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Found 55 hits Enz. Inhib. hit(s) with Target = 'Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058752
PNG
(CHEMBL3335630)
Show SMILES COCCOCc1ccc(CN2CCN(Cc3ccc(cc3)C(=O)Nc3ccc(cc3)C#CC34CC5CC(CC(C5)C3)C4)[C@@H](C)C2)cn1
Show InChI InChI=1/C41H50N4O3/c1-30-26-44(27-33-7-12-39(42-25-33)29-48-18-17-47-2)15-16-45(30)28-32-3-8-37(9-4-32)40(46)43-38-10-5-31(6-11-38)13-14-41-22-34-19-35(23-41)21-36(20-34)24-41/h3-12,25,30,34-36H,15-24,26-29H2,1-2H3,(H,43,46)/t30-,34?,35?,36?,41?/s2
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n/an/a 0.470n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058757
PNG
(CHEMBL3335423)
Show SMILES O=C(Nc1ccc(cc1)C#CC12CC3CC(CC(C3)C1)C2)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C36H40N4O/c41-35(33-7-3-28(4-8-33)25-39-14-16-40(17-15-39)26-29-2-1-13-37-24-29)38-34-9-5-27(6-10-34)11-12-36-21-30-18-31(22-36)20-32(19-30)23-36/h1-10,13,24,30-32H,14-23,25-26H2,(H,38,41)
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n/an/a 0.970n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058753
PNG
(CHEMBL3335427)
Show SMILES COCc1ccc(CN2CCN(Cc3ccc(cc3)C(=O)Nc3ccc(cc3)C#CC34CC5CC(CC(C5)C3)C4)[C@@H](C)C2)cn1
Show InChI InChI=1/C39H46N4O2/c1-28-24-42(25-31-7-12-37(27-45-2)40-23-31)15-16-43(28)26-30-3-8-35(9-4-30)38(44)41-36-10-5-29(6-11-36)13-14-39-20-32-17-33(21-39)19-34(18-32)22-39/h3-12,23,28,32-34H,15-22,24-27H2,1-2H3,(H,41,44)/t28-,32?,33?,34?,39?/s2
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n/an/a 1.10n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058754
PNG
(CHEMBL3335426)
Show SMILES C[C@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C#CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1/C37H42N4O/c1-27-24-40(25-30-3-2-14-38-23-30)15-16-41(27)26-29-4-8-34(9-5-29)36(42)39-35-10-6-28(7-11-35)12-13-37-20-31-17-32(21-37)19-33(18-31)22-37/h2-11,14,23,27,31-33H,15-22,24-26H2,1H3,(H,39,42)/t27-,31?,32?,33?,37?/s2
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n/an/a 2.60n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058760
PNG
(CHEMBL3335421)
Show SMILES O=C(Nc1ccc(cc1)C#CC1CCCCC1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C32H36N4O/c37-32(34-31-16-12-27(13-17-31)9-8-26-5-2-1-3-6-26)30-14-10-28(11-15-30)24-35-19-21-36(22-20-35)25-29-7-4-18-33-23-29/h4,7,10-18,23,26H,1-3,5-6,19-22,24-25H2,(H,34,37)
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n/an/a 3.10n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058766
PNG
(CHEMBL3335415)
Show SMILES C[C@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C26H27F3N4O/c1-19-16-32(17-21-3-2-12-30-15-21)13-14-33(19)18-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/s2
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n/an/a 3.30n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058755
PNG
(CHEMBL3335425)
Show SMILES Nc1ncccc1C(=O)N1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C#CC23CC4CC(CC(C4)C2)C3)CC1
Show InChI InChI=1S/C36H39N5O2/c37-33-32(2-1-13-38-33)35(43)41-16-14-40(15-17-41)24-26-3-7-30(8-4-26)34(42)39-31-9-5-25(6-10-31)11-12-36-21-27-18-28(22-36)20-29(19-27)23-36/h1-10,13,27-29H,14-24H2,(H2,37,38)(H,39,42)
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n/an/a 5.80n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058762
PNG
(CHEMBL3335419)
Show SMILES O=C(Nc1ccc(cc1)C#Cc1ccccc1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C32H30N4O/c37-32(34-31-16-12-27(13-17-31)9-8-26-5-2-1-3-6-26)30-14-10-28(11-15-30)24-35-19-21-36(22-20-35)25-29-7-4-18-33-23-29/h1-7,10-18,23H,19-22,24-25H2,(H,34,37)
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n/an/a 7.90n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058770
PNG
(CHEMBL3335411)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4ccncc4)CC3)cc2)cc1
Show InChI InChI=1S/C25H25F3N4O/c26-25(27,28)22-5-7-23(8-6-22)30-24(33)21-3-1-19(2-4-21)17-31-13-15-32(16-14-31)18-20-9-11-29-12-10-20/h1-12H,13-18H2,(H,30,33)
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n/an/a 7.90n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058771
PNG
(CHEMBL3335410)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4ccccc4)CC3)cc2)cc1
Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)23-10-12-24(13-11-23)30-25(33)22-8-6-21(7-9-22)19-32-16-14-31(15-17-32)18-20-4-2-1-3-5-20/h1-13H,14-19H2,(H,30,33)
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n/an/a 13n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058765
PNG
(CHEMBL3335416)
Show SMILES C[C@@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C26H27F3N4O/c1-19-16-32(17-21-3-2-12-30-15-21)13-14-33(19)18-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/s2
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n/an/a 13n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058768
PNG
(CHEMBL3335413)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4cccnc4)CC3)cc2)cc1
Show InChI InChI=1S/C25H25F3N4O/c26-25(27,28)22-7-9-23(10-8-22)30-24(33)21-5-3-19(4-6-21)17-31-12-14-32(15-13-31)18-20-2-1-11-29-16-20/h1-11,16H,12-15,17-18H2,(H,30,33)
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n/an/a 14n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058756
PNG
(CHEMBL3335424)
Show SMILES Nc1ncccc1C(=O)N1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C#Cc2ccccc2)CC1
Show InChI InChI=1S/C32H29N5O2/c33-30-29(7-4-18-34-30)32(39)37-21-19-36(20-22-37)23-26-10-14-27(15-11-26)31(38)35-28-16-12-25(13-17-28)9-8-24-5-2-1-3-6-24/h1-7,10-18H,19-23H2,(H2,33,34)(H,35,38)
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n/an/a 21n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058764
PNG
(CHEMBL3335417)
Show SMILES C[C@@H]1CN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C(F)(F)F)CCN1Cc1cccnc1
Show InChI InChI=1/C26H27F3N4O/c1-19-16-32(13-14-33(19)18-21-3-2-12-30-15-21)17-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/s2
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n/an/a 30n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058761
PNG
(CHEMBL3335420)
Show SMILES O=C(Nc1ccc(cc1)C#Cc1cccnc1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C31H29N5O/c37-31(34-30-13-9-25(10-14-30)5-6-26-3-1-15-32-21-26)29-11-7-27(8-12-29)23-35-17-19-36(20-18-35)24-28-4-2-16-33-22-28/h1-4,7-16,21-22H,17-20,23-24H2,(H,34,37)
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n/an/a 34n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058763
PNG
(CHEMBL3335418)
Show SMILES C[C@H]1CN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C(F)(F)F)CCN1Cc1cccnc1
Show InChI InChI=1/C26H27F3N4O/c1-19-16-32(13-14-33(19)18-21-3-2-12-30-15-21)17-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/s2
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n/an/a 35n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058769
PNG
(CHEMBL3335412)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CC3CCN(Cc4ccncc4)CC3)cc2)cc1
Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)23-5-7-24(8-6-23)31-25(33)22-3-1-19(2-4-22)17-20-11-15-32(16-12-20)18-21-9-13-30-14-10-21/h1-10,13-14,20H,11-12,15-18H2,(H,31,33)
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n/an/a 110n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058767
PNG
(CHEMBL3335414)
Show SMILES CN(CCN(C)Cc1cccnc1)Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O/c1-31(14-15-32(2)18-20-4-3-13-29-16-20)17-19-5-7-21(8-6-19)24(33)30-23-11-9-22(10-12-23)25(26,27)28/h3-13,16H,14-15,17-18H2,1-2H3,(H,30,33)
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n/an/a 120n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058758
PNG
(CHEMBL3335422)
Show SMILES OC1(CCCCC1)C#Cc1ccc(NC(=O)c2ccc(CN3CCN(Cc4cccnc4)CC3)cc2)cc1
Show InChI InChI=1S/C32H36N4O2/c37-31(34-30-12-8-26(9-13-30)14-17-32(38)15-2-1-3-16-32)29-10-6-27(7-11-29)24-35-19-21-36(22-20-35)25-28-5-4-18-33-23-28/h4-13,18,23,38H,1-3,15-16,19-22,24-25H2,(H,34,37)
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n/an/a>200n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058778
PNG
(CHEMBL3335403)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)cn2)cc1
Show InChI InChI=1S/C18H18F3N3O2/c19-18(20,21)14-2-4-15(5-3-14)23-17(25)16-6-1-13(11-22-16)12-24-7-9-26-10-8-24/h1-6,11H,7-10,12H2,(H,23,25)
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n/an/a 230n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058783
PNG
(CHEMBL3335135)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)cc2)cc1
Show InChI InChI=1S/C19H19F3N2O2/c20-19(21,22)16-5-7-17(8-6-16)23-18(25)15-3-1-14(2-4-15)13-24-9-11-26-12-10-24/h1-8H,9-13H2,(H,23,25)
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n/an/a 280n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058784
PNG
(CHEMBL3335134)
Show SMILES Ic1ccc(NC(=O)c2ccc(CN3CCOCC3)cc2)cc1
Show InChI InChI=1S/C18H19IN2O2/c19-16-5-7-17(8-6-16)20-18(22)15-3-1-14(2-4-15)13-21-9-11-23-12-10-21/h1-8H,9-13H2,(H,20,22)
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n/an/a 560n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058775
PNG
(CHEMBL3335406)
Show SMILES FC(F)(F)c1ccc(\C=C\c2ccc(CN3CCOCC3)cc2)cc1
Show InChI InChI=1S/C20H20F3NO/c21-20(22,23)19-9-7-17(8-10-19)2-1-16-3-5-18(6-4-16)15-24-11-13-25-14-12-24/h1-10H,11-15H2/b2-1+
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n/an/a 880n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058776
PNG
(CHEMBL3335405)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)s2)cc1
Show InChI InChI=1S/C17H17F3N2O2S/c18-17(19,20)12-1-3-13(4-2-12)21-16(23)15-6-5-14(25-15)11-22-7-9-24-10-8-22/h1-6H,7-11H2,(H,21,23)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058773
PNG
(CHEMBL3335408)
Show SMILES Cl.CN(C(=O)c1ccc(CN2CCOCC2)cc1)c1ccc(I)cc1
Show InChI InChI=1S/C19H21IN2O2.ClH/c1-21(18-8-6-17(20)7-9-18)19(23)16-4-2-15(3-5-16)14-22-10-12-24-13-11-22;/h2-9H,10-14H2,1H3;1H
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n/an/a 2.20E+3n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058785
PNG
(CHEMBL3335136)
Show SMILES Ic1cccc(NC(=O)c2ccc(CN3CCOCC3)cc2)c1
Show InChI InChI=1S/C18H19IN2O2/c19-16-2-1-3-17(12-16)20-18(22)15-6-4-14(5-7-15)13-21-8-10-23-11-9-21/h1-7,12H,8-11,13H2,(H,20,22)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058772
PNG
(CHEMBL3335409)
Show SMILES Ic1ccc(cc1)C(=O)Nc1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C18H19IN2O2/c19-16-5-3-15(4-6-16)18(22)20-17-7-1-14(2-8-17)13-21-9-11-23-12-10-21/h1-8H,9-13H2,(H,20,22)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058774
PNG
(CHEMBL3335407)
Show SMILES Ic1ccc(NCc2ccc(CN3CCOCC3)cc2)cc1
Show InChI InChI=1S/C18H21IN2O/c19-17-5-7-18(8-6-17)20-13-15-1-3-16(4-2-15)14-21-9-11-22-12-10-21/h1-8,20H,9-14H2
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n/an/a 2.50E+3n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058781
PNG
(CHEMBL3335139)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)cc2)nc1
Show InChI InChI=1S/C18H18F3N3O2/c19-18(20,21)15-5-6-16(22-11-15)23-17(25)14-3-1-13(2-4-14)12-24-7-9-26-10-8-24/h1-6,11H,7-10,12H2,(H,22,23,25)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058777
PNG
(CHEMBL3335404)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)nc2)cc1
Show InChI InChI=1S/C18H18F3N3O2/c19-18(20,21)14-2-5-15(6-3-14)23-17(25)13-1-4-16(22-11-13)12-24-7-9-26-10-8-24/h1-6,11H,7-10,12H2,(H,23,25)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058787
PNG
(CHEMBL3335137)
Show SMILES O=C(Nc1ccccc1)c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C18H20N2O2/c21-18(19-17-4-2-1-3-5-17)16-8-6-15(7-9-16)14-20-10-12-22-13-11-20/h1-9H,10-14H2,(H,19,21)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058779
PNG
(CHEMBL3335402)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccccc2CN2CCOCC2)cc1
Show InChI InChI=1S/C19H19F3N2O2/c20-19(21,22)15-5-7-16(8-6-15)23-18(25)17-4-2-1-3-14(17)13-24-9-11-26-12-10-24/h1-8H,9-13H2,(H,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058780
PNG
(CHEMBL3335401)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2cccc(CN3CCOCC3)c2)cc1
Show InChI InChI=1S/C19H19F3N2O2/c20-19(21,22)16-4-6-17(7-5-16)23-18(25)15-3-1-2-14(12-15)13-24-8-10-26-11-9-24/h1-7,12H,8-11,13H2,(H,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105308
PNG
(CHEMBL3597784)
Show SMILES Fc1cc(Br)cc(c1)[C@@H]1C[C@H](c2ccccc2)n2nnnc2N1
Show InChI InChI=1/C16H13BrFN5/c17-12-6-11(7-13(18)8-12)14-9-15(10-4-2-1-3-5-10)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/s2
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n/an/a 1.01E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058782
PNG
(CHEMBL3335133)
Show SMILES COc1ccc(NC(=O)c2ccc(CN3CCOCC3)cc2)cc1
Show InChI InChI=1S/C19H22N2O3/c1-23-18-8-6-17(7-9-18)20-19(22)16-4-2-15(3-5-16)14-21-10-12-24-13-11-21/h2-9H,10-14H2,1H3,(H,20,22)
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n/an/a 1.39E+4n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105274
PNG
(CHEMBL3597696)
Show SMILES Clc1ccccc1[C@H]1C[C@H](Nc2nnnn12)c1cccc(Br)c1
Show InChI InChI=1/C16H13BrClN5/c17-11-5-3-4-10(8-11)14-9-15(12-6-1-2-7-13(12)18)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/s2
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n/an/a 1.59E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058786
PNG
(CHEMBL3335138)
Show SMILES Ic1ccccc1NC(=O)c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C18H19IN2O2/c19-16-3-1-2-4-17(16)20-18(22)15-7-5-14(6-8-15)13-21-9-11-23-12-10-21/h1-8H,9-13H2,(H,20,22)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105280
PNG
(CHEMBL3597780)
Show SMILES Clc1ccc(Br)cc1[C@H]1C[C@H](Nc2nnnn12)c1cccc(Br)c1
Show InChI InChI=1/C16H12Br2ClN5/c17-10-3-1-2-9(6-10)14-8-15(24-16(20-14)21-22-23-24)12-7-11(18)4-5-13(12)19/h1-7,14-15H,8H2,(H,20,21,23)/t14-,15+/s2
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n/an/a 2.39E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105277
PNG
(CHEMBL3597699)
Show SMILES Brc1cccc(c1)[C@H]1C[C@@H](c2cccc(Br)c2)n2nnnc2N1
Show InChI InChI=1/C16H13Br2N5/c17-12-5-1-3-10(7-12)14-9-15(11-4-2-6-13(18)8-11)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105278
PNG
(CHEMBL3597778)
Show SMILES Brc1cccc(c1)[C@@H]1C[C@H](c2cccc(I)c2)n2nnnc2N1
Show InChI InChI=1/C16H13BrIN5/c17-12-5-1-3-10(7-12)14-9-15(11-4-2-6-13(18)8-11)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105279
PNG
(CHEMBL3597779)
Show SMILES Brc1cccc(c1)[C@H]1C[C@@H](c2cccc(I)c2)n2nnnc2N1
Show InChI InChI=1/C16H13BrIN5/c17-12-5-1-3-10(7-12)14-9-15(11-4-2-6-13(18)8-11)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105304
PNG
(CHEMBL3597781)
Show SMILES Clc1ccc(Br)cc1[C@@H]1C[C@@H](Nc2nnnn12)c1cccc(Br)c1
Show InChI InChI=1/C16H12Br2ClN5/c17-10-3-1-2-9(6-10)14-8-15(24-16(20-14)21-22-23-24)12-7-11(18)4-5-13(12)19/h1-7,14-15H,8H2,(H,20,21,23)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105276
PNG
(CHEMBL3597698)
Show SMILES Brc1cccc(c1)[C@@H]1C[C@H](c2cccc(Br)c2)n2nnnc2N1
Show InChI InChI=1/C16H13Br2N5/c17-12-5-1-3-10(7-12)14-9-15(11-4-2-6-13(18)8-11)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105273
PNG
(CHEMBL3597695)
Show SMILES Brc1cccc(c1)[C@H]1C[C@@H](c2ccccc2Br)n2nnnc2N1
Show InChI InChI=1/C16H13Br2N5/c17-11-5-3-4-10(8-11)14-9-15(12-6-1-2-7-13(12)18)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105271
PNG
(CHEMBL3597693)
Show SMILES Ic1cccc(c1)[C@H]1C[C@@H](c2ccccc2)n2nnnc2N1
Show InChI InChI=1/C16H14IN5/c17-13-8-4-7-12(9-13)14-10-15(11-5-2-1-3-6-11)22-16(18-14)19-20-21-22/h1-9,14-15H,10H2,(H,18,19,21)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105270
PNG
(CHEMBL3597692)
Show SMILES Ic1cccc(c1)[C@@H]1C[C@H](c2ccccc2)n2nnnc2N1
Show InChI InChI=1/C16H14IN5/c17-13-8-4-7-12(9-13)14-10-15(11-5-2-1-3-6-11)22-16(18-14)19-20-21-22/h1-9,14-15H,10H2,(H,18,19,21)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105269
PNG
(CHEMBL3597691)
Show SMILES Brc1cccc(c1)[C@H]1C[C@@H](c2ccccc2)n2nnnc2N1
Show InChI InChI=1/C16H14BrN5/c17-13-8-4-7-12(9-13)14-10-15(11-5-2-1-3-6-11)22-16(18-14)19-20-21-22/h1-9,14-15H,10H2,(H,18,19,21)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105268
PNG
(CHEMBL3597690)
Show SMILES Brc1cccc(c1)[C@@H]1C[C@H](c2ccccc2)n2nnnc2N1
Show InChI InChI=1/C16H14BrN5/c17-13-8-4-7-12(9-13)14-10-15(11-5-2-1-3-6-11)22-16(18-14)19-20-21-22/h1-9,14-15H,10H2,(H,18,19,21)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105312
PNG
(CHEMBL3597787)
Show SMILES Fc1cc(Br)cc(c1)[C@H]1C[C@@H](c2cccc(Br)c2)n2nnnc2N1
Show InChI InChI=1/C16H12Br2FN5/c17-11-3-1-2-9(4-11)15-8-14(20-16-21-22-23-24(15)16)10-5-12(18)7-13(19)6-10/h1-7,14-15H,8H2,(H,20,21,23)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105275
PNG
(CHEMBL3597697)
Show SMILES Clc1ccccc1[C@@H]1C[C@@H](Nc2nnnn12)c1cccc(Br)c1
Show InChI InChI=1/C16H13BrClN5/c17-11-5-3-4-10(8-11)14-9-15(12-6-1-2-7-13(12)18)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)

More data for this
Ligand-Target Pair
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