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Compile Data Set for Download or QSAR

Found 461 hits Enz. Inhib. hit(s) with Target = 'Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50303774
PNG
(CHEMBL566340 | phenylacetyl-Arg-Val-Arg-4-amidinob...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H50N12O4/c1-20(2)27(45-30(48)25(11-7-17-41-33(38)39)43-26(46)18-21-8-4-3-5-9-21)31(49)44-24(10-6-16-40-32(36)37)29(47)42-19-22-12-14-23(15-13-22)28(34)35/h3-5,8-9,12-15,20,24-25,27H,6-7,10-11,16-19H2,1-2H3,(H3,34,35)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t24-,25-,27-/m0/s1
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0.810n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50303774
PNG
(CHEMBL566340 | phenylacetyl-Arg-Val-Arg-4-amidinob...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H50N12O4/c1-20(2)27(45-30(48)25(11-7-17-41-33(38)39)43-26(46)18-21-8-4-3-5-9-21)31(49)44-24(10-6-16-40-32(36)37)29(47)42-19-22-12-14-23(15-13-22)28(34)35/h3-5,8-9,12-15,20,24-25,27H,6-7,10-11,16-19H2,1-2H3,(H3,34,35)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t24-,25-,27-/m0/s1
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0.810n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50386999
PNG
(CHEMBL2049152)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NCC(=O)Oc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C32H48N12O5/c1-19(2)26(44-28(46)23(10-6-16-39-31(35)36)41-18-25(45)49-22-8-4-3-5-9-22)30(48)43-24(11-7-17-40-32(37)38)29(47)42-21-14-12-20(13-15-21)27(33)34/h3-5,8-9,12-15,19,23-24,26,41H,6-7,10-11,16-18H2,1-2H3,(H3,33,34)(H,42,47)(H,43,48)(H,44,46)(H4,35,36,39)(H4,37,38,40)/t23-,24-,26-/m0/s1
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0.810n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Inhibition of furin


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349574
PNG
(CHEMBL1808902)
Show SMILES NC(N)=NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](CNC(N)=N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C32H49N15O4/c33-26(34)21-12-10-20(11-13-21)17-43-27(49)22(8-4-14-41-30(35)36)46-29(51)24(18-44-32(39)40)47-28(50)23(9-5-15-42-31(37)38)45-25(48)16-19-6-2-1-3-7-19/h1-3,6-7,10-13,22-24H,4-5,8-9,14-18H2,(H3,33,34)(H,43,49)(H,45,48)(H,46,51)(H,47,50)(H4,35,36,41)(H4,37,38,42)(H4,39,40,44)/t22-,23-,24-/m0/s1
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0.830n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349575
PNG
(CHEMBL1808903)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H52N12O4/c1-3-21(2)28(46-31(49)26(12-8-18-42-34(39)40)44-27(47)19-22-9-5-4-6-10-22)32(50)45-25(11-7-17-41-33(37)38)30(48)43-20-23-13-15-24(16-14-23)29(35)36/h4-6,9-10,13-16,21,25-26,28H,3,7-8,11-12,17-20H2,1-2H3,(H3,35,36)(H,43,48)(H,44,47)(H,45,50)(H,46,49)(H4,37,38,41)(H4,39,40,42)/t21-,25-,26-,28-/m0/s1
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0.840n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50303775
PNG
((S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbe...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H46N12O4/c1-15(2)21(39-24(42)20(37-16(3)40)7-5-13-35-27(32)33)25(43)38-19(6-4-12-34-26(30)31)23(41)36-14-17-8-10-18(11-9-17)22(28)29/h8-11,15,19-21H,4-7,12-14H2,1-3H3,(H3,28,29)(H,36,41)(H,37,40)(H,38,43)(H,39,42)(H4,30,31,34)(H4,32,33,35)/t19-,20-,21-/m0/s1
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1n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50387001
PNG
(CHEMBL2049154)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C26H44N12O4/c1-14(2)20(38-23(41)18(35-15(3)39)6-4-12-33-25(29)30)24(42)37-19(7-5-13-34-26(31)32)22(40)36-17-10-8-16(9-11-17)21(27)28/h8-11,14,18-20H,4-7,12-13H2,1-3H3,(H3,27,28)(H,35,39)(H,36,40)(H,37,42)(H,38,41)(H4,29,30,33)(H4,31,32,34)/t18-,19-,20-/m0/s1
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1n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Inhibition of furin


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349576
PNG
(CHEMBL1808904)
Show SMILES NC(N)=NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C37H50N12O4/c38-32(39)27-17-15-26(16-18-27)23-46-33(51)28(13-7-19-44-36(40)41)48-35(53)30(21-24-9-3-1-4-10-24)49-34(52)29(14-8-20-45-37(42)43)47-31(50)22-25-11-5-2-6-12-25/h1-6,9-12,15-18,28-30H,7-8,13-14,19-23H2,(H3,38,39)(H,46,51)(H,47,50)(H,48,53)(H,49,52)(H4,40,41,44)(H4,42,43,45)/t28-,29-,30-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50399754
PNG
(CHEMBL2179836)
Show SMILES NCCCC[C@H](NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C37H69N15O13/c38-15-3-1-7-21(47-29(58)20(40)11-13-27(54)55)30(59)50-24(12-14-28(56)57)33(62)48-23(9-5-17-45-36(41)42)32(61)52-26(19-53)34(63)49-22(8-2-4-16-39)31(60)51-25(35(64)65)10-6-18-46-37(43)44/h20-26,53H,1-19,38-40H2,(H,47,58)(H,48,62)(H,49,63)(H,50,59)(H,51,60)(H,52,61)(H,54,55)(H,56,57)(H,64,65)(H4,41,42,45)(H4,43,44,46)/t20-,21-,22-,23-,24-,25-,26-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349603
PNG
(CHEMBL1808933)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H50N10O4/c1-21(2)28(43-31(46)26(12-8-18-39-33(37)38)41-27(44)19-22-9-4-3-5-10-22)32(47)42-25(11-6-7-17-34)30(45)40-20-23-13-15-24(16-14-23)29(35)36/h3-5,9-10,13-16,21,25-26,28H,6-8,11-12,17-20,34H2,1-2H3,(H3,35,36)(H,40,45)(H,41,44)(H,42,47)(H,43,46)(H4,37,38,39)/t25-,26-,28-/m0/s1
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1.5n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50303776
PNG
(CHEMBL568525 | N-((6S,9S,12S)-1,17-diamino-6-(4-ca...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N12O4/c1-4-5-6-7-8-9-10-15-28(48)45-27(14-12-21-43-35(40)41)32(50)47-29(23(2)3)33(51)46-26(13-11-20-42-34(38)39)31(49)44-22-24-16-18-25(19-17-24)30(36)37/h16-19,23,26-27,29H,4-15,20-22H2,1-3H3,(H3,36,37)(H,44,49)(H,45,48)(H,46,51)(H,47,50)(H4,38,39,42)(H4,40,41,43)/t26-,27-,29-/m0/s1
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1.60n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50387000
PNG
(CHEMBL2049153)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H60N12O4/c1-4-5-6-7-8-9-10-15-27(47)44-25(13-11-20-41-33(37)38)31(49)46-28(22(2)3)32(50)45-26(14-12-21-42-34(39)40)30(48)43-24-18-16-23(17-19-24)29(35)36/h16-19,22,25-26,28H,4-15,20-21H2,1-3H3,(H3,35,36)(H,43,48)(H,44,47)(H,45,50)(H,46,49)(H4,37,38,41)(H4,39,40,42)/t25-,26-,28-/m0/s1
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1.60n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Inhibition of furin


