BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 45 hits Enz. Inhib. hit(s) with Target = 'Human herpesvirus 2 protease' AND taxid = 10315   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075142
PNG
(CHEMBL138470 | N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[...)
Show SMILES C[C@H](NC(=O)C=C(c1cccs1)c1cccs1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C20H16N2O3S3/c1-11-10-28-19-17(11)20(24)25-18(22-19)12(2)21-16(23)9-13(14-5-3-7-26-14)15-6-4-8-27-15/h3-10,12H,1-2H3,(H,21,23)/t12-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 110n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075167
PNG
((E)-3-(4-Bromo-thiophen-2-yl)-N-[(S)-1-(5-methyl-4...)
Show SMILES C[C@H](NC(=O)\C=C\c1cc(Br)cs1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C16H13BrN2O3S2/c1-8-6-24-15-13(8)16(21)22-14(19-15)9(2)18-12(20)4-3-11-5-10(17)7-23-11/h3-7,9H,1-2H3,(H,18,20)/b4-3+/t9-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 190n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075146
PNG
((E)-3-(2,5-Dimethyl-thiophen-3-yl)-N-[(S)-1-(5-met...)
Show SMILES C[C@H](NC(=O)\C=C\c1cc(C)sc1C)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H18N2O3S2/c1-9-8-24-17-15(9)18(22)23-16(20-17)11(3)19-14(21)6-5-13-7-10(2)25-12(13)4/h5-8,11H,1-4H3,(H,19,21)/b6-5+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 190n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075155
PNG
((E)-3-(2-Bromo-thiophen-3-yl)-N-[(S)-1-(5-methyl-4...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccsc1Br)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C16H13BrN2O3S2/c1-8-7-24-15-12(8)16(21)22-14(19-15)9(2)18-11(20)4-3-10-5-6-23-13(10)17/h3-7,9H,1-2H3,(H,18,20)/b4-3+/t9-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 200n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075138
PNG
((E)-3-(5-Chloro-thiophen-2-yl)-N-[(S)-1-(5-methyl-...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(Cl)s1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C16H13ClN2O3S2/c1-8-7-23-15-13(8)16(21)22-14(19-15)9(2)18-12(20)6-4-10-3-5-11(17)24-10/h3-7,9H,1-2H3,(H,18,20)/b6-4+/t9-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 210n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075152
PNG
((E)-3-(2-Chloro-4-hydroxy-phenyl)-N-[(S)-1-(5-meth...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(O)cc1Cl)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H15ClN2O4S/c1-9-8-26-17-15(9)18(24)25-16(21-17)10(2)20-14(23)6-4-11-3-5-12(22)7-13(11)19/h3-8,10,22H,1-2H3,(H,20,23)/b6-4+/t10-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 230n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075168
PNG
((E)-3-(3-Bromo-thiophen-2-yl)-N-[(S)-1-(5-methyl-4...)
Show SMILES C[C@H](NC(=O)\C=C\c1sccc1Br)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C16H13BrN2O3S2/c1-8-7-24-15-13(8)16(21)22-14(19-15)9(2)18-12(20)4-3-11-10(17)5-6-23-11/h3-7,9H,1-2H3,(H,18,20)/b4-3+/t9-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 250n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075159
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccnc2ccccc12)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C21H17N3O3S/c1-12-11-28-20-18(12)21(26)27-19(24-20)13(2)23-17(25)8-7-14-9-10-22-16-6-4-3-5-15(14)16/h3-11,13H,1-2H3,(H,23,25)/b8-7+/t13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 250n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075163
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C(\c1cccs1)c1ccccc1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C22H18N2O3S2/c1-13-12-29-21-19(13)22(26)27-20(24-21)14(2)23-18(25)11-16(17-9-6-10-28-17)15-7-4-3-5-8-15/h3-12,14H,1-2H3,(H,23,25)/b16-11+/t14-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 260n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075158
PNG
((E)-3-(5-Bromo-thiophen-2-yl)-N-[(S)-1-(5-methyl-4...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(Br)s1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C16H13BrN2O3S2/c1-8-7-23-15-13(8)16(21)22-14(19-15)9(2)18-12(20)6-4-10-3-5-11(17)24-10/h3-7,9H,1-2H3,(H,18,20)/b6-4+/t9-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 270n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075164
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccccc1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H16N2O3S/c1-11-10-24-17-15(11)18(22)23-16(20-17)12(2)19-14(21)9-8-13-6-4-3-5-7-13/h3-10,12H,1-2H3,(H,19,21)/b9-8+/t12-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 300n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075147
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1sccc1C)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C17H16N2O3S2/c1-9-6-7-23-12(9)4-5-13(20)18-11(3)15-19-16-14(17(21)22-15)10(2)8-24-16/h4-8,11H,1-3H3,(H,18,20)/b5-4+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 330n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075140
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccsc1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C16H14N2O3S2/c1-9-7-23-15-13(9)16(20)21-14(18-15)10(2)17-12(19)4-3-11-5-6-22-8-11/h3-8,10H,1-2H3,(H,17,19)/b4-3+/t10-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 330n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075165
PNG
((E)-3-(3,5-Dimethoxy-phenyl)-N-[(S)-1-(5-methyl-4-...)
