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Found 84 hits Enz. Inhib. hit(s) with Target = 'Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM105221
PNG
(US8580778, 21)
Show SMILES FC1(F)CN(C1)c1cc(ncn1)-n1[nH]cc(-n2cc(nn2)C#N)c1=O
Show InChI InChI=1S/C13H9F2N9O/c14-13(15)5-22(6-13)10-1-11(18-7-17-10)24-12(25)9(3-19-24)23-4-8(2-16)20-21-23/h1,3-4,7,19H,5-6H2
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US Patent
n/an/a 70n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...


US Patent US8580778 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM105220
PNG
(US8580778, 20)
Show SMILES FC1(F)CN(C1)c1cc(ncn1)-n1[nH]cc(-n2cnc(c2)C#N)c1=O
Show InChI InChI=1S/C14H10F2N8O/c15-14(16)5-23(6-14)11-1-12(19-7-18-11)24-13(25)10(3-21-24)22-4-9(2-17)20-8-22/h1,3-4,7-8,21H,5-6H2
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n/an/a 90n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...


US Patent US8580778 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM105219
PNG
(US8580778, 17)
Show SMILES FC1(F)CCN(C1)c1cc(ncn1)-n1[nH]cc(-n2cc(nn2)C#N)c1=O
Show InChI InChI=1S/C14H11F2N9O/c15-14(16)1-2-23(7-14)11-3-12(19-8-18-11)25-13(26)10(5-20-25)24-6-9(4-17)21-22-24/h3,5-6,8,20H,1-2,7H2
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n/an/a 130n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...


US Patent US8580778 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM105224
PNG
(US8580778, 29)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCO1)-n1cc(nn1)C#N
Show InChI InChI=1S/C14H13N9O2/c15-6-10-8-21(20-19-10)11-7-18-23(14(11)24)13-5-12(16-9-17-13)22-3-1-2-4-25-22/h5,7-9,18H,1-4H2
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n/an/a 170n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...


US Patent US8580778 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM105222
PNG
(US8580778, 25)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCOCC1)-n1cnc(c1)C#N
Show InChI InChI=1S/C16H16N8O2/c17-7-12-9-23(11-20-12)13-8-21-24(16(13)25)15-6-14(18-10-19-15)22-2-1-4-26-5-3-22/h6,8-11,21H,1-5H2
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n/an/a 180n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...


US Patent US8580778 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3527
PNG
(US8524699, 18)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-c1cccnc1
Show InChI InChI=1S/C16H16N6O2/c23-16-13(12-2-1-3-17-9-12)10-20-22(16)15-8-14(18-11-19-15)21-4-6-24-7-5-21/h1-3,8-11,20H,4-7H2
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n/an/a 180n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50042876
PNG
(CHEMBL332005 | [2,2']Bipyridinyl-5,5'-dicarboxylic...)
Show SMILES OC(=O)c1ccc(nc1)-c1ccc(cn1)C(O)=O
Show InChI InChI=1S/C12H8N2O4/c15-11(16)7-1-3-9(13-5-7)10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)
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n/an/a 185n/an/an/an/an/an/a



Zeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumna


J Med Chem 36: 3853-8 (1994)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50042876
PNG
(CHEMBL332005 | [2,2']Bipyridinyl-5,5'-dicarboxylic...)
Show SMILES OC(=O)c1ccc(nc1)-c1ccc(cn1)C(O)=O
Show InChI InChI=1S/C12H8N2O4/c15-11(16)7-1-3-9(13-5-7)10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)
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n/an/a 190n/an/an/an/an/an/a



Zeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumna


J Med Chem 36: 3853-8 (1994)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109268
PNG
(US8609698, 10)
Show SMILES OC(=O)c1ccc(nc1)-n1[nH]cc(-c2cncc(Br)c2)c1=O
Show InChI InChI=1S/C14H9BrN4O3/c15-10-3-9(4-16-6-10)11-7-18-19(13(11)20)12-2-1-8(5-17-12)14(21)22/h1-7,18H,(H,21,22)
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n/an/a 260n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50042873
PNG
(5'-(4-Ethoxy-phenylcarbamoyl)-[2,2']bipyridinyl-5-...)
Show SMILES CCOc1ccc(NC(=O)c2ccc(nc2)-c2ccc(cn2)C(O)=O)cc1
Show InChI InChI=1S/C20H17N3O4/c1-2-27-16-7-5-15(6-8-16)23-19(24)13-3-9-17(21-11-13)18-10-4-14(12-22-18)20(25)26/h3-12H,2H2,1H3,(H,23,24)(H,25,26)
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n/an/a 320n/an/an/an/an/an/a



Zeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumna


J Med Chem 36: 3853-8 (1994)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM105223
PNG
(US8580778, 26)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCOCC1)-n1cc(nn1)C#N
Show InChI InChI=1S/C15H15N9O2/c16-7-11-9-23(21-20-11)12-8-19-24(15(12)25)14-6-13(17-10-18-14)22-2-1-4-26-5-3-22/h6,8-10,19H,1-5H2
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n/an/a 380n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...


US Patent US8580778 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3543
PNG
(US8524699, 16)
Show SMILES Clc1ccc(cn1)-c1c[nH]n(-c2cc(ncn2)N2CCOCC2)c1=O
Show InChI InChI=1S/C16H15ClN6O2/c17-13-2-1-11(8-18-13)12-9-21-23(16(12)24)15-7-14(19-10-20-15)22-3-5-25-6-4-22/h1-2,7-10,21H,3-6H2
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n/an/a 480n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM105217
PNG
(US8580778, 5)
Show SMILES OC(=O)C1CN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O
Show InChI InChI=1S/C14H13N7O3/c22-13-10(19-2-1-15-8-19)4-18-21(13)12-3-11(16-7-17-12)20-5-9(6-20)14(23)24/h1-4,7-9,18H,5-6H2,(H,23,24)
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n/an/a 540n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...


US Patent US8580778 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3555
PNG
(US8524699, 3)
Show SMILES Cc1cc(C)n(n1)-c1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C17H15N7O/c1-11-6-12(2)23(22-11)15-7-16(20-10-19-15)24-17(25)14(9-21-24)13-4-3-5-18-8-13/h3-10,21H,1-2H3
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n/an/a 700n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM105218
PNG
(US8580778, 9)
Show SMILES CN(C)C1CN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C14H17N9O/c1-20(2)10-7-21(8-10)12-5-13(16-9-15-12)23-14(24)11(6-18-23)22-4-3-17-19-22/h3-6,9-10,18H,7-8H2,1-2H3
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n/an/a 760n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...


US Patent US8580778 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM105216
PNG
(US8580778, 2)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCN(CC1)C1CCC1)-n1ccnn1
Show InChI InChI=1S/C17H21N9O/c27-17-14(25-5-4-20-22-25)11-21-26(17)16-10-15(18-12-19-16)24-8-6-23(7-9-24)13-2-1-3-13/h4-5,10-13,21H,1-3,6-9H2
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n/an/a 880n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...


US Patent US8580778 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3591
PNG
(US8524699, 7)
Show SMILES Clc1ccc(cc1)-c1nnc(s1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C16H10ClN5OS/c17-12-5-3-10(4-6-12)14-20-21-16(24-14)22-15(23)13(9-19-22)11-2-1-7-18-8-11/h1-9,19H
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n/an/a 880n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3623
PNG
(US8524699, 28)
Show SMILES COCCN1CCN(CC1)c1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C19H23N7O2/c1-28-10-9-24-5-7-25(8-6-24)17-11-18(22-14-21-17)26-19(27)16(13-23-26)15-3-2-4-20-12-15/h2-4,11-14,23H,5-10H2,1H3
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n/an/a 890n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109271
PNG
(US8609698, 65)
Show SMILES Clc1cccc(Cl)c1NC(=O)NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C21H16Cl2N6O2/c22-16-4-1-5-17(23)19(16)28-21(31)26-10-13-6-8-25-18(9-13)29-20(30)15(12-27-29)14-3-2-7-24-11-14/h1-9,11-12,27H,10H2,(H2,26,28,31)
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n/an/a 900n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109269
PNG
(US8609698, 18)
Show SMILES CC(C)(C)NC(=O)c1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C18H19N5O2/c1-18(2,3)22-16(24)13-6-7-15(20-10-13)23-17(25)14(11-21-23)12-5-4-8-19-9-12/h4-11,21H,1-3H3,(H,22,24)
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n/an/a 910n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3629
PNG
(US8524699, 46)
Show SMILES O=c1c(c[nH]n1-c1cnccn1)-c1cccnc1
Show InChI InChI=1S/C12H9N5O/c18-12-10(9-2-1-3-13-6-9)7-16-17(12)11-8-14-4-5-15-11/h1-8,16H
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n/an/a 930n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50368560
PNG
(CHEMBL1744254)
Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(nc1)C([O-])=O
Show InChI InChI=1S/C14H12N2O6S/c1-22-10-3-5-11(6-4-10)23(20,21)16-13(17)9-2-7-12(14(18)19)15-8-9/h2-8H,1H3,(H,16,17)(H,18,19)/p-1
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n/an/a 1.00E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000409
PNG
(5-Benzenesulfonylaminocarbonyl-pyridine-2-carboxyl...)
Show SMILES OC(=O)c1ccc(cn1)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C13H10N2O5S/c16-12(9-6-7-11(13(17)18)14-8-9)15-21(19,20)10-4-2-1-3-5-10/h1-8H,(H,15,16)(H,17,18)
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n/an/a 1.10E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3643
PNG
(US8524699, 44)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCC1)-c1cncc(c1)C#N
Show InChI InChI=1S/C18H17N7O/c19-8-13-6-14(10-20-9-13)15-11-23-25(18(15)26)17-7-16(21-12-22-17)24-4-2-1-3-5-24/h6-7,9-12,23H,1-5H2
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n/an/a 1.12E+3n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50368564
PNG
(CHEMBL1203805)
Show SMILES CC(C)S(=O)(=O)NC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C10H12N2O5S/c1-6(2)18(16,17)12-9(13)7-3-4-8(10(14)15)11-5-7/h3-6H,1-2H3,(H,12,13)(H,14,15)
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n/an/a 1.60E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109272
PNG
(US8609698, 80)
Show SMILES Cc1ccccc1NC(=O)OCc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C22H19N5O3/c1-15-5-2-3-7-19(15)26-22(29)30-14-16-8-9-20(24-11-16)27-21(28)18(13-25-27)17-6-4-10-23-12-17/h2-13,25H,14H2,1H3,(H,26,29)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3644
PNG
(US8524699, 55)
Show SMILES CCN(CC)CCCCCCNc1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C22H31N7O/c1-3-28(4-2)13-8-6-5-7-12-24-20-14-21(26-17-25-20)29-22(30)19(16-27-29)18-10-9-11-23-15-18/h9-11,14-17,27H,3-8,12-13H2,1-2H3,(H,24,25,26)
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n/an/a 1.70E+3n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50368562
PNG
(CHEMBL1744252)
Show SMILES [O-]C(=O)c1ccc(cn1)C(=O)[N-]S(=O)(=O)c1cccc2cccnc12
Show InChI InChI=1S/C16H11N3O5S/c20-15(11-6-7-12(16(21)22)18-9-11)19-25(23,24)13-5-1-3-10-4-2-8-17-14(10)13/h1-9H,(H2,19,20,21,22)/p-2
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n/an/a 1.80E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50368565
PNG
(CHEMBL1203806)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C8H8N2O5S/c1-16(14,15)10-7(11)5-2-3-6(8(12)13)9-4-5/h2-4H,1H3,(H,10,11)(H,12,13)
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n/an/a 1.80E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50368561
PNG
(CHEMBL1744251)
Show SMILES [O-]C(=O)c1ccc(cn1)C(=O)[N-]S(=O)(=O)c1ccc(Cl)s1
Show InChI InChI=1S/C11H7ClN2O5S2/c12-8-3-4-9(20-8)21(18,19)14-10(15)6-1-2-7(11(16)17)13-5-6/h1-5H,(H2,14,15,16,17)/p-2
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n/an/a 2.40E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3698
PNG
(US8524699, 22)
Show SMILES O=c1c(c[nH]n1-c1ccc(nn1)-c1ccccc1)-c1cccnc1
Show InChI InChI=1S/C18H13N5O/c24-18-15(14-7-4-10-19-11-14)12-20-23(18)17-9-8-16(21-22-17)13-5-2-1-3-6-13/h1-12,20H
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n/an/a 2.70E+3n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3723
PNG
(US8524699, 6)
Show SMILES O=c1c(c[nH]n1-c1nc2ccccc2s1)-c1cccnc1
Show InChI InChI=1S/C15H10N4OS/c20-14-11(10-4-3-7-16-8-10)9-17-19(14)15-18-12-5-1-2-6-13(12)21-15/h1-9,17H
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n/an/a 2.80E+3n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000400
PNG
(5-Phenylmethanesulfonylaminocarbonyl-pyridine-2-ca...)
Show SMILES OC(=O)c1ccc(cn1)C(=O)NS(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C14H12N2O5S/c17-13(11-6-7-12(14(18)19)15-8-11)16-22(20,21)9-10-4-2-1-3-5-10/h1-8H,9H2,(H,16,17)(H,18,19)
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n/an/a 3.00E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109270
PNG
(US8609698, 22)
Show SMILES O=c1c(c[nH]n1-c1ccc(Cn2cccc2)cn1)-c1cccnc1
Show InChI InChI=1S/C18H15N5O/c24-18-16(15-4-3-7-19-11-15)12-21-23(18)17-6-5-14(10-20-17)13-22-8-1-2-9-22/h1-12,21H,13H2
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n/an/a 3.24E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109273
PNG
(US8609698, 89)
Show SMILES CC(C)(C)COc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C18H20N4O2/c1-18(2,3)12-24-14-6-7-16(20-10-14)22-17(23)15(11-21-22)13-5-4-8-19-9-13/h4-11,21H,12H2,1-3H3
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n/an/a 3.70E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3734
PNG
(US8524699, 26)
Show SMILES CN(C)CCOc1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C16H18N6O2/c1-21(2)6-7-24-15-8-14(18-11-19-15)22-16(23)13(10-20-22)12-4-3-5-17-9-12/h3-5,8-11,20H,6-7H2,1-2H3
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n/an/a 4.00E+3n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000438
PNG
(5-(4-Dimethylamino-phenylcarbamoyl)-pyridine-2-car...)
Show SMILES CN(C)c1ccc(NC(=O)c2ccc(nc2)C(O)=O)cc1
Show InChI InChI=1S/C15H15N3O3/c1-18(2)12-6-4-11(5-7-12)17-14(19)10-3-8-13(15(20)21)16-9-10/h3-9H,1-2H3,(H,17,19)(H,20,21)
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n/an/a 4.10E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