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50399753
PNG
(CHEMBL2179835)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C37H74N18O9/c1-20(40)28(57)50-22(10-3-5-15-38)29(58)51-24(12-7-17-47-35(41)42)30(59)52-25(13-8-18-48-36(43)44)32(61)55-27(21(2)56)33(62)53-23(11-4-6-16-39)31(60)54-26(34(63)64)14-9-19-49-37(45)46/h20-27,56H,3-19,38-40H2,1-2H3,(H,50,57)(H,51,58)(H,52,59)(H,53,62)(H,54,60)(H,55,61)(H,63,64)(H4,41,42,47)(H4,43,44,48)(H4,45,46,49)/t20-,21+,22-,23-,24-,25-,26-,27-/m0/s1
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1.70n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349577
PNG
(CHEMBL1808905)
Show SMILES NC(N)=NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C37H50N12O5/c38-32(39)26-14-10-25(11-15-26)22-46-33(52)28(8-4-18-44-36(40)41)48-35(54)30(20-24-12-16-27(50)17-13-24)49-34(53)29(9-5-19-45-37(42)43)47-31(51)21-23-6-2-1-3-7-23/h1-3,6-7,10-17,28-30,50H,4-5,8-9,18-22H2,(H3,38,39)(H,46,52)(H,47,51)(H,48,54)(H,49,53)(H4,40,41,44)(H4,42,43,45)/t28-,29-,30-/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50448473
PNG
(CHEMBL3126399)
Show SMILES C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C49H90N24O8/c1-28(67-41(77)33(68-29(2)74)13-7-23-62-46(54)55)39(75)69-35(14-8-24-63-47(56)57)43(79)72-37(16-10-26-65-49(60)61)45(81)73-36(15-9-25-64-48(58)59)44(80)71-34(12-4-6-22-51)42(78)70-32(11-3-5-21-50)40(76)66-27-30-17-19-31(20-18-30)38(52)53/h17-20,28,32-37H,3-16,21-27,50-51H2,1-2H3,(H3,52,53)(H,66,76)(H,67,77)(H,68,74)(H,69,75)(H,70,78)(H,71,80)(H,72,79)(H,73,81)(H4,54,55,62)(H4,56,57,63)(H4,58,59,64)(H4,60,61,65)/t28-,32-,33-,34-,35-,36-,37-/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant furin (unknown origin) using as substrate after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50399752
PNG
(CHEMBL2179429)
Show SMILES CC(C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C39H78N16O9/c1-22(2)29(43)35(61)52-25(13-5-8-18-41)32(58)50-24(12-4-7-17-40)31(57)51-27(15-10-20-48-38(44)45)34(60)55-30(23(3)56)36(62)53-26(14-6-9-19-42)33(59)54-28(37(63)64)16-11-21-49-39(46)47/h22-30,56H,4-21,40-43H2,1-3H3,(H,50,58)(H,51,57)(H,52,61)(H,53,62)(H,54,59)(H,55,60)(H,63,64)(H4,44,45,48)(H4,46,47,49)/t23-,24+,25+,26+,27+,28+,29+,30+/m1/s1
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2.90n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349578
PNG
(CHEMBL1808906)
Show SMILES NC(N)=NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H53N15O4/c35-28(36)23-14-12-22(13-15-23)20-46-29(51)24(9-4-16-43-32(37)38)48-31(53)26(11-6-18-45-34(41)42)49-30(52)25(10-5-17-44-33(39)40)47-27(50)19-21-7-2-1-3-8-21/h1-3,7-8,12-15,24-26H,4-6,9-11,16-20H2,(H3,35,36)(H,46,51)(H,47,50)(H,48,53)(H,49,52)(H4,37,38,43)(H4,39,40,44)(H4,41,42,45)/t24-,25-,26-/m0/s1
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3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349579
PNG
(CHEMBL1808907)
Show SMILES NC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C31H47N13O4/c32-17-24(44-28(47)23(9-5-15-40-31(37)38)42-25(45)16-19-6-2-1-3-7-19)29(48)43-22(8-4-14-39-30(35)36)27(46)41-18-20-10-12-21(13-11-20)26(33)34/h1-3,6-7,10-13,22-24H,4-5,8-9,14-18,32H2,(H3,33,34)(H,41,46)(H,42,45)(H,43,48)(H,44,47)(H4,35,36,39)(H4,37,38,40)/t22-,23-,24-/m0/s1
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3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50387002
PNG
(CHEMBL2049155)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H60N10O4/c1-4-5-6-7-8-9-10-16-28(45)42-26(15-13-22-40-34(38)39)32(47)44-29(23(2)3)33(48)43-27(14-11-12-21-35)31(46)41-25-19-17-24(18-20-25)30(36)37/h17-20,23,26-27,29H,4-16,21-22,35H2,1-3H3,(H3,36,37)(H,41,46)(H,42,45)(H,43,48)(H,44,47)(H4,38,39,40)/t26-,27-,29-/m0/s1
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3.30n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Inhibition of furin


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50303781
PNG
(CHEMBL565931 | N-((4S,7S,10S)-15-amino-4-(4-aminob...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N10O4/c1-4-5-6-7-8-9-10-16-29(46)43-28(15-13-22-41-35(39)40)33(48)45-30(24(2)3)34(49)44-27(14-11-12-21-36)32(47)42-23-25-17-19-26(20-18-25)31(37)38/h17-20,24,27-28,30H,4-16,21-23,36H2,1-3H3,(H3,37,38)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,39,40,41)/t27-,28-,30-/m0/s1
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3.30n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50031248
PNG
(6-Amino-2-[2-(2-decylamino-5-guanidino-pentanoylam...)
Show SMILES CCCCCCCCCCN[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(N)=O
Show InChI InChI=1S/C44H87N15O7/c1-7-8-9-10-11-12-13-16-23-51-32(21-18-25-53-44(49)50)39(63)59-37(29(4)5)42(66)57-33(19-14-15-22-45)40(64)56-31(20-17-24-52-43(47)48)34(60)26-54-30(6)38(62)58-36(28(2)3)41(65)55-27-35(46)61/h28-33,36-37,51,54H,7-27,45H2,1-6H3,(H2,46,61)(H,55,65)(H,56,64)(H,57,66)(H,58,62)(H,59,63)(H4,47,48,52)(H4,49,50,53)/t30-,31-,32-,33-,36-,37-/m0/s1
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3.40n/an/an/an/an/an/an/an/a



Friedrich Miescher-Institut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against furin


J Med Chem 38: 4014-8 (1995)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349580
PNG
(CHEMBL1808908)
Show SMILES NCCCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H53N13O4/c35-17-5-4-10-27(47-31(50)26(12-7-19-43-34(40)41)45-28(48)20-22-8-2-1-3-9-22)32(51)46-25(11-6-18-42-33(38)39)30(49)44-21-23-13-15-24(16-14-23)29(36)37/h1-3,8-9,13-16,25-27H,4-7,10-12,17-21,35H2,(H3,36,37)(H,44,49)(H,45,48)(H,46,51)(H,47,50)(H4,38,39,42)(H4,40,41,43)/t25-,26-,27-/m0/s1
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3.60n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349604
PNG
(CHEMBL1808934)
Show SMILES NCCCC[C@H](NC(=O)[C@H](CN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C31H47N11O4/c32-15-5-4-9-23(28(44)39-19-21-11-13-22(14-12-21)27(34)35)41-30(46)25(18-33)42-29(45)24(10-6-16-38-31(36)37)40-26(43)17-20-7-2-1-3-8-20/h1-3,7-8,11-14,23-25H,4-6,9-10,15-19,32-33H2,(H3,34,35)(H,39,44)(H,40,43)(H,41,46)(H,42,45)(H4,36,37,38)/t23-,24-,25-/m0/s1
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3.70n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50446944
PNG
(CHEMBL3115771)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H90N14O8/c1-28(2)23-38(59-33(11)66)46(69)62-40(25-30(5)6)48(71)64-41(26-31(7)8)49(72)63-39(24-29(3)4)47(70)60-37(16-14-22-57-51(55)56)45(68)65-42(32(9)10)50(73)61-36(15-12-13-21-52)44(67)58-27-34-17-19-35(20-18-34)43(53)54/h17-20,28-32,36-42H,12-16,21-27,52H2,1-11H3,(H3,53,54)(H,58,67)(H,59,66)(H,60,70)(H,61,73)(H,62,69)(H,63,72)(H,64,71)(H,65,68)(H4,55,56,57)/t36-,37-,38-,39-,40-,41-,42-/m0/s1
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4.30n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50031245
PNG
(CHEMBL341266 | {2-[2-(3-{6-Amino-2-[2-(2-decylamin...)
Show SMILES CCCCCCCCCCN[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)OC
Show InChI InChI=1S/C45H88N14O8/c1-8-9-10-11-12-13-14-17-24-51-33(22-19-26-53-45(49)50)40(63)59-38(30(4)5)43(66)57-34(20-15-16-23-46)41(64)56-32(21-18-25-52-44(47)48)35(60)27-54-31(6)39(62)58-37(29(2)3)42(65)55-28-36(61)67-7/h29-34,37-38,51,54H,8-28,46H2,1-7H3,(H,55,65)(H,56,64)(H,57,66)(H,58,62)(H,59,63)(H4,47,48,52)(H4,49,50,53)/t31-,32-,33-,34-,37-,38-/m0/s1
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5.10n/an/an/an/an/an/an/an/a



Friedrich Miescher-Institut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against furin


J Med Chem 38: 4014-8 (1995)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50399751
PNG
(CHEMBL2179431)
Show SMILES CC(C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C40H80N18O8/c1-22(2)29(43)35(63)55-24(12-5-7-17-41)31(59)53-26(14-9-19-50-38(44)45)32(60)54-27(15-10-20-51-39(46)47)34(62)58-30(23(3)4)36(64)56-25(13-6-8-18-42)33(61)57-28(37(65)66)16-11-21-52-40(48)49/h22-30H,5-21,41-43H2,1-4H3,(H,53,59)(H,54,60)(H,55,63)(H,56,64)(H,57,61)(H,58,62)(H,65,66)(H4,44,45,50)(H4,46,47,51)(H4,48,49,52)/t24-,25-,26-,27-,28-,29-,30-/m0/s1
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5.30n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349581
PNG
(CHEMBL1808909)
Show SMILES NC(N)=NCCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C31H46N12O4S/c32-26(33)21-12-10-20(11-13-21)17-40-27(45)22(8-4-14-38-30(34)35)42-29(47)24(18-48)43-28(46)23(9-5-15-39-31(36)37)41-25(44)16-19-6-2-1-3-7-19/h1-3,6-7,10-13,22-24,48H,4-5,8-9,14-18H2,(H3,32,33)(H,40,45)(H,41,44)(H,42,47)(H,43,46)(H4,34,35,38)(H4,36,37,39)/t22-,23-,24-/m0/s1
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5.90n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50279582
PNG
(CHEMBL488769 | N-[(1S,2S,4R,5R)-5-Guanidino-4-(4-g...)
Show SMILES NC(N)=N[C@H]1C[C@@H](N=C(N)N)[C@@H](C[C@@H]1Oc1ccc(cc1)N=C(N)N)Oc1ccc(N=C(N)N)c2ccccc12
Show InChI InChI=1S/C26H34N12O2/c27-23(28)35-13-5-7-14(8-6-13)39-21-12-22(19(38-26(33)34)11-18(21)37-25(31)32)40-20-10-9-17(36-24(29)30)15-3-1-2-4-16(15)20/h1-10,18-19,21-22H,11-12H2,(H4,27,28,35)(H4,29,30,36)(H4,31,32,37)(H4,33,34,38)/t18-,19+,21-,22+/m0/s1
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6n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin-dependent anthrax protective antigen processing


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50448472
PNG
(CHEMBL3126398)
Show SMILES C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NC\C=C\CN=C(N)N
Show InChI InChI=1S/C46H91N25O8/c1-27(65-37(75)30(66-28(2)72)15-9-23-61-43(51)52)35(73)67-32(16-10-24-62-44(53)54)39(77)70-34(18-12-26-64-46(57)58)41(79)71-33(17-11-25-63-45(55)56)40(78)69-31(14-4-6-20-48)38(76)68-29(13-3-5-19-47)36(74)59-21-7-8-22-60-42(49)50/h7-8,27,29-34H,3-6,9-26,47-48H2,1-2H3,(H,59,74)(H,65,75)(H,66,72)(H,67,73)(H,68,76)(H,69,78)(H,70,77)(H,71,79)(H4,49,50,60)(H4,51,52,61)(H4,53,54,62)(H4,55,56,63)(H4,57,58,64)/b8-7+/t27-,29-,30-,31-,32-,33-,34-/m0/s1
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6n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant furin (unknown origin) using as substrate after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349582
PNG
(CHEMBL1808910)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C32H48N12O5/c1-19(45)26(44-29(48)24(10-6-16-40-32(37)38)42-25(46)17-20-7-3-2-4-8-20)30(49)43-23(9-5-15-39-31(35)36)28(47)41-18-21-11-13-22(14-12-21)27(33)34/h2-4,7-8,11-14,19,23-24,26,45H,5-6,9-10,15-18H2,1H3,(H3,33,34)(H,41,47)(H,42,46)(H,43,49)(H,44,48)(H4,35,36,39)(H4,37,38,40)/t19-,23+,24+,26+/m1/s1
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6n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349605
PNG
(CHEMBL1808911)
Show SMILES NC(N)=NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H48N14O4/c35-29(36)23-12-10-22(11-13-23)18-44-30(50)25(8-4-14-42-33(37)38)47-32(52)27(17-24-19-41-20-45-24)48-31(51)26(9-5-15-43-34(39)40)46-28(49)16-21-6-2-1-3-7-21/h1-3,6-7,10-13,19-20,25-27H,4-5,8-9,14-18H2,(H3,35,36)(H,41,45)(H,44,50)(H,46,49)(H,47,52)(H,48,51)(H4,37,38,42)(H4,39,40,43)/t25-,26-,27-/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349583
PNG
(CHEMBL1808912)
Show SMILES NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C39H51N13O4/c40-34(41)26-16-14-25(15-17-26)22-49-35(54)30(12-6-18-46-38(42)43)51-37(56)32(21-27-23-48-29-11-5-4-10-28(27)29)52-36(55)31(13-7-19-47-39(44)45)50-33(53)20-24-8-2-1-3-9-24/h1-5,8-11,14-17,23,30-32,48H,6-7,12-13,18-22H2,(H3,40,41)(H,49,54)(H,50,53)(H,51,56)(H,52,55)(H4,42,43,46)(H4,44,45,47)/t30-,31-,32-/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50031249
PNG
((S)-2-((S)-3-{(S)-6-Amino-2-[(S)-2-((S)-2-decylami...)
Show SMILES CCCCCCCCCCN[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CN[C@@H](C)C(=O)OC
Show InChI InChI=1S/C38H76N12O6/c1-6-7-8-9-10-11-12-15-22-44-29(20-17-24-46-38(42)43)33(52)50-32(26(2)3)35(54)49-30(18-13-14-21-39)34(53)48-28(19-16-23-45-37(40)41)31(51)25-47-27(4)36(55)56-5/h26-30,32,44,47H,6-25,39H2,1-5H3,(H,48,53)(H,49,54)(H,50,52)(H4,40,41,45)(H4,42,43,46)/t27-,28-,29-,30-,32-/m0/s1
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7.5n/an/an/an/an/an/an/an/a



Friedrich Miescher-Institut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against furin


J Med Chem 38: 4014-8 (1995)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50448481
PNG
(CHEMBL3126400)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)CN(CCCN=C(N)N)NC(C)=O)C(N)=O
Show InChI InChI=1S/C51H102N28O11/c1-28(70-37(82)27-79(78-30(3)81)26-12-25-69-51(63)64)40(84)71-33(15-8-21-65-47(55)56)43(87)74-35(17-10-23-67-49(59)60)45(89)75-34(16-9-22-66-48(57)58)44(88)73-31(13-4-6-19-52)41(85)72-32(14-5-7-20-53)42(86)76-36(18-11-24-68-50(61)62)46(90)77-38(29(2)80)39(54)83/h28-29,31-36,38,80H,4-27,52-53H2,1-3H3,(H2,54,83)(H,70,82)(H,71,84)(H,72,85)(H,73,88)(H,74,87)(H,75,89)(H,76,86)(H,77,90)(H,78,81)(H4,55,56,65)(H4,57,58,66)(H4,59,60,67)(H4,61,62,68)(H4,63,64,69)/t28-,29+,31-,32-,33-,34-,35-,36-,38-/m0/s1
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8n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant furin (unknown origin) using as substrate after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50399750
PNG
(CHEMBL2179428)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C41H82N20O8/c1-22(2)21-24(43)31(62)56-26(12-7-17-52-38(44)45)32(63)57-27(13-8-18-53-39(46)47)33(64)58-28(14-9-19-54-40(48)49)35(66)61-30(23(3)4)36(67)59-25(11-5-6-16-42)34(65)60-29(37(68)69)15-10-20-55-41(50)51/h22-30H,5-21,42-43H2,1-4H3,(H,56,62)(H,57,63)(H,58,64)(H,59,67)(H,60,65)(H,61,66)(H,68,69)(H4,44,45,52)(H4,46,47,53)(H4,48,49,54)(H4,50,51,55)/t24-,25-,26-,27-,28-,29-,30-/m0/s1
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9n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349584
PNG
(CHEMBL1808913)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H50N12O4S/c1-50-18-15-26(45-30(48)25(10-6-17-41-33(38)39)43-27(46)19-21-7-3-2-4-8-21)31(49)44-24(9-5-16-40-32(36)37)29(47)42-20-22-11-13-23(14-12-22)28(34)35/h2-4,7-8,11-14,24-26H,5-6,9-10,15-20H2,1H3,(H3,34,35)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t24-,25-,26-/m0/s1
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9.70n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349585
PNG
(CHEMBL1808914)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H52N12O4/c1-21(2)18-27(46-31(49)26(11-7-17-42-34(39)40)44-28(47)19-22-8-4-3-5-9-22)32(50)45-25(10-6-16-41-33(37)38)30(48)43-20-23-12-14-24(15-13-23)29(35)36/h3-5,8-9,12-15,21,25-27H,6-7,10-11,16-20H2,1-2H3,(H3,35,36)(H,43,48)(H,44,47)(H,45,50)(H,46,49)(H4,37,38,41)(H4,39,40,42)/t25-,26-,27-/m0/s1
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12n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50279584
PNG
(CHEMBL485694 | N-[(1S,2S,4R,5R)-5-Guanidino-2,4-bi...)
Show SMILES NC(N)=N[C@@H]1C[C@H](N=C(N)N)[C@H](C[C@H]1Oc1ccc(cc1)N=C(N)N)Oc1ccc(cc1)N=C(N)N
Show InChI InChI=1S/C22H32N12O2/c23-19(24)31-11-1-5-13(6-2-11)35-17-10-18(16(34-22(29)30)9-15(17)33-21(27)28)36-14-7-3-12(4-8-14)32-20(25)26/h1-8,15-18H,9-10H2,(H4,23,24,31)(H4,25,26,32)(H4,27,28,33)(H4,29,30,34)/t15-,16+,17-,18+
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12n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin-dependent anthrax protective antigen processing


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50399749
PNG
(CHEMBL2179430)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C39H77N17O8/c1-21(2)19-24(41)31(58)56-29(20-22(3)4)35(62)54-27(13-9-17-49-38(44)45)33(60)53-26(12-8-16-48-37(42)43)32(59)51-23(5)30(57)52-25(11-6-7-15-40)34(61)55-28(36(63)64)14-10-18-50-39(46)47/h21-29H,6-20,40-41H2,1-5H3,(H,51,59)(H,52,57)(H,53,60)(H,54,62)(H,55,61)(H,56,58)(H,63,64)(H4,42,43,48)(H4,44,45,49)(H4,46,47,50)/t23-,24-,25-,26-,27-,28-,29-/m0/s1
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12.4n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349586
PNG
(CHEMBL1808915)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H49N13O5/c34-26(47)15-14-25(46-30(50)24(9-5-17-42-33(39)40)44-27(48)18-20-6-2-1-3-7-20)31(51)45-23(8-4-16-41-32(37)38)29(49)43-19-21-10-12-22(13-11-21)28(35)36/h1-3,6-7,10-13,23-25H,4-5,8-9,14-19H2,(H2,34,47)(H3,35,36)(H,43,49)(H,44,48)(H,45,51)(H,46,50)(H4,37,38,41)(H4,39,40,42)/t23-,24-,25-/m0/s1
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13n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50448480
PNG
(CHEMBL3126392)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CN(CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O
Show InChI InChI=1S/C51H102N28O11/c1-28(70-41(85)31(71-30(3)81)15-8-21-65-47(55)56)40(84)78-79(26-12-25-69-51(63)64)27-37(82)72-32(16-9-22-66-48(57)58)42(86)75-35(17-10-23-67-49(59)60)45(89)74-33(13-4-6-19-52)43(87)73-34(14-5-7-20-53)44(88)76-36(18-11-24-68-50(61)62)46(90)77-38(29(2)80)39(54)83/h28-29,31-36,38,80H,4-27,52-53H2,1-3H3,(H2,54,83)(H,70,85)(H,71,81)(H,72,82)(H,73,87)(H,74,89)(H,75,86)(H,76,88)(H,77,90)(H,78,84)(H4,55,56,65)(H4,57,58,66)(H4,59,60,67)(H4,61,62,68)(H4,63,64,69)/t28-,29+,31-,32-,33-,34-,35-,36-,38-/m0/s1
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18n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant furin (unknown origin) using as substrate after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349587
PNG
(CHEMBL1808916)
Show SMILES C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C31H46N12O4/c1-19(41-29(47)24(10-6-16-39-31(36)37)42-25(44)17-20-7-3-2-4-8-20)27(45)43-23(9-5-15-38-30(34)35)28(46)40-18-21-11-13-22(14-12-21)26(32)33/h2-4,7-8,11-14,19,23-24H,5-6,9-10,15-18H2,1H3,(H3,32,33)(H,40,46)(H,41,47)(H,42,44)(H,43,45)(H4,34,35,38)(H4,36,37,39)/t19-,23-,24-/m0/s1
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19n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50448479
PNG
(CHEMBL3126397)
Show SMILES C[C@@H](O)[C@H](NC(=O)CN(CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O
Show InChI InChI=1S/C51H102N28O11/c1-28(70-41(85)31(71-30(3)81)15-8-21-65-47(55)56)40(84)72-33(16-9-22-66-48(57)58)43(87)74-35(18-11-24-68-50(61)62)45(89)75-34(17-10-23-67-49(59)60)44(88)73-32(13-4-6-19-52)42(86)76-36(14-5-7-20-53)46(90)78-79(26-12-25-69-51(63)64)27-37(82)77-38(29(2)80)39(54)83/h28-29,31-36,38,80H,4-27,52-53H2,1-3H3,(H2,54,83)(H,70,85)(H,71,81)(H,72,84)(H,73,88)(H,74,87)(H,75,89)(H,76,86)(H,77,82)(H,78,90)(H4,55,56,65)(H4,57,58,66)(H4,59,60,67)(H4,61,62,68)(H4,63,64,69)/t28-,29+,31-,32-,33-,34-,35-,36-,38-/m0/s1
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21n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant furin (unknown origin) using as substrate after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50279581
PNG
(CHEMBL522615 | N-[(1S,2S,4R,5R)-2-(2-Amino-4-guani...)
Show SMILES NC(N)=N[C@H]1C[C@@H](N=C(N)N)[C@@H](C[C@@H]1Oc1ccc(cc1N)N=C(N)N)Oc1ccc(N=C(N)N)c2ccccc12
Show InChI InChI=1S/C26H35N13O2/c27-15-9-12(36-23(28)29)5-7-20(15)41-22-11-21(17(38-25(32)33)10-18(22)39-26(34)35)40-19-8-6-16(37-24(30)31)13-3-1-2-4-14(13)19/h1-9,17-18,21-22H,10-11,27H2,(H4,28,29,36)(H4,30,31,37)(H4,32,33,38)(H4,34,35,39)/t17-,18+,21-,22+/m1/s1
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22n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin-dependent anthrax protective antigen processing


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349588
PNG
(CHEMBL1808917)
Show SMILES NC(=O)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C32H47N13O5/c33-25(46)17-24(45-29(49)23(9-5-15-41-32(38)39)43-26(47)16-19-6-2-1-3-7-19)30(50)44-22(8-4-14-40-31(36)37)28(48)42-18-20-10-12-21(13-11-20)27(34)35/h1-3,6-7,10-13,22-24H,4-5,8-9,14-18H2,(H2,33,46)(H3,34,35)(H,42,48)(H,43,47)(H,44,50)(H,45,49)(H4,36,37,40)(H4,38,39,41)/t22-,23-,24-/m0/s1
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23n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50270054
PNG
(CHEMBL502642 | TPRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C58H113N29O13/c1-30(78-45(92)35(16-8-24-73-54(63)64)85-52(99)40-21-13-29-87(40)53(100)41(61)31(2)88)44(91)79-36(17-9-25-74-55(65)66)48(95)82-38(19-11-27-76-57(69)70)50(97)83-37(18-10-26-75-56(67)68)49(96)81-33(14-4-6-22-59)46(93)80-34(15-5-7-23-60)47(94)84-39(20-12-28-77-58(71)72)51(98)86-42(32(3)89)43(62)90/h30-42,88-89H,4-29,59-61H2,1-3H3,(H2,62,90)(H,78,92)(H,79,91)(H,80,93)(H,81,96)(H,82,95)(H,83,97)(H,84,94)(H,85,99)(H,86,98)(H4,63,64,73)(H4,65,66,74)(H4,67,68,75)(H4,69,70,76)(H4,71,72,77)/t30-,31+,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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23n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50270243
PNG
(CHEMBL525961 | TPRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C58H112N28O14/c1-30(77-44(90)35(16-8-24-72-54(62)63)84-51(97)40-21-13-29-86(40)52(98)41(61)31(2)87)43(89)78-36(17-9-25-73-55(64)65)47(93)81-38(19-11-27-75-57(68)69)49(95)82-37(18-10-26-74-56(66)67)48(94)80-33(14-4-6-22-59)45(91)79-34(15-5-7-23-60)46(92)83-39(20-12-28-76-58(70)71)50(96)85-42(32(3)88)53(99)100/h30-42,87-88H,4-29,59-61H2,1-3H3,(H,77,90)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,95)(H,83,92)(H,84,97)(H,85,96)(H,99,100)(H4,62,63,72)(H4,64,65,73)(H4,66,67,74)(H4,68,69,75)(H4,70,71,76)/t30-,31+,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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23n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50349589
PNG
(CHEMBL1808918)
Show SMILES NC(N)=NCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C31H46N12O5/c32-26(33)21-12-10-20(11-13-21)17-40-27(46)22(8-4-14-38-30(34)35)42-29(48)24(18-44)43-28(47)23(9-5-15-39-31(36)37)41-25(45)16-19-6-2-1-3-7-19/h1-3,6-7,10-13,22-24,44H,4-5,8-9,14-18H2,(H3,32,33)(H,40,46)(H,41,45)(H,42,48)(H,43,47)(H4,34,35,38)(H4,36,37,39)/t22-,23-,24-/m0/s1
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24n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50448478
PNG
(CHEMBL3126396)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O
Show InChI InChI=1S/C51H101N27O11/c1-27(70-40(83)30(71-29(3)80)15-8-22-65-47(55)56)39(82)72-33(16-9-23-66-48(57)58)43(86)75-35(18-11-25-68-50(61)62)45(88)76-34(17-10-24-67-49(59)60)44(87)74-31(13-4-6-20-52)41(84)73-32(14-5-7-21-53)42(85)77-36(19-12-26-69-51(63)64)46(89)78-37(28(2)79)38(54)81/h27-28,30-37,79H,4-26,52-53H2,1-3H3,(H2,54,81)(H,70,83)(H,71,80)(H,72,82)(H,73,84)(H,74,87)(H,75,86)(H,76,88)(H,77,85)(H,78,89)(H4,55,56,65)(H4,57,58,66)(H4,59,60,67)(H4,61,62,68)(H4,63,64,69)/t27-,28+,30-,31-,32-,33-,34-,35-,36-,37-/m0/s1
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25n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant furin (unknown origin) using as substrate after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens)
BDBM50031247
PNG
(6-Amino-2-[2-(2-decylamino-5-guanidino-pentanoylam...)
Show SMILES CCCCCCCCCCN[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCNC(N)=N)C(=O)CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(N)=O
Show InChI InChI=1S/C44H87N15O7/c1-7-8-9-10-11-12-13-16-23-51-32(21-18-25-53-44(49)50)39(63)59-37(29(4)5)42(66)57-33(19-14-15-22-45)40(64)56-31(20-17-24-52-43(47)48)34(60)26-54-30(6)38(62)58-36(28(2)3)41(65)55-27-35(46)61/h28-33,36-37,51,54H,7-27,45H2,1-6H3,(H2,46,61)(H,55,65)(H,56,64)(H,57,66)(H,58,62)(H,59,63)(H4,47,48,52)(H4,49,50,53)/t30-,31+,32-,33-,36-,37-/m0/s1
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26n/an/an/an/an/an/an/an/a



Friedrich Miescher-Institut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against furin


J Med Chem 38: 4014-8 (1995)

More data for this
Ligand-Target Pair
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