Show SMILES COc1cc(OC)cc(\C=C\C(=O)N[C@@H](C)c2nc3scc(C)c3c(=O)o2)c1
Show InChI InChI=1S/C20H20N2O5S/c1-11-10-28-19-17(11)20(24)27-18(22-19)12(2)21-16(23)6-5-13-7-14(25-3)9-15(8-13)26-4/h5-10,12H,1-4H3,(H,21,23)/b6-5+/t12-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 350n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075157
PNG
((E)-3-(2-Bromo-phenyl)-N-[(S)-1-(5-methyl-4-oxo-4H...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccccc1Br)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H15BrN2O3S/c1-10-9-25-17-15(10)18(23)24-16(21-17)11(2)20-14(22)8-7-12-5-3-4-6-13(12)19/h3-9,11H,1-2H3,(H,20,22)/b8-7+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 480n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075162
PNG
((E)-3-(5-Bromo-furan-2-yl)-N-[(S)-1-(5-methyl-4-ox...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(Br)o1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C16H13BrN2O4S/c1-8-7-24-15-13(8)16(21)23-14(19-15)9(2)18-12(20)6-4-10-3-5-11(17)22-10/h3-7,9H,1-2H3,(H,18,20)/b6-4+/t9-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 490n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075151
PNG
(CHEMBL141722 | N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[...)
Show SMILES C[C@H](NC(=O)C=C(c1ccccc1)c1ccccc1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C24H20N2O3S/c1-15-14-30-23-21(15)24(28)29-22(26-23)16(2)25-20(27)13-19(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-14,16H,1-2H3,(H,25,27)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 500n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075150
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccccn1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C17H15N3O3S/c1-10-9-24-16-14(10)17(22)23-15(20-16)11(2)19-13(21)7-6-12-5-3-4-8-18-12/h3-9,11H,1-2H3,(H,19,21)/b7-6+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 500n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075156
PNG
((E)-3-(2-Chloro-6-fluoro-phenyl)-N-[(S)-1-(5-methy...)
Show SMILES C[C@H](NC(=O)\C=C\c1c(F)cccc1Cl)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H14ClFN2O3S/c1-9-8-26-17-15(9)18(24)25-16(22-17)10(2)21-14(23)7-6-11-12(19)4-3-5-13(11)20/h3-8,10H,1-2H3,(H,21,23)/b7-6+/t10-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 520n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075153
PNG
((E)-3-(4-Formyl-phenyl)-N-[(S)-1-(5-methyl-4-oxo-4...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(C=O)cc1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C19H16N2O4S/c1-11-10-26-18-16(11)19(24)25-17(21-18)12(2)20-15(23)8-7-13-3-5-14(9-22)6-4-13/h3-10,12H,1-2H3,(H,20,23)/b8-7+/t12-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 530n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075154
PNG
((E)-3-(2-Ethoxy-phenyl)-N-[(S)-1-(5-methyl-4-oxo-4...)
Show SMILES CCOc1ccccc1\C=C\C(=O)N[C@@H](C)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C20H20N2O4S/c1-4-25-15-8-6-5-7-14(15)9-10-16(23)21-13(3)18-22-19-17(20(24)26-18)12(2)11-27-19/h5-11,13H,4H2,1-3H3,(H,21,23)/b10-9+/t13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 560n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075161
PNG
((E)-3-(4-Dimethylamino-phenyl)-N-[(S)-1-(5-methyl-...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(cc1)N(C)C)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C20H21N3O3S/c1-12-11-27-19-17(12)20(25)26-18(22-19)13(2)21-16(24)10-7-14-5-8-15(9-6-14)23(3)4/h5-11,13H,1-4H3,(H,21,24)/b10-7+/t13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 570n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075149
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(s1)[N+]([O-])=O)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C16H13N3O5S2/c1-8-7-25-15-13(8)16(21)24-14(18-15)9(2)17-11(20)5-3-10-4-6-12(26-10)19(22)23/h3-7,9H,1-2H3,(H,17,20)/b5-3+/t9-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 570n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075143
PNG
((E)-3-(2-Chloro-phenyl)-N-[(S)-1-(5-methyl-4-oxo-4...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccccc1Cl)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H15ClN2O3S/c1-10-9-25-17-15(10)18(23)24-16(21-17)11(2)20-14(22)8-7-12-5-3-4-6-13(12)19/h3-9,11H,1-2H3,(H,20,22)/b8-7+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 610n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075145
PNG
((E)-3-(2,6-Difluoro-phenyl)-N-[(S)-1-(5-methyl-4-o...)
