BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 141 hits Enz. Inhib. hit(s) with Target = 'Histone lysine demethylase PHF8' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276044
PNG
(2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276067
PNG
(2-[1-[(3-chloro-2-fluorophenyl)methyl]imidazol-4-y...)
Show SMILES Fc1c(Cl)cccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C17H12ClFN6/c18-13-3-1-2-12(17(13)19)8-25-9-16(21-10-25)14-6-11(4-5-20-14)15-7-22-24-23-15/h1-7,9-10H,8H2,(H,22,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276050
PNG
(2-[1-(3,4-dihydro-2H-chromen-4-ylmethyl)imidazol-4...)
Show SMILES C(C1CCOc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C20H18N6O/c1-2-4-20-16(3-1)15(6-8-27-20)11-26-12-19(22-13-26)17-9-14(5-7-21-17)18-10-23-25-24-18/h1-5,7,9-10,12-13,15H,6,8,11H2,(H,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276044
PNG
(2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276067
PNG
(2-[1-[(3-chloro-2-fluorophenyl)methyl]imidazol-4-y...)
Show SMILES Fc1c(Cl)cccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C17H12ClFN6/c18-13-3-1-2-12(17(13)19)8-25-9-16(21-10-25)14-6-11(4-5-20-14)15-7-22-24-23-15/h1-7,9-10H,8H2,(H,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276050
PNG
(2-[1-(3,4-dihydro-2H-chromen-4-ylmethyl)imidazol-4...)
Show SMILES C(C1CCOc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C20H18N6O/c1-2-4-20-16(3-1)15(6-8-27-20)11-26-12-19(22-13-26)17-9-14(5-7-21-17)18-10-23-25-24-18/h1-5,7,9-10,12-13,15H,6,8,11H2,(H,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155508
PNG
(CHEMBL3780833)
Show SMILES C[C@@H](N1CCC[C@@H](CNCc2cc(ccn2)C(O)=O)C1=O)c1ccccc1
Show InChI InChI=1S/C21H25N3O3/c1-15(16-6-3-2-4-7-16)24-11-5-8-18(20(24)25)13-22-14-19-12-17(21(26)27)9-10-23-19/h2-4,6-7,9-10,12,15,18,22H,5,8,11,13-14H2,1H3,(H,26,27)/t15-,18+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a<250n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00437
BindingDB Entry DOI: 10.7270/Q2CJ8GC9
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155507
PNG
(CHEMBL3780904)
Show SMILES C[C@@H](N1CC[C@@H](CNCc2cc(ccn2)C(O)=O)C1=O)c1ccccc1
Show InChI InChI=1S/C20H23N3O3/c1-14(15-5-3-2-4-6-15)23-10-8-17(19(23)24)12-21-13-18-11-16(20(25)26)7-9-22-18/h2-7,9,11,14,17,21H,8,10,12-13H2,1H3,(H,25,26)/t14-,17+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<250n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00437
BindingDB Entry DOI: 10.7270/Q2CJ8GC9
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155505
PNG
(CHEMBL3781414)
Show SMILES CCN1CCC(CNCc2cc(ccn2)C(O)=O)C1=O
Show InChI InChI=1S/C14H19N3O3/c1-2-17-6-4-11(13(17)18)8-15-9-12-7-10(14(19)20)3-5-16-12/h3,5,7,11,15H,2,4,6,8-9H2,1H3,(H,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<250n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00437
BindingDB Entry DOI: 10.7270/Q2CJ8GC9
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155450
PNG
(CHEMBL3779953)
Show SMILES Cc1cn2CCN(Cc3cc(ccn3)C(O)=O)CCc2n1
Show InChI InChI=1S/C15H18N4O2/c1-11-9-19-7-6-18(5-3-14(19)17-11)10-13-8-12(15(20)21)2-4-16-13/h2,4,8-9H,3,5-7,10H2,1H3,(H,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<250n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00437
BindingDB Entry DOI: 10.7270/Q2CJ8GC9
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155449
PNG
(CHEMBL3780958)
Show SMILES COc1ccc(cc1)[C@@H](C)N1CCC[C@@H](CNCc2cc(ccn2)C(O)=O)C1=O
Show InChI InChI=1S/C22H27N3O4/c1-15(16-5-7-20(29-2)8-6-16)25-11-3-4-18(21(25)26)13-23-14-19-12-17(22(27)28)9-10-24-19/h5-10,12,15,18,23H,3-4,11,13-14H2,1-2H3,(H,27,28)/t15-,18+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<250n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00437
BindingDB Entry DOI: 10.7270/Q2CJ8GC9
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155509
PNG
(CHEMBL3780689)
Show SMILES C[C@@H](N1CCC[C@H](CNCc2cc(ccn2)C(O)=O)C1=O)c1ccccc1
Show InChI InChI=1S/C21H25N3O3/c1-15(16-6-3-2-4-7-16)24-11-5-8-18(20(24)25)13-22-14-19-12-17(21(26)27)9-10-23-19/h2-4,6-7,9-10,12,15,18,22H,5,8,11,13-14H2,1H3,(H,26,27)/t15-,18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<250n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00437
BindingDB Entry DOI: 10.7270/Q2CJ8GC9
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50395083
PNG
(CHEMBL2164246)
Show SMILES NNC(=O)CCC(O)=O
Show InChI InChI=1S/C4H8N2O3/c5-6-3(7)1-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 480n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assay


J Med Chem 55: 6639-43 (2012)


Article DOI: 10.1021/jm300677j
BindingDB Entry DOI: 10.7270/Q2JH3N9S
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50395076
PNG
(CHEMBL2164243)
Show SMILES CN(C)NC(=O)CCC(O)=O
Show InChI InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 550n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assay


J Med Chem 55: 6639-43 (2012)


Article DOI: 10.1021/jm300677j
BindingDB Entry DOI: 10.7270/Q2JH3N9S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276039
PNG
(2-(1-methylimidazol-4-yl)-4-(1H-triazol-4-yl)pyrid...)
Show SMILES Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C11H10N6/c1-17-6-11(13-7-17)9-4-8(2-3-12-9)10-5-14-16-15-10/h2-7H,1H3,(H,14,15,16)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276040
PNG
(2-[1-[(2-chlorophenyl)methyl]imidazol-4-yl]-4-(1H-...)
Show SMILES Clc1ccccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C17H13ClN6/c18-14-4-2-1-3-13(14)9-24-10-17(20-11-24)15-7-12(5-6-19-15)16-8-21-23-22-16/h1-8,10-11H,9H2,(H,21,22,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276041
PNG
(2-[5-(4-fluorophenyl)-1-methylimidazol-4-yl]-4-(1H...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C17H13FN6/c1-24-10-20-16(17(24)11-2-4-13(18)5-3-11)14-8-12(6-7-19-14)15-9-21-23-22-15/h2-10H,1H3,(H,21,22,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276043
PNG
(2-[1-(1-phenylethyl)imidazol-4-yl]-4-(1H-triazol-4...)
Show SMILES CC(c1ccccc1)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C18H16N6/c1-13(14-5-3-2-4-6-14)24-11-18(20-12-24)16-9-15(7-8-19-16)17-10-21-23-22-17/h2-13H,1H3,(H,21,22,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276045
PNG
(2-[1-[2-(2-methoxyphenyl)ethyl]imidazol-4-yl]-4-(1...)
Show SMILES COc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C19H18N6O/c1-26-19-5-3-2-4-14(19)7-9-25-12-18(21-13-25)16-10-15(6-8-20-16)17-11-22-24-23-17/h2-6,8,10-13H,7,9H2,1H3,(H,22,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276046
PNG
(2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)imid...)
Show SMILES C(C1CCCc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C21H20N6/c1-2-7-18-15(4-1)5-3-6-17(18)12-27-13-21(23-14-27)19-10-16(8-9-22-19)20-11-24-26-25-20/h1-2,4,7-11,13-14,17H,3,5-6,12H2,(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276047
PNG
(2-[1-[2-(2-ethoxyphenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES CCOc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C20H20N6O/c1-2-27-20-6-4-3-5-15(20)8-10-26-13-19(22-14-26)17-11-16(7-9-21-17)18-12-23-25-24-18/h3-7,9,11-14H,2,8,10H2,1H3,(H,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276048
PNG
(4-(1H-triazol-4-yl)-2-[1-[2-[2-(2,2,2-trifluoroeth...)
Show SMILES FC(F)(F)COc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)12-30-19-4-2-1-3-14(19)6-8-29-11-18(25-13-29)16-9-15(5-7-24-16)17-10-26-28-27-17/h1-5,7,9-11,13H,6,8,12H2,(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276049
PNG
(2-[1-[2-[2-(cyclopropylmethoxy)phenyl]ethyl]imidaz...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1OCC1CC1
Show InChI InChI=1S/C22H22N6O/c1-2-4-22(29-14-16-5-6-16)17(3-1)8-10-28-13-21(24-15-28)19-11-18(7-9-23-19)20-12-25-27-26-20/h1-4,7,9,11-13,15-16H,5-6,8,10,14H2,(H,25,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276053
PNG
(4-[2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)i...)
Show SMILES N#Cc1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCCc3ccccc23)cn1
Show InChI InChI=1S/C22H19N7/c23-11-20-22(27-28-26-20)16-8-9-24-19(10-16)21-13-29(14-25-21)12-17-6-3-5-15-4-1-2-7-18(15)17/h1-2,4,7-10,13-14,17H,3,5-6,12H2,(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276054
PNG
(4-[2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]pyri...)
Show SMILES N#Cc1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2cccc3ccccc23)cn1
Show InChI InChI=1S/C23H17N7/c24-13-21-23(28-29-27-21)18-8-10-25-20(12-18)22-14-30(15-26-22)11-9-17-6-3-5-16-4-1-2-7-19(16)17/h1-8,10,12,14-15H,9,11H2,(H,27,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276057
PNG
(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2I)c1Cl
Show InChI InChI=1S/C17H11Cl2IN6/c18-12-3-1-2-11(15(12)19)7-26-8-14(22-9-26)13-6-10(4-5-21-13)16-17(20)24-25-23-16/h1-6,8-9H,7H2,(H,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276058
PNG
(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Show SMILES Fc1[nH]nnc1-c1ccnc(c1)-c1cn(Cc2cccc(Cl)c2Cl)cn1
Show InChI InChI=1S/C17H11Cl2FN6/c18-12-3-1-2-11(15(12)19)7-26-8-14(22-9-26)13-6-10(4-5-21-13)16-17(20)24-25-23-16/h1-6,8-9H,7H2,(H,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276059
PNG
(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1Cl
Show InChI InChI=1S/C17H12Cl2N6/c18-13-3-1-2-12(17(13)19)8-25-9-16(21-10-25)14-6-11(4-5-20-14)15-7-22-24-23-15/h1-7,9-10H,8H2,(H,22,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276060
PNG
(2-[1-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]i...)
Show SMILES FC(F)(F)c1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1Cl
Show InChI InChI=1S/C18H12ClF3N6/c19-17-12(2-1-3-13(17)18(20,21)22)8-28-9-16(24-10-28)14-6-11(4-5-23-14)15-7-25-27-26-15/h1-7,9-10H,8H2,(H,25,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276061
PNG
(2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]-4-(1H-...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1cccc2ccccc12
Show InChI InChI=1S/C22H18N6/c1-2-7-19-16(4-1)5-3-6-17(19)9-11-28-14-22(24-15-28)20-12-18(8-10-23-20)21-13-25-27-26-21/h1-8,10,12-15H,9,11H2,(H,25,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276062
PNG
(2-[5-(4-fluoro-3-methoxyphenyl)-1-methylimidazol-4...)
