O)CCNC(=O)[C@@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2OP(O)(O)=O)n2cnc3c(N)ncnc23)nn1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C78H137N31O34P4S/c1-41(96-44(4)111)65(118)100-49(19-13-25-89-76(83)84)68(121)101-48(17-8-11-24-80)69(122)103-51(35-138-144(128,129)130)70(123)104-57(43(3)110)72(125)92-32-55(113)91-33-56(114)98-47(66(119)97-42(2)74(127)108-30-15-21-52(108)71(124)102-50(20-14-26-90-77(85)86)67(120)99-46(63(82)117)16-7-10-23-79)18-9-12-29-107-34-45(105-106-107)37-148-31-28-87-54(112)22-27-88-73(126)61(116)78(5,6)38-140-147(136,137)143-146(134,135)139-36-53-60(142-145(131,132)133)59(115)75(141-53)109-40-95-58-62(81)93-39-94-64(58)109/h34,39-43,46-53,57,59-61,75,110,115-116H,7-33,35-38,79-80H2,1-6H3,(H2,82,117)(H,87,112)(H,88,126)(H,91,113)(H,92,125)(H,96,111)(H,97,119)(H,98,114)(H,99,120)(H,100,118)(H,101,121)(H,102,124)(H,103,122)(H,104,123)(H,134,135)(H,136,137)(H2,81,93,94)(H4,83,84,89)(H4,85,86,90)(H2,128,129,130)(H2,131,132,133)/t41-,42-,43+,46-,47-,48-,49-,50-,51-,52-,53+,57-,59+,60+,61+,75+/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Utrecht University

Curated by ChEMBL


Assay Description
Inhibition of PCAF (unknown origin) using histone H3 derived peptide as substrate after 20 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247839
PNG
(CHEMBL447612 | methyl 3-(5-chloro-3-oxoisothiazol-...)
Show SMILES COC(=O)CCn1sc(Cl)cc1=O
Show InChI InChI=1S/C7H8ClNO3S/c1-12-7(11)2-3-9-6(10)4-5(8)13-9/h4H,2-3H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant histone acetyltransferase PCAF assessed as CoA-SH activity preincubated for 15 mins by CPM fluorescent assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247839
PNG
(CHEMBL447612 | methyl 3-(5-chloro-3-oxoisothiazol-...)
Show SMILES COC(=O)CCn1sc(Cl)cc1=O
Show InChI InChI=1S/C7H8ClNO3S/c1-12-7(11)2-3-9-6(10)4-5(8)13-9/h4H,2-3H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346555
PNG
(CHEMBL1795609)
Show SMILES COc1ccc(cc1)-n1sc2ncc(cc2c1=O)[N+]([O-])=O
Show InChI InChI=1S/C13H9N3O4S/c1-20-10-4-2-8(3-5-10)15-13(17)11-6-9(16(18)19)7-14-12(11)21-15/h2-7H,1H3
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n/an/a 1.83E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247843
PNG
(CHEMBL510872 | Ethyl 3-(5-chloro-3-oxoisothiazol-2...)
Show SMILES CCOC(=O)CCn1sc(Cl)cc1=O
Show InChI InChI=1S/C8H10ClNO3S/c1-2-13-8(12)3-4-10-7(11)5-6(9)14-10/h5H,2-4H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50255522
PNG
(Ac-ARTKQTARKSTGGK(CoA)APRKQL | CHEMBL526343)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C116H205N42O45P3S/c1-57(2)48-74(112(190)191)152-101(180)72(32-34-78(120)164)148-96(175)66(24-12-16-37-117)146-99(178)70(29-21-42-133-114(125)126)150-105(184)76-31-23-46-157(76)110(189)60(5)142-95(174)65(27-15-19-40-129-83(169)53-207-47-45-130-80(166)36-44-131-109(188)90(171)116(10,11)54-200-206(197,198)203-205(195,196)199-52-77-89(202-204(192,193)194)88(170)111(201-77)158-56-139-87-91(122)137-55-138-92(87)158)143-82(168)50-135-81(167)49-136-106(185)84(61(6)160)154-104(183)75(51-159)153-100(179)67(25-13-17-38-118)147-98(177)69(28-20-41-132-113(123)124)144-94(173)59(4)141-107(186)85(62(7)161)155-103(182)73(33-35-79(121)165)149-97(176)68(26-14-18-39-119)151-108(187)86(63(8)162)156-102(181)71(30-22-43-134-115(127)128)145-93(172)58(3)140-64(9)163/h55-63,65-77,84-86,88-90,111,159-162,170-171H,12-54,117-119H2,1-11H3,(H2,120,164)(H2,121,165)(H,129,169)(H,130,166)(H,131,188)(H,135,167)(H,136,185)(H,140,163)(H,141,186)(H,142,174)(H,143,168)(H,144,173)(H,145,172)(H,146,178)(H,147,177)(H,148,175)(H,149,176)(H,150,184)(H,151,187)(H,152,180)(H,153,179)(H,154,183)(H,155,182)(H,156,181)(H,190,191)(H,195,196)(H,197,198)(H2,122,137,138)(H4,123,124,132)(H4,125,126,133)(H4,127,128,134)(H2,192,193,194)/t58-,59-,60-,61+,62+,63+,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77+,84-,85-,86-,88+,89+,90-,111+/m0/s1
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n/an/a 2.27E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of PCAF HAT domain (493-658) expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50300427
PNG
(4,5-Dichloro-2-ethylisothiazol-3(2H)-one | CHEMBL5...)
Show SMILES CCn1sc(Cl)c(Cl)c1=O
Show InChI InChI=1S/C5H5Cl2NOS/c1-2-8-5(9)3(6)4(7)10-8/h2H2,1H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant histone acetyltransferase PCAF assessed as CoA-SH activity preincubated for 15 mins by CPM fluorescent assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247840
PNG
(CHEMBL489116 | Methyl 4-(5-chloro-3-oxoisothiazol-...)
Show SMILES COC(=O)CCCn1sc(Cl)cc1=O
Show InChI InChI=1S/C8H10ClNO3S/c1-13-8(12)3-2-4-10-7(11)5-6(9)14-10/h5H,2-4H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247844
PNG
(5-Chloro-2-(3-chloro-4-fluorophenyl)isothiazol-3(2...)
Show SMILES Fc1ccc(cc1Cl)-n1sc(Cl)cc1=O
Show InChI InChI=1S/C9H4Cl2FNOS/c10-6-3-5(1-2-7(6)12)13-9(14)4-8(11)15-13/h1-4H
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247845
PNG
(Benzyl [2-(5-chloro-3-oxoisothiazol-2(3H)-yl)ethyl...)
Show SMILES Clc1cc(=O)n(CCNC(=O)OCc2ccccc2)s1
Show InChI InChI=1S/C13H13ClN2O3S/c14-11-8-12(17)16(20-11)7-6-15-13(18)19-9-10-4-2-1-3-5-10/h1-5,8H,6-7,9H2,(H,15,18)
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50300425
PNG
(CHEMBL573028 | Methyl 3-(4,5-dichloro-3-oxoisothia...)
Show SMILES COC(=O)CCn1sc(Cl)c(Cl)c1=O
Show InChI InChI=1S/C7H7Cl2NO3S/c1-13-4(11)2-3-10-7(12)5(8)6(9)14-10/h2-3H2,1H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant histone acetyltransferase PCAF assessed as CoA-SH activity preincubated for 15 mins by CPM fluorescent assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346556
PNG
(CHEMBL1795611)
Show SMILES Cc1cnc2sn(-c3ccc(cc3)[N+]([O-])=O)c(=O)c2c1
Show InChI InChI=1S/C13H9N3O3S/c1-8-6-11-12(14-7-8)20-15(13(11)17)9-2-4-10(5-3-9)16(18)19/h2-7H,1H3
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n/an/a 2.72E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247841
PNG
(CHEMBL443133 | Methyl 4-(5-chloro-3-oxoisothiazol-...)
Show SMILES COC(=O)CCCCn1sc(Cl)cc1=O
Show InChI InChI=1S/C9H12ClNO3S/c1-14-9(13)4-2-3-5-11-8(12)6-7(10)15-11/h6H,2-5H2,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50445038
PNG
(CHEMBL3098705)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCn1cc(CSCCNC(=O)CCNC(=O)[C@@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2OP(O)(O)=O)n2cnc3c(N)ncnc23)nn1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C78H136N31O31P3S/c1-41(96-44(4)112)65(119)100-49(19-13-25-89-76(83)84)68(122)101-48(17-8-11-24-80)69(123)103-51(35-110)70(124)104-57(43(3)111)72(126)92-32-55(114)91-33-56(115)98-47(66(120)97-42(2)74(128)108-30-15-21-52(108)71(125)102-50(20-14-26-90-77(85)86)67(121)99-46(63(82)118)16-7-10-23-79)18-9-12-29-107-34-45(105-106-107)37-144-31-28-87-54(113)22-27-88-73(127)61(117)78(5,6)38-137-143(134,135)140-142(132,133)136-36-53-60(139-141(129,130)131)59(116)75(138-53)109-40-95-58-62(81)93-39-94-64(58)109/h34,39-43,46-53,57,59-61,75,110-111,116-117H,7-33,35-38,79-80H2,1-6H3,(H2,82,118)(H,87,113)(H,88,127)(H,91,114)(H,92,126)(H,96,112)(H,97,120)(H,98,115)(H,99,121)(H,100,119)(H,101,122)(H,102,125)(H,103,123)(H,104,124)(H,132,133)(H,134,135)(H2,81,93,94)(H4,83,84,89)(H4,85,86,90)(H2,129,130,131)/t41-,42-,43+,46-,47-,48-,49-,50-,51-,52-,53+,57-,59+,60+,61+,75+/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Utrecht University

Curated by ChEMBL


Assay Description
Inhibition of PCAF (unknown origin) using histone H3 derived peptide as substrate after 20 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247838
PNG
(CHEMBL466866 | Methyl 2-(5-chloro-3-oxoisothiazol-...)
Show SMILES COC(=O)Cn1sc(Cl)cc1=O
Show InChI InChI=1S/C6H6ClNO3S/c1-11-6(10)3-8-5(9)2-4(7)12-8/h2H,3H2,1H3
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247837
PNG
(5-Chloro-2-pentylisothiazol-3(2H)-one | CHEMBL4891...)
Show SMILES CCCCCn1sc(Cl)cc1=O
Show InChI InChI=1S/C8H12ClNOS/c1-2-3-4-5-10-8(11)6-7(9)12-10/h6H,2-5H2,1H3
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346561
PNG
(CHEMBL1795604)
Show SMILES Cc1cnc2sn(-c3ccc(Br)cc3)c(=O)c2c1
Show InChI InChI=1S/C13H9BrN2OS/c1-8-6-11-12(15-7-8)18-16(13(11)17)10-4-2-9(14)3-5-10/h2-7H,1H3
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n/an/a 2.99E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346557
PNG
(CHEMBL99137)
Show SMILES [O-][N+](=O)c1ccc(cc1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C12H7N3O3S/c16-12-10-2-1-7-13-11(10)19-14(12)8-3-5-9(6-4-8)15(17)18/h1-7H
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n/an/a 2.99E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247820
PNG
(5-Chloro-2-ethylisothiazol-3(2H)-one | CHEMBL46147...)
Show SMILES CCn1sc(Cl)cc1=O
Show InChI InChI=1S/C5H6ClNOS/c1-2-7-5(8)3-4(6)9-7/h3H,2H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247820
PNG
(5-Chloro-2-ethylisothiazol-3(2H)-one | CHEMBL46147...)
Show SMILES CCn1sc(Cl)cc1=O
Show InChI InChI=1S/C5H6ClNOS/c1-2-7-5(8)3-4(6)9-7/h3H,2H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant histone acetyltransferase PCAF assessed as CoA-SH activity preincubated for 15 mins by CPM fluorescent assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247615
PNG
(2-(3,4,5-trifluorophenyl)isothiazol-3(2H)-one | CH...)
Show SMILES Fc1cc(cc(F)c1F)-n1sccc1=O
Show InChI InChI=1S/C9H4F3NOS/c10-6-3-5(4-7(11)9(6)12)13-8(14)1-2-15-13/h1-4H
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n/an/a 3.10E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant HAT PCAF expressed in Escherichia coli by filter assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247842
PNG
(CHEMBL442599 | Methyl 6-(5-chloro-3-oxoisothiazol-...)
Show SMILES COC(=O)CCCCCn1sc(Cl)cc1=O
Show InChI InChI=1S/C10H14ClNO3S/c1-15-10(14)5-3-2-4-6-12-9(13)7-8(11)16-12/h7H,2-6H2,1H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346555
PNG
(CHEMBL1795609)
Show SMILES COc1ccc(cc1)-n1sc2ncc(cc2c1=O)[N+]([O-])=O
Show InChI InChI=1S/C13H9N3O4S/c1-20-10-4-2-8(3-5-10)15-13(17)11-6-9(16(18)19)7-14-12(11)21-15/h2-7H,1H3
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n/an/a 3.42E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346567
PNG
(CHEMBL318367)
Show SMILES Clc1ccc(cc1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C12H7ClN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H
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n/an/a 3.53E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346579
PNG
(CHEMBL1795800)
Show SMILES Cc1ccc(cc1)-n1sc2cc(F)ccc2c1=O
Show InChI InChI=1S/C14H10FNOS/c1-9-2-5-11(6-3-9)16-14(17)12-7-4-10(15)8-13(12)18-16/h2-8H,1H3
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n/an/a 3.69E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346557
PNG
(CHEMBL99137)
Show SMILES [O-][N+](=O)c1ccc(cc1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C12H7N3O3S/c16-12-10-2-1-7-13-11(10)19-14(12)8-3-5-9(6-4-8)15(17)18/h1-7H
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n/an/a 4.10E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247868
PNG
(2-(3-Chloro-4-fluorophenyl)isothiazol-3(2H)-one | ...)
Show SMILES Fc1ccc(cc1Cl)-n1sccc1=O
Show InChI InChI=1S/C9H5ClFNOS/c10-7-5-6(1-2-8(7)11)12-9(13)3-4-14-12/h1-5H
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n/an/a 4.20E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346562
PNG
(CHEMBL101422)
Show SMILES Brc1ccc(cc1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C12H7BrN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H
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n/an/a 4.43E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346568
PNG
(CHEMBL1795614)
Show SMILES Clc1ccc(cc1Cl)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C12H6Cl2N2OS/c13-9-4-3-7(6-10(9)14)16-12(17)8-2-1-5-15-11(8)18-16/h1-6H
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n/an/a 4.57E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346570
PNG
(CHEMBL1795616)
Show SMILES Cc1ccc(cc1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C13H10N2OS/c1-9-4-6-10(7-5-9)15-13(16)11-3-2-8-14-12(11)17-15/h2-8H,1H3
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n/an/a 4.63E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346580
PNG
(CHEMBL1795796)
Show SMILES [O-][N+](=O)c1cc(ccc1Cl)-n1sccc1=O
Show InChI InChI=1S/C9H5ClN2O3S/c10-7-2-1-6(5-8(7)12(14)15)11-9(13)3-4-16-11/h1-5H
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n/an/a 4.80E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247871
PNG
(CHEMBL521965 | Methyl 3-[4-{[(benzyloxy)carbonyl]a...)
Show SMILES COC(=O)CCn1sc(Cl)c(NC(=O)OCc2ccccc2)c1=O
Show InChI InChI=1S/C15H15ClN2O5S/c1-22-11(19)7-8-18-14(20)12(13(16)24-18)17-15(21)23-9-10-5-3-2-4-6-10/h2-6H,7-9H2,1H3,(H,17,21)
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n/an/a 4.90E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346563
PNG
(CHEMBL1795605)
Show SMILES [O-][N+](=O)c1cnc2sn(-c3ccc(Br)cc3)c(=O)c2c1
Show InChI InChI=1S/C12H6BrN3O3S/c13-7-1-3-8(4-2-7)15-12(17)10-5-9(16(18)19)6-14-11(10)20-15/h1-6H
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n/an/a 4.91E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346571
PNG
(CHEMBL102387)
Show SMILES COc1cccc(c1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C13H10N2O2S/c1-17-10-5-2-4-9(8-10)15-13(16)11-6-3-7-14-12(11)18-15/h2-8H,1H3
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n/an/a 5.03E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247616
PNG
(2-(3-chloro-2-fluorophenyl)isothiazol-3(2H)-one | ...)
Show SMILES Fc1c(Cl)cccc1-n1sccc1=O
Show InChI InChI=1S/C9H5ClFNOS/c10-6-2-1-3-7(9(6)11)12-8(13)4-5-14-12/h1-5H
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n/an/a 5.40E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant HAT PCAF expressed in Escherichia coli by filter assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247912
PNG
(2-(4-Dimethylaminoaniline)-isothiazol-3(2H)-one | ...)
Show SMILES CN(C)c1ccc(cc1)-n1sccc1=O
Show InChI InChI=1S/C11H12N2OS/c1-12(2)9-3-5-10(6-4-9)13-11(14)7-8-15-13/h3-8H,1-2H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant HAT PCAF expressed in Escherichia coli by filter assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247869
PNG
(CHEMBL509992 | methyl 3-(5-chloro-1-oxido-3-oxoiso...)
Show SMILES COC(=O)CCn1c(=O)cc(Cl)s1=O
Show InChI InChI=1S/C7H8ClNO4S/c1-13-7(11)2-3-9-6(10)4-5(8)14(9)12/h4H,2-3H2,1H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247869
PNG
(CHEMBL509992 | methyl 3-(5-chloro-1-oxido-3-oxoiso...)
Show SMILES COC(=O)CCn1c(=O)cc(Cl)s1=O
Show InChI InChI=1S/C7H8ClNO4S/c1-13-7(11)2-3-9-6(10)4-5(8)14(9)12/h4H,2-3H2,1H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant histone acetyltransferase PCAF assessed as CoA-SH activity preincubated for 15 mins by CPM fluorescent assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346565
PNG
(CHEMBL95284)
Show SMILES COc1ccc(cc1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C13H10N2O2S/c1-17-10-6-4-9(5-7-10)15-13(16)11-3-2-8-14-12(11)18-15/h2-8H,1H3
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n/an/a 5.71E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346569
PNG
(CHEMBL1795615)
Show SMILES Fc1ccc(cc1F)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C12H6F2N2OS/c13-9-4-3-7(6-10(9)14)16-12(17)8-2-1-5-15-11(8)18-16/h1-6H
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n/an/a 5.90E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50241990
PNG
(CHEMBL502489 | Camboginol | Garcinol | Garcinol, 1)
Show SMILES CC(C)=CC[C@@H](C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)C1=O)C2=O)C(C)=C
Show InChI InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,31,39-40H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,31?,37+,38-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of HAT PCAF


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50037078
PNG
(2-(Phenyl)-isothiazolo[5,4-b]pyridin-3(2H)-one | 2...)
Show SMILES O=c1n(sc2ncccc12)-c1ccccc1
Show InChI InChI=1S/C12H8N2OS/c15-12-10-7-4-8-13-11(10)16-14(12)9-5-2-1-3-6-9/h1-8H
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n/an/a 6.10E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant HAT PCAF expressed in Escherichia coli by filter assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50247913
PNG
(2-(3-Pyridyl)-isothiazol-3(2H)-one | CHEMBL487498)
Show SMILES O=c1ccsn1-c1cccnc1
Show InChI InChI=1S/C8H6N2OS/c11-8-3-5-12-10(8)7-2-1-4-9-6-7/h1-6H
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n/an/a 6.50E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant HAT PCAF expressed in Escherichia coli by filter assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens)
BDBM50346581
PNG
(CHEMBL1795612)
Show SMILES COc1ccc(cc1)-n1sc2ncc(C)cc2c1=O
Show InChI InChI=1S/C14H12N2O2S/c1-9-7-12-13(15-8-9)19-16(14(12)17)10-3-5-11(18-2)6-4-10/h3-8H,1-2H3
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n/an/a 6.51E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histo...


Citation and Details
More data for this
Ligand-Target Pair
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