J Med Chem 35: 804-7 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000416
PNG
(5-(Naphthalene-1-sulfonylaminocarbonyl)-pyridine-2...)
Show SMILES OC(=O)c1ccc(cn1)C(=O)NS(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C17H12N2O5S/c20-16(12-8-9-14(17(21)22)18-10-12)19-25(23,24)15-7-3-5-11-4-1-2-6-13(11)15/h1-10H,(H,19,20)(H,21,22)
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n/an/a 4.40E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000430
PNG
(5-(4-Ethoxy-phenylcarbamoyl)-pyridine-2-carboxylic...)
Show SMILES CCOc1ccc(NC(=O)c2ccc(nc2)C(O)=O)cc1
Show InChI InChI=1S/C15H14N2O4/c1-2-21-12-6-4-11(5-7-12)17-14(18)10-3-8-13(15(19)20)16-9-10/h3-9H,2H2,1H3,(H,17,18)(H,19,20)
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n/an/a 5.00E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


J Med Chem 35: 804-7 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50042872
PNG
(3-phenylsulfonamidocarbonyl-6-(5-phenylsulfonamido...)
Show SMILES O=C(NS(=O)(=O)c1ccccc1)c1ccc(nc1)-c1ccc(cn1)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H18N4O6S2/c29-23(27-35(31,32)19-7-3-1-4-8-19)17-11-13-21(25-15-17)22-14-12-18(16-26-22)24(30)28-36(33,34)20-9-5-2-6-10-20/h1-16H,(H,27,29)(H,28,30)
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n/an/a 5.04E+3n/an/an/an/an/an/a



Zeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumna


J Med Chem 36: 3853-8 (1994)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM26114
PNG
(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Show SMILES OC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-5(7(11)12)8-3-4/h1-3H,(H,9,10)(H,11,12)
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n/an/a 5.18E+3n/an/an/an/an/an/a



Zeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumna


J Med Chem 36: 3853-8 (1994)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109267
PNG
(US8609698, 8)
Show SMILES Cc1ccnc(c1)-n1[nH]cc(-c2cncc(c2)C#N)c1=O
Show InChI InChI=1S/C15H11N5O/c1-10-2-3-18-14(4-10)20-15(21)13(9-19-20)12-5-11(6-16)7-17-8-12/h2-5,7-9,19H,1H3
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n/an/a 5.20E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM26114
PNG
(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Show SMILES OC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-5(7(11)12)8-3-4/h1-3H,(H,9,10)(H,11,12)
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n/an/a 5.50E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


J Med Chem 35: 804-7 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM26114
PNG
(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Show SMILES OC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-5(7(11)12)8-3-4/h1-3H,(H,9,10)(H,11,12)
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n/an/a 5.50E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109266
PNG
(US8609698, 5)
Show SMILES COCCNCc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C17H19N5O2/c1-24-8-7-19-9-13-4-5-16(20-10-13)22-17(23)15(12-21-22)14-3-2-6-18-11-14/h2-6,10-12,19,21H,7-9H2,1H3
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n/an/a 6.30E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50368563
PNG
(CHEMBL1744253)
Show SMILES [O-]C(=O)c1ccc(cn1)C(=O)[N-]S(=O)(=O)c1ccc(cc1)-c1cc(Cl)c2ccc(Cl)cc2n1
Show InChI InChI=1S/C22H13Cl2N3O5S/c23-14-4-7-16-17(24)10-19(26-20(16)9-14)12-1-5-15(6-2-12)33(31,32)27-21(28)13-3-8-18(22(29)30)25-11-13/h1-11H,(H2,27,28,29,30)/p-2
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n/an/a 6.60E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000437
PNG
(5-p-Tolylcarbamoyl-pyridine-2-carboxylic acid; ace...)
Show SMILES Cc1ccc(NC(=O)c2ccc(nc2)C(O)=O)cc1
Show InChI InChI=1S/C14H12N2O3/c1-9-2-5-11(6-3-9)16-13(17)10-4-7-12(14(18)19)15-8-10/h2-8H,1H3,(H,16,17)(H,18,19)
KEGG

UniProtKB/SwissProt

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antibodypedia
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AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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PubMed
n/an/a 8.30E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


J Med Chem 35: 804-7 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50368559
PNG
(CHEMBL1744255)
Show SMILES [O-]C(=O)c1ccc(cn1)C(=O)[N-]S(=O)(=O)c1cc(Br)c(Br)s1
Show InChI InChI=1S/C11H6Br2N2O5S2/c12-6-3-8(21-9(6)13)22(19,20)15-10(16)5-1-2-7(11(17)18)14-4-5/h1-4H,(H2,15,16,17,18)/p-2
KEGG

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PC cid
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PubMed
n/an/a 8.50E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000406
PNG
(5-(2-Carboxy-ethyl)-pyridine-2-carboxylic acid | C...)
Show SMILES OC(=O)CCc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C9H9NO4/c11-8(12)4-2-6-1-3-7(9(13)14)10-5-6/h1,3,5H,2,4H2,(H,11,12)(H,13,14)
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
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PubMed
n/an/a 9.60E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000414
PNG
(5-Carboxymethyl-pyridine-2-carboxylic acid | CHEMB...)
Show SMILES OC(=O)Cc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C8H7NO4/c10-7(11)3-5-1-2-6(8(12)13)9-4-5/h1-2,4H,3H2,(H,10,11)(H,12,13)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
n/an/a 9.60E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase


J Med Chem 35: 800-4 (1992)

More data for this
Ligand-Target Pair
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