Show SMILES C[C@H](NC(=O)\C=C\c1c(F)cccc1F)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H14F2N2O3S/c1-9-8-26-17-15(9)18(24)25-16(22-17)10(2)21-14(23)7-6-11-12(19)4-3-5-13(11)20/h3-8,10H,1-2H3,(H,21,23)/b7-6+/t10-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 630n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075136
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(C)s1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C17H16N2O3S2/c1-9-8-23-16-14(9)17(21)22-15(19-16)11(3)18-13(20)7-6-12-5-4-10(2)24-12/h4-8,11H,1-3H3,(H,18,20)/b7-6+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 650n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075173
PNG
((E)-4-(3-Methoxy-phenyl)-4-oxo-but-2-enoic acid [(...)
Show SMILES COc1cccc(c1)C(=O)\C=C\C(=O)N[C@@H](C)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C20H18N2O5S/c1-11-10-28-19-17(11)20(25)27-18(22-19)12(2)21-16(24)8-7-15(23)13-5-4-6-14(9-13)26-3/h4-10,12H,1-3H3,(H,21,24)/b8-7+/t12-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 680n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075141
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccccc1[N+]([O-])=O)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H15N3O5S/c1-10-9-27-17-15(10)18(23)26-16(20-17)11(2)19-14(22)8-7-12-5-3-4-6-13(12)21(24)25/h3-9,11H,1-2H3,(H,19,22)/b8-7+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 720n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075179
PNG
((E)-4-Oxo-pent-2-enoic acid [(S)-1-(5-methyl-4-oxo...)
Show SMILES C[C@H](NC(=O)C=CC(C)=O)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C14H14N2O4S/c1-7-6-21-13-11(7)14(19)20-12(16-13)9(3)15-10(18)5-4-8(2)17/h4-6,9H,1-3H3,(H,15,18)/t9-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 790n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075144
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(cc1)[N+]([O-])=O)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H15N3O5S/c1-10-9-27-17-15(10)18(23)26-16(20-17)11(2)19-14(22)8-5-12-3-6-13(7-4-12)21(24)25/h3-9,11H,1-2H3,(H,19,22)/b8-5+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 940n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075169
PNG
((E)-3-(3-Chloro-phenyl)-N-[(S)-1-(5-methyl-4-oxo-4...)
Show SMILES C[C@H](NC(=O)\C=C\c1cccc(Cl)c1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H15ClN2O3S/c1-10-9-25-17-15(10)18(23)24-16(21-17)11(2)20-14(22)7-6-12-4-3-5-13(19)8-12/h3-9,11H,1-2H3,(H,20,22)/b7-6+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 980n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075148
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1cccn1C)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C17H17N3O3S/c1-10-9-24-16-14(10)17(22)23-15(19-16)11(2)18-13(21)7-6-12-5-4-8-20(12)3/h4-9,11H,1-3H3,(H,18,21)/b7-6+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075139
PNG
((E)-3-(2,6-Dimethoxy-phenyl)-N-[(S)-1-(5-methyl-4-...)
Show SMILES COc1cccc(OC)c1\C=C\C(=O)N[C@@H](C)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C20H20N2O5S/c1-11-10-28-19-17(11)20(24)27-18(22-19)12(2)21-16(23)9-8-13-14(25-3)6-5-7-15(13)26-4/h5-10,12H,1-4H3,(H,21,23)/b9-8+/t12-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075137
PNG
((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccccc1C)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C19H18N2O3S/c1-11-6-4-5-7-14(11)8-9-15(22)20-13(3)17-21-18-16(19(23)24-17)12(2)10-25-18/h4-10,13H,1-3H3,(H,20,22)/b9-8+/t13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075166
PNG
((E)-3-(2,6-Dichloro-phenyl)-N-[(S)-1-(5-methyl-4-o...)
Show SMILES C[C@H](NC(=O)\C=C\c1c(Cl)cccc1Cl)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C18H14Cl2N2O3S/c1-9-8-26-17-15(9)18(24)25-16(22-17)10(2)21-14(23)7-6-11-12(19)4-3-5-13(11)20/h3-8,10H,1-2H3,(H,21,23)/b7-6+/t10-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.97E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay


Bioorg Med Chem Lett 9: 443-8 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075177
PNG
((E)-4-(3-Cyano-phenyl)-4-oxo-but-2-enoic acid [(S)...)
Show SMILES C[C@H](NC(=O)\C=C\C(=O)c1cccc(c1)C#N)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C20H15N3O4S/c1-11-10-28-19-17(11)20(26)27-18(23-19)12(2)22-16(25)7-6-15(24)14-5-3-4-13(8-14)9-21/h3-8,10,12H,1-2H3,(H,22,25)/b7-6+/t12-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075178
PNG
((E)-4-(2-Nitro-phenyl)-4-oxo-but-2-enoic acid [(S)...)
Show SMILES C[C@H](NC(=O)\C=C\C(=O)c1ccccc1[N+]([O-])=O)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C19H15N3O6S/c1-10-9-29-18-16(10)19(25)28-17(21-18)11(2)20-15(24)8-7-14(23)12-5-3-4-6-13(12)22(26)27/h3-9,11H,1-2H3,(H,20,24)/b8-7+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075181
PNG
((E)-But-2-enedioic acid [(S)-1-(5-methyl-4-oxo-4H-...)
Show SMILES C[C@H](NC(=O)\C=C\C(=O)Nc1ccccc1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C19H17N3O4S/c1-11-10-27-18-16(11)19(25)26-17(22-18)12(2)20-14(23)8-9-15(24)21-13-6-4-3-5-7-13/h3-10,12H,1-2H3,(H,20,23)(H,21,24)/b9-8+/t12-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075176
PNG
((E)-4-Oxo-4-phenyl-but-2-enoic acid [(S)-1-(5-meth...)
Show SMILES C[C@H](NC(=O)\C=C\C(=O)c1ccccc1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C19H16N2O4S/c1-11-10-26-18-16(11)19(24)25-17(21-18)12(2)20-15(23)9-8-14(22)13-6-4-3-5-7-13/h3-10,12H,1-2H3,(H,20,23)/b9-8+/t12-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 2.70E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075175
PNG
((E)-4-(3-Nitro-phenyl)-4-oxo-but-2-enoic acid [(S)...)
Show SMILES C[C@H](NC(=O)\C=C\C(=O)c1cccc(c1)[N+]([O-])=O)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C19H15N3O6S/c1-10-9-29-18-16(10)19(25)28-17(21-18)11(2)20-15(24)7-6-14(23)12-4-3-5-13(8-12)22(26)27/h3-9,11H,1-2H3,(H,20,24)/b7-6+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075171
PNG
((E)-4-Oxo-4-thiophen-2-yl-but-2-enoic acid [(S)-1-...)
Show SMILES C[C@H](NC(=O)\C=C\C(=O)c1cccs1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C17H14N2O4S2/c1-9-8-25-16-14(9)17(22)23-15(19-16)10(2)18-13(21)6-5-11(20)12-4-3-7-24-12/h3-8,10H,1-2H3,(H,18,21)/b6-5+/t10-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 4.60E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075172
PNG
(CHEMBL138045 | N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[...)
Show SMILES C[C@H](NC(=O)CCC(=O)c1cccs1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C17H16N2O4S2/c1-9-8-25-16-14(9)17(22)23-15(19-16)10(2)18-13(21)6-5-11(20)12-4-3-7-24-12/h3-4,7-8,10H,5-6H2,1-2H3,(H,18,21)/t10-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 4.70E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075174
PNG
(CHEMBL344631 | N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[...)
Show SMILES C[C@H](NC(=O)CCC(=O)c1ccccc1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C19H18N2O4S/c1-11-10-26-18-16(11)19(24)25-17(21-18)12(2)20-15(23)9-8-14(22)13-6-4-3-5-7-13/h3-7,10,12H,8-9H2,1-2H3,(H,20,23)/t12-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075180
PNG
((E)-4-(4-Chloro-phenyl)-4-oxo-but-2-enoic acid [(S...)
Show SMILES C[C@H](NC(=O)\C=C\C(=O)c1ccc(Cl)cc1)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C19H15ClN2O4S/c1-10-9-27-18-16(10)19(25)26-17(22-18)11(2)21-15(24)8-7-14(23)12-3-5-13(20)6-4-12/h3-9,11H,1-2H3,(H,21,24)/b8-7+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair
Human herpesvirus 2 protease


(Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...)
BDBM50075170
PNG
((E)-4-(4-Ethoxy-phenyl)-4-oxo-but-2-enoic acid [(S...)
Show SMILES CCOc1ccc(cc1)C(=O)\C=C\C(=O)N[C@@H](C)c1nc2scc(C)c2c(=O)o1
Show InChI InChI=1S/C21H20N2O5S/c1-4-27-15-7-5-14(6-8-15)16(24)9-10-17(25)22-13(3)19-23-20-18(21(26)28-19)12(2)11-29-20/h5-11,13H,4H2,1-3H3,(H,22,25)/b10-9+/t13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.60E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex virus protease (HSV-2)


Bioorg Med Chem Lett 9: 449-52 (1999)

More data for this
Ligand-Target Pair