Show SMILES COc1cc(ccc1F)-c1c(ncn1C)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C18H15FN6O/c1-25-10-21-17(18(25)12-3-4-13(19)16(8-12)26-2)14-7-11(5-6-20-14)15-9-22-24-23-15/h3-10H,1-2H3,(H,22,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276066
PNG
(2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-y...)
Show SMILES Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F
Show InChI InChI=1S/C18H15FN6/c1-12-3-2-4-14(18(12)19)9-25-10-17(21-11-25)15-7-13(5-6-20-15)16-8-22-24-23-16/h2-8,10-11H,9H2,1H3,(H,22,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276068
PNG
(2-[1-[(2-fluoro-3-methoxyphenyl)methyl]imidazol-4-...)
Show SMILES COc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F
Show InChI InChI=1S/C18H15FN6O/c1-26-17-4-2-3-13(18(17)19)9-25-10-16(21-11-25)14-7-12(5-6-20-14)15-8-22-24-23-15/h2-8,10-11H,9H2,1H3,(H,22,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276069
PNG
(4-(1H-triazol-4-yl)-2-[1-[2-[2-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C19H15F3N6/c20-19(21,22)15-4-2-1-3-13(15)6-8-28-11-18(24-12-28)16-9-14(5-7-23-16)17-10-25-27-26-17/h1-5,7,9-12H,6,8H2,(H,25,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276070
PNG
(2-[1-[2-(2-chlorophenyl)-2-methylpropyl]imidazol-4...)
Show SMILES CC(C)(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1Cl
Show InChI InChI=1S/C20H19ClN6/c1-20(2,15-5-3-4-6-16(15)21)12-27-11-19(23-13-27)17-9-14(7-8-22-17)18-10-24-26-25-18/h3-11,13H,12H2,1-2H3,(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276072
PNG
(4-(1H-triazol-4-yl)-2-[1-[2-[2-(trifluoromethoxy)p...)
Show SMILES FC(F)(F)Oc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C19H15F3N6O/c20-19(21,22)29-18-4-2-1-3-13(18)6-8-28-11-17(24-12-28)15-9-14(5-7-23-15)16-10-25-27-26-16/h1-5,7,9-12H,6,8H2,(H,25,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276073
PNG
(4-(5-fluoro-1H-triazol-4-yl)-2-[1-(2-naphthalen-1-...)
Show SMILES Fc1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2cccc3ccccc23)cn1
Show InChI InChI=1S/C22H17FN6/c23-22-21(26-28-27-22)17-8-10-24-19(12-17)20-13-29(14-25-20)11-9-16-6-3-5-15-4-1-2-7-18(15)16/h1-8,10,12-14H,9,11H2,(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276082
PNG
(1-benzyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}...)
Show SMILES C(c1ccccc1)n1cnc(c1)-c1cc2[nH]nnc2cn1
Show InChI InChI=1S/C15H12N6/c1-2-4-11(5-3-1)8-21-9-15(17-10-21)12-6-13-14(7-16-12)19-20-18-13/h1-7,9-10H,8H2,(H,18,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276093
PNG
(2-(5-bromo-1-(2-chlorobenzyl)-1H-imidazol-4-yl)-4-...)
Show SMILES Clc1ccccc1Cn1cnc(c1Br)-c1cc(ccn1)-c1cn[nH]n1
Show InChI InChI=1S/C17H12BrClN6/c18-17-16(14-7-11(5-6-20-14)15-8-22-24-23-15)21-10-25(17)9-12-3-1-2-4-13(12)19/h1-8,10H,9H2,(H,22,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10071984 (2018)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276039
PNG
(2-(1-methylimidazol-4-yl)-4-(1H-triazol-4-yl)pyrid...)
Show SMILES Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C11H10N6/c1-17-6-11(13-7-17)9-4-8(2-3-12-9)10-5-14-16-15-10/h2-7H,1H3,(H,14,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276040
PNG
(2-[1-[(2-chlorophenyl)methyl]imidazol-4-yl]-4-(1H-...)
Show SMILES Clc1ccccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C17H13ClN6/c18-14-4-2-1-3-13(14)9-24-10-17(20-11-24)15-7-12(5-6-19-15)16-8-21-23-22-16/h1-8,10-11H,9H2,(H,21,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276041
PNG
(2-[5-(4-fluorophenyl)-1-methylimidazol-4-yl]-4-(1H...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C17H13FN6/c1-24-10-20-16(17(24)11-2-4-13(18)5-3-11)14-8-12(6-7-19-14)15-9-21-23-22-15/h2-10H,1H3,(H,21,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276043
PNG
(2-[1-(1-phenylethyl)imidazol-4-yl]-4-(1H-triazol-4...)
Show SMILES CC(c1ccccc1)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C18H16N6/c1-13(14-5-3-2-4-6-14)24-11-18(20-12-24)16-9-15(7-8-19-16)17-10-21-23-22-17/h2-13H,1H3,(H,21,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276045
PNG
(2-[1-[2-(2-methoxyphenyl)ethyl]imidazol-4-yl]-4-(1...)
Show SMILES COc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C19H18N6O/c1-26-19-5-3-2-4-14(19)7-9-25-12-18(21-13-25)16-10-15(6-8-20-16)17-11-22-24-23-17/h2-6,8,10-13H,7,9H2,1H3,(H,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276046
PNG
(2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)imid...)
Show SMILES C(C1CCCc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C21H20N6/c1-2-7-18-15(4-1)5-3-6-17(18)12-27-13-21(23-14-27)19-10-16(8-9-22-19)20-11-24-26-25-20/h1-2,4,7-11,13-14,17H,3,5-6,12H2,(H,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276047
PNG
(2-[1-[2-(2-ethoxyphenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES CCOc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C20H20N6O/c1-2-27-20-6-4-3-5-15(20)8-10-26-13-19(22-14-26)17-11-16(7-9-21-17)18-12-23-25-24-18/h3-7,9,11-14H,2,8,10H2,1H3,(H,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276048
PNG
(4-(1H-triazol-4-yl)-2-[1-[2-[2-(2,2,2-trifluoroeth...)
Show SMILES FC(F)(F)COc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)12-30-19-4-2-1-3-14(19)6-8-29-11-18(25-13-29)16-9-15(5-7-24-16)17-10-26-28-27-17/h1-5,7,9-11,13H,6,8,12H2,(H,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276049
PNG
(2-[1-[2-[2-(cyclopropylmethoxy)phenyl]ethyl]imidaz...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1OCC1CC1
Show InChI InChI=1S/C22H22N6O/c1-2-4-22(29-14-16-5-6-16)17(3-1)8-10-28-13-21(24-15-28)19-11-18(7-9-23-19)20-12-25-27-26-20/h1-4,7,9,11-13,15-16H,5-6,8,10,14H2,(H,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM319596
PNG
(4-[2-[1-(1,2,3,4-tetrahydronaphthalen- 1-ylmethyl)...)
Show SMILES [C-]#[N+]c1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCCc3ccccc23)cn1
Show InChI InChI=1S/C22H19N7/c1-23-22-21(26-28-27-22)16-9-10-24-19(11-16)20-13-29(14-25-20)12-17-7-4-6-15-5-2-3-8-18(15)17/h2-3,5,8-11,13-14,17H,4,6-7,12H2,(H,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM319597
PNG
(4-[2-[1-(2-naphthalen-1-ylethyl)imidazol- 4-yl]pyr...)
Show SMILES [C-]#[N+]c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2cccc3ccccc23)cn1
Show InChI InChI=1S/C23H17N7/c1-24-23-22(27-29-28-23)18-9-11-25-20(13-18)21-14-30(15-26-21)12-10-17-7-4-6-16-5-2-3-8-19(16)17/h2-9,11,13-15H,10,12H2,(H,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 141 total )  |  Next  |  Last  >>
Jump to: