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Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Homoserine kinase' AND taxid = 83333   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homoserine kinase


(Escherichia coli)
BDBM85124
PNG
(Thr1 inhibitor, 4)
Show SMILES Oc1c(CC2C(=O)OC3C=CCC=C3C2=O)c(=O)oc2ccccc12
Show InChI InChI=1S/C19H14O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1,3-8,13,15,20H,2,9H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
460 -37.6n/an/an/an/an/a7.537



McMaster University



Assay Description
The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...


Chembiochem 12: 1179-82 (2011)

More data for this
Ligand-Target Pair
Homoserine kinase


(Escherichia coli)
BDBM85126
PNG
(Thr1 inhibitor, 6)
Show SMILES CC1NN(c2nc(cc(O)c12)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C14H12F3N3O/c1-8-12-10(21)7-11(14(15,16)17)18-13(12)20(19-8)9-5-3-2-4-6-9/h2-8,19H,1H3,(H,18,21)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
8.60E+3 -30.1n/an/an/an/an/a7.537



McMaster University



Assay Description
The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...


Chembiochem 12: 1179-82 (2011)

More data for this
Ligand-Target Pair
Homoserine kinase


(Escherichia coli)
BDBM24941
PNG
((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)
Show SMILES CC(=O)C(C#N)C(=O)Nc1cc(Br)ccc1Br
Show InChI InChI=1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,8H,1H3,(H,15,17)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
1.20E+4 -29.2n/an/an/an/an/a7.537



McMaster University



Assay Description
The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...


Chembiochem 12: 1179-82 (2011)

More data for this
Ligand-Target Pair
Homoserine kinase


(Escherichia coli)
BDBM85123
PNG
(Thr1 inhibitor, 3 | cid_235240)
Show SMILES OC1C(=O)C(Oc2cc(O)c(O)cc12)c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H12O7/c16-8-2-1-6(3-9(8)17)15-14(21)13(20)7-4-10(18)11(19)5-12(7)22-15/h1-5,13,15-20H
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
2.71E+4 -27.1n/an/an/an/an/a7.537



McMaster University



Assay Description
The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...


Chembiochem 12: 1179-82 (2011)

More data for this
Ligand-Target Pair
Homoserine kinase


(Escherichia coli)
BDBM85122
PNG
(Thr1 inhibitor, 1)
Show SMILES C=CC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
3.20E+4 -26.7n/an/an/an/an/a7.537



McMaster University



Assay Description
The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...


Chembiochem 12: 1179-82 (2011)

More data for this
Ligand-Target Pair
Homoserine kinase


(Escherichia coli)
BDBM85125
PNG
(Thr1 inhibitor, 5)
Show SMILES CC(C)Cc1nc2sc3CCCCCc3c2c(=O)o1
Show InChI InChI=1S/C15H19NO2S/c1-9(2)8-12-16-14-13(15(17)18-12)10-6-4-3-5-7-11(10)19-14/h9H,3-8H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
3.58E+4 -26.4n/an/an/an/an/a7.537



McMaster University



Assay Description
The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...


Chembiochem 12: 1179-82 (2011)

More data for this
Ligand-Target Pair