BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 51 hits Enz. Inhib. hit(s) with Target = 'Histone-arginine methyltransferase CARM1' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27641
PNG
(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNC(=O)[C@H](C)N)c1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N5O3/c1-14(27)21(32)28-12-15-6-5-8-17(10-15)31-18(11-20(30-31)23(24,25)26)22(33)29-13-16-7-3-4-9-19(16)34-2/h3-11,14H,12-13,27H2,1-2H3,(H,28,32)(H,29,33)/t14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 60n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27641
PNG
(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNC(=O)[C@H](C)N)c1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N5O3/c1-14(27)21(32)28-12-15-6-5-8-17(10-15)31-18(11-20(30-31)23(24,25)26)22(33)29-13-16-7-3-4-9-19(16)34-2/h3-11,14H,12-13,27H2,1-2H3,(H,28,32)(H,29,33)/t14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27642
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1csc(CNC(=O)[C@H](C)N)c1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3S/c1-12(25)19(30)27-10-15-7-14(11-33-15)29-16(8-18(28-29)21(22,23)24)20(31)26-9-13-5-3-4-6-17(13)32-2/h3-8,11-12H,9-10,25H2,1-2H3,(H,26,31)(H,27,30)/t12-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 60n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27659
PNG
(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-be...)
Show SMILES C[C@H](N)C(=O)NCc1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O2/c1-14(26)20(31)27-13-16-8-5-9-17(10-16)30-18(11-19(29-30)22(23,24)25)21(32)28-12-15-6-3-2-4-7-15/h2-11,14H,12-13,26H2,1H3,(H,27,31)(H,28,32)/t14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 80n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311688
PNG
(CHEMBL1080460 | N-(2-methoxybenzyl)-1-(3-((2-(meth...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1OC)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O2/c1-27-10-11-28-14-16-6-5-8-18(12-16)31-19(13-21(30-31)23(24,25)26)22(32)29-15-17-7-3-4-9-20(17)33-2/h3-9,12-13,27-28H,10-11,14-15H2,1-2H3,(H,29,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27650
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...)
Show SMILES C[C@H](N)C(=O)NCc1cc(cs1)-n1nc(cc1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2S/c1-12(24)18(29)26-10-15-7-14(11-31-15)28-16(8-17(27-28)20(21,22)23)19(30)25-9-13-5-3-2-4-6-13/h2-8,11-12H,9-10,24H2,1H3,(H,25,30)(H,26,29)/t12-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 220n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27655
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-2-y...)
Show SMILES C[C@H](N)C(=O)NCc1ccc(s1)-n1nc(cc1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2S/c1-12(24)18(29)26-11-14-7-8-17(31-14)28-15(9-16(27-28)20(21,22)23)19(30)25-10-13-5-3-2-4-6-13/h2-9,12H,10-11,24H2,1H3,(H,25,30)(H,26,29)/t12-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 230n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27651
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...)
Show SMILES C[C@H](N)C(=O)NCc1cc(cs1)-n1nc(cc1C(=O)NCc1ccccc1C)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O2S/c1-12-5-3-4-6-14(12)9-26-20(31)17-8-18(21(22,23)24)28-29(17)15-7-16(32-11-15)10-27-19(30)13(2)25/h3-8,11,13H,9-10,25H2,1-2H3,(H,26,31)(H,27,30)/t13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 260n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27643
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-2-y...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1ccc(CNC(=O)[C@H](C)N)s1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3S/c1-12(25)19(30)27-11-14-7-8-18(33-14)29-15(9-17(28-29)21(22,23)24)20(31)26-10-13-5-3-4-6-16(13)32-2/h3-9,12H,10-11,25H2,1-2H3,(H,26,31)(H,27,30)/t12-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 300n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311707
PNG
(1-(3-((2-(methylamino)ethylamino)methyl)phenyl)-N-...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1cccc2ccccc12)C(F)(F)F
Show InChI InChI=1S/C26H26F3N5O/c1-30-12-13-31-16-18-6-4-10-21(14-18)34-23(15-24(33-34)26(27,28)29)25(35)32-17-20-9-5-8-19-7-2-3-11-22(19)20/h2-11,14-15,30-31H,12-13,16-17H2,1H3,(H,32,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 320n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27652
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...)
Show SMILES COc1cccc(CNC(=O)c2cc(nn2-c2csc(CNC(=O)[C@H](C)N)c2)C(F)(F)F)c1
Show InChI InChI=1S/C21H22F3N5O3S/c1-12(25)19(30)27-10-16-7-14(11-33-16)29-17(8-18(28-29)21(22,23)24)20(31)26-9-13-4-3-5-15(6-13)32-2/h3-8,11-12H,9-10,25H2,1-2H3,(H,26,31)(H,27,30)/t12-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 370n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311700
PNG
(CHEMBL1087114 | N-(5-fluoro-2-methoxybenzyl)-1-(3-...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1cc(F)ccc1OC)C(F)(F)F
Show InChI InChI=1S/C23H25F4N5O2/c1-28-8-9-29-13-15-4-3-5-18(10-15)32-19(12-21(31-32)23(25,26)27)22(33)30-14-16-11-17(24)6-7-20(16)34-2/h3-7,10-12,28-29H,8-9,13-14H2,1-2H3,(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 710n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311699
PNG
(CHEMBL1087540 | N-((2,3-dihydrobenzo[b][1,4]dioxin...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1cccc2OCCOc12)C(F)(F)F
Show InChI InChI=1S/C24H26F3N5O3/c1-28-8-9-29-14-16-4-2-6-18(12-16)32-19(13-21(31-32)24(25,26)27)23(33)30-15-17-5-3-7-20-22(17)35-11-10-34-20/h2-7,12-13,28-29H,8-11,14-15H2,1H3,(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 710n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27653
PNG
(methyl 2-({[1-(5-{[(2S)-2-aminopropanamido]methyl}...)
Show SMILES COC(=O)c1ccccc1CNC(=O)c1cc(nn1-c1csc(CNC(=O)[C@H](C)N)c1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O4S/c1-12(26)19(31)28-10-15-7-14(11-35-15)30-17(8-18(29-30)22(23,24)25)20(32)27-9-13-5-3-4-6-16(13)21(33)34-2/h3-8,11-12H,9-10,26H2,1-2H3,(H,27,32)(H,28,31)/t12-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 770n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27649
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...)
Show SMILES C[C@H](N)C(=O)NCc1cc(cs1)-n1nc(cc1C(=O)NCc1ccccc1F)C(F)(F)F
Show InChI InChI=1S/C20H19F4N5O2S/c1-11(25)18(30)27-9-14-6-13(10-32-14)29-16(7-17(28-29)20(22,23)24)19(31)26-8-12-4-2-3-5-15(12)21/h2-7,10-11H,8-9,25H2,1H3,(H,26,31)(H,27,30)/t11-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 790n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311698
PNG
(CHEMBL1088320 | N-(2-ethoxybenzyl)-1-(3-((2-(methy...)
Show SMILES CCOc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNCCNC)c1)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O2/c1-3-34-21-10-5-4-8-18(21)16-30-23(33)20-14-22(24(25,26)27)31-32(20)19-9-6-7-17(13-19)15-29-12-11-28-2/h4-10,13-14,28-29H,3,11-12,15-16H2,1-2H3,(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 900n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311689
PNG
(1-(3-((2-aminoethylamino)methyl)phenyl)-N-(2-metho...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNCCN)c1)C(F)(F)F
Show InChI InChI=1S/C22H24F3N5O2/c1-32-19-8-3-2-6-16(19)14-28-21(31)18-12-20(22(23,24)25)29-30(18)17-7-4-5-15(11-17)13-27-10-9-26/h2-8,11-12,27H,9-10,13-14,26H2,1H3,(H,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311697
PNG
(CHEMBL1088188 | N-(2-ethylbenzyl)-1-(3-((2-(methyl...)
Show SMILES CCc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNCCNC)c1)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O/c1-3-18-8-4-5-9-19(18)16-30-23(33)21-14-22(24(25,26)27)31-32(21)20-10-6-7-17(13-20)15-29-12-11-28-2/h4-10,13-14,28-29H,3,11-12,15-16H2,1-2H3,(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.61E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311706
PNG
(CHEMBL1087878 | N-(2-(1H-indol-3-yl)ethyl)-1-(3-((...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCCc1c[nH]c2ccccc12)C(F)(F)F
Show InChI InChI=1S/C25H27F3N6O/c1-29-11-12-30-15-17-5-4-6-19(13-17)34-22(14-23(33-34)25(26,27)28)24(35)31-10-9-18-16-32-21-8-3-2-7-20(18)21/h2-8,13-14,16,29-30,32H,9-12,15H2,1H3,(H,31,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27644
PNG
(1-(4-{[(2S)-2-aminopropanamido]methyl}-1,3-thiazol...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1nc(CNC(=O)[C@H](C)N)cs1)C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O3S/c1-11(24)17(30)26-9-13-10-33-19(27-13)29-14(7-16(28-29)20(21,22)23)18(31)25-8-12-5-3-4-6-15(12)32-2/h3-7,10-11H,8-9,24H2,1-2H3,(H,25,31)(H,26,30)/t11-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 2.20E+3n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27654
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-2-y...)
Show SMILES C[C@H](N)C(=O)NCc1ccc(s1)-n1nc(cc1C(=O)NCc1ccccc1F)C(F)(F)F
Show InChI InChI=1S/C20H19F4N5O2S/c1-11(25)18(30)27-10-13-6-7-17(32-13)29-15(8-16(28-29)20(22,23)24)19(31)26-9-12-4-2-3-5-14(12)21/h2-8,11H,9-10,25H2,1H3,(H,26,31)(H,27,30)/t11-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.31E+3n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27657
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-2-y...)
Show SMILES CC(C)Oc1ccccc1CNC(=O)c1cc(nn1-c1ccc(CNC(=O)[C@H](C)N)s1)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3S/c1-13(2)34-18-7-5-4-6-15(18)11-28-22(33)17-10-19(23(24,25)26)30-31(17)20-9-8-16(35-20)12-29-21(32)14(3)27/h4-10,13-14H,11-12,27H2,1-3H3,(H,28,33)(H,29,32)/t14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.92E+3n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27646
PNG
(1-(6-{[(2S)-2-aminopropanamido]methyl}pyridin-2-yl...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNC(=O)[C@H](C)N)n1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N6O3/c1-13(26)20(32)28-12-15-7-5-9-19(29-15)31-16(10-18(30-31)22(23,24)25)21(33)27-11-14-6-3-4-8-17(14)34-2/h3-10,13H,11-12,26H2,1-2H3,(H,27,33)(H,28,32)/t13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 3.05E+3n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27658
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...)
Show SMILES C[C@H](N)C(=O)NCc1cc(cs1)-n1nc(cc1C(=O)NCc1ccccn1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N6O2S/c1-11(23)17(29)26-9-14-6-13(10-31-14)28-15(7-16(27-28)19(20,21)22)18(30)25-8-12-4-2-3-5-24-12/h2-7,10-11H,8-9,23H2,1H3,(H,25,30)(H,26,29)/t11-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.35E+3n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311708
PNG
(CHEMBL1080335 | N-((2-methoxynaphthalen-1-yl)methy...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1c(OC)ccc2ccccc12)C(F)(F)F
Show InChI InChI=1S/C27H28F3N5O2/c1-31-12-13-32-16-18-6-5-8-20(14-18)35-23(15-25(34-35)27(28,29)30)26(36)33-17-22-21-9-4-3-7-19(21)10-11-24(22)37-2/h3-11,14-15,31-32H,12-13,16-17H2,1-2H3,(H,33,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.35E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311703
PNG
(CHEMBL1088567 | N-(cyclohexylmethyl)-1-(3-((2-(met...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCC1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C22H30F3N5O/c1-26-10-11-27-14-17-8-5-9-18(12-17)30-19(13-20(29-30)22(23,24)25)21(31)28-15-16-6-3-2-4-7-16/h5,8-9,12-13,16,26-27H,2-4,6-7,10-11,14-15H2,1H3,(H,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.60E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27645
PNG
(1-(4-{[(2S)-2-aminopropanamido]methyl}pyridin-2-yl...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cc(CNC(=O)[C@H](C)N)ccn1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N6O3/c1-13(26)20(32)28-11-14-7-8-27-19(9-14)31-16(10-18(30-31)22(23,24)25)21(33)29-12-15-5-3-4-6-17(15)34-2/h3-10,13H,11-12,26H2,1-2H3,(H,28,32)(H,29,33)/t13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 4.20E+3n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311705
PNG
(CHEMBL1087877 | N-((1H-benzo[d]imidazol-2-yl)methy...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1nc2ccccc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N7O/c1-27-9-10-28-13-15-5-4-6-16(11-15)33-19(12-20(32-33)23(24,25)26)22(34)29-14-21-30-17-7-2-3-8-18(17)31-21/h2-8,11-12,27-28H,9-10,13-14H2,1H3,(H,29,34)(H,30,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27656
PNG
(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-2-y...)
Show SMILES C[C@H](N)C(=O)NCc1ccc(s1)-n1nc(cc1C(=O)NCc1ccccc1C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H19F6N5O2S/c1-11(28)18(33)30-10-13-6-7-17(35-13)32-15(8-16(31-32)21(25,26)27)19(34)29-9-12-4-2-3-5-14(12)20(22,23)24/h2-8,11H,9-10,28H2,1H3,(H,29,34)(H,30,33)/t11-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.48E+3n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311684
PNG
((S)-1-(3-((2-aminopropanethioamido)methyl)phenyl)-...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNC(=S)[C@H](C)N)c1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N5O2S/c1-14(27)22(34)29-12-15-6-5-8-17(10-15)31-18(11-20(30-31)23(24,25)26)21(32)28-13-16-7-3-4-9-19(16)33-2/h3-11,14H,12-13,27H2,1-2H3,(H,28,32)(H,29,34)/t14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 4.50E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311704
PNG
(CHEMBL1088568 | N-((1-methyl-1H-benzo[d]imidazol-2...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1nc2ccccc2n1C)C(F)(F)F
Show InChI InChI=1S/C24H26F3N7O/c1-28-10-11-29-14-16-6-5-7-17(12-16)34-20(13-21(32-34)24(25,26)27)23(35)30-15-22-31-18-8-3-4-9-19(18)33(22)2/h3-9,12-13,28-29H,10-11,14-15H2,1-2H3,(H,30,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.70E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311709
PNG
(1-(4-fluoro-3-((2-(methylamino)ethylamino)methyl)p...)
Show SMILES CNCCNCc1cc(ccc1F)-n1nc(cc1C(=O)NCc1ccccc1OC)C(F)(F)F
Show InChI InChI=1S/C23H25F4N5O2/c1-28-9-10-29-13-16-11-17(7-8-18(16)24)32-19(12-21(31-32)23(25,26)27)22(33)30-14-15-5-3-4-6-20(15)34-2/h3-8,11-12,28-29H,9-10,13-14H2,1-2H3,(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.60E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311701
PNG
(1-(3-((2-(methylamino)ethylamino)methyl)phenyl)-N-...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1OC(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H23F6N5O2/c1-30-9-10-31-13-15-5-4-7-17(11-15)34-18(12-20(33-34)22(24,25)26)21(35)32-14-16-6-2-3-8-19(16)36-23(27,28)29/h2-8,11-12,30-31H,9-10,13-14H2,1H3,(H,32,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 6.50E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311691
PNG
(1-(3-((2-(ethylamino)ethylamino)methyl)phenyl)-N-(...)
Show SMILES CCNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1OC)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O2/c1-3-28-11-12-29-15-17-7-6-9-19(13-17)32-20(14-22(31-32)24(25,26)27)23(33)30-16-18-8-4-5-10-21(18)34-2/h4-10,13-14,28-29H,3,11-12,15-16H2,1-2H3,(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 7.70E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311690
PNG
(1-(3-((2-(dimethylamino)ethylamino)methyl)phenyl)-...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNCCN(C)C)c1)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O2/c1-31(2)12-11-28-15-17-7-6-9-19(13-17)32-20(14-22(30-32)24(25,26)27)23(33)29-16-18-8-4-5-10-21(18)34-3/h4-10,13-14,28H,11-12,15-16H2,1-3H3,(H,29,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 7.90E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311710
PNG
(CHEMBL1080519 | N-(2-methoxybenzyl)-1-(4-methyl-3-...)
Show SMILES CNCCNCc1cc(ccc1C)-n1nc(cc1C(=O)NCc1ccccc1OC)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O2/c1-16-8-9-19(12-18(16)14-29-11-10-28-2)32-20(13-22(31-32)24(25,26)27)23(33)30-15-17-6-4-5-7-21(17)34-3/h4-9,12-13,28-29H,10-11,14-15H2,1-3H3,(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.94E+3n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311702
PNG
(CHEMBL1087234 | N-(2-aminobenzyl)-1-(3-((2-(methyl...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1N)C(F)(F)F
Show InChI InChI=1S/C22H25F3N6O/c1-27-9-10-28-13-15-5-4-7-17(11-15)31-19(12-20(30-31)22(23,24)25)21(32)29-14-16-6-2-3-8-18(16)26/h2-8,11-12,27-28H,9-10,13-14,26H2,1H3,(H,29,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27648
PNG
(1-(2-{[(2S)-2-aminopropanamido]methyl}-1-benzofura...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc2cc(CNC(=O)[C@H](C)N)oc12)C(F)(F)F
Show InChI InChI=1S/C25H24F3N5O4/c1-14(29)23(34)31-13-17-10-15-7-5-8-18(22(15)37-17)33-19(11-21(32-33)25(26,27)28)24(35)30-12-16-6-3-4-9-20(16)36-2/h3-11,14H,12-13,29H2,1-2H3,(H,30,35)(H,31,34)/t14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM27647
PNG
(1-{2-[(2S)-2-aminopropanoyl]-2,3-dihydro-1H-isoind...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc2CN(Cc12)C(=O)[C@H](C)N)C(F)(F)F
Show InChI InChI=1S/C24H24F3N5O3/c1-14(28)23(34)31-12-16-7-5-8-18(17(16)13-31)32-19(10-21(30-32)24(25,26)27)22(33)29-11-15-6-3-4-9-20(15)35-2/h3-10,14H,11-13,28H2,1-2H3,(H,29,33)/t14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/a9.022



MethylGene Inc.



Assay Description
Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311712
PNG
(5-(2-methoxybenzyl)-8-((2-(methylamino)ethylamino)...)
Show SMILES CNCCNCc1ccc2n(Cc3ccccc3OC)c(=O)c3cc(nn3c2c1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N5O2/c1-27-9-10-28-13-15-7-8-17-18(11-15)31-19(12-21(29-31)23(24,25)26)22(32)30(17)14-16-5-3-4-6-20(16)33-2/h3-8,11-12,27-28H,9-10,13-14H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311695
PNG
(CHEMBL1086763 | N-benzyl-1-(3-((2-(methylamino)eth...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H24F3N5O/c1-26-10-11-27-14-17-8-5-9-18(12-17)30-19(13-20(29-30)22(23,24)25)21(31)28-15-16-6-3-2-4-7-16/h2-9,12-13,26-27H,10-11,14-15H2,1H3,(H,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311696
PNG
(1-(3-((2-(methylamino)ethylamino)methyl)phenyl)-N-...)
Show SMILES CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1C)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O/c1-16-6-3-4-8-18(16)15-29-22(32)20-13-21(23(24,25)26)30-31(20)19-9-5-7-17(12-19)14-28-11-10-27-2/h3-9,12-13,27-28H,10-11,14-15H2,1-2H3,(H,29,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.31E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311686
PNG
((S)-1-(3-(5-(1-aminoethyl)-1H-1,2,4-triazol-3-yl)p...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(c1)-c1nnc([nH]1)[C@H](C)N)C(F)(F)F
Show InChI InChI=1S/C23H22F3N7O2/c1-13(27)20-29-21(31-30-20)14-7-5-8-16(10-14)33-17(11-19(32-33)23(24,25)26)22(34)28-12-15-6-3-4-9-18(15)35-2/h3-11,13H,12,27H2,1-2H3,(H,28,34)(H,29,30,31)/t13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311692
PNG
(CHEMBL1080125 | N-(2-methoxybenzyl)-1-(3-((pyrroli...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNC2CCNC2)c1)C(F)(F)F
Show InChI InChI=1S/C24H26F3N5O2/c1-34-21-8-3-2-6-17(21)14-30-23(33)20-12-22(24(25,26)27)31-32(20)19-7-4-5-16(11-19)13-29-18-9-10-28-15-18/h2-8,11-12,18,28-29H,9-10,13-15H2,1H3,(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311687
PNG
((S)-1-(3-(5-(1-aminoethyl)-1,2,4-oxadiazol-3-yl)ph...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(c1)-c1noc(n1)[C@H](C)N)C(F)(F)F
Show InChI InChI=1S/C23H21F3N6O3/c1-13(27)22-29-20(31-35-22)14-7-5-8-16(10-14)32-17(11-19(30-32)23(24,25)26)21(33)28-12-15-6-3-4-9-18(15)34-2/h3-11,13H,12,27H2,1-2H3,(H,28,33)/t13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311694
PNG
(CHEMBL1080477 | N-(2-methoxybenzyl)-1-(3-(2-(methy...)
Show SMILES CNCCNC(=O)c1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1OC)C(F)(F)F
Show InChI InChI=1S/C23H24F3N5O3/c1-27-10-11-28-21(32)15-7-5-8-17(12-15)31-18(13-20(30-31)23(24,25)26)22(33)29-14-16-6-3-4-9-19(16)34-2/h3-9,12-13,27H,10-11,14H2,1-2H3,(H,28,32)(H,29,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311683
PNG
((S)-1-(3-(2-(2-aminopropanamido)ethyl)phenyl)-N-(2...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CCNC(=O)[C@H](C)N)c1)C(F)(F)F
Show InChI InChI=1S/C24H26F3N5O3/c1-15(28)22(33)29-11-10-16-6-5-8-18(12-16)32-19(13-21(31-32)24(25,26)27)23(34)30-14-17-7-3-4-9-20(17)35-2/h3-9,12-13,15H,10-11,14,28H2,1-2H3,(H,29,33)(H,30,34)/t15-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311711
PNG
(CHEMBL1079702 | N-(2-methoxybenzyl)-1-(3-((2-(meth...)
Show SMILES CNCCNCc1cc(cc(c1)C(F)(F)F)-n1nc(cc1C(=O)NCc1ccccc1OC)C(F)(F)F
Show InChI InChI=1S/C24H25F6N5O2/c1-31-7-8-32-13-15-9-17(23(25,26)27)11-18(10-15)35-19(12-21(34-35)24(28,29)30)22(36)33-14-16-5-3-4-6-20(16)37-2/h3-6,9-12,31-32H,7-8,13-14H2,1-2H3,(H,33,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311685
PNG
((S)-1-(3-((2-hydroxypropanamido)methyl)phenyl)-N-(...)
Show SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNC(=O)[C@H](C)O)c1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O4/c1-14(31)21(32)27-12-15-6-5-8-17(10-15)30-18(11-20(29-30)23(24,25)26)22(33)28-13-16-7-3-4-9-19(16)34-2/h3-11,14,31H,12-13H2,1-2H3,(H,27,32)(H,28,33)/t14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Histone-Arginine Methyltransferase CARM1


(Mus musculus (mouse))
BDBM50311693
PNG
(CHEMBL1076431 | N-(2-methoxybenzyl)-1-(3-(1-(2-(me...)
Show SMILES CNCCNC(C)c1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1OC)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O2/c1-16(29-12-11-28-2)17-8-6-9-19(13-17)32-20(14-22(31-32)24(25,26)27)23(33)30-15-18-7-4-5-10-21(18)34-3/h4-10,13-14,16,28-29H,11-12,15H2,1-3H3,(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 51 total )  |  Next  |  Last  >>
Jump to: