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Compile Data Set for Download or QSAR

Found 24 hits Enz. Inhib. hit(s) with Target = 'Hypoxia-inducible factor 1 (FIH)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM26108
PNG
((2R)-2-(formamidoformic acid)-4-phenylbutanoic aci...)
Show SMILES OC(=O)[C@@H](CCc1ccccc1)NC(=O)C(O)=O
Show InChI InChI=1S/C12H13NO5/c14-10(12(17)18)13-9(11(15)16)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,13,14)(H,15,16)(H,17,18)/t9-/m1/s1
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8.30E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of asparaginyl hydroxylase factor-inhibiting-HIF


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM26106
PNG
(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Show SMILES OC(=O)CNC(=O)C(O)=O
Show InChI InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
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1.20E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of asparaginyl hydroxylase factor-inhibiting-HIF


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 1.02E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FIH1


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50361473
PNG
(CHEMBL1435274)
Show SMILES OC(=O)c1ccnc2c(O)cccc12
Show InChI InChI=1S/C10H7NO3/c12-8-3-1-2-6-7(10(13)14)4-5-11-9(6)8/h1-5,12H,(H,13,14)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Kyoto Prefectural University of Medicine

Curated by ChEMBL


Assay Description
Inhibition of FIH


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50361475
PNG
(CHEMBL1938900)
Show SMILES ON(CCCCNCc1ccc(COC(=O)Nc2cccc3ccccc23)cc1)C(=O)C=CC(O)=O
Show InChI InChI=1S/C27H29N3O6/c31-25(14-15-26(32)33)30(35)17-4-3-16-28-18-20-10-12-21(13-11-20)19-36-27(34)29-24-9-5-7-22-6-1-2-8-23(22)24/h1-2,5-15,28,35H,3-4,16-19H2,(H,29,34)(H,32,33)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Kyoto Prefectural University of Medicine

Curated by ChEMBL


Assay Description
Inhibition of FIH


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50304610
PNG
(3-(5-(2-methoxybenzylidene)-4-oxo-2-thioxothiazoli...)
Show SMILES COc1ccccc1\C=C1/SC(=S)N(CCC(=O)Nc2ccc(cc2)S(N)(=O)=O)C1=O
Show InChI InChI=1S/C20H19N3O5S3/c1-28-16-5-3-2-4-13(16)12-17-19(25)23(20(29)30-17)11-10-18(24)22-14-6-8-15(9-7-14)31(21,26)27/h2-9,12H,10-11H2,1H3,(H,22,24)(H2,21,26,27)/b17-12-
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n/an/a 3.21E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FIH1


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50304612
PNG
(2-(5-((3-(4-(ethylthio)phenyl)-1-phenyl-1H-pyrazol...)
Show SMILES CCSc1ccc(cc1)-c1nn(cc1\C=C1\SC(=S)N(CC(O)=O)C1=O)-c1ccccc1
Show InChI InChI=1S/C23H19N3O3S3/c1-2-31-18-10-8-15(9-11-18)21-16(13-26(24-21)17-6-4-3-5-7-17)12-19-22(29)25(14-20(27)28)23(30)32-19/h3-13H,2,14H2,1H3,(H,27,28)/b19-12+
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n/an/a 3.62E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FIH1


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50304617
PNG
(6-((2-methoxyphenoxy)methyl)-3-(quinolin-2-yl)thia...)
Show SMILES COc1ccccc1OCc1cn2c(nnc2s1)-c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16N4O2S/c1-26-18-8-4-5-9-19(18)27-13-15-12-25-20(23-24-21(25)28-15)17-11-10-14-6-2-3-7-16(14)22-17/h2-12H,13H2,1H3
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n/an/a 4.14E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FIH1


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50304614
PNG
(CHEMBL594893 | N-(benzo[c][1,2,5]oxadiazol-4-yl)-2...)
Show SMILES COc1cccc(\C=C2/SC(=S)N(CC(=O)Nc3cccc4nonc34)C2=O)c1
Show InChI InChI=1S/C19H14N4O4S2/c1-26-12-5-2-4-11(8-12)9-15-18(25)23(19(28)29-15)10-16(24)20-13-6-3-7-14-17(13)22-27-21-14/h2-9H,10H2,1H3,(H,20,24)/b15-9-
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n/an/a 4.53E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FIH1


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50304616
PNG
(6-(2-methoxystyryl)-3-(quinolin-2-yl)thiazolo[2,3-...)
Show SMILES COc1ccccc1\C=C\c1cn2c(nnc2s1)-c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16N4OS/c1-27-20-9-5-3-7-16(20)10-12-17-14-26-21(24-25-22(26)28-17)19-13-11-15-6-2-4-8-18(15)23-19/h2-14H,1H3/b12-10+
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n/an/a 4.75E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FIH1


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50304613
PNG
(CHEMBL593127 | N-(benzo[c][1,2,5]oxadiazol-4-yl)-3...)
Show SMILES O=C(CCN1C(=S)S\C(=C\C=C\c2ccco2)C1=O)Nc1cccc2nonc12
Show InChI InChI=1S/C19H14N4O4S2/c24-16(20-13-6-2-7-14-17(13)22-27-21-14)9-10-23-18(25)15(29-19(23)28)8-1-4-12-5-3-11-26-12/h1-8,11H,9-10H2,(H,20,24)/b4-1+,15-8+
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n/an/a 4.86E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FIH1


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50304611
PNG
(3-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-o...)
Show SMILES OC(=O)CCN1C(=S)S\C(=C\c2ccc(o2)-c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C17H12ClNO4S2/c18-11-3-1-10(2-4-11)13-6-5-12(23-13)9-14-16(22)19(17(24)25-14)8-7-15(20)21/h1-6,9H,7-8H2,(H,20,21)/b14-9+
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n/an/a 6.60E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FIH1


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50304615
PNG
(CHEMBL593738 | N-(benzo[c][1,2,5]oxadiazol-4-yl)-3...)
Show SMILES COc1cccc(\C=C2/SC(=S)N(CCC(=O)Nc3cccc4nonc34)C2=O)c1
Show InChI InChI=1S/C20H16N4O4S2/c1-27-13-5-2-4-12(10-13)11-16-19(26)24(20(29)30-16)9-8-17(25)21-14-6-3-7-15-18(14)23-28-22-15/h2-7,10-11H,8-9H2,1H3,(H,21,25)/b16-11-
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n/an/a 7.31E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FIH1


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50395076
PNG
(CHEMBL2164243)
Show SMILES CN(C)NC(=O)CCC(O)=O
Show InChI InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human FIH expressed in Escherichia coli by MALDI assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50197063
PNG
(4,6-dioxoheptanoic acid | CHEMBL222824 | succinyla...)
Show SMILES CC(=O)CC(=O)CCC(O)=O
Show InChI InChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human FIH expressed in Escherichia coli by MALDI assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50395081
PNG
(CHEMBL2164248)
Show SMILES CC(C)NC(=O)CCC(O)=O
Show InChI InChI=1S/C7H13NO3/c1-5(2)8-6(9)3-4-7(10)11/h5H,3-4H2,1-2H3,(H,8,9)(H,10,11)
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University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human FIH expressed in Escherichia coli by MALDI assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50395082
PNG
(CHEMBL2164247)
Show SMILES CN(C)N(C)C(=O)CCC(O)=O
Show InChI InChI=1S/C7H14N2O3/c1-8(2)9(3)6(10)4-5-7(11)12/h4-5H2,1-3H3,(H,11,12)
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University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human FIH expressed in Escherichia coli by MALDI assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50129197
PNG
(4-(Hydroxyamino)-4-oxobutanoic acid | CHEMBL51979 ...)
Show SMILES ONC(=O)CCC(O)=O
Show InChI InChI=1S/C4H7NO4/c6-3(5-9)1-2-4(7)8/h9H,1-2H2,(H,5,6)(H,7,8)
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University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human FIH expressed in Escherichia coli by MALDI assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50395083
PNG
(CHEMBL2164246)
Show SMILES NNC(=O)CCC(O)=O
Show InChI InChI=1S/C4H8N2O3/c5-6-3(7)1-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)
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University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human FIH expressed in Escherichia coli by MALDI assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50395078
PNG
(CHEMBL2164245)
Show SMILES CNNC(=O)CCC(O)=O
Show InChI InChI=1S/C5H10N2O3/c1-6-7-4(8)2-3-5(9)10/h6H,2-3H2,1H3,(H,7,8)(H,9,10)
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University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human FIH expressed in Escherichia coli by MALDI assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50395079
PNG
(CHEMBL2164244)
Show SMILES C[N+](C)(C)NC(=O)CCC(O)=O
Show InChI InChI=1S/C7H14N2O3/c1-9(2,3)8-6(10)4-5-7(11)12/h4-5H2,1-3H3,(H-,8,10,11,12)/p+1
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University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human FIH expressed in Escherichia coli by MALDI assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50395077
PNG
(CHEMBL2164250)
Show SMILES CN(C)NC(=O)CCC(=O)NN(C)C
Show InChI InChI=1S/C8H18N4O2/c1-11(2)9-7(13)5-6-8(14)10-12(3)4/h5-6H2,1-4H3,(H,9,13)(H,10,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human FIH expressed in Escherichia coli by MALDI assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM223320
PNG
(KDOAM-25)
Show SMILES CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(N)=O
Show InChI InChI=1S/C15H25N5O2/c1-4-20(8-7-19(2)3)14(21)11-17-10-13-9-12(15(16)22)5-6-18-13/h5-6,9,17H,4,7-8,10-11H2,1-3H3,(H2,16,22)
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n/an/a<1.00E+5n/an/an/an/an/an/a



University of Oxford





Cell Chem Biol 24: 371-380 (2017)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 (FIH)


(Homo sapiens (Human))
BDBM50395080
PNG
(CHEMBL2164249)
Show SMILES CN(C)OC(=O)CCC(O)=O
Show InChI InChI=1S/C6H11NO4/c1-7(2)11-6(10)4-3-5(8)9/h3-4H2,1-2H3,(H,8,9)
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University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human FIH expressed in Escherichia coli by MALDI assay


Citation and Details
More data for this
Ligand-Target Pair