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Found 90 hits Enz. Inhib. hit(s) with Target = 'Histone acetyltransferase p300' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone acetyltransferase p300


(Homo sapiens)
BDBM50346552
PNG
(CHEMBL1797936)
Show SMILES Cc1cc(-c2ccc(C=c3c(=C)[nH]n(-c4ccc(cc4)C(O)=O)c3=O)o2)c(cc1C)[N+]([O-])=O
Show InChI InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12,25H,3H2,1-2H3,(H,29,30)
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400n/an/an/an/an/an/an/an/a



Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL


Assay Description
Competitive inhibition of p300 HAT


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081125
PNG
(CHEMBL3421961)
Show SMILES Cc1cc(O)cc(C)c1C=C1C(=O)N(Cc2ccccc2)C(=O)N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C27H24N2O4/c1-18-13-22(30)14-19(2)23(18)15-24-25(31)28(16-20-9-5-3-6-10-20)27(33)29(26(24)32)17-21-11-7-4-8-12-21/h3-15,30H,16-17H2,1-2H3
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2.00E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of P300 (unknown origin) using acetyl CoA as substrate after 15 mins by double reciprocal plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50377962
PNG
(CAMBOGIN)
Show SMILES CC(C)=CC[C@H]1C[C@@]23C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c4ccc(O)c(O)c4)=C2OC1(C)C)C3=O
Show InChI InChI=1S/C38H50O6/c1-22(2)11-14-26-20-37-21-27(15-12-23(3)4)36(9,10)44-33(37)30(31(41)25-13-16-28(39)29(40)19-25)32(42)38(34(37)43,35(26,7)8)18-17-24(5)6/h11-13,16-17,19,26-27,39-40H,14-15,18,20-21H2,1-10H3/t26-,27+,37+,38+/m1/s1
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3.90E+3n/an/an/an/an/an/an/an/a



Jawaharlal Nehru Centre for Advanced Scientific Research

Curated by ChEMBL


Assay Description
Inhibition of HAT p300 catalytic domain by equilibrium dialysis


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50241990
PNG
(CHEMBL502489 | Camboginol | Garcinol | Garcinol, 1)
Show SMILES CC(C)=CC[C@@H](C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)C1=O)C2=O)C(C)=C
Show InChI InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,31,39-40H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,31?,37+,38-/m0/s1
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4.90E+3n/an/an/an/an/an/an/an/a



Jawaharlal Nehru Centre for Advanced Scientific Research

Curated by ChEMBL


Assay Description
Inhibition of HAT p300 catalytic domain by equilibrium dialysis


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50265449
PNG
((1R,3S,9S,11R)-7-(3-Hydroxy-4-methoxy-benzoyl)-4,4...)
Show SMILES COc1ccc(cc1O)C(=O)C1=C2OC(C)(C)[C@@H](CC=C(C)C)C[C@@]22C[C@@H](CC=C(C)C)C(C)(C)[C@](CC=C(C)C)(C2)C1=O
Show InChI InChI=1S/C39H54O5/c1-24(2)12-15-28-21-38-22-29(16-13-25(3)4)37(9,10)44-35(38)32(33(41)27-14-17-31(43-11)30(40)20-27)34(42)39(23-38,36(28,7)8)19-18-26(5)6/h12-14,17-18,20,28-29,40H,15-16,19,21-23H2,1-11H3/t28-,29+,38-,39-/m1/s1
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5.10E+3n/an/an/an/an/an/an/an/a



Jawaharlal Nehru Centre for Advanced Scientific Research

Curated by ChEMBL


Assay Description
Inhibition of HAT p300 catalytic domain by equilibrium dialysis


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081125
PNG
(CHEMBL3421961)
Show SMILES Cc1cc(O)cc(C)c1C=C1C(=O)N(Cc2ccccc2)C(=O)N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C27H24N2O4/c1-18-13-22(30)14-19(2)23(18)15-24-25(31)28(16-20-9-5-3-6-10-20)27(33)29(26(24)32)17-21-11-7-4-8-12-21/h3-15,30H,16-17H2,1-2H3
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9.40E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of P300 (unknown origin) using biotinylated H3 as substrate after 15 mins by double reciprocal plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076494
PNG
(CHEMBL3416552)
Show SMILES CCN(CC)c1ccc2c(C)c(-c3ccc(cc3)N3C(=O)C=CC3=O)c(=O)oc2c1
Show InChI InChI=1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3
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n/an/a 260n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM53290
PNG
(2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynapht...)
Show SMILES OC(=O)CSc1cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc2c1O
Show InChI InChI=1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22)
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n/an/a 330n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50420797
PNG
(CHEMBL2030281)
Show SMILES Oc1c(Sc2nnc[nH]2)cc(NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc12
Show InChI InChI=1S/C22H16N4O3S2/c27-21-18-8-4-3-7-17(18)19(12-20(21)30-22-23-13-24-25-22)26-31(28,29)16-10-9-14-5-1-2-6-15(14)11-16/h1-13,26-27H,(H,23,24,25)
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n/an/a 510n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50396170
PNG
(CHEMBL2031566)
Show SMILES OC(=O)CSc1cc(NS(=O)(=O)c2ccc(cc2)C(O)=O)c2ccccc2c1O
Show InChI InChI=1S/C19H15NO7S2/c21-17(22)10-28-16-9-15(13-3-1-2-4-14(13)18(16)23)20-29(26,27)12-7-5-11(6-8-12)19(24)25/h1-9,20,23H,10H2,(H,21,22)(H,24,25)
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n/an/a 660n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50255529
PNG
(Ac-Lys(CoA)-NH2 | CHEMBL505121 | NA)
Show SMILES CC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)C(N)=O
Show InChI InChI=1S/C31H53N10O19P3S/c1-17(42)40-18(27(33)47)6-4-5-8-34-21(44)13-64-11-10-35-20(43)7-9-36-29(48)25(46)31(2,3)14-57-63(54,55)60-62(52,53)56-12-19-24(59-61(49,50)51)23(45)30(58-19)41-16-39-22-26(32)37-15-38-28(22)41/h15-16,18-19,23-25,30,45-46H,4-14H2,1-3H3,(H2,33,47)(H,34,44)(H,35,43)(H,36,48)(H,40,42)(H,52,53)(H,54,55)(H2,32,37,38)(H2,49,50,51)/t18-,19+,23+,24+,25-,30+/m0/s1
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n/an/a 980n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of recombinant p300


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076493
PNG
(CHEMBL3416536)
Show SMILES OC(=O)CCSc1cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc2c1O
Show InChI InChI=1S/C19H16BrNO5S2/c20-12-5-7-13(8-6-12)28(25,26)21-16-11-17(27-10-9-18(22)23)19(24)15-4-2-1-3-14(15)16/h1-8,11,21,24H,9-10H2,(H,22,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076451
PNG
(CHEMBL3235887)
Show SMILES Oc1c(Sc2nc[nH]n2)cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc12
Show InChI InChI=1S/C18H13BrN4O3S2/c19-11-5-7-12(8-6-11)28(25,26)23-15-9-16(27-18-20-10-21-22-18)17(24)14-4-2-1-3-13(14)15/h1-10,23-24H,(H,20,21,22)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076260
PNG
(CHEMBL3416321)
Show SMILES [O-][N+](=O)c1c(Sc2nnnn2-c2ccccc2)cc(Cl)c2nonc12
Show InChI InChI=1S/C13H6ClN7O3S/c14-8-6-9(12(21(22)23)11-10(8)16-24-17-11)25-13-15-18-19-20(13)7-4-2-1-3-5-7/h1-6H
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n/an/a 1.10E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081162
PNG
(CHEMBL3421943)
Show SMILES COc1cc(C=C2C(=O)N(Cc3ccccc3)C(=O)N(Cc3ccccc3)C2=O)ccc1O
Show InChI InChI=1S/C26H22N2O5/c1-33-23-15-20(12-13-22(23)29)14-21-24(30)27(16-18-8-4-2-5-9-18)26(32)28(25(21)31)17-19-10-6-3-7-11-19/h2-15,29H,16-17H2,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrate


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081160
PNG
(CHEMBL3421941)
Show SMILES Oc1ccc(C=C2C(=O)N(Cc3ccccc3)C(=O)N(Cc3ccccc3)C2=O)cc1O
Show InChI InChI=1S/C25H20N2O5/c28-21-12-11-19(14-22(21)29)13-20-23(30)26(15-17-7-3-1-4-8-17)25(32)27(24(20)31)16-18-9-5-2-6-10-18/h1-14,28-29H,15-16H2
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n/an/a 1.60E+3n/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrate


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081170
PNG
(CHEMBL3421960)
Show SMILES CC1=NN(C(=O)\C1=C/Cc1ccc(Cc2cc(C)c(C)cc2[N+]([O-])=O)o1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H23N3O6/c1-15-12-19(24(29(33)34)13-16(15)2)14-22-9-8-21(35-22)10-11-23-17(3)27-28(25(23)30)20-6-4-18(5-7-20)26(31)32/h4-9,11-13H,10,14H2,1-3H3,(H,31,32)/b23-11-
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n/an/a 1.60E+3n/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrate


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50241990
PNG
(CHEMBL502489 | Camboginol | Garcinol | Garcinol, 1)
Show SMILES CC(C)=CC[C@@H](C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)C1=O)C2=O)C(C)=C
Show InChI InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,31,39-40H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,31?,37+,38-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM34786
PNG
(3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...)
Show SMILES Cc1ccc(cc1)-c1nc(N)s[n+]1-c1ccccc1
Show InChI InChI=1S/C15H13N3S/c1-11-7-9-12(10-8-11)14-17-15(16)19-18(14)13-5-3-2-4-6-13/h2-10,16H,1H3/p+1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076450
PNG
(CHEMBL3416537)
Show SMILES Oc1c(Cl)cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc12
Show InChI InChI=1S/C16H11BrClNO3S/c17-10-5-7-11(8-6-10)23(21,22)19-15-9-14(18)16(20)13-4-2-1-3-12(13)15/h1-9,19-20H
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n/an/a 1.80E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076328
PNG
(CHEMBL3416335)
Show SMILES CNc1nc(-c2ccccc2)[n+](s1)-c1ccccc1
Show InChI InChI=1S/C15H13N3S/c1-16-15-17-14(12-8-4-2-5-9-12)18(19-15)13-10-6-3-7-11-13/h2-11H,1H3/p+1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM34791
PNG
(MLS000392355 | N-methyl-2-(4-methylphenyl)-3-pheny...)
Show SMILES CNc1nc(-c2ccccc2)[n+](s1)-c1ccc(C)cc1
Show InChI InChI=1S/C16H15N3S/c1-12-8-10-14(11-9-12)19-15(18-16(17-2)20-19)13-6-4-3-5-7-13/h3-11H,1-2H3/p+1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081159
PNG
(CHEMBL3421940)
Show SMILES Oc1ccc(C=C2C(=O)N(Cc3ccccc3)C(=O)N(Cc3ccccc3)C2=O)cc1
Show InChI InChI=1S/C25H20N2O4/c28-21-13-11-18(12-14-21)15-22-23(29)26(16-19-7-3-1-4-8-19)25(31)27(24(22)30)17-20-9-5-2-6-10-20/h1-15,28H,16-17H2
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n/an/a 2.10E+3n/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrate


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076256
PNG
(CHEMBL3416317)
Show SMILES [O-][N+](=O)c1cc(Br)c2nsnc2c1Sc1ncnc2[nH]cnc12
Show InChI InChI=1S/C11H4BrN7O2S2/c12-4-1-5(19(20)21)9(7-6(4)17-23-18-7)22-11-8-10(14-2-13-8)15-3-16-11/h1-3H,(H,13,14,15,16)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076432
PNG
(CHEMBL3416526)
Show SMILES COc1ccc(cc1)-c1nnc(SC2CC(=O)N(C2=O)c2ccc(Cl)cc2)[nH]1
Show InChI InChI=1/C19H15ClN4O3S/c1-27-14-8-2-11(3-9-14)17-21-19(23-22-17)28-15-10-16(25)24(18(15)26)13-6-4-12(20)5-7-13/h2-9,15H,10H2,1H3,(H,21,22,23)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50255524
PNG
(Ac-SGRGK(CoA)GGKGLGKGGAKRHRK | CHEMBL505605)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CO)NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C107H188N43O40P3S/c1-58(2)40-70(95(170)132-48-80(159)141-62(20-7-12-29-108)91(166)128-43-75(154)126-45-77(156)138-59(3)90(165)145-66(22-9-14-31-110)97(172)146-68(27-19-36-125-106(117)118)99(174)149-71(41-61-42-119-55-134-61)100(175)147-67(26-18-35-124-105(115)116)98(173)148-69(103(177)178)24-10-15-32-111)144-82(161)50-131-93(168)63(21-8-13-30-109)140-78(157)46-127-76(155)44-129-92(167)64(142-79(158)47-130-94(169)65(25-17-34-123-104(113)114)143-81(160)49-133-96(171)72(51-151)139-60(4)152)23-11-16-33-120-83(162)53-194-39-38-121-74(153)28-37-122-101(176)87(164)107(5,6)54-187-193(184,185)190-192(182,183)186-52-73-86(189-191(179,180)181)85(163)102(188-73)150-57-137-84-88(112)135-56-136-89(84)150/h42,55-59,62-73,85-87,102,151,163-164H,7-41,43-54,108-111H2,1-6H3,(H,119,134)(H,120,162)(H,121,153)(H,122,176)(H,126,154)(H,127,155)(H,128,166)(H,129,167)(H,130,169)(H,131,168)(H,132,170)(H,133,171)(H,138,156)(H,139,152)(H,140,157)(H,141,159)(H,142,158)(H,143,160)(H,144,161)(H,145,165)(H,146,172)(H,147,175)(H,148,173)(H,149,174)(H,177,178)(H,182,183)(H,184,185)(H2,112,135,136)(H4,113,114,123)(H4,115,116,124)(H4,117,118,125)(H2,179,180,181)/t59-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73+,85+,86+,87-,102+/m0/s1
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n/an/a 2.88E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of recombinant p300


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081125
PNG
(CHEMBL3421961)
Show SMILES Cc1cc(O)cc(C)c1C=C1C(=O)N(Cc2ccccc2)C(=O)N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C27H24N2O4/c1-18-13-22(30)14-19(2)23(18)15-24-25(31)28(16-20-9-5-3-6-10-20)27(33)29(26(24)32)17-21-11-7-4-8-12-21/h3-15,30H,16-17H2,1-2H3
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n/an/a 2.90E+3n/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Inhibition of recombinant P300 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50247911
PNG
(2-(4-Pyridyl)-isothiazol-3(2H)-one | CHEMBL499919)
Show SMILES O=c1ccsn1-c1ccncc1
Show InChI InChI=1S/C8H6N2OS/c11-8-3-6-12-10(8)7-1-4-9-5-2-7/h1-6H
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n/an/a 3.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant HAT p300 expressed in Escherichia coli by filter assay


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076449
PNG
(CHEMBL3235890)
Show SMILES Oc1c(Sc2nnnn2-c2ccccc2)cc(NS(=O)(=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H17N5O3S2/c29-22-19-14-8-7-13-18(19)20(25-33(30,31)17-11-5-2-6-12-17)15-21(22)32-23-24-26-27-28(23)16-9-3-1-4-10-16/h1-15,25,29H
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n/an/a 3.10E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076431
PNG
(CHEMBL3416525)
Show SMILES Oc1ccccc1-c1nnc(SC2CC(=O)N(C2=O)c2ccc(Br)cc2)o1
Show InChI InChI=1/C18H12BrN3O4S/c19-10-5-7-11(8-6-10)22-15(24)9-14(17(22)25)27-18-21-20-16(26-18)12-3-1-2-4-13(12)23/h1-8,14,23H,9H2
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n/an/a 3.70E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081168
PNG
(CHEMBL3421950)
Show SMILES COc1cc(C=C2C(=O)N(CC(C)C)C(=O)N(CC(C)C)C2=O)ccc1O
Show InChI InChI=1S/C20H26N2O5/c1-12(2)10-21-18(24)15(19(25)22(20(21)26)11-13(3)4)8-14-6-7-16(23)17(9-14)27-5/h6-9,12-13,23H,10-11H2,1-5H3
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n/an/a 4.20E+3n/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrate


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50255526
PNG
(Ac-SGRGKGGKGLGK(CoA)GGAKRHRK | CHEMBL500256)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CO)NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C107H188N43O40P3S/c1-58(2)40-70(144-82(161)50-131-93(168)63(21-8-13-30-109)140-78(157)46-127-76(155)44-128-91(166)62(20-7-12-29-108)141-79(158)47-130-94(169)65(25-17-34-123-104(113)114)143-81(160)49-133-96(171)72(51-151)139-60(4)152)95(170)132-48-80(159)142-64(23-11-16-33-120-83(162)53-194-39-38-121-74(153)28-37-122-101(176)87(164)107(5,6)54-187-193(184,185)190-192(182,183)186-52-73-86(189-191(179,180)181)85(163)102(188-73)150-57-137-84-88(112)135-56-136-89(84)150)92(167)129-43-75(154)126-45-77(156)138-59(3)90(165)145-66(22-9-14-31-110)97(172)146-68(27-19-36-125-106(117)118)99(174)149-71(41-61-42-119-55-134-61)100(175)147-67(26-18-35-124-105(115)116)98(173)148-69(103(177)178)24-10-15-32-111/h42,55-59,62-73,85-87,102,151,163-164H,7-41,43-54,108-111H2,1-6H3,(H,119,134)(H,120,162)(H,121,153)(H,122,176)(H,126,154)(H,127,155)(H,128,166)(H,129,167)(H,130,169)(H,131,168)(H,132,170)(H,133,171)(H,138,156)(H,139,152)(H,140,157)(H,141,158)(H,142,159)(H,143,160)(H,144,161)(H,145,165)(H,146,172)(H,147,175)(H,148,173)(H,149,174)(H,177,178)(H,182,183)(H,184,185)(H2,112,135,136)(H4,113,114,123)(H4,115,116,124)(H4,117,118,125)(H2,179,180,181)/t59-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73+,85+,86+,87-,102+/m0/s1
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n/an/a 4.35E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of recombinant p300


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50207586
PNG
(2,6-bis(3-bromo-4-hydroxybenzylidene)cyclohexanone...)
Show SMILES Oc1ccc(\C=C2/CCC\C(=C/c3ccc(O)c(Br)c3)C2=O)cc1Br
Show InChI InChI=1S/C20H16Br2O3/c21-16-10-12(4-6-18(16)23)8-14-2-1-3-15(20(14)25)9-13-5-7-19(24)17(22)11-13/h4-11,23-24H,1-3H2/b14-8+,15-9+
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n/an/a 5.00E+3n/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibition of GST-p300 HAT assessed as histone acetylation


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50292429
PNG
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-Pentadecyl...)
Show SMILES OC(=O)c1c(O)cccc1CCCCCCC\C=C/C\C=C/CC=C
Show InChI InChI=1S/C22H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h2,4-5,7-8,15,17-18,23H,1,3,6,9-14,16H2,(H,24,25)/b5-4-,8-7-
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n/an/a 5.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged HAT p300 expressed in Sf21-Baculovirus system


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50292429
PNG
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-Pentadecyl...)
Show SMILES OC(=O)c1c(O)cccc1CCCCCCC\C=C/C\C=C/CC=C
Show InChI InChI=1S/C22H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h2,4-5,7-8,15,17-18,23H,1,3,6,9-14,16H2,(H,24,25)/b5-4-,8-7-
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged p300 HAT domain expressed in Escherichia coli BL21(DE3) cells using [14C]Ac-AoA and histone H4 as substrat...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50395258
PNG
(CHEMBL2163602)
Show SMILES CC(C)CN(Cc1ccc2OC(C)(C)C=Cc2c1)S(=O)(=O)c1nccs1
Show InChI InChI=1S/C19H24N2O3S2/c1-14(2)12-21(26(22,23)18-20-9-10-25-18)13-15-5-6-17-16(11-15)7-8-19(3,4)24-17/h5-11,14H,12-13H2,1-4H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University CSI

Curated by ChEMBL


Assay Description
Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50395259
PNG
(CHEMBL2163601)
Show SMILES CC(C)CN(Cc1ccc2OC(C)(C)C=Cc2c1)S(=O)(=O)c1nccn1C
Show InChI InChI=1S/C20H27N3O3S/c1-15(2)13-23(27(24,25)19-21-10-11-22(19)5)14-16-6-7-18-17(12-16)8-9-20(3,4)26-18/h6-12,15H,13-14H2,1-5H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University CSI

Curated by ChEMBL


Assay Description
Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50395260
PNG
(CHEMBL2163598)
Show SMILES COc1cc(CN(C(C)C)S(=O)(=O)c2ccccn2)cc2C=CC(C)(C)Oc12
Show InChI InChI=1S/C21H26N2O4S/c1-15(2)23(28(24,25)19-8-6-7-11-22-19)14-16-12-17-9-10-21(3,4)27-20(17)18(13-16)26-5/h6-13,15H,14H2,1-5H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University CSI

Curated by ChEMBL


Assay Description
Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50395261
PNG
(CHEMBL2163594)
Show SMILES CC(C)CN(Cc1ccc2OC(C)(C)C=Cc2c1)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C21H26N2O3S/c1-16(2)14-23(27(24,25)20-7-5-6-12-22-20)15-17-8-9-19-18(13-17)10-11-21(3,4)26-19/h5-13,16H,14-15H2,1-4H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University CSI

Curated by ChEMBL


Assay Description
Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081166
PNG
(CHEMBL3421948)
Show SMILES CC(C)CN1C(=O)N(CC(C)C)C(=O)C(=Cc2ccc(O)c(O)c2)C1=O
Show InChI InChI=1S/C19H24N2O5/c1-11(2)9-20-17(24)14(7-13-5-6-15(22)16(23)8-13)18(25)21(19(20)26)10-12(3)4/h5-8,11-12,22-23H,9-10H2,1-4H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrate


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081161
PNG
(CHEMBL3421942)
Show SMILES COc1ccc(C=C2C(=O)N(Cc3ccccc3)C(=O)N(Cc3ccccc3)C2=O)cc1O
Show InChI InChI=1S/C26H22N2O5/c1-33-23-13-12-20(15-22(23)29)14-21-24(30)27(16-18-8-4-2-5-9-18)26(32)28(25(21)31)17-19-10-6-3-7-11-19/h2-15,29H,16-17H2,1H3
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n/an/a 5.90E+3n/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrate


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50241990
PNG
(CHEMBL502489 | Camboginol | Garcinol | Garcinol, 1)
Show SMILES CC(C)=CC[C@@H](C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)C1=O)C2=O)C(C)=C
Show InChI InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,31,39-40H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,31?,37+,38-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of HAT p300


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076255
PNG
(CHEMBL3416316)
Show SMILES O=S1(=O)C=C(Sc2nnc(o2)-c2ccncc2)c2ccccc12
Show InChI InChI=1S/C15H9N3O3S2/c19-23(20)9-12(11-3-1-2-4-13(11)23)22-15-18-17-14(21-15)10-5-7-16-8-6-10/h1-9H
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n/an/a 6.20E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076254
PNG
(CHEMBL3416315)
Show SMILES O=S1(=O)C=C(Sc2nnnn2-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C15H10N4O2S2/c20-23(21)10-13(12-8-4-5-9-14(12)23)22-15-16-17-18-19(15)11-6-2-1-3-7-11/h1-10H
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n/an/a 6.20E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50067040
PNG
(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Show SMILES COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3
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n/an/a 6.50E+3n/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrate


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50255527
PNG
(Ac-SGRGKGGKGLGKGGAK(CoA)RHRK | CHEMBL504265)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CO)NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C107H188N43O40P3S/c1-58(2)40-70(144-82(161)50-131-93(168)64(22-9-14-31-110)140-78(157)46-127-76(155)44-129-91(166)62(20-7-12-29-108)141-79(158)47-130-94(169)65(25-17-34-123-104(113)114)143-81(160)49-133-96(171)72(51-151)139-60(4)152)95(170)132-48-80(159)142-63(21-8-13-30-109)92(167)128-43-75(154)126-45-77(156)138-59(3)90(165)145-66(97(172)146-68(27-19-36-125-106(117)118)99(174)149-71(41-61-42-119-55-134-61)100(175)147-67(26-18-35-124-105(115)116)98(173)148-69(103(177)178)24-10-15-32-111)23-11-16-33-120-83(162)53-194-39-38-121-74(153)28-37-122-101(176)87(164)107(5,6)54-187-193(184,185)190-192(182,183)186-52-73-86(189-191(179,180)181)85(163)102(188-73)150-57-137-84-88(112)135-56-136-89(84)150/h42,55-59,62-73,85-87,102,151,163-164H,7-41,43-54,108-111H2,1-6H3,(H,119,134)(H,120,162)(H,121,153)(H,122,176)(H,126,154)(H,127,155)(H,128,167)(H,129,166)(H,130,169)(H,131,168)(H,132,170)(H,133,171)(H,138,156)(H,139,152)(H,140,157)(H,141,158)(H,142,159)(H,143,160)(H,144,161)(H,145,165)(H,146,172)(H,147,175)(H,148,173)(H,149,174)(H,177,178)(H,182,183)(H,184,185)(H2,112,135,136)(H4,113,114,123)(H4,115,116,124)(H4,117,118,125)(H2,179,180,181)/t59-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73+,85+,86+,87-,102+/m0/s1
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n/an/a 6.62E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of recombinant p300


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50076246
PNG
(CHEMBL3416307)
Show SMILES OC(=O)c1ccc(cc1)-n1nnnc1SC1=CS(=O)(=O)c2ccccc12
Show InChI InChI=1S/C16H10N4O4S2/c21-15(22)10-5-7-11(8-6-10)20-16(17-18-19-20)25-13-9-26(23,24)14-4-2-1-3-12(13)14/h1-9H,(H,21,22)
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n/an/a 7.50E+3n/an/an/an/an/an/a



Mayo Clinic College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50255522
PNG
(Ac-ARTKQTARKSTGGK(CoA)APRKQL | CHEMBL526343)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C116H205N42O45P3S/c1-57(2)48-74(112(190)191)152-101(180)72(32-34-78(120)164)148-96(175)66(24-12-16-37-117)146-99(178)70(29-21-42-133-114(125)126)150-105(184)76-31-23-46-157(76)110(189)60(5)142-95(174)65(27-15-19-40-129-83(169)53-207-47-45-130-80(166)36-44-131-109(188)90(171)116(10,11)54-200-206(197,198)203-205(195,196)199-52-77-89(202-204(192,193)194)88(170)111(201-77)158-56-139-87-91(122)137-55-138-92(87)158)143-82(168)50-135-81(167)49-136-106(185)84(61(6)160)154-104(183)75(51-159)153-100(179)67(25-13-17-38-118)147-98(177)69(28-20-41-132-113(123)124)144-94(173)59(4)141-107(186)85(62(7)161)155-103(182)73(33-35-79(121)165)149-97(176)68(26-14-18-39-119)151-108(187)86(63(8)162)156-102(181)71(30-22-43-134-115(127)128)145-93(172)58(3)140-64(9)163/h55-63,65-77,84-86,88-90,111,159-162,170-171H,12-54,117-119H2,1-11H3,(H2,120,164)(H2,121,165)(H,129,169)(H,130,166)(H,131,188)(H,135,167)(H,136,185)(H,140,163)(H,141,186)(H,142,174)(H,143,168)(H,144,173)(H,145,172)(H,146,178)(H,147,177)(H,148,175)(H,149,176)(H,150,184)(H,151,187)(H,152,180)(H,153,179)(H,154,183)(H,155,182)(H,156,181)(H,190,191)(H,195,196)(H,197,198)(H2,122,137,138)(H4,123,124,132)(H4,125,126,133)(H4,127,128,134)(H2,192,193,194)/t58-,59-,60-,61+,62+,63+,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77+,84-,85-,86-,88+,89+,90-,111+/m0/s1
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n/an/a 7.54E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of recombinant p300


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50081164
PNG
(CHEMBL3421945)
Show SMILES COc1ccc(C=C2C(=O)N(Cc3ccccc3)C(=O)N(Cc3ccccc3)C2=O)cc1
Show InChI InChI=1S/C26H22N2O4/c1-32-22-14-12-19(13-15-22)16-23-24(29)27(17-20-8-4-2-5-9-20)26(31)28(25(23)30)18-21-10-6-3-7-11-21/h2-16H,17-18H2,1H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrate


Citation and Details
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens)
BDBM50255525
PNG
(Ac-SGRGKGGK(CoA)GLGKGGAKRHRK | CHEMBL448227)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CO)NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C107H188N43O40P3S/c1-58(2)40-70(95(170)132-48-80(159)142-63(21-8-13-30-109)92(167)128-43-75(154)126-45-77(156)138-59(3)90(165)145-66(22-9-14-31-110)97(172)146-68(27-19-36-125-106(117)118)99(174)149-71(41-61-42-119-55-134-61)100(175)147-67(26-18-35-124-105(115)116)98(173)148-69(103(177)178)24-10-15-32-111)144-82(161)50-131-93(168)64(140-78(157)46-127-76(155)44-129-91(166)62(20-7-12-29-108)141-79(158)47-130-94(169)65(25-17-34-123-104(113)114)143-81(160)49-133-96(171)72(51-151)139-60(4)152)23-11-16-33-120-83(162)53-194-39-38-121-74(153)28-37-122-101(176)87(164)107(5,6)54-187-193(184,185)190-192(182,183)186-52-73-86(189-191(179,180)181)85(163)102(188-73)150-57-137-84-88(112)135-56-136-89(84)150/h42,55-59,62-73,85-87,102,151,163-164H,7-41,43-54,108-111H2,1-6H3,(H,119,134)(H,120,162)(H,121,153)(H,122,176)(H,126,154)(H,127,155)(H,128,167)(H,129,166)(H,130,169)(H,131,168)(H,132,170)(H,133,171)(H,138,156)(H,139,152)(H,140,157)(H,141,158)(H,142,159)(H,143,160)(H,144,161)(H,145,165)(H,146,172)(H,147,175)(H,148,173)(H,149,174)(H,177,178)(H,182,183)(H,184,185)(H2,112,135,136)(H4,113,114,123)(H4,115,116,124)(H4,117,118,125)(H2,179,180,181)/t59-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73+,85+,86+,87-,102+/m0/s1
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Article
PubMed
n/an/a 8.15E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of recombinant p300


Citation and Details
More data for this
Ligand-Target Pair
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