BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 71 hits Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase SMYD3' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293375
PNG
(Mixture of N- ((1S,2R,4S)-4-((R)-3- aminobutanamid...)
Show SMILES C[C@@H](N)CC(=O)N[C@H]1CC[C@H](NC(=O)c2cc(on2)C2CC2)[C@H](Cc2ccccc2)C1
Show InChI InChI=1S/C24H32N4O3/c1-15(25)11-23(29)26-19-9-10-20(18(13-19)12-16-5-3-2-4-6-16)27-24(30)21-14-22(31-28-21)17-7-8-17/h2-6,14-15,17-20H,7-13,25H2,1H3,(H,26,29)(H,27,30)/t15-,18-,19+,20+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 28.6n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293337
PNG
(Mixture of N- ((1S,2R,4S)-4-((R)- 3-aminobutanamid...)
Show SMILES CC[C@@H]1C[C@H](CC[C@@H]1NC(=O)c1cc(CC)on1)NC(=O)C[C@@H](C)N
Show InChI InChI=1S/C18H30N4O3/c1-4-12-9-13(20-17(23)8-11(3)19)6-7-15(12)21-18(24)16-10-14(5-2)25-22-16/h10-13,15H,4-9,19H2,1-3H3,(H,20,23)(H,21,24)/t11-,12-,13+,15+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 97.3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293338
PNG
(Mixture of N- ((1S,2R,4S)-4-((S)- 3-aminobutanamid...)
Show SMILES CC[C@@H]1C[C@H](CC[C@@H]1NC(=O)c1cc(CC)on1)NC(=O)C[C@H](C)N
Show InChI InChI=1S/C18H30N4O3/c1-4-12-9-13(20-17(23)8-11(3)19)6-7-15(12)21-18(24)16-10-14(5-2)25-22-16/h10-13,15H,4-9,19H2,1-3H3,(H,20,23)(H,21,24)/t11-,12+,13-,15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 170n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293342
PNG
(5-cyclopropyl-N-((1r,4r)- 4-(3-(pyrrolidin-1- yl)p...)
Show SMILES O=C(CCN1CCCC1)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C20H30N4O3/c25-19(9-12-24-10-1-2-11-24)21-15-5-7-16(8-6-15)22-20(26)17-13-18(27-23-17)14-3-4-14/h13-16H,1-12H2,(H,21,25)(H,22,26)/t15-,16-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 188n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293357
PNG
(N-((1R,4r)-4-((1r,3R)-3- aminocyclobutane-1- carbo...)
Show SMILES N[C@H]1C[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C18H26N4O3/c19-12-7-11(8-12)17(23)20-13-3-5-14(6-4-13)21-18(24)15-9-16(25-22-15)10-1-2-10/h9-14H,1-8,19H2,(H,20,23)(H,21,24)/t11-,12-,13-,14-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 269n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293359
PNG
(N-((1r,4r)-4-((3- aminopropyl)amino) cyclohexyl)-5...)
Show SMILES NCCCN[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C16H26N4O2/c17-8-1-9-18-12-4-6-13(7-5-12)19-16(21)14-10-15(22-20-14)11-2-3-11/h10-13,18H,1-9,17H2,(H,19,21)/t12-,13-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 342n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293344
PNG
(N-((1R,4r)-4-((1s,4S)-4- aminocyclohexane-1- carbo...)
Show SMILES N[C@H]1CC[C@H](CC1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C20H30N4O3/c21-14-5-3-13(4-6-14)19(25)22-15-7-9-16(10-8-15)23-20(26)17-11-18(27-24-17)12-1-2-12/h11-16H,1-10,21H2,(H,22,25)(H,23,26)/t13-,14+,15-,16-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 352n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293336
PNG
(N-((1R,4r)-4-((R)-3- aminobutanamido) cyclohexyl)-...)
Show SMILES C[C@@H](N)CC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C17H26N4O3/c1-10(18)8-16(22)19-12-4-6-13(7-5-12)20-17(23)14-9-15(24-21-14)11-2-3-11/h9-13H,2-8,18H2,1H3,(H,19,22)(H,20,23)/t10-,12-,13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 400n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293369
PNG
(N-((1r,4r)-4-(3-amino- N-(3-aminopropyl) propanami...)
Show SMILES NCCCN([C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1)C(=O)CCN
Show InChI InChI=1S/C19H31N5O3/c20-9-1-11-24(18(25)8-10-21)15-6-4-14(5-7-15)22-19(26)16-12-17(27-23-16)13-2-3-13/h12-15H,1-11,20-21H2,(H,22,26)/t14-,15-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 428n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293332
PNG
(N-((1r,4r)-4-(3- aminobutanamido) cyclohexyl)-5- c...)
Show SMILES CC(N)CC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C17H26N4O3/c1-10(18)8-16(22)19-12-4-6-13(7-5-12)20-17(23)14-9-15(24-21-14)11-2-3-11/h9-13H,2-8,18H2,1H3,(H,19,22)(H,20,23)/t10?,12-,13-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 466n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293335
PNG
(N-((1r,4r)-4-(3- aminopropanamido) cyclohexyl)-5- ...)
Show SMILES NCCC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C16H24N4O3/c17-8-7-15(21)18-11-3-5-12(6-4-11)19-16(22)13-9-14(23-20-13)10-1-2-10/h9-12H,1-8,17H2,(H,18,21)(H,19,22)/t11-,12-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 475n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293356
PNG
(N-((1S,4r)-4-((1S,3R)-3- aminocyclopentane-1- carb...)
Show SMILES N[C@@H]1CC[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C19H28N4O3/c20-13-4-3-12(9-13)18(24)21-14-5-7-15(8-6-14)22-19(25)16-10-17(26-23-16)11-1-2-11/h10-15H,1-9,20H2,(H,21,24)(H,22,25)/t12-,13+,14-,15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 511n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293334
PNG
(N-((1r,4r)-4-(2-amino- cyclobutane-1- carboxamido)...)
Show SMILES NC1CCC1C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C18H26N4O3/c19-14-8-7-13(14)17(23)20-11-3-5-12(6-4-11)21-18(24)15-9-16(25-22-15)10-1-2-10/h9-14H,1-8,19H2,(H,20,23)(H,21,24)/t11-,12-,13?,14?
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 545n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293368
PNG
(N-((1S,4r)-4-((1S,3S)-3- aminocyclopentane-1- carb...)
Show SMILES N[C@H]1CC[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C19H28N4O3/c20-13-4-3-12(9-13)18(24)21-14-5-7-15(8-6-14)22-19(25)16-10-17(26-23-16)11-1-2-11/h10-15H,1-9,20H2,(H,21,24)(H,22,25)/t12-,13-,14-,15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 562n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293363
PNG
(N-((1r,4r)-4-(3-amino-2- hydroxypropanamido) cyclo...)
Show SMILES NCC(O)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C16H24N4O4/c17-8-13(21)16(23)19-11-5-3-10(4-6-11)18-15(22)12-7-14(24-20-12)9-1-2-9/h7,9-11,13,21H,1-6,8,17H2,(H,18,22)(H,19,23)/t10-,11-,13?
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 567n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293349
PNG
(N-((1R,4r)-4-((1r,4R)-4- aminocyclohexane-1- carbo...)
Show SMILES N[C@H]1CC[C@@H](CC1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C20H30N4O3/c21-14-5-3-13(4-6-14)19(25)22-15-7-9-16(10-8-15)23-20(26)17-11-18(27-24-17)12-1-2-12/h11-16H,1-10,21H2,(H,22,25)(H,23,26)/t13-,14-,15-,16-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 606n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293355
PNG
(N-((1S,4r)-4-((1S,3S)-3- aminocyclohexane-1- carbo...)
Show SMILES N[C@H]1CCC[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C20H30N4O3/c21-14-3-1-2-13(10-14)19(25)22-15-6-8-16(9-7-15)23-20(26)17-11-18(27-24-17)12-4-5-12/h11-16H,1-10,21H2,(H,22,25)(H,23,26)/t13-,14-,15-,16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 625n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293339
PNG
(N-((1r,4r)-4-(3-amino-2- methylpropanamido) cycloh...)
Show SMILES CC(CN)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C17H26N4O3/c1-10(9-18)16(22)19-12-4-6-13(7-5-12)20-17(23)14-8-15(24-21-14)11-2-3-11/h8,10-13H,2-7,9,18H2,1H3,(H,19,22)(H,20,23)/t10?,12-,13-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 654n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293351
PNG
(N-((1r,4r)-4-(3- (benzylamino) propanamido) cycloh...)
Show SMILES O=C(CCNCc1ccccc1)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C23H30N4O3/c28-22(12-13-24-15-16-4-2-1-3-5-16)25-18-8-10-19(11-9-18)26-23(29)20-14-21(30-27-20)17-6-7-17/h1-5,14,17-19,24H,6-13,15H2,(H,25,28)(H,26,29)/t18-,19-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 671n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293364
PNG
(N-((1r,4r)-4-((2- aminoethyl)amino) cyclohexyl)-5-...)
Show SMILES NCCN[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C15H24N4O2/c16-7-8-17-11-3-5-12(6-4-11)18-15(20)13-9-14(21-19-13)10-1-2-10/h9-12,17H,1-8,16H2,(H,18,20)/t11-,12-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 853n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293343
PNG
(5-cyclopropyl-N-((1r,4r)- 4-(3-(methylamino) propa...)
Show SMILES CNCCC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C17H26N4O3/c1-18-9-8-16(22)19-12-4-6-13(7-5-12)20-17(23)14-10-15(24-21-14)11-2-3-11/h10-13,18H,2-9H2,1H3,(H,19,22)(H,20,23)/t12-,13-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 867n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293340
PNG
(N-((1r,4r)-4-(3-amino- N-(2-hydroxyethyl) propanam...)
Show SMILES NCCC(=O)N(CCO)[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C18H28N4O4/c19-8-7-17(24)22(9-10-23)14-5-3-13(4-6-14)20-18(25)15-11-16(26-21-15)12-1-2-12/h11-14,23H,1-10,19H2,(H,20,25)/t13-,14-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 883n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293352
PNG
(5-cyclopropyl-N- ((1r,4r)-4-(3- (isobutylamino) pr...)
Show SMILES CC(C)CNCCC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C20H32N4O3/c1-13(2)12-21-10-9-19(25)22-15-5-7-16(8-6-15)23-20(26)17-11-18(27-24-17)14-3-4-14/h11,13-16,21H,3-10,12H2,1-2H3,(H,22,25)(H,23,26)/t15-,16-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 919n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293367
PNG
(N-((1S,4r)-4-((S)- 4-amino-3-hydroxy- butanamido) ...)
Show SMILES NC[C@@H](O)CC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C17H26N4O4/c18-9-13(22)7-16(23)19-11-3-5-12(6-4-11)20-17(24)14-8-15(25-21-14)10-1-2-10/h8,10-13,22H,1-7,9,18H2,(H,19,23)(H,20,24)/t11-,12-,13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.08E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293350
PNG
(5-cyclopropyl-N-((1r,4r)- 4-(3-(piperazin-1- yl)pr...)
Show SMILES O=C(CCN1CCNCC1)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C20H31N5O3/c26-19(7-10-25-11-8-21-9-12-25)22-15-3-5-16(6-4-15)23-20(27)17-13-18(28-24-17)14-1-2-14/h13-16,21H,1-12H2,(H,22,26)(H,23,27)/t15-,16-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.15E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293346
PNG
(N-((1R,4r)-4-((1s,3S)-3- aminocyclobutane-1- carbo...)
Show SMILES N[C@H]1C[C@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C18H26N4O3/c19-12-7-11(8-12)17(23)20-13-3-5-14(6-4-13)21-18(24)15-9-16(25-22-15)10-1-2-10/h9-14H,1-8,19H2,(H,20,23)(H,21,24)/t11-,12+,13-,14-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.18E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293362
PNG
(N-((1S,4r)-4-((1S,3R)-3- aminocyclohexane-1- carbo...)
Show SMILES N[C@@H]1CCC[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C20H30N4O3/c21-14-3-1-2-13(10-14)19(25)22-15-6-8-16(9-7-15)23-20(26)17-11-18(27-24-17)12-4-5-12/h11-16H,1-10,21H2,(H,22,25)(H,23,26)/t13-,14+,15-,16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.19E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293374
PNG
(N-((1r,4r)-4-(3-amino- N-(3-hydroxypropyl) propana...)
Show SMILES NCCC(=O)N(CCCO)[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C19H30N4O4/c20-9-8-18(25)23(10-1-11-24)15-6-4-14(5-7-15)21-19(26)16-12-17(27-22-16)13-2-3-13/h12-15,24H,1-11,20H2,(H,21,26)/t14-,15-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293370
PNG
(N-((1r,4r)-4-((3-amino- propyl)sulfonamido) cycloh...)
Show SMILES NCCCS(=O)(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C16H26N4O4S/c17-8-1-9-25(22,23)20-13-6-4-12(5-7-13)18-16(21)14-10-15(24-19-14)11-2-3-11/h10-13,20H,1-9,17H2,(H,18,21)/t12-,13-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.34E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293366
PNG
(N-((1R,4r)-4-((R)- 4-amino- 3-hydroxybutanamido) c...)
Show SMILES NC[C@H](O)CC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C17H26N4O4/c18-9-13(22)7-16(23)19-11-3-5-12(6-4-11)20-17(24)14-8-15(25-21-14)10-1-2-10/h8,10-13,22H,1-7,9,18H2,(H,19,23)(H,20,24)/t11-,12-,13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.69E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293340
PNG
(N-((1r,4r)-4-(3-amino- N-(2-hydroxyethyl) propanam...)
Show SMILES NCCC(=O)N(CCO)[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C18H28N4O4/c19-8-7-17(24)22(9-10-23)14-5-3-13(4-6-14)20-18(25)15-11-16(26-21-15)12-1-2-12/h11-14,23H,1-10,19H2,(H,20,25)/t13-,14-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.28E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293333
PNG
(N-((1S,2R,4S)-4- amino-2- ethylcyclohexyl)-5- ethy...)
Show SMILES CC[C@@H]1C[C@@H](N)CC[C@@H]1NC(=O)c1cc(CC)on1
Show InChI InChI=1S/C14H23N3O2/c1-3-9-7-10(15)5-6-12(9)16-14(18)13-8-11(4-2)19-17-13/h8-10,12H,3-7,15H2,1-2H3,(H,16,18)/t9-,10+,12+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.44E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293360
PNG
(5-cyclopropyl-N- ((1r,4r)-4- (isobutylamino) cyclo...)
Show SMILES CC(C)CN[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C17H27N3O2/c1-11(2)10-18-13-5-7-14(8-6-13)19-17(21)15-9-16(22-20-15)12-3-4-12/h9,11-14,18H,3-8,10H2,1-2H3,(H,19,21)/t13-,14-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.56E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293365
PNG
(N-((1r,4r)-4-((2- aminoethyl)sulfonamido) cyclohex...)
Show SMILES NCCS(=O)(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C15H24N4O4S/c16-7-8-24(21,22)19-12-5-3-11(4-6-12)17-15(20)13-9-14(23-18-13)10-1-2-10/h9-12,19H,1-8,16H2,(H,17,20)/t11-,12-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.90E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293383
PNG
(N-((1R,4r)-4-((R)-3- aminobutanamido) cyclohexyl)-...)
Show SMILES CC(C)CN([C@H]1CC[C@@H](CC1)NC(=O)C[C@@H](C)N)C(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C21H34N4O3/c1-13(2)12-25(21(27)18-11-19(28-24-18)15-4-5-15)17-8-6-16(7-9-17)23-20(26)10-14(3)22/h11,13-17H,4-10,12,22H2,1-3H3,(H,23,26)/t14-,16-,17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.12E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM321293
PNG
(5-cyclopropyl-N-((2R)-2-methyl-1- (vinylsulfonyl)p...)
Show SMILES C[C@@H]1CC(CCN1S(=O)(=O)C=C)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C15H21N3O4S/c1-3-23(20,21)18-7-6-12(8-10(18)2)16-15(19)13-9-14(22-17-13)11-4-5-11/h3,9-12H,1,4-8H2,2H3,(H,16,19)/t10-,12?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.68E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....


US Patent US10179773 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293384
PNG
(N-((1S,4r)-4-((S)-3- aminobutanamido) cyclohexyl)-...)
Show SMILES CC(C)CN([C@H]1CC[C@@H](CC1)NC(=O)C[C@H](C)N)C(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C21H34N4O3/c1-13(2)12-25(21(27)18-11-19(28-24-18)15-4-5-15)17-8-6-16(7-9-17)23-20(26)10-14(3)22/h11,13-17H,4-10,12,22H2,1-3H3,(H,23,26)/t14-,16-,17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293382
PNG
(N-((1r,4r)-4-(3- aminopropanamido) cyclohexyl)-N-b...)
Show SMILES NCCC(=O)N[C@H]1CC[C@@H](CC1)N(Cc1ccccc1)C(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C23H30N4O3/c24-13-12-22(28)25-18-8-10-19(11-9-18)27(15-16-4-2-1-3-5-16)23(29)20-14-21(30-26-20)17-6-7-17/h1-5,14,17-19H,6-13,15,24H2,(H,25,28)/t18-,19-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.34E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293379
PNG
(N-((1r,4r)-4-(3- aminopropanamido) cyclohcxyl)-5- ...)
Show SMILES CC(C)CN([C@H]1CC[C@@H](CC1)NC(=O)CCN)C(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C20H32N4O3/c1-13(2)12-24(20(26)17-11-18(27-23-17)14-3-4-14)16-7-5-15(6-8-16)22-19(25)9-10-21/h11,13-16H,3-10,12,21H2,1-2H3,(H,22,25)/t15-,16-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.49E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM321292
PNG
(5-cyclopropyl-N-((2S)-2-methyl-1- (vinylsulfonyl)p...)
Show SMILES C[C@H]1CC(CCN1S(=O)(=O)C=C)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C15H21N3O4S/c1-3-23(20,21)18-7-6-12(8-10(18)2)16-15(19)13-9-14(22-17-13)11-4-5-11/h3,9-12H,1,4-8H2,2H3,(H,16,19)/t10-,12?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.28E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....


US Patent US10179773 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293396
PNG
(N-((1r,4r)-4-(3- aminopropanamido) cyclohexyl)-5- ...)
Show SMILES CN([C@H]1CC[C@@H](CC1)NC(=O)CCN)C(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C17H26N4O3/c1-21(17(23)14-10-15(24-20-14)11-2-3-11)13-6-4-12(5-7-13)19-16(22)8-9-18/h10-13H,2-9,18H2,1H3,(H,19,22)/t12-,13-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.29E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293377
PNG
(N-((1R,4r)-4-((R)-3- aminobutanamido) cyclohexyl)-...)
Show SMILES C[C@@H](N)CC(=O)N[C@H]1CC[C@@H](CC1)N(CCc1ccccc1)C(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C25H34N4O3/c1-17(26)15-24(30)27-20-9-11-21(12-10-20)29(14-13-18-5-3-2-4-6-18)25(31)22-16-23(32-28-22)19-7-8-19/h2-6,16-17,19-21H,7-15,26H2,1H3,(H,27,30)/t17-,20-,21-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.71E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293394
PNG
(N-((1S,4r)-4-((S)-3- aminobutanamido) cyclohexyl)-...)
Show SMILES C[C@H](N)CC(=O)N[C@H]1CC[C@@H](CC1)N(C)C(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C18H28N4O3/c1-11(19)9-17(23)20-13-5-7-14(8-6-13)22(2)18(24)15-10-16(25-21-15)12-3-4-12/h10-14H,3-9,19H2,1-2H3,(H,20,23)/t11-,13-,14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.11E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293373
PNG
(5-cyclopropyl-N- ((1r,4r)-4- (ethylsulfonamido) cy...)
Show SMILES CCS(=O)(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C15H23N3O4S/c1-2-23(20,21)18-12-7-5-11(6-8-12)16-15(19)13-9-14(22-17-13)10-3-4-10/h9-12,18H,2-8H2,1H3,(H,16,19)/t11-,12-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.36E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293372
PNG
(N-((1r,4r)-4-(N- (3-aminopropyl)- 3-hydroxypropana...)
Show SMILES NCCCN([C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1)C(=O)CCO
Show InChI InChI=1S/C19H30N4O4/c20-9-1-10-23(18(25)8-11-24)15-6-4-14(5-7-15)21-19(26)16-12-17(27-22-16)13-2-3-13/h12-15,24H,1-11,20H2,(H,21,26)/t14-,15-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.03E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293341
PNG
(5-cyclopropyl-N-((1r,4r)- 4-(3-(4-methylpiperazin-...)
Show SMILES CN1CCN(CCC(=O)N[C@H]2CC[C@@H](CC2)NC(=O)c2cc(on2)C2CC2)CC1
Show InChI InChI=1S/C21H33N5O3/c1-25-10-12-26(13-11-25)9-8-20(27)22-16-4-6-17(7-5-16)23-21(28)18-14-19(29-24-18)15-2-3-15/h14-17H,2-13H2,1H3,(H,22,27)(H,23,28)/t16-,17-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.72E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293381
PNG
(N-((1R,4r)-4-((R)-3- aminobutanamido) cyclohexyl)-...)
Show SMILES C[C@@H](N)CC(=O)N[C@H]1CC[C@@H](CC1)N(Cc1ccccc1)C(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C24H32N4O3/c1-16(25)13-23(29)26-19-9-11-20(12-10-19)28(15-17-5-3-2-4-6-17)24(30)21-14-22(31-27-21)18-7-8-18/h2-6,14,16,18-20H,7-13,15,25H2,1H3,(H,26,29)/t16-,19-,20-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.22E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293361
PNG
(5-cyclopropyl-N-((1r,4r)- 4-(isopentylamino) cyclo...)
Show SMILES CC(C)CCN[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C18H29N3O2/c1-12(2)9-10-19-14-5-7-15(8-6-14)20-18(22)16-11-17(23-21-16)13-3-4-13/h11-15,19H,3-10H2,1-2H3,(H,20,22)/t14-,15-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.24E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293392
PNG
(N-((1R,4r)-4-((R)-3- aminobutanamido) cyclohexyl)-...)
Show SMILES C[C@@H](N)CC(=O)N[C@H]1CC[C@@H](CC1)N(C)C(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C18H28N4O3/c1-11(19)9-17(23)20-13-5-7-14(8-6-13)22(2)18(24)15-10-16(25-21-15)12-3-4-12/h10-14H,3-9,19H2,1-2H3,(H,20,23)/t11-,13-,14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.28E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM293376
PNG
(N-((1R,4r)-4-((R)-3- aminobutanamido) cyclohexyl)-...)
Show SMILES COCCN([C@H]1CC[C@@H](CC1)NC(=O)C[C@@H](C)N)C(=O)c1cc(on1)C1CC1
Show InChI InChI=1S/C20H32N4O4/c1-13(21)11-19(25)22-15-5-7-16(8-6-15)24(9-10-27-2)20(26)17-12-18(28-23-17)14-3-4-14/h12-16H,3-11,21H2,1-2H3,(H,22,25)/t13-,15-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.69E+3n/an/an/an/an/an/a



EPIZYME, INC.

US Patent


Assay Description
S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), Tris, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl...


US Patent US10106510 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 71 total )  |  Next  |  Last  >>
Jump to: